Wishing everyone a lovely, restful, inspiring holiday season. So grateful for what 2025 has brought. Thanks to our partners, collaborators, funders, and the amazing community coming together to build a healthier, more compassionate, sustainable world. With Gratitude, Martin

Happy Winter Solstice ❄️ Let's celebrate the extra photons that will enter lives from this day forward.

Really interesting research showing that while ultra-specialization in a single discipline might lead to better results early in one’s career, multi-discipline training and practice pays off big time in the long run. This applies to a range of professions from scientists to athletes and more

Happy weekend

Nature’s beauty comes in many ways

Blooming geranium in morning sunlight

Mitochondrial diversity From @neurowoodworks.bsky.social

NAD+ is the critical electron carrier that enables the metabolic circuitry of your cells to flow electrons from food to oxygen

Tomorrow is the 2025 MiSBIE Symposium! Registration and zoom link here: picardlab.org/MiSBIE Thanks to the >550 registered. It should be fun.

Superb energy patterns emerge after an egg is fertilized

2025 MiSBIE Symposium Mitochondrial Psychobiology, Stress, and Health This Friday December 12 In person in NYC and on Zoom around the globe Free registration: www.PicardLab.org/MiSBIE Preliminary agenda:

Completely agree. And if I can make a self-promoting plug here, we have a nice table in this paper trying to separate some of these ideas out. The brain is very information-efficient (bits/ATP), while still being very expensive in energy consumption (ATP/sec). www.sciencedirect.com/science/arti...

Metabolic states change behavior by altering biological structures. Energy transformation all the way.

RESEARCH | M Kurade, @martinpicardenergy.bsky.social et al (Columbia Univ) FGF21 levels increase in response to acute mental stress and correlate with stress-related hormones. 🧪

Our interview with @martinpicardenergy.bsky.social on MitoWorld’s MitoBlog is live! Martin tells us about MiSBIE, how it came about, what it is and who should attend the 2025 MiSBIE Symposium mitoworld.org/attention-mi...

The metabolic engine of cognition: microglia–neuron interactions in health, ageing and disease www.nature.com/articles/s42...

Stress exposure can trigger hair/fur greying in mice, and also in humans. In humans, the graying process is at least temporarily reversible. Like the rest of our psychobiology, the aging process is not a linear process. It is dynamic, energetic, and malleable. www.the-scientist.com/how-does-str...

Spectacular time of year

“Look again at that dot. That's here. That's home. That's us. On it everyone you love, everyone you know, everyone you ever heard of, every human being who ever was, lived out their lives…. on a mote of dust suspended in a sunbeam.” -the Pale Blue Dot by Carl Sagan ✨🌏

Interested in energy-based thinking around health? Interested in mitochondria and body-mind processes? Join us for the 2025 Mitochondrial Stress, Brain Imaging, and Epigenetics (MiSBIE) Symposium on December 12th. Poster abstract submission open. www.picardlab.org/misbie

The Energy Resistance Principle (ERP) is a quantitative framework that bridges physics and biology, revealing metabolism as the energetic circuitry through which electrons flow, from food to oxygen, to fuel our lives @msahsorin.bsky.social authors.elsevier.com/a/1luVK5WXUl...

Quite likely that abnormal cellular metabolism (excess energy resistance, éR) is a driver of inflammation and atherosclerosis

Metabolism is an energetic circuitry that transcends cellular and organellar boundaries www.nature.com/articles/s42...

Just leaving this right here....👀

Hot of the press #mitochondria paper!! 🎉 @jevbio.bsky.social New evidence that #mitonuclear discordance and early-life #diet jointly shape development and adult behaviour in #Drosophila. 🪰🦠🧬🍝 @fcamus.bsky.social @dk-dowling.bsky.social et al., academic.oup.com/jeb/advance-...

The fallacies from animal studies applied to humans extend beyond addiction and mental health, likely to calorie restriction and metabolic health. In attempting to control every variable, we can distort context and conclusions. Video of Johann Hari

"The most precious gift we can offer others is our presence" ⎸ Thich Nhat Hanh When we are present and listen, we open up energetically to be moved by another person. We offer them something to resonate with. It is among the most precious gifts. Discussion with the brilliant Lily Mujica-Parodi.

Isn’t it interesting that both chlorophyll and heme, 2 most important pigments of life, share the same #quantum architecture? Beautiful to think that the 2 organelles (chloroplasts and mitochondria) born of endosymbiosis operate on this shared, quantum-informed design.

We are exited to welcome Nicco Reggente from the Institute for Advanced Consciousness Studies His talk: Heartbeat Evoked Potentials as a Neural Marker of Real-Time Meditative Depth Monday, October 27th, 12pm ET Zoom link: columbiacuimc.zoom.us/j/5779841445

Automn when the trees let go of their leaves is spectacular

BOLD signal changes can oppose oxygen metabolism across the human cortex | bioRxiv www.biorxiv.org/content/10.1...

Love it! All of the most actionable knowledge lies at the intersection of disciplines. Kudos for engaging in this way.

🚨Publication alert! 🚨 Why does stress drive psychopathology & transdiagnostic disease? We present the Allostatic Triage Model of Psychopathology (ATP Model), which explains stress-induced transdiagnostic disease pathogenesis through a bioenergetic lens. www.sciencedirect.com/science/arti...

The brain did not evolve to think, but to regulate our energetic state. Several brain regions involved in cognition work together to monitor and coordinate psychological processes. Beautiful paper on the neuroscience behind allostasis by Jordan Theriault. www.cell.com/neuron/fullt...

Every day, without missing a beat, the sun rises and throws its energy at us

New book covering the many functions of mitochondria, by Daria Mochly-Rosen and Emanuel Rosen

Most processes in life require cycling, including firing neurons, the heart contraction/relaxation cycle, sleep/wake rhythms, and many more.

The way we feel and the psychiatric symptoms some of us end up experiencing could emerge from the way energy flows, or fails to flow smoothly, in mitochondria. The ATP model (Allostatic Triage in Psychopathology) by Parker Kelley @sequencemyneuro.bsky.social www.sciencedirect.com/science/arti...

Wonderful meeting organized by @johnspeakman4.bsky.social on energy in Shenzhen—I learnt so much! Thank you. Below John humoring the dancing robot 😅

Out now in @natmetabolism.nature.com 🧪 FGF21 levels increase in response to acute mental stress in individuals with impaired OxPhos capacity, and correlate with stress-related hormones and psychosocial factors. Read the full study by @martinpicardenergy.bsky.social here: doi.org/10.1038/s422...

Deep questions @ricardsole.bsky.social Maybe by understanding death we can understand the energetic nature of life a little better?

The metabolic hormone FGF21 is one of the most studied hormone in the field of diabetes and energy metabolism. We report here that it is also regulated mental stress and psychosocial factors. How people’s FGF21 levels responded to stress depends on the health of their mitochondria.

The lure that drugs are the solution for health disorders and dis-ease will likely hurt us in the long run.

Each person is a unique energy pattern. We get to clean some of this uniqueness in the way the brain fluxes energy.

Similar energy transforming hardware, yet such different outcomes