Continuing to see so much blatantly anti-vaccine messaging nowadays that looks no different than foodie messaging (embraced by many legit folks) from a decade ago. If your nutrition messaging can be co-opted into an anti-vaccine tropes w minimal rewording, consider changing your nutrition messaging

Credit to MDPI for retracting this vitamin D/COVID-19 meta-analysis that @gidmk.bsky.social and I flagged: pubpeer.com/publications...

There are ongoing claims that acetaminophen (Tylenol) use in pregnancy causes autism. Here’s five things you should know 🧵

The academic debates arnd saturated fat have largely questioned whether they're as 'bad' as once thought, given the limited association w CVD in cohort studies assessing self reported intakes in relation to risk (despite controlled feeding trials clearly showing a linear relationship w LDL/ApoB).

You may have read that your protein supplements are giving you lead poisoning. That's not the case. If you want to have protein shakes, that's fine. But whether you need to and whether they're safely regulated is a different story. My latest for @vox.com. www.vox.com/future-perfe...

Meet Richard Frye, whose research record on leucovorin traces the gulf between promise and proof. By Brendan Borrell www.thetransmitter.org/spectrum/exc...

Folks following the leucovorin & autism story should be aware of a ton of PubPeer activity on one of the major trials. Many inconsistencies, statistical concerns, etc raised. pubpeer.com/publications...

A good insider view of a dysfunctional FDA, helping to explain why Makary said leucovorin would treat 100Ks of kids w autism, meanwhile they pursued an indication for the rare disease of CFD. FDA is choosing political wins at the expense of false hope for millions of families/ individuals w autism.

MMWR stole the show in the first round of headlines about CDC cuts but in the chaos, many missed that the NHANES mobile team remains RIF'd. This is the backbone of this key survey that contains some of the only representative anthropometric, biochemical, clinical and dietary data on the country.

This moment -- when we have a failing traditional healthcare system + increasing acceptance of low evidence, hyperbolic 'food is medicine'/lifestyle/functional medicine' + a government eager to co-opt/endorse wellness slop -- is particularly scary for folks who care abt evidence-based nutrition

BREAKING: Friday night massacre underway at CDC. Doznes of "disease detectives," high-level scientists, entire Washington staff and editors of the MMWR (Morbidity and Mortality Weekly Report) have all been RIFed and received the following notice:

Gave some quotes to NPR about the coming chaos with the DGAs. Full primer here: kcklatt.substack.com/p/what-to-ex...

Peer Review reports went live on the 'Harvard' citation the administration is using to support the Tylenol-Autism/ADHD link. Pretty eyebrow raising ehjournal.biomedcentral.com/articles/10....

Nancy Mace on Bill Maher telling pregnant women to take Ibuprofen instead of Tylenol is so emblematic of everything wrong with this administrations approach to health.

It was a pleasure to chat with @drjessicaknurick.bsky.social about ultra-processed foods and other topics discussed in my new book Food Intelligence co-authored with @juliabelluz.bsky.social. substack.com/home/post/p-...

The leucovorin story is already blending with existing misinformation online about folic acid and MTHFR genotypes to create a new generation of medicalized claims without much evidence.

Every basic scientist & PhD program director should be watching how cell culture and rodent models of Tylenol exposure are being used by motivated parties (e.g. it depletes your glutathione! Science proves it PMID...) to sell a narrative and sow confusion right now.

Really excited to announce that I've accepted an Assistant Professor position in the Department of Nutritional Sciences in the Faculty of Medicine at the University of Toronto! Looking forward to venturing north (🥶) & building out my own research group focused on human nutrition & metabolism 🥳

Excited to listen to the new nutrition science book from @kevinh-phd.bsky.social & @juliabelluz.bsky.social ! It's rare I recommend a popular book about food and nutrition but this is an absolute must read for anyone interested in the science. amzn.to/42akyvM

It's very bizarre that the admin pursued a leucovorin indication for children with cerebral folate deficiency and autism symptoms, not for general autism. CFD is rare and the diagnosis is confirmed by measuring folate levels in cerebrospinal fluid, which most general cases of autism won't have.

For an admin that loves to weaponize the quality of the science behind COVID pandemic public health restrictions and emphasizes needing gold standard science, it's interesting we are inflating the risks of Tylenol & benefits of Leucovorin based on pretty weak evidence

The hilariously butchered pronouncement of acetaminophen makes me really wish someone had tried to call leucovorin by its chemical name, 5-formyltetrahydrofolate

As the admin continues to purport to have found environmental causes of autism (& pretend to care about nutrition), I find myself thinking a lot the failed National Children's Study. There's a push to have answers w/o reckoning w the reality of the studies we haven't done undark.org/2016/05/25/t...

