just got knocked over by this new paper from the Andrei Chagin lab: www.science.org/doi/epdf/10.... physically dropped the paper in delighted surprise when I got to the second half of Fig 5:

💪new 1st author publication @grithhojfeldt.bsky.social and Joris Michaud from fantastic #CollaborativeScience team effort bewteen @ismcopenhagen.bsky.social and Nestle @feigelab.bsky.social on the role of NAM/PN in human muscle regeneration🙌🏃🙌 advanced.onlinelibrary.wiley.com/doi/10.1002/...

We are hiring a POSTDOC on an NIH award to measure inertial effects of (in)active muscle. Please share and re-post widely! Please send expressions of interest to my UML email.

We’re now on LinkedIn! Check us out and follow us there! www.linkedin.com/feed/update/...

We wrote this letter to address the overly rigid preregistration requirements imposed now by many journals on exploratory experimental physiology research - time to align guidelines with contemporary research methods! @ismcopenhagen.bsky.social @proferichter.bsky.social doi.org/10.1113/EP09...

"Prespecified analysis plans are not suitable for exploratory experimental physiology research" physoc.onlinelibrary.wiley.com/doi/10.1113/... @abigailmackey1.bsky.social

🚨 We are hiring TWO postdocs to join the Cell Migration Lab (cellmig.org) 🇫🇮 as part of the new Centre of Excellence in Immune–Endothelial Interfaces (IMMENs). Join us to decode immune regulation & develop next-gen imaging tools! 🧪🔬 Details in thread 🧵👇 #ScienceSky #Postdoc #AcademicJobs Please RT🫶

3 factors can explain most of the variation in individual responses to HReT: measurement error, within-person biological variability, and true effect of the intervention 🙌Casper Soendenbroe for generating these data from another @ismcopenhagen.bsky.social study! journals.plos.org/plosone/arti...

Big congrats to Max Ravn Merkel who successfully defended his PhD today on the topic of tendinopathy, backed by a strong team of supervisors and challenged by sharp opponents Profs Paul Ackermann 🇸🇪 and Jess Snedeker🇨🇭 🙌🥳🙌

Spinal motor neurons in dazzling detail. ✨ Each green dot is a spinal motor neuron - crucial but rare cells making up just 1% of neurons in the spinal cord. In diseases like ALS, they are selectively damaged, making them of special interest to neuroscientists. #neuroskyence #FluorescenceFriday

🚨This morning’s good news is that Max Merkel’s paper Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response is now online! 🥳🎅🎄 advanced.onlinelibrary.wiley.com/doi/10.1002/...

💪🧠Thrilled to be awarded this grant to study how exercise supports the motoneurone-muscle interaction during ageing - with awesome collaborators @kevinmurachphd.bsky.social and Kristine Freude @ismcopenhagen.bsky.social 🙏@lundbeckfonden.bsky.social lundbeckfonden.com/en/exercise-...

📣Latest from the PowerLab 🚨 journals.physiology.org/doi/abs/10.1... In this study we show that Eccentric overload training provided a more robust stimulus for longitudinal muscle remodelling than conventional resistance training.

Big Bones Mean Big Muscles: An MRI-Based Dataset of Muscle-Bone-Body Size Relationships Across 70 Human Muscles of the Upper Limb, Trunk, and Lower Limb journals.physiology.org/doi/abs/10.1...

Allison M. Owen et al. present this #TopicalReview examining therapeutic and pathological actions for fibro-adipogenic progenitors following #musculoskeletal injury 🏋️ 🔬 🔗 Read it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

This was a fun team effort with @grithhojfeldt.bsky.social Christian Hoegsbjerg, Arvind von Keudell👏 covering the full spectrum of human skeletal muscle regenerative capacity 💪 from sports🏃‍♀️to trauma 🏥 settings. Lots more work to do in this field! @ismcopenhagen.bsky.social

Yesterday, Christian Couppé defended his doctorate of medical science (DMSc) investigating the Effects of Loading on Human Tendon in Health & Disease. Big thanks to the opponents Taija Finni & @larslandersen.bsky.social, chair Per Hölmich, & Jørn Wulff Helge for leading the ceremony 🥳 Congrats!

Two guest lecturers today! Håvard Visnes and Taija Finni give us new perspectives on the treatment of tendon ruptures, tendinopathy and ACL injuries.

In the snowy north❄️🇫🇮 today presenting our work on muscle memory in ageing and tissue injury, and learning about inter-individual variation🧠 Thank you Juha Ahtiainen and Mike Roberts for the invitation to this very interesting meeting🙏 Great to see old and new friends too🤗 @ismcopenhagen.bsky.social

Our review on all things muscle in CP is now published in Dev Med Child Neurology. Massive effort by Sebastian Edman with great support from Eva Ponten, Sudarshan Dayanidhi and @ferdinandvw.bsky.social onlinelibrary.wiley.com/doi/10.1111/...

New results presented at this morning's meeting by Birgitte Hougs Kjær from her impressive #PASEtrial testing treatment options for patients with chronic rotator cuff tendinopathy👏👏

Recruiting a comp PDRA for the lab 🚨 Working on multiple projects using integrated multi omics in bulk & single cell level Passion for data, coding, bioinformatics & keen to lead our labs comp workflow 12 months in first instance but extendable for further 19 months my.corehr.com/pls/coreport...

Day 2 of the Matrix Biology PhD course and we’re in the new Fælleshuset building starting our group work brain storming. Thanks to @douglaspdyer.bsky.social and @tranejoan.bsky.social for laying the foundations of ECM biology in yesterday’s lectures!

