🔬 Ever seen a mitochondrion “flicker”? We designed HBmito, a membrane voltage sensor, to catch nanoscale nanoscale electrical spikes in real time—the first optical glimpse of single mitochondrial channels in action. #Mitochondria #CellBiology #Biophysics link.springer.com/article/10.1...

Website is live, registration is open! meetings.embo.org/event/26-mus...

🚨 Join us for the EMBO Workshop Muscle development, maintenance & pathology: in vitro models to physiology 🚨 📍 Aghia Pelagia, Greece 📆 11 – 15 October 2026

Excited to share a new collaborative paper with Lena Koslover's team, fueled by @chanzuckerberg.bsky.social Metabolism Across Scales Program 🧪 1/ www.pnas.org/doi/10.1073/...

Edward C. T. Waters from @kings-bmeis.bsky.social et al. conducted this recent study where sarcolemmal and mitochondrial #membrane potentials were measured ex vivo and in vivo in the #heart by #pharmacokinetic modelling of [99mTc]sestamibi 🫀 🔎 📜 physoc.onlinelibrary.wiley.com/doi/10.1113/...

MitoAtlas: a Domain-Resolved Spatial Map of the HumanMitochondrial Proteome https://www.biorxiv.org/content/10.64898/2026.04.03.716438v1

1/9 🚨 New paper out in Nature Metabolism! Chapter 2 of our mitochondria zonation story (following our 2024 Nature Communications work). We asked how zonated liver mitochondria adapt when lipid flux surges. 🧵👇 www.nature.com/articles/s42...

Mitochondrial lactate venting limits oxidative stress www.cell.com/cell-metabol...

We are hiring POSTDOC now!🚨please repost! Fully-funded 5-year position 👩🏻‍🔬👨‍🔬🧬Looking forward to your application!✉️

It's been a long time since I sat down and enjoyed reading a paper cover-to-cover as much as this. Some cracking work and experiments. www.science.org/doi/10.1126/...

Pluripotent stem-cell-based screening uncovers sildenafil as a mitochondrial disease therapy @cellcellpress.bsky.social @aleprigio.bsky.social www.cell.com/cell/fulltex...

Another preprint is out from the Neal Lab! 🎉 Excited to share the first systematic side-by-side comparison of ERAD Derlin paralogs, revealing distinct cellular functions for Derlin-1, Derlin-2, and Derlin-3. www.biorxiv.org/content/10.6...

Bravo Liza, Brendan and colleagues for the elegant work on multiple live imaging strategies to untangle mechanisms of muscular dystrophy! www.nature.com/articles/s41...

Two funded PhD positions investigating the evolution of sarcomeres @ibdm.bsky.social in @biancah0406.bsky.social and our lab, together with @cnidevo.bsky.social - Interested to explore how similar or different Jellyfish sarcomeres are to Drosophila or human ones? www.ibdm.univ-amu.fr/ibdm_job/2-a...

Now recruiting an experienced Post‑Doc in Skeletal Muscle Molecular Physiology @nih-sport-sciences.bsky.social Oslo, Norway Join our multi‑omics EMMA project on mitochondrial epigenetic memory in human muscle aging 4‑year position Start May Apply at Jobbnorge: www.jobbnorge.no/en/available...

Macroscopic to Ultrastructural Analyses Identify the Loss of Myofibrils as the Primary Mediator of Muscle Fiber Atrophy in Aging and Disuse https://www.biorxiv.org/content/10.64898/2026.02.16.706166v1

Can we make brains “smarter”? By boosting mitochondrial metabolism in neurons of memory circuits, we improved memory in flies and mice. Thrilled to see this work out - congrats to @amrapalianjali.bsky.social for spectacular work, and to all lab members for invaluable contributions!

We are ready to scale up glycogen analysis using electron microscopy. By applying a new AI-based image analysis pipeline, workload for 50 samples was reduced from ~600 hours to ~20 hours. This moves us beyond small-scale TEM studies. Details below 👇

The innervation of the tibialis anterior muscle in a rat has never been so clear! Processed with SmartBatch+ by the UIC/Structural Circuits Core, for @greisinglab.bsky.social in the UMN School of Kinesiology. Red = nerves, yellow = neuromuscular junctions. #3DThursday @lifecanvastech.bsky.social

We are hiring! Fully funded PhD position on an exciting project to understand a fundamental mechanism of mitochondrial biogenesis. We will primarily rely on cryo-EM and protein-biochemical approaches. Please share! More about us: martinottlab.com Apply here: web103.reachmee.com/ext/I005/103...

