☕Xu, Kong, Li, Pisignano et al provide a map of pseudouridine sites in human noncoding RNA. Using a systematic knockout approach, they associate each pseudouridine site with the activity of a specific pseudouridine synthase. bit.ly/48hM65C

Postdoc depression and anxiety rates are rising, finds survey of 872 researchers The Max Planck Society is good at attracting international postdocs but struggles to retain them, survey finds. www.nature.com/articles/d41...

Great resource!

Excellent commentary on transgenerational inheritance and the importance of rigor and reproducibility. Subtitled: when a colleague drags and tries to throw you under the bus because they couldn't follow protocols @ctmurphy1.bsky.social

Launching celldynamicslab.com, the homepage of our new group at EPFL working on cell fragmentation, membrane and cortex mechanics, FLIM imaging, and microfluidics tools. MSc/PhD or postdocs interested in quantitative cell biology are welcome to reach out. We're also hiring a lab manager in 2026!

𝗖𝗮𝗻 𝗰𝗲𝗹𝗹𝘀 𝗲𝘃𝗲𝗿 𝘁𝗿𝘂𝗹𝘆 𝗿𝗲𝗰𝗼𝘃𝗲𝗿 𝗳𝗿𝗼𝗺 𝗗𝗡𝗔 𝗱𝗮𝗺𝗮𝗴𝗲?Excited to share our new study “Repair of DNA double-strand breaks leaves heritable impairment to genome function”, revealing DNA repair’s hidden cost, out now @science.org tinyurl.com/5n6zw3ye. Led by @sbantele.bsky.social and Jiri Lukas.🧵👇1/n

Having a lot of fun at #EMBOMobileGenome 😃 Perfect timing for our paper from the lab of @toddmacfarlan.bsky.social to be out @natcomms.nature.com!! …and I’m currently on the job market looking for a new scientific home! www.nature.com/articles/s41...

And another interesting paper from Bonasio lab @upenn.edu www.biorxiv.org/content/10.1... "Pseudouridine selects RNAs for extracellular transport" noting among other things "..that MYL6 is a pU-binding protein required for secretion of RNAs." notable MYL6 is found in the Kossiakoff work as a csRBP!

Pseudouridine selects RNAs for extracellular transport https://www.biorxiv.org/content/10.1101/2025.10.28.685156v1

Pseudouridine selects RNAs for extracellular transport https://www.biorxiv.org/content/10.1101/2025.10.28.685156v1

RNAs outside of cells?! How did they get there? (Thread coming soon 👀) www.biorxiv.org/content/10.1...

Exciting news for the RNA research community! The Human RNome Project has been launched: a global effort to map all human RNAs and their chemical modifications. Proud to support it and contribute to the article in Genome Biology doi.org/10.1186/s130... #RNA #bioinformatics #RNAstructure #modomics

Congratulations to Roberto Bonasio (@PennCDB), recipient of the NIH Director's Pioneer Award! Learn more about Dr. Bonasio & his research interests here➡️ www.bonasiolab.org #NIHHighRisk

AWESOME CONFERENCE ALERT!! I had an absolute blast at the Fusion “Genome Regulation Through RNA” meeting back in 2024, and psyched to see its upcoming return! Let’s geek out about all things Chromatin and RNA together, in Cancun! Talk abstract deadline: 10/17 Details👇

New from the lab led by @natrigg.bsky.social. We started by characterizing mRNA in sperm, EVs, and the epithelium across epididymal transit. This revealed evidence that sperm acquire specific mRNAs through fusion with epididymal EVs, which we further established with in vitro co-incubation assays

Epididymal extracellular vesicles harbor and convey mRNA to sperm for transfer to zygotes https://www.biorxiv.org/content/10.1101/2025.08.18.670952v1

🎼 Did you know all #ISEV2025 Education Day Talks are on our YouTube channel? 🤩 Check out our playlist: youtu.be/ovtLcTMeyQU?...

What?!

For what I consider the best inter-generational study to date @jamiehackett.bsky.social used over 2,000 mice. www.nature.com/articles/s41... While that's a lot of mice, it is better animal welfare to perform a definitive study than to perform hundreds of uninterpretable studies.

I am happy to share our last preprint, where we identified FASN as an endogenous dsRNA-associated factor and demonstrated that its depletion triggers endodsRNA accumulation and a stronger antiviral response to exogenous dsRNAs,#RNA, #interferon,#immunometabolism www.biorxiv.org/cgi/content/...

Leclerc gets back on the podium!!! 🔥 What a drive!!

RNA can control cell migration by acting at focal adhesions www.lifescienceeditors.com/2025/06/24/r...

THAT’S THE FRONT ROW!!! P2 for Leclerc!! 👏

Highly recommended - amazing programme!

Protocol to assess the impact of sperm RNA on mouse preimplantation embryos using microinjection #protocol #starprotocols #cellpress

tRNA-derived RNA processing in sperm transmits non-genetically inherited phenotypes to offspring in C. elegans https://www.biorxiv.org/content/10.1101/2025.04.14.648817v1

The first C. elegans paper from lab! We find that, similar to mammals, tRNA-fragments (or the new name in the field tDRs) accumulate in worm sperm and can transmit non-genetically inherited phenotypes to offspring. We also find an RNase that regulates their processing, showing that length matters

The amount wiped out from the world economy in 2 days was enough to finance all biomedical research in the world for 10 years

Beautiful work from my labmate Julia Tasca. If you are wondering how to scan point mutants affecting the function of your favorite RNA binding protein in a single assay, check this out! www.biorxiv.org/content/10.1...

Charles Leclerc. Lewis Hamilton. Together in front of the world as Ferrari team mates 😍

Not all tRNA fragments (tDRs) are created equal. Here we share methods to differentiate: 1) real tDRs and those produced by dissociation of nicked tRNAs, 2) nicked tRNAs / tDRs in extracellular vesicles vs outside. 1) www.sciencedirect.com/science/arti... 2) www.sciencedirect.com/science/arti...

New year, new name 👊

Benvenuto, Lewis!

www.biorxiv.org/content/10.1... keen to read this! From @gladfelterlab.bsky.social

Happy to have contributed to this led by the Nixon lab. We helped show temperarure can alter sperm small RNAs which modulate postfertiilzation embryonic gene expression and development in 🐁 www.pnas.org/doi/10.1073/...