Our June cover shows a transmission electron micrograph of mitochondria in human skeletal muscle. In this issue, de Almeida et al report that HIIT increases mitochondrial cristae density in skeletal muscle, including in men with #T2D link.springer.com/article/10.1...

Hey, do you need more evidence in support of NOT attending scientific conferences in the US if you take your science seriously? www.nytimes.com/2026/06/05/w...

Jones RO, Areta JL, Bennett S, Pugh J, Louis JB. Dose-Response of Dietary Carbohydrate Intake on Skeletal Muscle Glycogen, Gastrointestinal Comfort and Body Composition in Endurance-Trained Individuals in Simulated Preparation for Competition. onlinelibrary.wiley.com/share/QGJR54...

Skeletal muscle proteomics links mitochondrial abundance with peak fat oxidation in physically active young males - Tarry - The Journal of Physiology - Wiley Online Library physoc.onlinelibrary.wiley.com/doi/10.1113/...

Excellent news! Nature is expanding Registered Reports to all the fields in which they publish! A great result by all those proposing this strong solution to publication bias and selective reporting (and getting expert feedback before data collection)! www.nature.com/articles/d41...

Our June issue is online now! link.springer.com/journal/125/... @easdnews.bsky.social @springernature.com @springermedicine.com

Beyond Glycogen Storage: AMPKγ2 Regulates Cardiac Hypertrophy and Electrophysiology via Myosin Interaction Qianyun Ge et al. biorxiv.org/content/10.648…

Check out our highlight of the most recent example of subcellular mitochondrial specialization in @currentbiology.bsky.social. Be sure to also check out the beautiful work from David Sherwood's lab www.cell.com/current-biol...

Our paper is now out in Science! Super excited to share our discovery that #mitochondria #pearling is the elusive mechanism driving the regular distribution and inheritance of #mtDNA nucleoids 🧬 [1/6]

Stress-Encoded Mitochondrial Plasticity: ATF4 Control of Mega-Mitochondria and Nanotunnel Communication www.biorxiv.org/content/10.6...

Insulin-independent glucose uptake in skeletal muscle by coupled SGLT and Na,K-ATPase transport www.biorxiv.org/content/10.6...

Adrβ2 in skeletal muscle cells is required for exercise-induced Pgc1α but not for metabolic benefits of exercise on diet-induced obesity www.biorxiv.org/content/10.6...

🚨New paper out today in @acs.org ACS Nano, showing how expansion microscopy can visually quantify the cell surface receptor turnover mediated by signalling & receptor organising machineries on the surfaces of endosomes, some of the smallest organelles in cells. 🧪 🔬 1/ pubs.acs.org/doi/10.1021/...

Deconvoluting fibre type proportions from human skeletal muscle transcriptomics and proteomics data using FibeRtypeR physoc.onlinelibrary.wiley.com/doi/10.1113/...

Proud to share our latest findings: A nutrient-hormone axis pivots an energy trade-off between resting thermogenesis and movement expenditure www.sciencedirect.com/science/arti...

Mitochondrial cristae density is trainable in human skeletal muscle rdcu.be/e7pc5 Thanks to the reviewers and @diabetologiajnl.bsky.social for the constructive feedback and for publishing our work. Thread below:

Low-dose lithium, oestrogen deficiency and the sarcoplasmic reticulum: Are they connected onlinelibrary.wiley.com/share/author... Low-dose lithium supplementation promotes musculoskeletal and metabolic health in ovariectomized female mice physoc.onlinelibrary.wiley.com/share/IMJBJH...

A network-based atlas of human skeletal muscle aging www.medrxiv.org/content/10.6...

Our new project unveiling an integrative single-fiber framework that connect multi-omic cellular heterogeneity to molecular function in ICU-related muscle wasting! Congratulations to all authors especially Alexandra who led the whole project! Thank you to @lundbeckfonden.bsky.social for the support

Our latest work showing that GLUT4 exofacial antibodies can measure translocation in humans and rodent skeletal muscle fibers and is impaired in TBC1D4 KO rats despite rescued GLUT4 expression. Congrats Kaspar and co-authors. DM me for open access version: diabetesjournals.org/diabetes/art...

Beha GH, Stemmerik MG, Boer VO, et al. Quantification of muscle glycogen distribution in Pompe disease using 7 Tesla 13C NMR spectroscopy jnnp.bmj.com/content/97/3...

We are ready to scale up glycogen analysis using electron microscopy. By applying a new AI-based image analysis pipeline, workload for 50 samples was reduced from ~600 hours to ~20 hours. This moves us beyond small-scale TEM studies. Details below 👇

For ~century, we’ve asked: why do proliferating cells ferment glucose even when O2 is around? I’m thrilled to share our latest work @natmetabolism.nature.com, led by @thebiokimist.bsky.social. By leveraging conditional essentiality in HPLM, we propose a provocative new answer to this classic Q. 🧵

Mitochondrial contact site and cristae organizing system promotes modular assembly of cytochrome c oxidase: Cell Reports www.cell.com/cell-reports...

