Breaking down the folate/leucovorin/ASD story here: open.substack.com/pub/kcklatt/... This is an important one for the media to get right & pressure HHS to fund $$ solid trials. The energy of this moment could really get citizens and caregivers/pts involved in the scientific process.

The administration that has attacked Medicaid, SNAP, WIC and school lunch resources is now not going to survey food insecurity anymore because it's been too politicized. Hunger is an intrinsically political issue in the richest country in the world. www.wsj.com/economy/trum...

I know spitballing how to improve rigor and reproducibility feels silly these days but my time in academia has radicalized me to believe: 1) there should be preregistration & a flow diagram (eg CONSORT) for final published 🧫🐀🧪 data 2) a detailed SOP for every method in the paper should be published

Kennedy is over on X trying to rile up his base to cover up the ACIP disaster this week by pretending that community water fluoridation policies are about medical freedom, when fluoride exists naturally in the water supply and we simply regulate therapeutic and upper limit thresholds.

Alt headline: processed meat producers to reformulate to appease MAHA, remove none of the ingredients implicated in chronic disease risk. www.ktvu.com/news/tyson-f...

Sad state of things when my first thought seeing this post, as a researcher in maternal health, wasn't that pregnant and lactating individuals are so underrepresented in studies but that I was worried for what this administration plans to do with data collected on exposures during lactation.

The Monnarez testimony is pretty wild. But even more unprecedented is the use of HHS social media in an all out blitz against her. I know we hear that this admin requires loyalty but this is full blown propaganda state to simultaneously destroy the reputation of a past director & suck up to Trump.

The American Journal of Clinical Nutrition is recruiting its 3rd Early Career Editor! Please consider applying and sharing across your networks, especially with physicians interested in nutrition or adjacent specialties. nutrition.org/foundation/a...

It's still a little bewildering to me that the same folks pushing designer vitamins with methylated folates also emphasize methyl B12, despite evidence of upper axial ligand removal from any B12 you consume & that the cobalamin is accepting the methyl group from folate b4 transfer to homocysteine.

I'm so full from the nothingburgers this admin keeps putting out. The report reads like a list of aspirations or pledges as opposed to a cogent look at what HHS & USDA have the power to do, what's needed from Congress & the states, what's needed from industry and what's needed from the culture.

For any #metabolism nerds looking for some indulgence (and an escapism from the news chaos), JIMDs podcast is a great listen! I enjoyed this weeks episode on Adenosine Kinase open.spotify.com/episode/1YRs...

Despite the headlines abt the coming HHS announcement, there isn't one folate-autism link. Several have been explored & the evidence ranges from speculative to promising hypotheses w prelimimary data -- but few conclusions to satisfy HHS' effort to find causes/tx's. open.substack.com/pub/kcklatt/...

Already getting DMs with questions from patients and providers about 5-formylTHF/leucovorin & Autism. It's a prescription, the existing response rate in trials is variable and likely depends on dose, timing, folate receptor autoantibody titers, so I encourage getting involved w clinical trials

I wonder how many supplement companies that ditched folic acid for 5MTHF are now frantically googling suppliers for 5FTHF.

I'll be interested to see where this goes - cerebral folate deficiency linked to folate receptor autoantibodies presenting with autism-like symptoms is a very small area of research. No population data to say how prevalent of a link it is and no landmark clinical trials that 5formylTHF/leucovorin

Despite all the rhetoric from folks amongst the altmed/MAHA crowds who think they're pwning corrupt hospitals and doctors with their anti-establishment health regimens... my group chats with various providers are full of everyone talking about how we've been busier than ever..

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

There's a strong chance that RFK Jr looks at kids in the airport and also sees chloroplast dysfunction.

Amidst all the chaos, I am saddened by how much potential to actually impact nutrition, science funding, rigor & reproducibility, etc is being wasted. Defense against existential threats & fundamentally anti-science sentiments is essential but can't distract entirely from the need for future reform.

For anyone wondering how we got to the point of an HHS Director who's thinking about children's mitochondria when he looks at them. There are so many academic medical centers complicit in how we got here because embracing the rise of bs integrative & functional medicine helped turn a profit.

CDC cut funding for FoodNet, a population-based surveillance program for 8 foodborne pathogens For any keeping score in this admin, that's zero real improvements on nutrition-related chronic disease risk while increasing nutrition-related infectious disease risk. share.google/UehmnDrKHWOd...

Metabolic Assessment 101: A) Assess Anthropometrics🟢 B) Assess Dietary Intake🟢 C) Assess Clinical Chemistries 🟢 D) Look at the pediatric patient to diagnose mitochondrial and inflammatory disease 🚫

More evidence that intensive lifestyle interventions make a meaningful impact - yet in the USA, there's such a poor coverage for these interventions. This new trial is great but we've known this since the early 2000s with the publishing of the DPP. When are we going to cover preventive RD services?

This year's Annual Review of Nutrition is out and full of really great reads. My contribution details the broad history of nutritional guidance in America & covers the forces (science/politics/culture) that have driven the evolution of nutrition guidance. www.annualreviews.org/content/jour...

Today’s episode of The Ezra Klein Show. Rachael Bedard and David Wallace-Wells on Covid disillusionment and the rise of the MAHA movement. open.spotify.com/episode/6VhH... youtu.be/VCaD4vh4XhI?...

