Strain and tissue-specie variation in murine transcriptomic signatures #genetics www.cell.com/cell-genomic... #genetics

AI has its uses, but in the end it’s not silicon but protein and lipids that do the best and final analysis

More #zebrafish! 🧪

The @EASDnews Journal leadership "call on the #diabetes community to join us in our endeavour: to publish robust research grounded in a foundation of strong EDI principles" highlighting that EDI is essential for rigorous science and good for health link.springer.com/article/10.1...

Lietzke et al. demonstrate that pluripotent stem cell-derived β cells exhibit reduced oxidative and mitochondrial fatty acid metabolism compared to primary human islets, which is related to limitations in key mitochondrial transcriptional networks. 🧪 #PancSky www.nature.com/articles/s41...

Srivastava et al. applied a β-cell degranulation strategy coupled with HLA-II immunopeptidome profiling to systematically identify islet-derived peptides presented in human peripheral blood. 🧪 #PancSky www.nature.com/articles/s41...

Kaylan et al. generated mice with genetic deletion of Gpr31b to test the hypothesis that the G protein-coupled receptor GPR31 promotes β-cell and macrophage inflammatory signaling and contributes to β-cell dysfunction in diabetes. 🧪 #PancSky www.biorxiv.org/content/10.1...

On the cusp of closing the genetic association and mechanism gap while laying the foundation for future precision medicine approaches in type 2 #diabetes #genetics @diabetologiajnl.bsky.social link.springer.com/article/10.1...

🎉Very excited to share our new work on senescence and insulin processing now out in @DiabetologiaJnl link.springer.com/article/10.100… Fantastic effort by my @dream-diabetes.bsky.social trainees, along with @yichunchen.bsky.social @bruceverchere.bsky.social @cirtn.bsky.social

Cool work using spatial transcriptomics among other methods to discover new mesenchyme signaling on developing pancreas niche #PancSky

Brown et al. demonstrated that stem cell–derived β cells can be engineered to express CD155 to preferentially promote T cell coinhibitory signaling through the CD155/TIGIT axis and restrain both NK cell and T cell activation. 🧪 #PancSky www.science.org/doi/10.1126/...

TT faculty job opening in #Neuroscience! We are looking for a colleague to join us in our fantastic Biology Department and Neuroscience Program at Brandeis. We are a group of *very* collaborative, supportive, and productive scientists (& humans!) so please apply academicjobsonline.org/ajo/jobs/30961

More #gastruloid studies. Benchmarking correlations between RNA/proteins w/ acquiring information @ phosphorylation across #mouse & #human www.biorxiv.org/content/10.1... Also looking at #Disease modelling. Fantastic #TourDForce Valuable bench marking and insight @dschweppe.bsky.social #SCBEMs

Happy to share that our preprint is now published at @embomolmed.org! We expanded on the benchmark of porcine ductal organoids by a pretty extensive proteomics dataset to compare organoids derived from different developmental stages of the pig #devbio #PancSky www.embopress.org/doi/full/10....

So cool embryonic pancreas epithelium modeling using stem cells by the Wells lab! #PancSky www.biorxiv.org/content/10.1...

New from the @heikolickert.bsky.social clan and great work from Carina together with all collaborators and the Theis lab to study pancreas development across species, bringing new insights into conserved pathways using multimodal computational analysis www.nature.com/articles/s41... #PancSky

Instead of listing every possible thing the latest AI/LLM CAN do, the question is, what are the sort of things in academia and publishing that we WANT humans to do? And are we funding/rewarding/prioritizing that?

Direct comparison of GLP1 therapies with metabolic surgery in obese www.nature.com/articles/s41...

Great work from my friend @lithoviusv.bsky.social with very nice combination of disease modeling and a drug gable solution to pair it with! @PancSky www.biorxiv.org/content/10.1...

Interesting knockout phenotype on intestinal stem cell regeneration. @embomolmed.org www.embopress.org/doi/full/10....

Further evidence for JAK inhibitors in improving beta cell function from a study cohort of human islets. www.science.org/doi/10.1126/... #PancSky

In preprints: gastruloids get (a)head Wilhelmus A. Brouwer @wesselbrouwer.bsky.social and Luca Braccioli @bracciolilab.bsky.social discuss the #preprint by Balaskas et al. "An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning” journals.biologists.com/dev/article/...

dos Santos et al. provide novel insights into the molecular underpinnings of islet cell dysfunction in #type1diabetes, highlighting pathways that may be leveraged to preserve residual β-cell function and modulate α-cell activity. 🧪 #PancSky www.jci.org/articles/vie...