📄 New preprint Using deep physiological and molecular phenotyping in individuals carrying a diabetogenic mtDNA mutation, we probe whether, which, and how mitochondrial defects drive insulin resistance in humans. 👇 Link in first comment #Physiology #Diabetes #Mitochondria #Metabolism

Acute effects of resistance exercise on skeletal muscle glycogen depletion: A systematic review and meta-analysis physoc.onlinelibrary.wiley.com/doi/10.14814...

⚡️Mitochondria make ATP, the energy that powers life. But in neurons, with axons up to a meter long, how do these tiny power plants stay functional in the right places? We went looking. 1/n www.biorxiv.org/content/10.6...

"We find that when glycogen stores are present, they provide remarkable resilience to dopamine nerve terminal function under extreme hypometabolic conditions, but ... impairment of access to glycogen, makes them hypersensitive to fuel deprivation." www.pnas.org/doi/suppl/10...

This ‘fundamental’ study uncovers how directing pyruvate into mitochondria can shrink cells by shifting their metabolism away from building amino acids and proteins. buff.ly/hFHjKy9

Super happy to share our latest study on muscle remodeling in human cachexia in patients with lung cancer: www.biorxiv.org/content/10.1...

Finally, someone has solved a real problem with AI! No more having to take a paper in the format for a journal that rejected you, and reformat it for a new journal. Well done!! formatmypaper.com

First post on Blue Sky New pre-print! Does muscle remember disuse muscle wasting? Our new study shows skeletal muscle retains a molecular memory of disuse! Young muscle shows transcriptional resilience to repeated atrophy. Aged muscle shows exaggerated susceptibility. doi.org/10.1101/2025...

Excited to launch an openRxiv partnership with the scientist-run AI review service qed (@qedscience.bsky.social), the brainchild of @odedrechavi.bsky.social 1/n openrxiv.org/enabling-rev...

IT'S HAPPENING! 💥 I'm psyched to launch the collaboration between @qedscience.bsky.social & @openrxiv.bsky.social @biorxivpreprint.bsky.social! Preprint + q.e.d = your science is out there, and anyone can appreciate it. Let's care about making discoveries, and not on “getting published” (1/3) 👇

Hopefully of interest to scientists and exercise practitioners with and interest in muscle mass and functional gains in human volunteers. doi.org/10.1113/JP28... @jphysiol.bsky.social

This article is a homecoming for me. As a PhD student, I focused on the growth-rate transcriptional regulation in yeast. Now, ~ 20 years later, we report protein regulation scaling with the growth rates of single cells in mammalian tissues. www.biorxiv.org/content/10.1...

Is Human Energy Expenditure Constrained? I recently debated Herman Pontzer on this topic in Shenzhen, China. My slides can be viewed here: www.linkedin.com/posts/javier...

Manuscript now accepted! 🥳 @steffendanielle.bsky.social @valerioizzi.bsky.social @abigailmackey1.bsky.social @ismcopenhagen.bsky.social Spatially distinct ECM-producing fibroblasts and myonuclei orchestrate early adaptation to mechanical loading in the human muscle-tendon unit

The Expanding Clinical and Genetic Spectrum of Muscle Glycogen Storage Disease 0, (GSD0B) - Donoghue - 2025 - American Journal of Medical Genetics Part A - Wiley Online Library onlinelibrary.wiley.com/doi/10.1002/...

New #scisignal paper: Phosphorylation of RYR1 at Ser2902 decreases Ca2+ leak in skeletal muscle and susceptibility to malignant hyperthermia and heat stroke. #Myoblue tinyurl.com/bddss3j6

Excited to share that our paper on mitochondrial cardiolipin dynamics is published in @natcomms.nature.com today! We provide molecular explanations for unique aspects of mitochondrial morphology and the mechanisms underlying cardiolipin-related Barth Syndrome. www.nature.com/articles/s41...

Our new preprint! Great effort by Martin de Almeida and Amalie Platz has led to the discovery that training increases mitochondrial cristae density. www.biorxiv.org/cgi/content/... Thanks to Niels Ørtenblad at SDU and Kurt Højlund and Maria Petersen at Steno Diabetes Center Odense. 🧵 Thread below…

Check out our latest preprint from the lab, spearheaded by researcher @itsmedipsikha.bsky.social , investigating the distinctive roles of regulatory gamma subunits of the AMPK protein complex in small molecule activator-stimulated skeletal muscle glucose uptake. www.biorxiv.org/content/10.1...

Does biological sex impact the rate of intrinsic mitochondrial respiration in the presence of creatine in human skeletal muscle? Emily J. Ferguson (@queensuresearch.bsky.social) et al. investigate! 📜 buff.ly/46B6lzL

Mechanical Loading Induces the Longitudinal Growth of Muscle Fibers via an mTORC1-Independent Mechanism https://www.biorxiv.org/content/10.1101/2025.09.19.676647v1

Divergent Changes in Peak Fat Oxidation and Fatmax Following 3-Day Dietary Interventions Are Related to Muscle Glycogen Availability in Men by Tarry, Vestergaard, Petersen, Olsen, Ingersen, Connor, Pilegaard, Dela, Larsen, Shaw, and Helge onlinelibrary.wiley.com/share/CDCGW2...

Sarcopenia is accelerated loss of skeletal muscle mass and function commonly, but not exclusively, associated with advancing age. It is observed across many species including humans in whom it can lead to decline in physical function and mobility. https://www.nature.c...