Can we make brains “smarter”? By boosting mitochondrial metabolism in neurons of memory circuits, we improved memory in flies and mice. Thrilled to see this work out - congrats to @amrapalianjali.bsky.social for spectacular work, and to all lab members for invaluable contributions!

We are ready to scale up glycogen analysis using electron microscopy. By applying a new AI-based image analysis pipeline, workload for 50 samples was reduced from ~600 hours to ~20 hours. This moves us beyond small-scale TEM studies. Details below 👇

The innervation of the tibialis anterior muscle in a rat has never been so clear! Processed with SmartBatch+ by the UIC/Structural Circuits Core, for @greisinglab.bsky.social in the UMN School of Kinesiology. Red = nerves, yellow = neuromuscular junctions. #3DThursday @lifecanvastech.bsky.social

We are hiring! Fully funded PhD position on an exciting project to understand a fundamental mechanism of mitochondrial biogenesis. We will primarily rely on cryo-EM and protein-biochemical approaches. Please share! More about us: martinottlab.com Apply here: web103.reachmee.com/ext/I005/103...

New #NatureComms paper: CHAMP1 is an essential regulator for human myoblast fusion and muscle development. #Myoblue tinyurl.com/2wyu39fr

High carotid blood flow velocity and pulsatility correlate with lower hippocampal mito oxygen consumption, while both low and high flow increase mito fusion protein expression compared to control. Thanks to Drs. J. Carson Smith and Gabriel Pena for the collaboration! ahajrnls.org/3YmmdMj

Mitochondrial Reticulum in Skeletal Muscles: Proven and Hypothetical Functions link.springer.com/article/10.1...

My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...

📄 New preprint Using deep physiological and molecular phenotyping in individuals carrying a diabetogenic mtDNA mutation, we probe whether, which, and how mitochondrial defects drive insulin resistance in humans. 👇 Link in first comment #Physiology #Diabetes #Mitochondria #Metabolism

⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...

Huge congratulations to Abigail Giles whose paper has just come out in Nature Cardiovascular Research - from a great collaboration with Bob Balaban, along with Thomas Krieg and Tish Murphy. doi.org/10.1038/s441...

Excited to share our new paper on high-throughput #optogenetic #exercise assays for tissue engineered skeletal muscle! We leverage a multi-well stimulation apparatus to study how exercise regimen of various durations + frequencies impact muscle gene expression: doi.org/10.1002/btm2... #myoblue

Nice work and congrats @kevinmurachphd.bsky.social & colleagues for their new #SkeletalMuscle paper: Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle. #Myoblue tinyurl.com/3vhxwku4

NCLX is a mitochondrial proton/calcium exchanger, not a sodium/calcium exchanger as previously thought www.nature.com/articles/s41...

Happy to have contributed to this beautiful work led by @elenaberezhnaya.bsky.social and Dr. Gyorgy Hajnoczky, and thrilled to see it finally out! 👏🏽👏🏽👏🏽 MICU2 controls mitochondrial calcium signaling and migration in neurons during development: Cell Reports www.cell.com/cell-reports...

Curious about muscle metabolism? 🚴‍♂️ We reveal PanK4 as a conserved exercise target in muscle! 💪 PanK4 regulates lipid & glucose use likely via acetyl-CoA. We think PanK4 belongs alongside Akt, mTOR, AMPK, Rac1 & more as a key player in muscle energy homeostasis. #Metabolism #MyoBlue

Intrinsic dysfunction in muscle stem cells lacking dystrophin begins during secondary myogenesis | Nature Communications www.nature.com/articles/s41... @myoblue.bsky.social

New @NatMetabolism paper: Impaired cAMP–PKA–CREB1 signalling drives mitochondrial dysfunction in skeletal muscle during cancer cachexia. #Myoblue tinyurl.com/4adh7uy3

If so, you might want to read our new preprint on @biorxivpreprint.bsky.social! We repeated this experiment (acute exercise in untrained and trained mice, analyzed at different time points, comparison of untrained and trained at rest) on the single nucleus level. 2/3 doi.org/10.1101/2025...

📰🧵📰 REGISTRATION ANNOUNCEMENT!! 💻🧵💻 1/ #IBEC2026 Conference dates are from June 1-3 in #RoanokeVA. Early registration will open January 1, 2026. Early registration/ eligibility for awards through March 1. Preliminary schedule available here: t.co/D2buRVHKGb

Some interesting data from postdoc Nate Serrano: “Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle” www.biorxiv.org/content/10.1...

Exercising fathers, enhanced endurance and metabolic heath in offspring, through sperm microRNAs (as demonstrated in mice) www.cell.com/cell-metabol...

We are looking for an enthusiastic MD or PhD to work on a postdoc project on the molecular mechanisms underlying human hibernating myocardium and ischemic cardiomyopathy. If interested send me an email! #heart #cardiomyopathy #sarcomere

Our new preprint! Great effort by Martin de Almeida and Amalie Platz has led to the discovery that training increases mitochondrial cristae density. www.biorxiv.org/cgi/content/... Thanks to Niels Ørtenblad at SDU and Kurt Højlund and Maria Petersen at Steno Diabetes Center Odense. 🧵 Thread below…

Title: Professor in Exercise and Sport Science or Exercise Physiology 📍Place: @newcastle 🇦🇺 💰Salary: $222,734 plus 17% superannuation plus annual leave loading 
📅Deadline: 12/10/25 ℹ For more details👇 www.livehire.com/careers/univ...

