Congrats to Sakari Mäntyselkä, et. al, for the #APSselect paper "Glycolytic metabolism and biomass production from glucose in human skeletal muscle growth" in @AJPCellPhys @juhahulmi.bsky.social @JYUBiolPA https://ow.ly/Ewtv50XFNhq

Open access here: journals.physiology.org/doi/full/10.... @smantyselka.bsky.social @riikka-k.bsky.social

New study! Those who responded well to resistance training did quite well also in the second training after a training break. So some people seem to be physiologically more talented. But the individual nature of training adaptations are still overexaggerated. onlinelibrary.wiley.com/doi/10.1002/...

Exogenous hormones in combined hormonal contraceptive users may maintain already suppressed hypothalamic–pituitary–ovarian axis function in the presence of low energy availability in athletes. @ritutm.bsky.social onlinelibrary.wiley.com/doi/10.1002/...

Lactylation of mTOR enhances autophagy in skeletal muscle during exercise www.cell.com/cell-chemica...

Hopefully of interest to scientists and exercise practitioners with and interest in muscle mass and functional gains in human volunteers. doi.org/10.1113/JP28... @jphysiol.bsky.social

Miksi toiset kehittyvät liikuntaharjoittelussa nopeammin kuin toiset? Miten perimä vaikuttaa tuloksiin? Tule kuulemaan uusinta tutkimusta Jyväskylään 19.–21.11.! Ilmoittaudu normaalihinnalla 31.10. mennessä 👉 www.jyu.fi/fi/uutinen/l...

Our new study together with @juhahulmi.bsky.social shows that: Mechanical loading induces distinct and shared responses in endothelial and muscle cells and reveals exercise-like molecular profiles @wrihelsinki.bsky.social www.biorxiv.org/content/10.1...

Played a small part in this project, but there some really interesting and cool findings from the Sharples Lab here. Focus on the memory of repeat muscle atrophy in human skeletal muscle 💪

In this #JournalClub, Igor Longobardi of uspoficial.bsky.social et al. examine the work of Hulmi et al. (2025) and what is next for the ‘muscle memory’ conundrum? ✍️ 🔗 Access it here: physoc.onlinelibrary.wiley.com/doi/10.1113/...

I am pleased to share our new research article (in press version) entitled Glycolytic metabolism and biomass production from glucose in human skeletal muscle growth. Link in the comments. 1/3 #myoblue #SkeletalMuscle

New study from our lab! Human muscle cells incorporate glucose into proteins, RNA, and lipids, and anabolic stimulation further increased these processes. Resistance training increased metabolites and enzymes of these processes, e.g., PHGDH, which was shown to be anabolic. tinyurl.com/2744e22s

Elite strength and physique athletes differ in sport-specific muscle size and power. In these athletes, the muscle size contributes to muscle strength. Finally, females have better strength endurance than males, independent of the training background. tinyurl.com/39dfz977

Researchers investigated muscle memory of exercise in mice and the results suggest that skeletal muscle retains a metabolic memory of endurance exercise, which enhances adaptations following retraining: journals.physiology.org/doi/full/10....

Our findings provide new insight into the metabolomic signature of low energy availability (LEA) and support metabolomics as a tool for early detection of LEA. physoc.onlinelibrary.wiley.com/doi/10.14814...

2 min video of our recent study in J Physiol. physoc.onlinelibrary.wiley.com/doi/10.1113/... The link below:

Why do some progress faster in resistance training? 💪 How do genetics and physiology shape training responses? 🏋️‍♀️ Join us in Jyväskylä, Finland, Nov 19–21 for the Inter-Individual Variation in Resistance Training Responses Conference. www.jyu.fi/en/news/indi...

Combined angiogenic and hypertrophic gene therapy enhances skeletal muscle growth journals.physiology.org/doi/abs/10.1...

Sarcopenia is accelerated loss of skeletal muscle mass and function commonly, but not exclusively, associated with advancing age. It is observed across many species including humans in whom it can lead to decline in physical function and mobility. https://www.nature.c...

The authors discuss our recent article (link in comments) and its implications. Many questions remain to be elucidated. Muscle memory research is still in its early stages. physoc.onlinelibrary.wiley.com/doi/10.1113/... @jphysiol.bsky.social

An interesting read: physoc.onlinelibrary.wiley.com/doi/10.1113/...

I truly enjoyed this discussion with Dr. Mike covering a range of topics on food, nutrition, and metabolism. We also discuss my reasons for leaving NIH and what’s needed to really improve nutrition science. youtu.be/WBllzAb_vAk?...

Conference: Inter-individual variation in exercise. Please join! The speakers are e.g. @mackinprof.bsky.social, @abigailmackey1.bsky.social, M Bamman, T Hornberger, M Roberts, B Schoenfeld, M Perola, G Nader, E Sillanpää, A Hecksteden, W Derave, P Atherton, J Ahtiainen and me. tinyurl.com/34xzsdss

We showed that varying proximity-to-failure may not enhance short-term RT adaptations, but it allows RT with lower RPE. RIR accuracy was already good at baseline in trained individuals, but further improved by RT, supporting its use to guide training practices. link.springer.com/article/10.1...

Congratulations to Niclas Rausch, Rebecca L. McIntyre, Fabian Finger & Jens Lund of cbmr.science for winning the #JournalClub 2024 Prize! 📖 🏆 See their winning paper 'Cutting through dogma: a novel tool to dissect lactate biology'⬇️ physoc.onlinelibrary.wiley.com/doi/10.1113/...

