We are ready to scale up glycogen analysis using electron microscopy. By applying a new AI-based image analysis pipeline, workload for 50 samples was reduced from ~600 hours to ~20 hours. This moves us beyond small-scale TEM studies. Details below 👇

For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵

Mitochondrial contact site and cristae organizing system promotes modular assembly of cytochrome c oxidase: Cell Reports www.cell.com/cell-reports...

📄 New preprint Using deep physiological and molecular phenotyping in individuals carrying a diabetogenic mtDNA mutation, we probe whether, which, and how mitochondrial defects drive insulin resistance in humans. 👇 Link in first comment #Physiology #Diabetes #Mitochondria #Metabolism

Acute effects of resistance exercise on skeletal muscle glycogen depletion: A systematic review and meta-analysis physoc.onlinelibrary.wiley.com/doi/10.14814...

⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...

"We find that when glycogen stores are present, they provide remarkable resilience to dopamine nerve terminal function under extreme hypometabolic conditions, but ... impairment of access to glycogen, makes them hypersensitive to fuel deprivation." www.pnas.org/doi/suppl/10...

This ‘fundamental’ study uncovers how directing pyruvate into mitochondria can shrink cells by shifting their metabolism away from building amino acids and proteins. buff.ly/hFHjKy9

Super happy to share our latest study on muscle remodeling in human cachexia in patients with lung cancer: www.biorxiv.org/content/10.1...

Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com

First post on Blue Sky New pre-print! Does muscle remember disuse muscle wasting? Our new study shows skeletal muscle retains a molecular memory of disuse! Young muscle shows transcriptional resilience to repeated atrophy. Aged muscle shows exaggerated susceptibility. doi.org/10.1101/2025...

Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n openrxiv.org/enabling-rev...

IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇

Hopefully of interest to scientists and exercise practitioners with and interest in muscle mass and functional gains in human volunteers. doi.org/10.1113/JP28... @jphysiol.bsky.social

This article is a homecoming for me. As a PhD student, I focused on the growth-rate transcriptional regulation in yeast. Now, ~ 20 years later, we report protein regulation scaling with the growth rates of single cells in mammalian tissues. www.biorxiv.org/content/10.1...

Is Human Energy Expenditure Constrained? I recently debated Herman Pontzer on this topic in Shenzhen, China. My slides can be viewed here: www.linkedin.com/posts/javier...

Manuscript now accepted! 🥳 @steffendanielle.bsky.social @valerioizzi.bsky.social @abigailmackey1.bsky.social @ismcopenhagen.bsky.social Spatially distinct ECM-producing fibroblasts and myonuclei orchestrate early adaptation to mechanical loading in the human muscle-tendon unit

The Expanding Clinical and Genetic Spectrum of Muscle Glycogen Storage Disease 0, (GSD0B) - Donoghue - 2025 - American Journal of Medical Genetics Part A - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...

New #scisignal paper: Phosphorylation of RYR1 at Ser2902 decreases Ca2+ leak in skeletal muscle and susceptibility to malignant hyperthermia and heat stroke. #Myoblue tinyurl.com/bddss3j6

Excited to share that our paper on mitochondrial cardiolipin dynamics is published in @natcomms.nature.com today! We provide molecular explanations for unique aspects of mitochondrial morphology and the mechanisms underlying cardiolipin-related Barth Syndrome. www.nature.com/articles/s41...

Our new preprint! Great effort by Martin de Almeida and Amalie Platz has led to the discovery that training increases mitochondrial cristae density. www.biorxiv.org/cgi/content/... Thanks to Niels Ørtenblad at SDU and Kurt Højlund and Maria Petersen at Steno Diabetes Center Odense. 🧵 Thread below…

Check out our latest preprint from the lab, spearheaded by researcher @itsmedipsikha.bsky.social , investigating the distinctive roles of regulatory gamma subunits of the AMPK protein complex in small molecule activator-stimulated skeletal muscle glucose uptake. www.biorxiv.org/content/10.1...

Does biological sex impact the rate of intrinsic mitochondrial respiration in the presence of creatine in human skeletal muscle? Emily J. Ferguson (@queensuresearch.bsky.social) et al. investigate! 📜 buff.ly/46B6lzL

Mechanical Loading Induces the Longitudinal Growth of Muscle Fibers via an mTORC1-Independent Mechanism https://www.biorxiv.org/content/10.1101/2025.09.19.676647v1

Divergent Changes in Peak Fat Oxidation and Fatmax Following 3-Day Dietary Interventions Are Related to Muscle Glycogen Availability in Men by Tarry, Vestergaard, Petersen, Olsen, Ingersen, Connor, Pilegaard, Dela, Larsen, Shaw, and Helge onlinelibrary.wiley.com/share/CDCGW2...

