Interested in energy-based thinking around health? Interested in mitochondria and body-mind processes? Join us for the 2025 Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) Symposium on December 12th. Poster abstract submission open. www.picardlab.org/misbie

The Energy Resistance Principle (ERP) is a quantitative framework that bridges physics and biology, revealing metabolism as the energetic circuitry through which electrons flow, from food to oxygen, to fuel our lives @msahsorin.bsky.social authors.elsevier.com/a/1luVK5WXUl...

Quite likely that abnormal cellular metabolism (excess energy resistance, éR) is a driver of inflammation and atherosclerosis

Metabolism is an energetic circuitry that transcends cellular and organellar boundaries www.nature.com/articles/s42...

Just leaving this right here....👀

Hot of the press #mitochondria paper!! 🎉 @jevbio.bsky.social New evidence that #mitonuclear discordance and early-life #diet jointly shape development and adult behaviour in #Drosophila. 🪰🦠🧬🍝 @fcamus.bsky.social @dk-dowling.bsky.social et al., academic.oup.com/jeb/advance-...

The fallacies from animal studies applied to humans extend beyond addiction and mental health, likely to calorie restriction and metabolic health. In attempting to control every variable, we can distort context and conclusions. Video of Johann Hari

"The most precious gift we can offer others is our presence" ⎸ Thich Nhat Hanh When we are present and listen, we open up energetically to be moved by another person. We offer them something to resonate with. It is among the most precious gifts. Discussion with the brilliant Lily Mujica-Parodi.

Isn’t it interesting that both chlorophyll and heme, 2 most important pigments of life, share the same #quantum architecture? Beautiful to think that the 2 organelles (chloroplasts and mitochondria) born of endosymbiosis operate on this shared, quantum-informed design.

We are exited to welcome Nicco Reggente from the Institute for Advanced Consciousness Studies His talk: Heartbeat Evoked Potentials as a Neural Marker of Real-Time Meditative Depth Monday, October 27th, 12pm ET Zoom link: columbiacuimc.zoom.us/j/5779841445

Automn when the trees let go of their leaves is spectacular

BOLD signal changes can oppose oxygen metabolism across the human cortex | bioRxiv www.biorxiv.org/content/10.1...

Love it! All of the most actionable knowledge lies at the intersection of disciplines. Kudos for engaging in this way.

🚨Publication alert! 🚨 Why does stress drive psychopathology & transdiagnostic disease? We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens. www.sciencedirect.com/science/arti...

The brain did not evolve to think, but to regulate our energetic state. Several brain regions involved in cognition work together to monitor and coordinate psychological processes. Beautiful paper on the neuroscience behind allostasis by Jordan Theriault. www.cell.com/neuron/fullt...

Every day, without missing a beat, the sun rises and throws its energy at us

New book covering the many functions of mitochondria, by Daria Mochly-Rosen and Emanuel Rosen

Most processes in life require cycling, including firing neurons, the heart contraction/relaxation cycle, sleep/wake rhythms, and many more.

The way we feel and the psychiatric symptoms some of us end up experiencing could emerge from the way energy flows, or fails to flow smoothly, in mitochondria. The ATP model (Allostatic Triage in Psychopathology) by Parker Kelley @sequencemyneuro.bsky.social www.sciencedirect.com/science/arti...

Wonderful meeting organized by @johnspeakman4.bsky.social on energy in Shenzhen—I learnt so much! Thank you. Below John humoring the dancing robot 😅

Out now in @natmetabolism.nature.com 🧪 FGF21 levels increase in response to acute mental stress in individuals with impaired OxPhos capacity, and correlate with stress-related hormones and psychosocial factors. Read the full study by @martinpicardenergy.bsky.social here: doi.org/10.1038/s422...

Deep questions @ricardsole.bsky.social Maybe by understanding death we can understand the energetic nature of life a little better?

The metabolic hormone FGF21 is one of the most studied hormone in the field of diabetes and energy metabolism. We report here that it is also regulated mental stress and psychosocial factors. How people’s FGF21 levels responded to stress depends on the health of their mitochondria.

The lure that drugs are the solution for health disorders and dis-ease will likely hurt us in the long run.

Each person is a unique energy pattern. We get to clean some of this uniqueness in the way the brain fluxes energy.

Similar energy transforming hardware, yet such different outcomes

The mitochondria of fibroblasts from people experiencing psychosis exhibit different subcellular distribution. Another piece of evidence that the biology of mitochondria is linked to human experiences. Some thoughts on the mind-mitochondria connection here: www.cell.com/trends/endoc...

🚨How do mitochondria sense and respond to metabolic stress from the environment in diabetes? 🤔 In new work out in #ScienceAdvances, we show that innate immune signaling promotes β cell compensation for metabolic stress by engaging mitophagy. 🚨1/n www.science.org/doi/10.1126/...

Without resistance there can be no transformation of anything into anything else. Like a beaming photon in outer space. But with too much resistance, energy cannot flow, damage accumulates, and we die. Like electrons trying to flow in a defective mitochondrion.

Excellent framework to understand the processes favoring health vs disease based on the Energy Resistance Principle. Makes me wonder whether the shape of this inverted-U curve, or linked parameters, are trait-like across individuals. Congrats @martinpicardenergy.bsky.social & @msahsorin.bsky.social

We don’t pass down our mitochondria, but we may pass down other things that contribute to the health of our little ones

One of my most exciting & frame-shifting papers to date. The Energy Resistance Principle shows how resistance to energy shapes the dynamics of life and health. A new lens to understand & optimize energy across the lifespan, inspiring tools that sense & tune the body’s energetic architecture.

GDF15 is one of the most fascinating hormones. Discovered separately in different fields, linked to energy and aging, and the best predictor of morbidity and mortality in humans. GDF15 is also induced by mental stress: linkinghub.elsevier.com/retrieve/pii...

This morning I felt a little sadness when I remembered that many of the colleagues I wished to share something dear to my heart with, had departed from X. @msahsorin.bsky.social and I would love to know what people think of the Energy Resistance Principle (ERP) authors.elsevier.com/a/1luVK5WXUl...