Neville Sanjana
@nevillesanjana.bsky.social
📤 1069
đź“Ą 112
đź“ť 87
Scientist at the New York Genome Center & NYU.
http://sanjanalab.org
Night Science is coming to NYGC!
add a skeleton here at some point
5 months ago
0
6
2
reposted by
Neville Sanjana
Matthew Cobb
5 months ago
Whimsical footnote from my CRICK biography. Amber was a renowned mutation in a bacteriophage virus that stopped protein synthesis (so, “end of message” or “stop”). Its RNA codon is UAG.
0
26
9
reposted by
Neville Sanjana
Markus Elsner
6 months ago
This is wild
add a skeleton here at some point
0
6
1
Amazing addition to
@nygenome.org
— very lucky to have a pioneer in functional genomics joining us. Welcome Bing! 🚀🚀🚀
add a skeleton here at some point
6 months ago
0
11
1
Enjoyed participating in this far-ranging podcast about CRISPR and genome editing and its transformative impact on human health — and even more important in these challenging times.
www.thenakedscientists.com/podcasts/nak...
loading . . .
CRISPR, and the ethics of gene editing
The potential and the philosophy...
https://www.thenakedscientists.com/podcasts/naked-scientists-podcast/crispr-and-ethics-gene-editing
7 months ago
0
4
1
reposted by
Neville Sanjana
Juanma Schvartzman
7 months ago
A patient reminded me of science’s power: 2 doses of immunotherapy and a fatal cancer GONE. Immunotherapy exists BECAUSE of basic research—work that can seem esoteric or wasteful. Before dismissing it, ask a scientist why it matters. Or ask the Nobel who discovered immunotherapy.
1
4
2
🔷 📰 BLUETORIAL time! 📰 🔷 Excited to share recent work from our lab on noncoding genomics 🔎🧬: High-resolution CRISPR perturbations of the MYC TAD (~3 Mb) in 6 different human cancer cell lines
www.nature.com/articles/s41...
loading . . .
Comprehensive dissection of cis-regulatory elements in a 2.8 Mb topologically associated domain in six human cancers - Nature Communications
The oncogene MYC plays a key role in cancer initiation and progression. Using thousands of CRISPR perturbations, the authors investigate regulators of MYC in six different cancers. These tumor-specifi...
https://www.nature.com/articles/s41467-025-56568-5
7 months ago
1
25
6
Wise words from Tom Maniatis — who helped launch the biotech revolution, which brought SO MANY health & tech advances in the ~50 years since the advent of programmable gene manipulation.
www.cell.com/cell/fulltex...
7 months ago
1
14
3
reposted by
Neville Sanjana
Nature Biotechnology
8 months ago
Precise RNA targeting with CRISPR–Cas13d -
@nevillesanjana.bsky.social
go.nature.com/4gEn95x
loading . . .
Precise RNA targeting with CRISPR–Cas13d - Nature Biotechnology
Careful selection of Cas13 variants and delivery methods minimizes collateral RNA degradation.
https://go.nature.com/4gEn95x
0
19
7
🎇🎄Some holiday reading: Overdue TWEETORIAL on the latest preprint from our lab 🎇🎄 In this work, superstar postdoc
@xinhexue.bsky.social
combined 2 kinds of pooled CRISPR screens to pinpoint noncoding regulatory elements and the transcription factors that activate these elements.
9 months ago
2
90
28
Delighted to share new work from our lab: MultiPerturb-seq 🎛️ ❌ ↕️ Over the last few years, we've been combining CRISPR screens with multimodal readouts of gene expression (RNA) and chromatin accessibility (DNA). In this study, we bring those together within the same cells.
add a skeleton here at some point
10 months ago
4
73
20
reposted by
Neville Sanjana
Nature Biotechnology
10 months ago
Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling
go.nature.com/4hXER5O
loading . . .
Pooled CRISPR screens with joint single-nucleus chromatin accessibility and transcriptome profiling - Nature Biotechnology
MultiPerturb-seq profiles gene expression and chromatin accessibility in single-cell pooled CRISPR screen.
https://go.nature.com/4hXER5O
0
99
32
you reached the end!!
feeds!
log in