The attempted coercion to have children claiming 'god will provide' is particularly gross coming from Greene, a rep for Georgia that gets a failing grade on most metrics of maternal & infant morbidity/mortality and coverage of social policies. We get a little closer to the Handmaid's Tale every day.

Every young scientist I know is scrambling to find a way out of USA academia. There is no amount of assurances or gaslighting abt the situation 'being overblown' that is going to convince folks who've sacrificed massively in training (both time & earnings) that academia is worth further risk.

Dear researchers in the USA, are you or someone you know a global expert in protein and food science and do you want to escape to Canada? My Department at the @umanitoba.bsky.social is looking for Candidates for a fancy Canada Excellence Research Chair (CERC) in Protein Foods Transformation!

We've heard rumblings about the Dietary Guidelines being reduced to a 4 page document - this might sound simple but has pretty huge implications for policy & labeling initiatives. A breakdown of the DGAs, what the admin has said abt them so far& what we might expect open.substack.com/pub/kcklatt/...

My latest on the Health Sec who promised to figure out what causes autism and the autism research that's been stopped along the way www.propublica.org/article/rfk-...

We've heard rumblings about the Dietary Guidelines being reduced to a 4 page document - this might sound simple but has pretty huge implications for policy & labeling initiatives. A breakdown of the DGAs, what the admin has said abt them so far& what we might expect open.substack.com/pub/kcklatt/...

Also reminds me of circa 2015 when groups dedicated to spreading abject misinformation about GMOs would invoke the need to pivot to other plant breeding techniques because the public doesn't trust GMOs.

HHS X account is tweeting that beef tallow fried potatoes are healthier than seed oil fried potatoes bc of handwavey mechanistic rationale based on the presence of oxidized lipid products & zero data with human health outcomes. Bonus points for shoehorned 1990s oxidative stress theories of disease.

Happy to contribute to the Federation of American Scientists x Good Science Project policy memos tackling systematic improvements needed in science. My memo calls for reinvigorated & reimagined funding and infrastructure for controlled nutrition trials research. fas.org/publication/...

I am currently choosing between faculty offers, including 1 non-American one, and this administration is really doing its best to beat out salary, start up & research environment as the major factor making my decision.

important read from Christopher Duggan MD MPH @hsph.harvard.edu @bostonchildrens.bsky.social calling for societies in pediatrics & gastroenterology to speak up/ advocate during this era of mass funding cuts & undue vaccine skepticism that will inevitably increase morbidity/mortality across the globe

important read from Christopher Duggan MD MPH @hsph.harvard.edu @bostonchildrens.bsky.social calling for societies in pediatrics & gastroenterology to speak up/ advocate during this era of mass funding cuts & undue vaccine skepticism that will inevitably increase morbidity/mortality across the globe

For an HHS Secretary claiming to prioritize transparency, the discarding of the usual process of making DGAs & secrecy around who is leading this process is yet another 'actions contradicting words' moment for MAHA. www.medpagetoday.com/special-repo...

Everyone. Please stop doing this. Validate your reagents. Thank you for your attention to this matter.

Always money for wars, tax cuts for the rich, and now apparently, golden ballrooms. Yet somehow there's a perpetual scarcity when it comes to food, medicine, and science funding. The swamp is bubbling over.

New from @stephaniemlee.bsky.social www.chronicle.com/article/thei...

Unfollow health and wellness influencers who regularly invoke that the products they sell are science-based, yet haven't used their large platforms to raise awareness about the proposed NIH/NSF budget cuts.

#Breaking: Trump administration blocks NIH from awarding any research grants and contracts www.statnews.com/2025/07/29/t...

I've seen a number of folks talking about grants they/colleagues had cut & lists of those going around - plz share this effort by @brindabee.bsky.social & @realdoctormike.bsky.social to gather stories of cancelled research grants and clip these into a media campaign docs.google.com/forms/d/e/1F...

Trying to care about my own and others' nutrition and metabolism science while the scientific funding apparatus and public health nutrition programs are being carelessly torn apart is... very challenging.

“The new policy means that the number of grants that can be funded this year will drop dramatically. And that will decimate US biomedical science labs across the country, and set back medical research and cures for disease by years.” open.substack.com/pub/donmoyniha…

1/Patient-derived xenografts (PDXs) are used in preclinical testing of cancer therapies, including metabolic therapies. We determined which metabolic properties are retained, and which are lost, when melanomas from patients are implanted and passaged as PDXs in mice. www.nature.com/articles/s42...

Online now: Gut substrate trap of D-lactate from microbiota improves blood glucose and fatty liver disease in obese mice

Everyone in nutrition - from advocates to researchers and clinicians - please read and share this from Tashara M. Leak, Ph.D., R.D. One example of many nutrition research cuts that flies in the face of the administration and MAHA's stated agenda. whyshoulditrustyou.substack.com/p/i-was-just...

Very excited for this review to be out! A dive into PET/MRS techniques for measuring brain glucose concentrations and cerebral metabolic rate of glucose in the context of diabetes and obesity. #neuroimaging #obesity #diabetes #metabolism #neuroendocrinology link.springer.com/article/10.1...