🚨Hiring a 2yr postdoc in the lab work on muscle biology, genomics & ALS. Expertise in the above advantageous, but work ethic, desire to learn/develop and being a good scientist/person more important Good collab with @droch.bsky.social so travel to CPH involved as well www.kcl.ac.uk/jobs/126245-...

Kinesiology and Applied Physiology at UD is hiring a biomechanist! We invite applications for a tenure-track assistant professor position with a preferred research focus in musuloskeletal modeling. careers.udel.edu/cw/en-us/job...

Mechanical Loading Induces the Longitudinal Growth of Muscle Fibers via an mTORC1-Independent Mechanism https://www.biorxiv.org/content/10.1101/2025.09.19.676647v1

One nice thing about working with muscles and myofibrils is that biophysicists love them, and so we collaborate with them. Here, Danielle Tokarz's group at @smuhalifax.bsky.social used polarization second-harmonic generation microscopy in single fibrils opg.optica.org/boe/fulltext...

Very excited to share new work out today in @natchembio.nature.com on a new approach - FACES - for selectively imaging of phospholipids and other biomolecules at spatial resolutions down to individual membrane leaflets (1/n) www.nature.com/articles/s41...

We are hiring! The University of Illinois Urbana-Champaign Department of Cell and Developmental Biology is hiring a faculty member in the area of Aging, broadly defined. Come join us! Deadline is soon! www.nature.com/naturecareer...

Regenerate to “Rejuvenate”: Insights From Adult Resident Stem Cells of Aged Flatworms and Mice. A fun collaboration! onlinelibrary.wiley.com/doi/10.1111/...

My MCDB dept is accepting applications for a faculty position at the Assistant Professor level! Applications Due by October 15, 2025 We welcome applications from all areas of physiology and neuroscience, spanning molecular, cellular, systems, and organismal levels. lsa.umich.edu/mcdb/news-ev...

We have an Open Rank tenure-track faculty position in the Department of Nutrition & Integrative Physiology! Looking for a new colleague interested in making the University of Utah their new home to build a metabolic research program. Please share! @uofunuip.bsky.social

Check out this cool preprint led by @ccstorytime.bsky.social with snRNAseq data on 60,000 nuclei from human muscle-tendon tissue 4 h after exercise @myoblue.bsky.social

I'm happy to share new work in collaboration with Elena Koslover's lab! First author Keaton developed a mathematical framework for diffusion of soluble material through mitochondrial networks. Then, Lewis lab PhD candidate Camryn used live cell imaging to parameterize... 1/3

Please repost! We have an open rank, tenure-line faculty position in biomechanics in the School of Kinesiology at the University of Michigan Ann Arbor. At U-M we have great colleagues, exceptional resources, and biomechanics can be found all across the campus. #BiomechSky

I am delighted to announce that the UW Department of Biochemistry has opened searches for TWO tenure-track positions. Descriptions and links in the following two posts.

🚀New preprint w/ @roberto_amv: We used chemogenetics to precisely control mitochondrial H2O2 in skeletal muscle in vivo. This exposes a dose-dependent sequence: translation suppression → proteolysis → denervation-like → degeneration @tejensen23 www.biorxiv.org/content/10.1...

Our department is recruiting a new tenure track Assistant/Associate Professor. Come join the #1 physiology department in the country and some awesome colleagues doing high impact science and training the next generation of scientists jobs.sciencecareers.org/job/674815/a...

JOB ALERT 🚨 We are hiring TWO principal investigators in cell, molecular, systems, or chemical biology in Toronto, Canada at @sinaihealth.bsky.social. We provide a generous startup, fully funded salary and academic appointment at U of Toronto. www.nature.com/naturecareer... Please repost!

I read the preprint. It's very beautiful work from Hadi Boukhatmi's group. They test how if at all #Drosophila can repair their #muscles. www.biorxiv.org/content/10.1...

New preprint! N-acetylcarnosine treatment shows an astonishing efficacy to improve age-associated survival by 50% at 24 months of age in female mice. Organ functions preserved primarily in heart, vasculature, muscle & bone. A huge team work led by Edwin who is on the job market this year.

Title: Exercise Physiologist
 📍Place: @apple‬⁩ 🇺🇸 💰Salary: $141,800 and $258,600 
📅Deadline: - ℹ For more details👇 jobs.apple.com/en-us/detail...

Love cell biology? Come be our neighbor! The Dept of Cell Biology at UT Southwestern is advertising two tenure-track Assistant Professor positions. Generous startup & a great academic community. See ads below: jobs.utsouthwestern.edu/job/22292356... jobs.utsouthwestern.edu/job/22292357...

💪💪 SPEAKER ANNOUNCEMENT Dr. Bert Blaauw will be joining IBEC 2026 from VIMM Padua to share his insights into the anabolic response of skeletal muscle to exercise!

Quantitative imaging of lipid transport in mammalian cells www.nature.com/articles/s41...

Recent work from Liang Feng and Ming-Feng Tsai's labs directly demonstrating that Tmem65 functions as the mitochondrial sodium-calcium exchanger. No NCLX needed. www.nature.com/articles/s41...

🍹Zhang, Chang et al. identify the protein TMEM65 as the #mitochondria Na+/Ca2+ exchanger, showing that it dimerizes to mediate ion transport and contains a binding site for a well-known inhibitor of mitochondrial Na+/Ca2+ exchange. 👉https://rdcu.be/eAN3r bit.ly/3UtNlag