New paper from @CNEM_Bath in @JPhysiol led by @lfbradshaw Isolating the effects of carbohydrate and lipid availability on exercise-induced skeletal muscle signalling doi.org/10.1113/JP28... (1/7) #exercise #metabolism #muscle #fasting

Born #OnThisDay in 1934 was astronomer, astrobiologist and science communicator Carl Sagan. As well as being one of the world's greatest science communicators, he worked on the Viking and Mariner missions. Listen to his famous 'Pale Blue Dot' monologue: https://bit.ly/2ANRX30

You categorised patients as responders or non responders by dichotomising a change from baseline? You triple criminal!

Stop interpreting clinical trials as if they were surveys. www.linkedin.com/pulse/illegi...

The target population for the research question is the population of people who would satisfy the eligibility criteria. “ Wrong x 2 1) The eligibility criteria define who doesn’t come into the trial not who does. 2) We generalise from quite different trials to populations eg bioequivalence trials.

Galton calling for data sharing in 1901 - does anyone know of earlier examples?

Is Human Energy Expenditure Constrained? I recently debated Herman Pontzer on this topic in Shenzhen, China. My slides can be viewed here: www.linkedin.com/posts/javier...

Mendelian randomization (MR) was partly a response to the many epidemiological studies suggesting vitamins were protective against various diseases, only for randomised trials to be null. The story of how fallacious MR attempted to resurrect the spurious claims here academic.oup.com/ije/article/...

It was a rewarding labour of love to work on this paper with a fantastic team of authors, “Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists”. @hk-ijsnem.bsky.social journals.humankinetics.com/view/journal...

New insights into glycogen recovery in endurance athletes 🧵 1️⃣ Our new study in The Journal of Physiology tested how muscle + liver glycogen recover after exhaustive cycling in well-trained cyclists.

The ideal, of course, is to have randomisation embedded into routine practice … then, the real world data of the future will be randomised data giving the best of both worlds 9/9

There has been a lot of debate recently about the promise of real world data - the routine (observational) data collected on patients eg  treatments received, clinical outcomes etc – for estimating treatment effects. But can they deliver? 1/9 #MethodologyMonday #123

New paper! Do ketone esters affect post-exercise recovery? doi.org/10.1007/s003... #ketones #exercise #sports #nutrition #recovery

🚨 3-year Post-doc opportunity at the Centre for Nutrition, Exercise and Metabolism Opportunity to lead on an RCT involving symbiotic supplementation and ketogenic diets www.bath.ac.uk/jobs/Vacancy... Building in our prior work pubmed.ncbi.nlm.nih.gov/39106867/

This is a very interesting study comparing physiological variables between two phases of the menstrual cycle across two whole cycles. The design resembles a replicate crossover trial which enables proper study of individual responses. physoc.onlinelibrary.wiley.com/doi/10.1113/...

This is, however, not clever or safe writing, it is a bad collective habit that needs to stop. Not by avoiding references to causality but by clear referencing to it pubmed.ncbi.nlm.nih.gov/37286459/

The mixed-meal tolerance test in appetite research 🧵 Topics covered: -Familiarisation/Standardisation 🟰 -Meal stimulus 🥣 -Appetite scales 😋 -Blood sampling 💉 -Blood analyses 🩸 -Data handling 📊 nature.com/articles/s41...

After very valuable comments from referees, here's the revised preprint for our paper "Understanding treatment response heterogeneity using randomised crossover trials: A primer for exercise and nutrition scientists" (@lorenzololli.bsky.social @j-t-gonzalez.bsky.social et al) osf.io/preprints/os...

Here is a link to the trial I refer to. The energy expenditure outcome was one of several outcomes. Not all showed such unreliable response heterogeneity. The crucial estimand is the person-by-treatment interaction variance, not what is seen on a waterfall plot link.springer.com/article/10.1...

No agreement at all. What we are dealing here is within-subjects (period-to-period) random variation swamping any response heterogeneity. Without a replicate trial, we wouldn't have known that 1st set of responses are not "true". Unfortunately, many conclusions on this topic are compromised by this.

Looks good doesn't it? This is how some researchers conclude there are individual differences in response. Some might even say participant 1 is an "extreme responder". But just to say that this trial was actually a replicate crossover. Here's the second set of differences plotted in the same order.

Waterfall plots present changes or differences for individual cases. While "show the data" is 👍, just a reminder that these plots don't inform about treatment response heterogeneity on their own. Here's a plot of the treatment-control differences in energy expenditure from a crossover trial.

New PhD opportunity in nutrition and metabolism at @uniofbath.bsky.social - closing date 31st March. Come and join CNEM! eur01.safelinks.protection.outlook.com?url=https%3A...