The E3 ubiquitin ligase mechanism specifying target-directed microRNA degradation (TDMD) is now published! 🎉🍾 We, @bartellab.bsky.social and Schulman lab, describe how 2-RNA factors control protein degradation by recruiting an E3 ligase. @mpibiochem.bsky.social www.nature.com/articles/s41...

Very happy to see this out. 👏 @yinanwan.bsky.social Bogdan Bintu and team. Whole-embryo spatial transcriptomics at subcellular resolution from gastrulation to organogenesis | free link Science www.science.org/eprint/5MHTM...

🐟 We are hiring a postdoc! Interested in RNA regulation, gene expression, and zebrafish embryogenesis? Join the Bazzini Lab at @stowersinstitute.bsky.social www.stowers.org/labs/bazzini... Please share! Details below 👇 #Postdoc #RNAbiology #zebrafish #devbio #Genomics

Please check out our latest #preprint to study #ACTIVELY TRANSLATING #tRNA populations and their dynamics upon #stress :) This was an wonderful collaborative effort between @novoalab.bsky.social @immagina.bsky.social and #Soares teams - thank you for making this possible!

With Eugene Koonin, we propose a concept of “the selfish ribosome”, under which evolution of life is viewed as a ribosomal takeover, where the ribosome evolved to consume most of the cell’s resources, while other cellular componentry ensures the propagation of the ribosome. arxiv.org/abs/2602.23268

I am delighted to report that this is now out! A giant congratulations and thank you to all the Bluesky-less coauthors: Hyeyeon Nam, Justin Deme, Soyeong Sim, Marco Boccitto and Susan Lea.

For those on the job market, University of Toronto 🇨🇦 is hiring a tenure-track Assistant Professor in Zebrafish Models of Genetic and Metabolic Pathologies 🐟 Yes, they want #zebrafish! 🔗 jobs.utoronto.ca/job/Toronto-...

🎉Proud to present our latest paper, out now in Nature Communications: www.nature.com/articles/s41... RNA Binding Proteins (RBPs) are often full of intrinsically disordered regions (IDRs), but what these regions do during RNA recognition is often unclear. 1/10 #RNA #IDR #RBP

Looks like Plasmodium delivers an anti-splicing RNA bomb to the nucleus of its host's WBC --oof! Nuclear import of malaria RNA rewires splicing in host immune cells: Cell Reports www.cell.com/cell-reports...

🚨Just join us🚨 This is a fantastic meeting with great science and better people, can't miss it!! 🦓🐟+🧑‍🔬+🇨🇦

🧵 Thread: What happens when transcription isn’t properly shut off during mitosis? Our new preprint explores just that 👇 www.biorxiv.org/content/10.6...

New online! Bridging technical innovation and computational advances in studies of RNA–protein assemblies

Happy to share the first review article from our lab! We discuss the landscape of available high-throughput approaches for profiling RNA–protein interactions in vitro and in vivo. We hope it will be useful when designing your next experiment. www.tandfonline.com/doi/full/10.... #RNAsky

@science.org Mechanisms linking cytoplasmic decay of translation-defective mRNA to transcriptional adaptation | Science www.science.org/doi/10.1126/...

How could a simple self-replicating system emerge at the origins of life? RNA polymerase ribozymes can replicate RNA, but existing ones are so large that their self-replication seems impossible. Could they be smaller? Excited to share our latest work in @science.org on a new small polymerase. 1/n

1/3 New bioRxiv preprint from the lab: “Minute-scale coupling of chromatin marks and transcriptional bursts”. Led by Xiohui Gao & Chaebeen Ko. bioRxiv : www.biorxiv.org/cgi/content/...

Thank you @cp-molcell.bsky.social for publishing our work

I am thrilled to share our paper introducing RBPscan, a novel approach to profile RNA–protein interactions in living cells. Free access link at the end ⬇️ 🧵 1/ www.cell.com/molecular-ce...

Does the noncoding genome actually carry more genetic information than coding seqs? Motivated by this question we mutated every bp in the 10kb MYC locus. Results are even more exciting: Decoding the MYC locus reveals a druggable ultraconserved RNA element www.biorxiv.org/content/10.6...

Programmable artificial RNA condensates in mammalian cells https://www.biorxiv.org/content/10.64898/2026.01.28.702393v1

Online Now: Signaling to make human ribosomes: Connections between the cytoplasm and the nucleolus Online now:

I’m happy to share the main result of my PhD, which you can find on bioRxiv www.biorxiv.org/content/10.6.... If you are interested in learning about a new way to perform DNA-PAINT multiplexing, which we call Combi-PAINT, or if you are interested in the study of mRNA conformation, keep reading! 1/10

Out now in @science.org Endogenous retroviruses synthesize heterologous chimeric RNAs to reinforce human early embryo development | Science www.science.org/doi/10.1126/...

Happy New Year all. I know it's been a draining and difficult year for science in general, but wanted to share some good news: our intrabody paper has now been published in Science Advances with lots of additional data. www.science.org/doi/10.1126/...

