First post on Blue Sky New pre-print! Does muscle remember disuse muscle wasting? Our new study shows skeletal muscle retains a molecular memory of disuse! Young muscle shows transcriptional resilience to repeated atrophy. Aged muscle shows exaggerated susceptibility. doi.org/10.1101/2025...

One of my former mentors now on BlueSky. Welcome @profadamsharples.bsky.social #MyoBlue 💪🏼

Played a small part in this project, but there some really interesting and cool findings from the Sharples Lab here. Focus on the memory of repeat muscle atrophy in human skeletal muscle 💪

Checkout the new paper from @hughesdc-muscle.bsky.social & Team, which also involved the CMR's @craigagoodman1.bsky.social Response of UBR-box E3 ubiquitin ligases & protein quality control pathways to perturbations in protein synthesis & skeletal muscle size journals.physiology.org/doi/abs/10.1...

Congrats to Steffen Raun, Lykke Sylow and Team for their new Redox Biology paper, "Skeletal muscle Rac1 mediates exercise training adaptations towards muscle glycogen resynthesis and protein synthesis", that included the CMR's Prof Paul Gregorevic www.sciencedirect.com/science/arti...

New Preprint alert 🚨 | Future insight into the direction of the lab too #MyoBlue Response of UBR-box E3 ubiquitin ligases and protein quality control pathways to perturbations in protein synthesis and skeletal muscle size www.biorxiv.org/content/10.1...

Applying lessons from limb muscle disuse and ageing to better understand ventilator-induced diaphragm dysfunction | #MyoBlue pubmed.ncbi.nlm.nih.gov/40638619/

Muscle AMP deaminase activity was lower in Neandertals than in modern humans pubmed.ncbi.nlm.nih.gov/40640132/

Sex differences in resting skeletal muscle and the acute and long-term response to endurance exercise in individuals with overweight and obesity pubmed.ncbi.nlm.nih.gov/40516819/

Reduction in Acetylation of Superoxide Dismutase 2 in Skeletal Muscle Improves Exercise Capacity in Mice With Heart Failure | #MyoBlue pubmed.ncbi.nlm.nih.gov/40511632/

Resistance exercise and skeletal muscle: protein synthesis, degradation, and controversies | #MyoBlue pubmed.ncbi.nlm.nih.gov/40512179/

A new Translational Perspective published in @jphysiol.bsky.social by Mark Viggars and @kaesser.bsky.social related to our previous manuscript on disuse and retraining physoc.onlinelibrary.wiley.com/doi/10.1113/...

The contribution of age and sex hormones to female neuromuscular function across the adult lifespan | #MyoBlue pubmed.ncbi.nlm.nih.gov/40349308/

3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights Into MFN-2-Mediated Changes onlinelibrary.wiley.com/doi/10.1111/...

Muscle mTOR controls iron homeostasis and ferritinophagy via NRF2, HIFs and AKT/PKB signaling pathways link.springer.com/article/10.1...

For those just returning from the APS Summit, I encourage you to submit your work to FUNCTION, an APS journal that covers a wide range of topics relevant to physiology.

Muscle wasting in cancer cachexia: Mechanisms and the role of exercise | #MyoBlue pubmed.ncbi.nlm.nih.gov/40159295/

Mechanotransduction and Skeletal Muscle Atrophy: The Interplay Between Focal Adhesions and Oxidative Stress www.mdpi.com/1422-0067/26...

Attention mitochondriacs! Mitochondrial supercomplexes by cryo-electron tomography. How can you not be blown away by how beautiful this is? Fascinating that ATP synthase is largely organized as dimers since this is one of the putative configurations of mPT pore. www.science.org/doi/10.1126/...

The Role and Regulation of Intramuscular Sex Hormones in Skeletal Muscle: A Systematic Review | #MyoBlue pubmed.ncbi.nlm.nih.gov/40101148/

Increased contact between lipid droplets and mitochondria in skeletal muscles of male elite endurance athletes | #MyoBlue pubmed.ncbi.nlm.nih.gov/40105858/

Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance pubmed.ncbi.nlm.nih.gov/40044687/ | #MyoBlue

Mitochondrial fatty acid oxidation regulates adult muscle stem cell function through modulating metabolic flux and protein acetylation pubmed.ncbi.nlm.nih.gov/40065099/ | #MyoBlue

Congrats to #RueggLab and colleagues on their new #NatComms paper: Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance. #Myoblue tinyurl.com/yeynb3t2

Deubiquitinating Enzymes Regulate Skeletal Muscle Mitochondrial Quality Control and Insulin Sensitivity in Patients With Type 2 Diabetes onlinelibrary.wiley.com/doi/10.1002/...