Sarcopenia is accelerated loss of skeletal muscle mass and function commonly, but not exclusively, associated with advancing age. It is observed across many species including humans in whom it can lead to decline in physical function and mobility. https://www.nature.c...

Congrats to Steffen Raun, Lykke Sylow and Team for their new Redox Biology paper, "Skeletal muscle Rac1 mediates exercise training adaptations towards muscle glycogen resynthesis and protein synthesis", that included the CMR's Prof Paul Gregorevic www.sciencedirect.com/science/arti...

🚨 The last paper of my PhD is out in @MSSE Regular Long Runs and Higher Training Volumes are Associated with Better Running Economy Durability in Performance Matched Well-Trained Male Runners 🙏🏻 Rich Blagrove & Jonathan Folland Temporary free download. 🔗 journals.lww.com/acsm-msse/ab... 🧵 1/7

Elegant study on glycogen using the one-legged exercise model: Exercise- and diet-induced glycogen depletion impairs performance during one-legged constant-load, high-intensity exercise in humans Thomassen, McKenna, Olmedillas, Wyckelsma, Bangsbo, Nordsborg www.frontiersin.org/journals/phy...

Congratulations to Researcher @itsmedipsikha.bsky.social for being one of the recipients of the EFSD/Lilly Young Investigator Awards! We celebrated her achievement with some cakes and bubbles earlier 🥳 @easdnews.bsky.social @cbmr.science www.europeandiabetesfoundation.org/recipients/e...

Join our PhD course in metabolism and EC coupling. November 10-15. University of Southern Denmark. Enrol here: www.sdu.dk/en/forskning...

New paper! Do ketone esters affect post-exercise recovery? doi.org/10.1007/s003... #ketones #exercise #sports #nutrition #recovery

“Muscle memory theory: A critical evaluation” in @JPhysiol led by postdoc Nate Serrano physoc.onlinelibrary.wiley.com/doi/10.1113/...

#Research by Léo Blervaque et al. examines #capillary-to-sarcolemma distance and location of cytochrome c oxidase, offering insights for maximal O2 uptake and muscle lactate release in trained athletes 🚴‍♂️ 🔎 📜 Read the study here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

The Hands-On Growth Laws Theory Cookbook doi.org/10.48550/arX...

Microtubules: the architect of muscles. Watch how microtubules transport mitochondria in proximity to energy consuming sarcomeres in muscles of flies and mice. @jeromeavellaneda.bsky.social @nunoluis.bsky.social @ibdm.bsky.social with @gomeslabo.bsky.social www.sciencedirect.com/science/arti...

Structure and function of the neuromuscular junction in health and myasthenia gravis www.sciencedirect.com/science/arti...

Morphological differences in myofibre size and shape: A comparative study of the soleus, gastrocnemius, triceps brachii and vastus lateralis in humans and mice onlinelibrary.wiley.com/doi/10.1111/...

I love the idea of "micropublications" www.micropublication.org (preparing one now)

Commentary by Researcher @itsmedipsikha.bsky.social on the emerging role of glycogen metabolism in regulating energy homeostasis in adipose tissue is out now on @natrevendo.nature.com @cbmr.science www.nature.com/articles/s41...

Our department @ucph.bsky.social is looking for a new faculty member! This is a nice environment for an ambitious PI with a research focus on cardiovascular system, metabolism and/or drug discovery! Happy to answer questions if you are interested!

News from our lab: 4 weeks of altitude decreases skeletal muscle mitochondrial cristae density in humans (but mitochondrial respiration increased). Great work by Camilla Schytz, Carsten Lundby, and colleagues. doi.org/10.1152/japp...

Capillary‐to‐sarcolemma distance and location of cytochrome c oxidase: Insights for maximal O2 uptake and muscle lactate release in trained athletes - Blervaque - The Journal of Physiology - Wiley Online Library physoc.onlinelibrary.wiley.com/doi/abs/10.1...

The Illusion of Simplicity in Therapeutic Exercise Therapeutic exercise requires personalization, supervision, and continuous adaptation. Read how we took this into account in our Nature Medicine paper www.nature.com/articles/s41...

Altered Relaxation and Mitochondria-Endoplasmic Reticulum Contacts Precede Major (Mal)Adaptations in Aging Skeletal Muscle and Are Prevented by Exercise onlinelibrary.wiley.com/doi/10.1111/...

Please consider to join us in Odense, Denmark, for this PhD course @myoblue.bsky.social

NEW: Statement from the PCI RR Managing Board on the withdrawal of Infant and Child Development as a PCI RR-friendly journal, and the decision by Wiley to refuse preprints that have been peer-reviewed by @peercommunityin.bsky.social / @pci-regreports.bsky.social Read here ➡️ osf.io/tn8mh