“Muscle memory theory: A critical evaluation” in @JPhysiol led by postdoc Nate Serrano physoc.onlinelibrary.wiley.com/doi/10.1113/...

This was a very cool project to work on! More to come on this topic from our lab, I hope soon!

Early-life exercise even when followed by a detraining extended healthspan in mice. No effects on lifespan. www.nature.com/articles/s41...

“Making Sense of MYC in Skeletal Muscle: Location, Duration, and Magnitude” journals.physiology.org/doi/abs/10.1...

Intramuscular adipose tissue restricts functional muscle recovery www.cell.com/cell-reports...

Skeletal muscle stem cell mitochondria are transferred to muscle fibers in response to a hypertrophic stimulus academic.oup.com/function/adv...

Muscle growth by sarcomere divisions www.science.org/doi/10.1126/...

Our study led by @riikka-k.bsky.social demonstrate benefits of the combined gene delivery of Pro-MSTN and VEGF-B on muscle growth & body comp. The scRNAseq results suggest various cell types & their crosstalk in muscle growth. tinyurl.com/4tnnrh7a @apsphysiology.bsky.social ‪

www.biorxiv.org/content/10.1... Check how differently muscle cells and endothelial cells respond to mechanical loading from our latest study. Great work by @erikniemi.bsky.social @smantyselka.bsky.social and collaboration with @juhahulmi.bsky.social. Supported by @wrihelsinki.bsky.social

Conference: Inter-individual variation in exercise. Please join! The speakers are e.g. @mackinprof.bsky.social, @abigailmackey1.bsky.social, M Bamman, T Hornberger, M Roberts, B Schoenfeld, M Perola, G Nader, E Sillanpää, A Hecksteden, W Derave, P Atherton, J Ahtiainen and me. tinyurl.com/34xzsdss

Activin/myostatin blockers are actively studied. We have had in house production for the blockers of these ligands without contacts to drug companies and have published side effects: - Decreased voluntary running, physical activity and markers of oxidative capacity & autophagy: tinyurl.com/2xytr7rb

I'm pleased to announce the publication of two important papers in Sports Medicine on the first every large replication project in sport and exercise science. Read the full papers: lnkd.in/gH3NCqK5   lnkd.in/gE7izySW #SportsScience #EvidenceBasedPractice #Research #OpenScience #Replication

Late breaking at #ASCO25: A 3-year structured exercise program after adjuvant chemotherapy for colon cancer improved disease-free and overall survival, physical functioning, and fitness, as compared with health education alone. Full CHALLENGE phase 3 trial: nej.md/4mh5RPL @ascocancer.bsky.social

Thrilled to share that our manuscript mapping proteomic & phosphoproteomic signatures of NGT, T2D, males & females — before and after hyperinsulinemic-euglycemic clamp — is now accepted in Cell. @annakrook.bsky.social @juleenrzierath.bsky.social @cbmr.science doi.org/10.1016/j.ce...

Does #antioxidant supplementation influence the outcomes of #SIT #training? #skeletalmuscle fans, we might have some information for you. #proteomics leads the way! doi.org/10.1113/JP28... Kudos to the great Håkan Westerblad for guiding this multidisciplinary effort and to the amazing team!

its amazing how chatgpt knows everything about subjects I know nothing about, but is wrong like 40% of the time in things im an expert on. not going to think about this any further

Histone Lactylation Antagonizes Senescence and Skeletal Muscle Aging by Modulating Aging-Related Pathways advanced.onlinelibrary.wiley.com/doi/10.1002/...

Muscle needs to make serine from glucose to protect the fibers from mitochondrial disease. Read our story, a tour de force of Anastasiia Marmyleva and Christopher Jackson @SWAN @STEMM Helsinki University www.cell.com/cell-reports...

Great study by the Hornberger et al. in Nature metabolism (doi.org/10.1038/s422...)! They identify MKK3b-p38 MAPK-pathway mediating muscle growth. Reminds me of our study in 2012 were MAPK´s gamma isoform of p38 was phosphorylated more after 5x10 reps vs. 15x1 reps. tinyurl.com/279mma3w

It was a pleasure & a privilege to work with Prof Sue Bodine on this News and Views piece for @natmetabolism.nature.com highlighting new Hornberger Lab data on mechanically-sensitive MKK3b/6, p38,MK2, mTORC1 signaling mediating resistance exercise-induced muscle growth www.nature.com/articles/s42...

🎓EDITOR'S CHOICE🎓 Hulmi of @uniofjyvaskyla.bsky.social et al. found that resistance training produces a substantial change in the proteome of skeletal muscle & some proteins remain elevated, implying "muscle memory" of training. 🔗 physoc.onlinelibrary.wiley.com/doi/10.1113/...

Happy that our article is Editor´s choice in the May issue of 2025 in @jphysiol.bsky.social. physoc.onlinelibrary.wiley.com/doi/10.1113/...

Happy to host potential candidates. Please DM or email ([email protected]) me if you are or know someone interested.

Our latest review is out now in @jphysiol.bsky.social The repair capacity spectrum of human skeletal muscle injury from sports to surgical trauma settings Great team effort 🙌 @grithhojfeldt.bsky.social, Christian Hoegsbjerg, Arvind von Keudell @ismcopenhagen.bsky.social doi.org/10.1113/JP28...