🚨🚨| For any American Physiological Society members, voting is open for President-Elect with the vote closing on Feb 28th. I encourage all to check out candidates but especially Sue Bodine, PhD who is on the ballot this year! #VoteBodine #MyoBlue

The ubiquitin-conjugating enzyme UBE2D maintains a youthful proteome and ensures protein quality control during aging by sustaining proteasome activity | #MyoBlue pubmed.ncbi.nlm.nih.gov/39879147/

Limiting cap-dependent translation increases 20S proteasomal degradation and protects the proteomic integrity in autophagy-deficient skeletal muscle pubmed.ncbi.nlm.nih.gov/39878121/ | #MyoBlue

Deubiquitinating enzyme USP2 alleviates muscle atrophy by stabilizing PPARγ pubmed.ncbi.nlm.nih.gov/39874418/ | #MyoBlue

Sex differences in the metabolism of glucose and fatty acids by adipose tissue and skeletal muscle in humans | #MyoBlue pubmed.ncbi.nlm.nih.gov/39869194/

The deubiquitinase USP5 prevents accumulation of protein aggregates in cardiomyocytes www.science.org/doi/10.1126/...

Want to come work with us to understand the role of mitochondrial permeability transition in skeletal muscle? Postdoc position available at UF on the BREATHE T32 (US citizens and permanent residents eligible). breathe.phhp.ufl.edu/training/bre...

I just reached out to my senators about the NIH situation. If you need to find out how much impact NIH has in your state in terms of dollars in and their economic impact here's a link: www.unitedformedicalresearch.org/nih-in-your-...

Starting off 2025 on a high with this review @jphysiol.bsky.social doi.org/10.1113/JP28... Casper Soendenbroe and I joined forces with 🤩neuroscientist Carl Johan Boraxbekk @ismcopenhagen.bsky.social Enhancing 💪 and 🧠 resilience: The role of prehabilitative exercise in mitigating disuse effects

The role of skeletal muscle respiratory capacity in exercise performance | #MyoBlue Review pubmed.ncbi.nlm.nih.gov/39755219/

In vivo imaging of glycogen in human muscle pubmed.ncbi.nlm.nih.gov/39737980/ | #MyoBlue

I'm excited about this- in this study we identified a new inhibitor of PFKFB kinase activities and we're hopeful for future applications. www.biorxiv.org/content/10.1...

Muscles growth by sarcomere divisions - how your muscles add new sarcomeres during developmental growth: they divide! Cool collaboration @friedrich-group.bsky.social @raunser-lab.bsky.social @Dirk Görlich @univ-amu.fr @cnrs.bsky.social sciencecast.org/casts/aspy9l... www.biorxiv.org/content/10.1...

Chaperone Proteins: The Rising Players in Muscle Atrophy | #MyoBlue pubmed.ncbi.nlm.nih.gov/39707668/

Abstract deadline to be considered for an oral presentation at the 2025 Advances in Skeletal Muscle Biology Conference is tomorrow (Dec 15) ⏱️✍️ @myoblue.bsky.social

Purification of mitochondria from skeletal muscle tissue for transcriptomic analyses reveals localization of nuclear-encoded noncoding RNAs faseb.onlinelibrary.wiley.com/doi/10.1096/...

Estradiol deficiency as a consequence of aging contributes to the depletion of the satellite cell pool in female mice | #MyoBlue pubmed.ncbi.nlm.nih.gov/39641290/

Diversity in Chemotherapy-Induced Cachexia journals.physiology.org/doi/abs/10.1...

Check it out ⤵️ Several of our scientists and outstanding trainees are on Bluesky. go.bsky.app/5oUbpNy

Congratulations to the CMR's newly graduated Dr Jin Dylan Chung & Prof Gordon Lynch & MCRI's Prof Enzo Porrello for their new review on "Muscle regeneration and muscle stem cells in metabolic disease" www.sciencedirect.com/science/arti...

I am excited to share a new review led by Spencer Procopio, a PhD student in the lab. Clockwork conditioning: Aligning the skeletal muscle clock with time of exercise focusing on cardiometabolic health. www.sciencedirect.com/science/arti...

Nicotinic acid improves mitochondrial function and associated transcriptional pathways in older inactive males www.degruyter.com/document/doi...

After a great visit last week to Virginia, next week is a visit to Florida. Enjoying these opportunities to share our latest work on E3 ligases, metabolism and protein synthesis. 💪🏼

Transcriptomic analysis of skeletal muscle regeneration across mouse lifespan identifies altered stem cell states www.nature.com/articles/s43...

Started a Starter Pack of Physiologists (and Physiology Journals) that have made the move 2 Bluesky. If you’re a #physiologist and I missed you! Please say hey in comments so I can update!Hoping 2 put together a pretty strong list 2 make it easier 4 us 2 find each other on here! go.bsky.app/6cccp6E