New #NatureComms paper: CHAMP1 is an essential regulator for human myoblast fusion and muscle development. #Myoblue tinyurl.com/2wyu39fr

High carotid blood flow velocity and pulsatility correlate with lower hippocampal mito oxygen consumption, while both low and high flow increase mito fusion protein expression compared to control. Thanks to Drs. J. Carson Smith and Gabriel Pena for the collaboration! ahajrnls.org/3YmmdMj

Mitochondrial Reticulum in Skeletal Muscles: Proven and Hypothetical Functions link.springer.com/article/10.1...

My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...

📄 New preprint Using deep physiological and molecular phenotyping in individuals carrying a diabetogenic mtDNA mutation, we probe whether, which, and how mitochondrial defects drive insulin resistance in humans. 👇 Link in first comment #Physiology #Diabetes #Mitochondria #Metabolism

⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...

Huge congratulations to Abigail Giles whose paper has just come out in Nature Cardiovascular Research - from a great collaboration with Bob Balaban, along with Thomas Krieg and Tish Murphy. doi.org/10.1038/s441...

Excited to share our new paper on high-throughput #optogenetic #exercise assays for tissue engineered skeletal muscle! We leverage a multi-well stimulation apparatus to study how exercise regimen of various durations + frequencies impact muscle gene expression: doi.org/10.1002/btm2... #myoblue

Nice work and congrats @kevinmurachphd.bsky.social & colleagues for their new #SkeletalMuscle paper: Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle. #Myoblue tinyurl.com/3vhxwku4

NCLX is a mitochondrial proton/calcium exchanger, not a sodium/calcium exchanger as previously thought www.nature.com/articles/s41...

Happy to have contributed to this beautiful work led by @elenaberezhnaya.bsky.social and Dr. Gyorgy Hajnoczky, and thrilled to see it finally out! 👏🏽👏🏽👏🏽 MICU2 controls mitochondrial calcium signaling and migration in neurons during development: Cell Reports www.cell.com/cell-reports...

Curious about muscle metabolism? 🚴‍♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue

Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis | Nature Communications www.nature.com/articles/s41... @myoblue.bsky.social

New @NatMetabolism paper: Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia. #Myoblue tinyurl.com/4adh7uy3

If so, you might want to read our new preprint on @biorxivpreprint.bsky.social! We repeated this experiment (acute exercise in untrained and trained mice, analyzed at different time points, comparison of untrained and trained at rest) on the single nucleus level. 2/3 doi.org/10.1101/2025...

📰🧵📰 REGISTRATION ANNOUNCEMENT!! 💻🧵💻 1/ #IBEC2026 Conference dates are from June 1-3 in #RoanokeVA. Early registration will open January 1, 2026. Early registration/ eligibility for awards through March 1. Preliminary schedule available here: t.co/D2buRVHKGb

Some interesting data from postdoc Nate Serrano: “Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle” www.biorxiv.org/content/10.1...

Exercising fathers, enhanced endurance and metabolic heath in offspring, through sperm microRNAs (as demonstrated in mice) www.cell.com/cell-metabol...

We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere

Our new preprint! Great effort by Martin de Almeida and Amalie Platz has led to the discovery that training increases mitochondrial cristae density. www.biorxiv.org/cgi/content/... Thanks to Niels Ørtenblad at SDU and Kurt Højlund and Maria Petersen at Steno Diabetes Center Odense. 🧵 Thread below…

Title: Professor in Exercise and Sport Science or Exercise Physiology 📍Place: @newcastle 🇦🇺 💰Salary: $222,734 plus 17% superannuation plus annual leave loading 
📅Deadline: 12/10/25 ℹ For more details👇 www.livehire.com/careers/univ...

🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important Good collab with @droch.bsky.social so travel to CPH involved as well www.kcl.ac.uk/jobs/126245-...

Kinesiology and Applied Physiology at UD is hiring a biomechanist! We invite applications for a tenure-track assistant professor position with a preferred research focus in musuloskeletal modeling. careers.udel.edu/cw/en-us/job...

Mechanical Loading Induces the Longitudinal Growth of Muscle Fibers via an mTORC1-Independent Mechanism https://www.biorxiv.org/content/10.1101/2025.09.19.676647v1

One nice thing about working with muscles and myofibrils is that biophysicists love them, and so we collaborate with them. Here, Danielle Tokarz's group at @smuhalifax.bsky.social used polarization second-harmonic generation microscopy in single fibrils opg.optica.org/boe/fulltext...

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

We are hiring! The University of Illinois Urbana-Champaign Department of Cell and Developmental Biology is hiring a faculty member in the area of Aging, broadly defined. Come join us! Deadline is soon! www.nature.com/naturecareer...

Regenerate to “Rejuvenate”: Insights From Adult Resident Stem Cells of Aged Flatworms and Mice. A fun collaboration! onlinelibrary.wiley.com/doi/10.1111/...

My MCDB dept is accepting applications for a faculty position at the Assistant Professor level! Applications Due by October 15, 2025 We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels. lsa.umich.edu/mcdb/news-ev...