What's larger, a protein or its templating mRNA ? > The mRNA is much larger. ⬛ 𝐀 𝐬𝐞𝐧𝐬𝐞 𝐨𝐟 𝐬𝐜𝐚𝐥𝐞 -- 𝐪𝐮𝐚𝐧𝐭𝐢𝐭𝐚𝐭𝐢𝐯𝐞 𝐢𝐧𝐭𝐮𝐢𝐭𝐢𝐨𝐧 & 𝐜𝐨𝐧𝐬𝐭𝐫𝐚𝐢𝐧𝐭𝐬 -- 𝐢𝐬 𝐚 𝐩𝐨𝐰𝐞𝐫𝐟𝐮𝐥 𝐞𝐧𝐚𝐛𝐥𝐞𝐫 𝐨𝐟 𝐫𝐞𝐬𝐞𝐚𝐫𝐜𝐡. The figure shows myoglobin protein drawn to scale next to its mRNA template. The coding sequence of an mRNA ...

Amazing: TimeVaults! www.science.org/doi/10.1126/...

Starting the New Year with exciting news! A major paper started during my postdoc and finished in my own lab has just been accepted. More details soon.

Greetings! I decided to make a YouTube video of my AlphaFold workshop that I've given a few times in the past year. Caveats aside, people seem to find this useful for thinking about how to model protein interactions and how to interpret various AF outputs 1/2 www.youtube.com/watch?v=u63o...

Happy to share two BioRxiv manuscripts from our lab. One on genetic Argonaute interaction and unexpected non-correlation between small RNAs and their targets: doi.org/10.64898/202... The second on IDR processing and IDR-mediated Argonaute loading control: doi.org/10.64898/202... Merry Xmas😊

Helix: a structure-aware deep learning model for accurate prediction of A-to-I RNA editing by endogenous ADARs https://www.biorxiv.org/content/10.64898/2025.12.18.695251v1

My "News & views" was published today @natmethods.nature.com Thanks @ritastrack.bsky.social for the invitation to write it and Allison Doerr for the editing after Rita left... www.nature.com/articles/s41...

Excited to share that this work is now published in its final form! link.springer.com/article/10.1...

After a huge amount of work w/ @alex-stark.bsky.social's group, a new version of our Ledidi preprint is now out! In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells. www.biorxiv.org/content/10.1...

Do you want to image RNA in living cells? Check out our new live-cell Click labeling approach. An amazing collaboration with the Meier Lab at UHH and the Wagenknecht Lab at KIT! doi.org/10.1002/anie... Congratulations, especially to Doerte, Eileen, and Iven! Thanks to DFG CRC1648

Looking forward to sharing our work!

Great collaboration with Dougherty and Pavlovic Djuranovic labs on using MPRAs to look into non-coding mutations. Approaches for identification of 5′ UTR mutations impacting translation and protein production from neurodevelopmental disorder genes www.sciencedirect.com/science/arti...

🌟G&D SPOTLIGHT 🌟 REVIEW: RNA granules: functional compartments or incidental condensates? By Andrea Putnam, Laura Thomas and Geraldine Seydoux ➡️ https://genesdev.cshlp.org/content/37/9-10/354.abstract #RNAmetabolism #RNAgranules #phaseseparation #RiboNucleoProteins #condensates

📣 I hereby make my Bluesky debut to announce that our work linking DNA binding affinities and kinetics 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 and 𝘪𝘯 𝘷𝘪𝘷𝘰 for the human transcription factor KLF1 just got published in Cell! @cp-cell.bsky.social www.cell.com/cell/fulltex... Key findings in a thread (1/6):

Excited about Kolya Aleksashin's new work, enabling preparation of active in vitro translation systems from primary human cells and difficult-to-edit cells (fibroblasts and cardiomyocytes). This opens new opportunities to probe mechanisms of translation regulation. www.biorxiv.org/content/10.1...

new Lai lab paper @natsmb.nature.com! Dicer is specifically mutated in cancer, but we don't fully understand its molecular/reg impacts. with @danweihuangfu.bsky.social, we characterized the first knockin Dicer hotspot in hESCs, and found unexpected defects in miRNA biogenesis! 🧬 1/4 rdcu.be/eOc0q

Gentle reminder that everyone should read Jacob and Monod, 1961. And then read it again every once in awhile. A master-class on clear writing (and, ya know, Nobel Prize winning stuff, too). www.sciencedirect.com/science/arti...

New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at @imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys

📅 Save the Date! The 4th Canadian Zebrafish Research Conference will take place on Friday, May 15, 2026, at CHU Sainte-Justine, Montreal (just before the Canadian Neuroscience Conference!) Multiple travel awards available with 2 Postdoctoral Rising Stars Awards! #izfs

Now online! Disparate leukemia mutations converge on nuclear phase-separated condensates

This is such an interesting paper. Why? Because the binding of transcription factor (TF) proteins to DNA governs how our genes are turned on/off/up/down, & so is the primary issue for how our genes work in development and how our cells respond to just about anything.🧵 www.nature.com/articles/s41...

Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇

Check out the latest work from our lab, led by Arash Latifkar @ara-latifkar.bsky.social , www.biorxiv.org/content/10.1...

(1/4) New Pre-print! 🌟 Embryonic development is usually seen as a continuous process, yet some embryos can pause their development to survive harsh conditions, a phenomenon known as diapause. How this pausing is actively maintained has remained a mystery.

Really grateful to see our work featured by @quantamagazine.bsky.social in this piece on the evolution of genome regulation. Huge thanks to @philipcball.bsky.social for such a beautifully written article.