After a huge amount of work w/ @alex-stark.bsky.social's group, a new version of our Ledidi preprint is now out! In an era of AI-designed proteins, the next leap will be controlling when, where, and how much of these proteins are expressed in living cells. www.biorxiv.org/content/10.1...

Do you want to image RNA in living cells? Check out our new live-cell Click labeling approach. An amazing collaboration with the Meier Lab at UHH and the Wagenknecht Lab at KIT! doi.org/10.1002/anie... Congratulations, especially to Doerte, Eileen, and Iven! Thanks to DFG CRC1648

Looking forward to sharing our work!

Great collaboration with Dougherty and Pavlovic Djuranovic labs on using MPRAs to look into non-coding mutations. Approaches for identification of 5′ UTR mutations impacting translation and protein production from neurodevelopmental disorder genes www.sciencedirect.com/science/arti...

🌟G&D SPOTLIGHT 🌟 REVIEW: RNA granules: functional compartments or incidental condensates? By Andrea Putnam, Laura Thomas and Geraldine Seydoux ➡️ https://genesdev.cshlp.org/content/37/9-10/354.abstract #RNAmetabolism #RNAgranules #phaseseparation #RiboNucleoProteins #condensates

📣 I hereby make my Bluesky debut to announce that our work linking DNA binding affinities and kinetics 𝘪𝘯 𝘷𝘪𝘵𝘳𝘰 and 𝘪𝘯 𝘷𝘪𝘷𝘰 for the human transcription factor KLF1 just got published in Cell! @cp-cell.bsky.social www.cell.com/cell/fulltex... Key findings in a thread (1/6):

Excited about Kolya Aleksashin's new work, enabling preparation of active in vitro translation systems from primary human cells and difficult-to-edit cells (fibroblasts and cardiomyocytes). This opens new opportunities to probe mechanisms of translation regulation. www.biorxiv.org/content/10.1...

new Lai lab paper @natsmb.nature.com! Dicer is specifically mutated in cancer, but we don't fully understand its molecular/reg impacts. with @danweihuangfu.bsky.social, we characterized the first knockin Dicer hotspot in hESCs, and found unexpected defects in miRNA biogenesis! 🧬 1/4 rdcu.be/eOc0q

Gentle reminder that everyone should read Jacob and Monod, 1961. And then read it again every once in awhile. A master-class on clear writing (and, ya know, Nobel Prize winning stuff, too). www.sciencedirect.com/science/arti...

New paper alert! Scientists in Clemens Plaschka’s lab at the IMP and @juliusbrennecke.bsky.social's lab at @imbavienna.bsky.social solved a decade-old puzzle, uncovering how the information molecule mRNA travels from the cell’s nucleus to its periphery. More: bit.ly/4nHcvys

📅 Save the Date! The 4th Canadian Zebrafish Research Conference will take place on Friday, May 15, 2026, at CHU Sainte-Justine, Montreal (just before the Canadian Neuroscience Conference!) Multiple travel awards available with 2 Postdoctoral Rising Stars Awards! #izfs

Now online! Disparate leukemia mutations converge on nuclear phase-separated condensates

This is such an interesting paper. Why? Because the binding of transcription factor (TF) proteins to DNA governs how our genes are turned on/off/up/down, & so is the primary issue for how our genes work in development and how our cells respond to just about anything.🧵 www.nature.com/articles/s41...

Colliding ribosomes are potent signals of cellular stress. But do cells use ‘programmed’ ribosome collisions to regulate gene expression? I’m excited to present a new story from my lab led by Frederick Rehfeld(@fred-rehfeld.bsky.social) which revealed that the answer is YES! Read on to find out how👇

Check out the latest work from our lab, led by Arash Latifkar @ara-latifkar.bsky.social , www.biorxiv.org/content/10.1...

(1/4) New Pre-print! 🌟 Embryonic development is usually seen as a continuous process, yet some embryos can pause their development to survive harsh conditions, a phenomenon known as diapause. How this pausing is actively maintained has remained a mystery.

Really grateful to see our work featured by @quantamagazine.bsky.social in this piece on the evolution of genome regulation. Huge thanks to @philipcball.bsky.social for such a beautifully written article.

Translation landscape of stress granules | Science Advances www.science.org/doi/10.1126/...

#ZebrafishFunFacts: As the most-cited #zebrafish cancer research paper, Amsterdam et al screened hundreds of heterozygous lines for embryonic lethal mutations & found elevated cancer incidence in ribosomal genes. This previously underappreciated finding was published @plosbiology.org 21 years ago. 🧪

We combine our yeast genetics experiments with the massive body of literature data to make a case for 40S scanning of 5’UTRs of by 1D diffusion (finalised version): m.rnajournal.cshlp.org/content/31/1...

1/5 Lab's first manuscript 🎉 is out @biorxivpreprint.bsky.social today! Beautifully, it is performed by a senior undergraduate thesis student, Mohammed! We developed a 3-D printed #zebrafish embryo imaging chamber 🔬and connected it to syringe pumps to be able to perfuse drugs in a timely fashion. 🧪

RNA-binding proteins provide specificity to the PAN2-PAN3 mRNA deadenylation complex https://www.biorxiv.org/content/10.1101/2025.09.27.678968v1

Congratulations Markus! Really cool work!👏

This is a fascinating paper that particular types of RNA binding proteins with IDRs that target nuclear speckles also can recruit their own RNAs to nuclear speckles as a negative feedback mechanism for condensation the authors call "interstasis" www.nature.com/articles/s41...

