In honour of the late Dr Simon J Marshall: www.lboro.ac.uk/research/ias...

We were fortunate enough to welcome Dr Eimear Dolan (@eimeardol.bsky.social) to our Editorial Board back in September as an Associate Editor! ✍🏼

Check out our exciting January 2026 issue line up! 🤩

New paper from @CNEM_Bath in @JPhysiol led by @lfbradshaw Isolating the effects of carbohydrate and lipid availability on exercise-induced skeletal muscle signalling doi.org/10.1113/JP28... (1/7) #exercise #metabolism #muscle #fasting

The link between the gut #microbiome and autism is not backed by science, researchers say. Read the full opinion piece in @cp-neuron.bsky.social: spkl.io/63322AbxpA#microbiome @wiringthebrain.bsky.social, @statsepi.bsky.social, & @deevybee.bsky.social

We did a thing. 😬

✨NOVEMBER 2025 ISSUE OUT NOW✨

The advances we've made in statistics, experimental study design, and causal inference over the past century are remarkably useful for understanding our world. But there is never been a push to make people use them like we are seeing with generative AI. Perhaps take a moment to consider why.

Our "#Physiology and the #Olympics" #SpecialIssue is out now! Included in-issue: Long-haul travel and athletic performance Sex differences in track and field Oxidative and diffusive function in swimmers' triceps And more! Read the issue below: 📖 buff.ly/RFAXfRu 📸 @benshunter.bsky.social et al

"Inter-Individual Variability of Acute Cardiovascular Responses to Low-Load Resistance Exercise with Different Methods of Blood Flow Restriction" journals.lww.com/acsm-msse/ab...

The term #estimand is now part of the technical language of trials - but it remains a concept that many find hard to understand. Recent work has aimed to make the term more accessible to researchers, patients & public 1/8 #MethodologyMonday #127

There is no need for a moral panic about the UK's welfare system. Far from perfect but recent discourse is nuts Spending is controlled, not spiralling Worklessness is near record lows My column www.ft.com/content/ee67...

Happiness, humour, truth and, most crucially, courage are the qualities needed to repel the racist tide. Because its architects offer whining, victimhood, lies and, most crucially, cowardice.

#SportScience, especially in elite sports, has an issue that can make effects seem more impressive than they really are... selection bias on the sample (explanation🧵 and a simulation pictured to illustrate below). 1/12

Read more about RCTs and why they’re so important: ourworldindata.org/randomized-c...

WHO statement on autism-related issues The World Health Organization (WHO) emphasizes that there is currently no conclusive scientific evidence confirming a possible link between #autism and use of acetaminophen (also known as paracetamol) during pregnancy Full statement bit.ly/47YsgwI

Good luck media fact checkers. You have my sympathy.

Find the full paper here 🔗 doi.org/10.1123/ijsn...

🚨LEAD FEATURE ARTICLE🚨 November 2025✨ We are very excited to announce our lead feature article for the November 2025 by Lolli et al titled ‘Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists’.

Restating a prediction I made on twitter that university rankings will be a thing of the past 10 years from now, and we'll look back on the university heads that first led us away from them with a great respect and appreciation....1/

Almost 900 fewer people have been injured on Welsh roads since the default speed limit was lowered from 30 to 20mph two years ago Casualties on 20 to 30mph roads between July and September 2024 were the lowest for the three month-period since records began in 1979 👏 Evidence-led policy

So happy to see this one out! Thank you so much for your help @gregatki.bsky.social, your insight and analysis of the data were invaluable (as always!). Look forward to working with you again.

Congrats to @lucymerrell.bsky.social on her new paper, "Basal Metabolic Requirements, Biomarkers of Cardiometabolic Health, & Anthropometric Measures of Obesity in Women & Men With Restricted Growth Conditions". It was a pleasure to work on this project. onlinelibrary.wiley.com/doi/10.1002/...

This is big! Worked with great statisticians on guidelines for meta-analysis & systematic review. We discuss rationales for systematic review, evaluation & interpretation of heterogeneity, & common errors in network meta-analysis, funnel plots etc. www.europeanurology.com/article/S030...

It is first important to stress that pilot and feasibility studies are *not* about detecting intervention effects. They are about exploring key uncertainties ahead of the main trial 2/6

I seem to have been discussing pilot and feasibility studies a lot this week. One question often asked is how big should my pilot/feasibility study be? 1/6 #MethodologyMonday #124

✨ NOVEMBER 2025 ISSUE LINE-UP✨ How are we already on the last issue of 2025?! This year has flown by but lucky for you, the IJSNEM content keeps on delivering. Stay tuned for papers to feature 🔔

Deborah Fuller, a microbiologist from UWash, wrote this article pointing out many of the false statements made by RFK in his senate hearing yesterday and explaining why they were false.

www.medrxiv.org/content/10.1... INSPECT-SR: A tool for assessing trustworthiness of randomised controlled trials.

