Physical #Fitness with #Exercise and #GLP1 Receptor Agonist Treatment Alone or Combined After Diet-Induced #WeightLoss: A Secondary Analysis of a Randomized Controlled Trial in Adults with #Obesity Our latest publication in Sports Medicine

Physiological and molecular characterization of individuals carrying a diabetogenic mtDNA mutation establishes a mitochondrial basis for insulin resistance in humans 👇Check out our preprint on @medrxivpreprint.bsky.social 💬Comments and feedback are very welcome

📄 New preprint Using deep physiological and molecular phenotyping in individuals carrying a diabetogenic mtDNA mutation, we probe whether, which, and how mitochondrial defects drive insulin resistance in humans. 👇 Link in first comment #Physiology #Diabetes #Mitochondria #Metabolism

✨Proud moment at #EASD2025 Tue L. Nielsen presented our MITO-DYS-IR study results in the plenary hall, uncovering the causal role of #muscle #mitochondrial defects in #diabetes pathophysiology Grateful to our collaborators and @easdnews.bsky.social Early Career Academy for the Best Abstract Award

If you’re at #EASD2025 and interested in potential mechanisms that protect against obesity, don’t miss: “LBA SO 02 – Thinking Big About Treating Obesity” 📍 Short Oral Station 23 (Hall C) 📅 Tuesday, 16 Sept ⏰ 13:15 @easdnews.bsky.social

A big day for preventing mitochondrial diseases from transmitting to the next generation www.nature.com/articles/d41... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10.... www.nejm.org/doi/full/10....

Here it is proposed that halofuginone, a FDA–approved anti-scleroderma and antiprotozoal drug, is a promising anti-#obesity agent acting via FGF-21 and GDF-15 in preclinical mouse and pig models www.science.org/doi/10.1126/...

Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans In our latest study, we provide mechanistic evidence implicating mitochondrial ROS in the development of muscle insulin resistance in hyperlipidemic states such as obesity. 1/7 🧵👇

Kicking off 2025 with a highlight from our 2024 study in #CellReportsMedicine @cellpress.bsky.social We uncovered the potential role of a metabokine-sphingolipid axis in sustaining weight loss in humans with #obesity. 1/10 🧵👇

Views about the causes of obesity have polarised. Characterised by low carb and energy balance models. Last year NovoNordisk invited the protagonists of these models to Copenhagen to discuss commonalities and differences. The resultant paper has now been published in Nature Metabolism rdcu.be/dZryb

Reducing the mitochondrial oxidative burden alleviates lipid-induced muscle insulin resistance in humans In our latest study, we provide mechanistic evidence implicating mitochondrial ROS in the development of muscle insulin resistance in hyperlipidemic states such as obesity. 1/7 🧵👇

A mechanism for why durable weight loss is so difficult: epigenetic memory of fat cells www.nature.com/articles/s41...

Hello @bsky.app #science community! I'll be sharing papers on #physiology, #metabolism, #diabetes, #obesity, #mitochondria, #muscle, and #exercise. If you are working in these areas, reach out and connect.

New preprint! We show that GLP1RA semaglutide increases skeletal muscle OXPHOS efficiency in mice. Improved energy efficiency would be predicted to lower energy expenditure and may contribute to propensity for weight regain. www.biorxiv.org/content/10.1...

People working on #cancermetabolism, #mitochondrialbiology, #metabolism, please reach out! Share this so I can follow who is here! I will share paper on cancer metabolism, but anything else related to mitochondria and metabolism.