🚀 Our new paper is out @natmethods.nature.com! Kuffer & Marzilli engineered conditionally stable MS2 & PP7 coat proteins (dMCP & dPCP) that degrade unless bound to RNA, enabling ultra–low-background, single-mRNA imaging in live cells. 🔗 www.nature.com/articles/s41... 🧬 www.addgene.org/John_Ngo/

We quantified mRNA abundance, translation, protein abundance, protein degradation and cell growth across thousands of single cells from a mammalian tissue. The results revealed 𝐜𝐨𝐦𝐩𝐥𝐞𝐱 regulation & 𝐬𝐢𝐦𝐩𝐥𝐞 organizing principles: www.biorxiv.org/content/10.1... 🧵

It is my pleasure to share with you the latest from @jsvejstrup.bsky.social lab, where we look at how the reduction of RNAPII levels has a severe, yet organized transcriptional response in the cell.

Congrats, Eric and Renfu!!!

Dream collaboration with the groups of Torben Heick Jensen (@heick.bsky.social; @au.dk) and Clemens Plaschka (@impvienna.bsky.social). Building in part on the incredible work from Ulrich Hohmann on human mRNA export. www.biorxiv.org/content/10.1...

How do cells sort which RNAs to keep or destroy? New preprint from THJ, Brenneke and Plaschka labs shows that export and decay machineries (TREX2/PAXT) both recognise UAP56-bound RNAs. Whether they’re exported or degraded depends on where in the nucleus this happens. www.biorxiv.org/content/10.1...

Excited to share our recent work about the role of the molecular chaperone TRAP1 as RNA-binding protein! #RBPs #HGSOC

Excited to share my postdoc work, out on bioRxiv today! Histones package DNA into nucleosomes to form the building blocks of chromatin, but how modular and programmable is this system? 1/9

NOT TO BE MISSED. My awesome colleague Rob Brewster may have COMPLETELY upended our understanding of how TFs work ... a must-read for anyone who cares in the slightest about gene regulation

New preprint: We isolate peptide–RNA photo-crosslinks with tunable RNA chains from living cells for mass spec. This maps over 4,700 crosslinking sites across 744 proteins and offers the first glimpse into the RNA sequences in crosslinks by MS. Read here: doi.org/10.1101/2025...

News in the history of molecular biology. The Science History Institute in Philadelphia has acquired a huge archive of correspondence and other scientific material from the pioneers of molecular biology (Franklin, Klug, Perutz, Delbrück etc, with items from Crick and Watson, too). 1/n

Since at least the time of Greek philosophers, many writers have discovered a deep, intuitive connection between walking, thinking, and writing.

Our work on the function of miR-51/miR-100 is out! miR-100 is widely conserved across eumetazoans but its function has been mysterious. Emilio Santillán found in worms it regulates signaling and extracellular matrix genes, some of which seem to be conserved targets! www.science.org/doi/10.1126/...

New paper from the Trcek lab, with Siran Tian as the lead author - congratulations Siran!: www.nature.com/articles/s41...

Huge Congrats, Amélie and team!

Everything (and more) you wanted to know about Nodal Signaling. A Paradigm for TGFβ Signaling in Embryonic Development | Annual Reviews - www.annualreviews.org/content/jour...

ICYMI: New Online! Chemical reprogramming of human blood cells

This preprint from Helen Sakharova is one of the coolest things to come out of my lab: “Protein language models reveal evolutionary constraints on synonymous codon choice.” Codon choice is a big puzzle in how information is encoded in genomes, and we have a new angle. www.biorxiv.org/content/10.1...

A paper from the JUMP Cell Painting Consortium presents image-based phenotypic profiles for 75% of the protein coding genome of human U-2 OS cells, offering a valuable resource for exploring gene relationships. @shantanu-singh.cc @drannecarpenter.bsky.social www.nature.com/articles/s41...

I am excited to share the second half of my postdoctoral work in the Yeo lab at UCSD! We found that neuronal aging leads to the accumulation of mitochondrial double-stranded RNA, which triggers the chronic stress response. 1/ www.biorxiv.org/content/10.1...

Our latest work, in collaboration with the terrific @kashishsingh.bsky.social in the Carter lab @mrclmb.bsky.social is out. So proud of this study and everyone involved...

I nice little story from the lab: dx.plos.org/10.1371/jour...

A Summer reading recommendation: new primer in @dev-journal.bsky.social explains how dynamical systems theory unlocks the logic of developmental patterning Everything from bistable switches & oscillators to phase portraits & more with Python code to explore journals.biologists.com/dev/article/...

New method drop: HCR-Proxy, a modular proximity labelling approach to profile local proteome composition around RNA at nanoscale, subcompartmental resolution. Thereby we resolved nested nucleolar layers and uncovered the grammar of spatial protein partitioning. www.biorxiv.org/content/10.1...