One of the most common misunderstandings about the use and value of placebos in clinical RCTs, often made by both methodological experts and experienced trialists: (from @stephensenn.bsky.social in academic.oup.com/jrsssa/advan...)

I wrote about gene-gene interactions (epistasis) and the implications for heritability, trait definitions, natural selection, and therapeutic interventions. Biology is clearly full of causal interactions, so why don't we see them in the data? A 🧵:

It was a rewarding labour of love to work on this paper with a fantastic team of authors, “Understanding Treatment Response Heterogeneity Using Crossover Randomized Controlled Trials: A Primer for Exercise and Nutrition Scientists”. @hk-ijsnem.bsky.social journals.humankinetics.com/view/journal...

Another nail in the coffin for ratios - this one in the context of running economy, "Quantifying Running Economy in Amateur Runners: Evaluating VO2 and Energy Cost with Model-based Normalization", www.jssm.org/jssm-24-684....

1/6. At present, I am thinking a lot about additive vs multiplicative treatment/intervention effects on tests of athletic performance, or athletic performance itself. I favour exploration rather than blanket assumptions.......

Pilot trials have a key role in preparing for definitive randomised trials, yet determining their sample size remains challenging. This article provides guidance, methods, and tools for calculating and justifying sample sizes in randomised pilot trials www.bmj.com/content/390/...

“…it is 𝒏𝒐𝒕 𝒈𝒆𝒏𝒆𝒓𝒂𝒍𝒍𝒚 𝒂𝒑𝒑𝒓𝒐𝒑𝒓𝒊𝒂𝒕𝒆 to determine the summary measure solely by examining either 𝙞𝙣𝙙𝙞𝙫𝙞𝙙𝙪𝙖𝙡 𝙥𝙧𝙤𝙛𝙞𝙡𝙚 𝙘𝙪𝙧𝙫𝙚𝙨 or mean curves 𝙥𝙚𝙧 𝙩𝙧𝙚𝙖𝙩𝙢𝙚𝙣𝙩 𝙜𝙧𝙤𝙪𝙥. Instead, it is best to study an 𝗮𝗽𝗽𝗿𝗼𝗽𝗿𝗶𝗮𝘁𝗲 𝗰𝗼𝗻𝘁𝗿𝗮𝘀𝘁 𝗯𝗲𝘁𝘄𝗲𝗲𝗻 𝗴𝗿𝗼𝘂𝗽𝘀.” @stephensenn.bsky.social et al. Stat Med. 2000 Mar 30;19(6):861-77.

Evaluating bias in the anchor method for the minimal clinically important difference: a simulation approach. Greg Hather & Polyna Khudyakov. Journal of Biopharmaceutical Statistics. www.tandfonline.com/doi/full/10....

The convenient labelling of small sample studies as "pilot studies" is rife in exercise science research. Next time you see one, ask the authors to remove all reference to a treatment/intervention effect and see what happens 😬

There has been a lot of debate recently about the promise of real world data - the routine (observational) data collected on patients eg  treatments received, clinical outcomes etc – for estimating treatment effects. But can they deliver? 1/9 #MethodologyMonday #123

New blog article in Statistical Thinking: www.fharrell.com/post/aci/ #Statistics #StatsSky #RStats

1 in 3 doctors were born overseas. 1 in 5 university academics were born overseas. 1 in 7 UK business founders were born overseas. 1 in 2 builders were born overseas. 1 in 5 nurses were born overseas. 1 in 4 transport workers were born overseas. The media, their framing, IS the problem

New paper! Do ketone esters affect post-exercise recovery? doi.org/10.1007/s003... #ketones #exercise #sports #nutrition #recovery

Why tests of moderation by gender are rarely significant in meta-analysis. psycnet.apa.org/record/2023-...

Papers often conclude "more research is needed" without explanation. This is a missed opportunity. You are the expert. This is your time to shine. Explain what the remaining uncertainties are, and give justified recommendations on what the research needed to resolve them should look like.

link 📈🤖 Covariate adjustment for linear models in estimating treatment effects in randomised clinical trials. Some useful theory to guide simulation (Senn, K\"onig, Posch) Building on key papers that were published in special issues of Biometrics in 1957 and 1982 we propose and develop a three-as

Q.E.D.

I did not have to click on this to know what is would refer to the Hazda in the first paragraph, and I was not disappointed. The research this is based on, imo, asks an ill-posed question that has little salience for individuals.

This is a very interesting study comparing physiological variables between two phases of the menstrual cycle across two whole cycles. The design resembles a replicate crossover trial which enables proper study of individual responses. physoc.onlinelibrary.wiley.com/doi/10.1113/...

For who still thinks this can’t happen here… it’s already happening. www.theatlantic.com/science/arch...

To Infinity and Beyond My talk from ICPM 2025 in Amsterdam earlier this year icpm2025.com/wp-content/u...