Upcoming Postdoc Position! With Chris Nelson’s lab at U of A, we are looking for a fully supported 2-year postdoc to work on muscle gene editing and detection of gene doping in vivo. If interested, email myself and Chris: [email protected] and [email protected] #myoblue

New month, new mesh! 🕸️🍂October newsletter is out; Latest on career opportunities, publications, upcoming events, initiatives💥A spotlight interview with P. Rosales that explores how funding cuts affects researchers📝Plus our monthly poll🗳️

Top Cited Review Article: Mechanisms of mechanical overload-induced skeletal muscle hypertrophy: current understanding and future directions Michael D. Roberts, et al. https://ow.ly/moMh50Xe5nU #hypertrophy #myofiber

A heavy lift from a literal strongman, PhD candidate PJ Koopmans “The Age-Dependent Resident Myonuclear Multi-Omic Response to a Skeletal Muscle Hypertrophic Stimulus” 💪🏻 www.biorxiv.org/content/10.1...

Our tendon enthusiasts @ccstorytime.bsky.social & @annesofieagergaard.bsky.social are in Nanjing, China for an international meeting focused on orthopedic surgery and sports medicine talking about their approach with circadian rhythms and exercise-based treatment on tackling tendinopathy ⏰🏋️‍♀️ #tendon

Hopefully of interest to scientists and exercise practitioners with and interest in muscle mass and functional gains in human volunteers. doi.org/10.1113/JP28... @jphysiol.bsky.social

Manuscript now accepted! 🥳 @steffendanielle.bsky.social @valerioizzi.bsky.social @abigailmackey1.bsky.social @ismcopenhagen.bsky.social Spatially distinct ECM-producing fibroblasts and myonuclei orchestrate early adaptation to mechanical loading in the human muscle-tendon unit

From the team, Bjørk Wulff West Helge & Kenneth Mertz presented data from our studies on ultrarunners & bodybuilders show the impact of extreme training volume and severe energy restriction 🏃‍♀️💪 (2/2)

Some interesting data from postdoc Nate Serrano: “Displaced myonuclei are attributable to both resident myonuclear migration and stem cell fusion during mechanical loading in adult skeletal muscle” www.biorxiv.org/content/10.1...

Looking for a PhD ? Don’t miss ⬇️ 12 PhDs available in the REMOD-HEALING European doctoral network, funded by Horizon Europe's MCSA-DN program, in Europe and Costa Rica ! www.euraxess.fr/jobs/375945 @themeshwork.bsky.social @matrixbiologie.bsky.social #ECM #collagen #WoundHealing #proteases

Can green proteins match animal protein in supporting muscle health after menopause? Congratulations to @grithhojfeldt.bsky.social on receiving nearly DKK 4 million from the @novo-nordisk.bsky.social to investigate sustainable proteins, strength training & healthy aging in women. 👏🌱🥛🧬

This morning we have a presentation from Kenneth Mertz about relative energy deficiency in sports, the myths around the topic, the sparse literature and how they aim to investigate REDS in athletes 💪🥗🏋️‍♀️ Check out his most recent work on effect on bone 🦴 onlinelibrary.wiley.com/doi/10.1155/...

Great postdoc opportunity here👇

Postdoc opportunity in muscle cell biology! You would not only be involved in an ambitious project but would also help develop cutting edge methods! Highly recommended! @robertseaborne.bsky.social

Time to bring out the big 🔫 for this morning meeting! Prof. Michael Krogsgaard gives an insightful presentation on the problem of the ankle and highlights the unanswered scientific questions of how to best treat them through surgical means💡

We quantified mRNA abundance, translation, protein abundance, protein degradation and cell growth across thousands of single cells from a mammalian tissue. The results revealed 𝐜𝐨𝐦𝐩𝐥𝐞𝐱 regulation & 𝐬𝐢𝐦𝐩𝐥𝐞 organizing principles: www.biorxiv.org/content/10.1... 🧵

"thought-provoking evidence that resident adult stem cells can rejuvenate aged tissue to a more youthful state" - fascinating!

Regenerate to “Rejuvenate”: Insights From Adult Resident Stem Cells of Aged Flatworms and Mice. A fun collaboration! onlinelibrary.wiley.com/doi/10.1111/...

The Molecular Foundations of High Heart Rates: Sarcomeric Protein Adaptations journals.physiology.org/doi/abs/10.1...

Today’s department meeting was presented by Max Ravn Merkel on the research MAGNETOM Free.Star MRI scanner and its possibilities. We also had an introduction to what the new CPH Center for Translational Research has to offer 🤩 Lots of new tools for our researchers with enthusiastic support 👩‍🔬

Congrats to our two winners of the @dsmb-dk.bsky.social annual meeting best oral presentation prizes! Best heparan sulfate talk sponsored by Amsbio goes to Jessica Oyie Sousa Onyeisi @gotteprof.bsky.social lab&best ECM talk sponsored by Tebubio goes to Ask Møbjerg @ismcopenhagen.bsky.social #proudPI

At the @dsmb-dk.bsky.social Annual Meeting 2025 and PhD student Ask Møbjerg is presenting our latest work on the acute effects of exercise on ECM remodelling of human muscle-tendon tissues using snRNAseq and RNAscope 🏋️‍♀️🔬 @ismcopenhagen.bsky.social

The authors discuss our recent article (link in comments) and its implications. Many questions remain to be elucidated. Muscle memory research is still in its early stages. physoc.onlinelibrary.wiley.com/doi/10.1113/... @jphysiol.bsky.social

An interesting read: physoc.onlinelibrary.wiley.com/doi/10.1113/...

Excited to start on this study with our collaborators at University Southern Denmark and learn about bones!

Check out this cool preprint led by @ccstorytime.bsky.social with snRNAseq data on 60,000 nuclei from human muscle-tendon tissue 4 h after exercise @myoblue.bsky.social