Do zebrafish regenerate their hearts equally? In our new paper at the @tillymommersteeg.bsky.social lab we uncovered variations in the regenerative response of 7 wt zebrafish strains leading us to identify a critical role of oxidative phosphorylation in long-term heart regeneration. rdcu.be/eI1v5

It's online! In this series of perspectives @dev-journal.bsky.social, yours truly talks about the exciting open questions and many things to do in the field of dev bio and neuroscience #DevBio🧪 #PIsOfTomorrow journals.biologists.com/dev/article/...

Out @natcomms.nature.com: our work on how the ❤️-supporting pericardium forms & acts in pediatric heart conditions.🎈🫀 Expanding our preprint & with our first HCR (thx to @thelovelylab.bsky.social!). Congrats all! #devbio #zebrafish #CHD @cupediatrics.bsky.social @cudevbio.bsky.social rdcu.be/eIJm5

New work on NKX2.2 on islet specification www.biorxiv.org/content/10.1... #PancSky

Hey friends and colleagues ! Vancouver Coastal Health Research Institute - VCHRI is now on Bluesky, give them a follow @vchresearch.bsky.social

New tool to study beta-cell biology on tissue slices www.biorxiv.org/content/10.1... #PancSky

Because science camaraderie is forever: New work on citrullination from the @genanderlab.bsky.social and my good friend Kim! This hits close to home as we had a lot of discussions with Kim about protein translation in development and OPP assays during our PhD time! www.science.org/doi/abs/10.1...

Clinical trial results on gluten-free diet effects in type 1 diabetes prevention have a look academic.oup.com/jes/article/... #PancSky

Blom et al. provide critical clues as to how β-cell secretory functions are specifically impacted by cytokines and nitric oxide that may contribute to the development of β-cell autoantigens relevant to #type1diabetes. 🧪 #PancSky doi.org/10.2337/db25...

Check out the latest manuscript from the @heikolickert.bsky.social lab on generating a defined stem-cell derived islet product for transplantation. A thorough characterization of the system particularly by our star PhD students Nike and Nicole! #PancSky www.biorxiv.org/content/10.1...

We’re excited to present this integrative analysis of single-cell proteomics and transcriptomics of the human HSPC hierarchy. Now published in @science.org together with @fabiantheis.bsky.social, @erwinschoof.bsky.social, @porsebo.bsky.social. www.science.org/doi/10.1126/... 🧵

Great tool need to test

Looking for a #postdoc opportunity? Funded positions available @cuanschutz.bsky.social to advance our #zebrafish transgenesis tools - and to look into developmental origins of congenital disease! #devbio

Interesting work on sirtuins in regulation of proliferation in the pancreas

Anyone here interested in #metabolism in #devbio ? We recently published a Review article by Jin Zhang & co discussing the relationship between metabolism and #embryogenesis. Enjoy the read! :D 👉https://rdcu.be/eADIT www.nature.com/articles/s41...

This thread is hilarious. Given the environmental impact of some of these privately-owned LLMs that reason like PhDs that can formulate our email responses one might have to rethink their general use. Maybe something good would be to charge 15 Euro per month for use

Transitions in development – an interview with Jeffrey Farrell @jeffreyafarrell.bsky.social talks about becoming a group leader, his insights on advocacy for developmental biology and his belief in unifying single-cell biology with classical approaches. journals.biologists.com/dev/article/...

Great opportunity here to build your skills and your professional network! Apply for the SciComm Interns program! #devbiolwriteclub @socdevbio.bsky.social

We developed MouseMapper AI, a deep learning ensemble for the analysis of whole-body systems, including the nervous and immune systems, to map disease/drug perturbations tissue by tissue, organ by organ, at the cellular level in 3D. biorxiv.org/content/10.1...

Good Sunday all. A beautiful selection of papers in #cancermetabolism and #mitochondrialbiology is ready for you here: biomed.news/bims-camemi/... @biomednews.bsky.social #keepreading "If your eyes are blinded with your worries, you cannot see the beauty of the sunset." - Jiddu Krishnamurti

Identifying reproducible biomarkers for microbiome association studies requires sample sizes of thousands www.sciencedirect.com/science/arti...

Auddino et al. discuss the potential link between cellular stresses and isomiR biogenesis, and how this association could improve our knowledge of islet inflammation and dysfunction. 🧪 #PancSky www.cell.com/trends/endoc...

Some journals are claiming that you need to pay big $$ for gold open access to comply with NIH's new public access policy. FYI that is total bs. You can comply by depositing the Accepted Manuscript into PubMed Central on the Date of Publication without embargo. Pass it on.

ICYMI: New content online: Highlights from ADA 85th Scientific Sessions

Nanaware et al. used mass spectrometry to identify native and post-translationally modified self-peptides presented by MHC proteins from human cadaveric islet samples treated in vitro with cytokines to identify epitopes in an inflamed pancreas. 🧪 #PancSky www.cell.com/cell-reports...