With the inevitable coming shortages of leuocovorin, there's going to be a huge push for influencers (& folks in our government) to profit off of folinic acid supplements. A few things: -doses used in trials are pharmacological and the OTC supplemental versions will last a few days to maybe a week.

Breaking down the folate/leucovorin/ASD story here: open.substack.com/pub/kcklatt/... This is an important one for the media to get right & pressure HHS to fund $$ solid trials. The energy of this moment could really get citizens and caregivers/pts involved in the scientific process.

The administration that has attacked Medicaid, SNAP, WIC and school lunch resources is now not going to survey food insecurity anymore because it's been too politicized. Hunger is an intrinsically political issue in the richest country in the world. www.wsj.com/economy/trum...

I know spitballing how to improve rigor and reproducibility feels silly these days but my time in academia has radicalized me to believe: 1) there should be preregistration & a flow diagram (eg CONSORT) for final published 🧫🐀🧪 data 2) a detailed SOP for every method in the paper should be published

Kennedy is over on X trying to rile up his base to cover up the ACIP disaster this week by pretending that community water fluoridation policies are about medical freedom, when fluoride exists naturally in the water supply and we simply regulate therapeutic and upper limit thresholds.

Alt headline: processed meat producers to reformulate to appease MAHA, remove none of the ingredients implicated in chronic disease risk. www.ktvu.com/news/tyson-f...

Sad state of things when my first thought seeing this post, as a researcher in maternal health, wasn't that pregnant and lactating individuals are so underrepresented in studies but that I was worried for what this administration plans to do with data collected on exposures during lactation.

The Monnarez testimony is pretty wild. But even more unprecedented is the use of HHS social media in an all out blitz against her. I know we hear that this admin requires loyalty but this is full blown propaganda state to simultaneously destroy the reputation of a past director & suck up to Trump.

The American Journal of Clinical Nutrition is recruiting its 3rd Early Career Editor! Please consider applying and sharing across your networks, especially with physicians interested in nutrition or adjacent specialties. nutrition.org/foundation/a...

It's still a little bewildering to me that the same folks pushing designer vitamins with methylated folates also emphasize methyl B12, despite evidence of upper axial ligand removal from any B12 you consume & that the cobalamin is accepting the methyl group from folate b4 transfer to homocysteine.

I'm so full from the nothingburgers this admin keeps putting out. The report reads like a list of aspirations or pledges as opposed to a cogent look at what HHS & USDA have the power to do, what's needed from Congress & the states, what's needed from industry and what's needed from the culture.

For any #metabolism nerds looking for some indulgence (and an escapism from the news chaos), JIMDs podcast is a great listen! I enjoyed this weeks episode on Adenosine Kinase open.spotify.com/episode/1YRs...

Despite the headlines abt the coming HHS announcement, there isn't one folate-autism link. Several have been explored & the evidence ranges from speculative to promising hypotheses w prelimimary data -- but few conclusions to satisfy HHS' effort to find causes/tx's. open.substack.com/pub/kcklatt/...

Already getting DMs with questions from patients and providers about 5-formylTHF/leucovorin & Autism. It's a prescription, the existing response rate in trials is variable and likely depends on dose, timing, folate receptor autoantibody titers, so I encourage getting involved w clinical trials

I wonder how many supplement companies that ditched folic acid for 5MTHF are now frantically googling suppliers for 5FTHF.

I'll be interested to see where this goes - cerebral folate deficiency linked to folate receptor autoantibodies presenting with autism-like symptoms is a very small area of research. No population data to say how prevalent of a link it is and no landmark clinical trials that 5formylTHF/leucovorin

Despite all the rhetoric from folks amongst the altmed/MAHA crowds who think they're pwning corrupt hospitals and doctors with their anti-establishment health regimens... my group chats with various providers are full of everyone talking about how we've been busier than ever..

Out today in @nature.com: Together with the Honigmann, Shevchenko, Drobot and Hof labs, we present a general workflow for imaging the localization and transport of individual lipids in cells and mapping their metabolism. www.nature.com/articles/s41...

There's a strong chance that RFK Jr looks at kids in the airport and also sees chloroplast dysfunction.

Amidst all the chaos, I am saddened by how much potential to actually impact nutrition, science funding, rigor & reproducibility, etc is being wasted. Defense against existential threats & fundamentally anti-science sentiments is essential but can't distract entirely from the need for future reform.

For anyone wondering how we got to the point of an HHS Director who's thinking about children's mitochondria when he looks at them. There are so many academic medical centers complicit in how we got here because embracing the rise of bs integrative & functional medicine helped turn a profit.

CDC cut funding for FoodNet, a population-based surveillance program for 8 foodborne pathogens For any keeping score in this admin, that's zero real improvements on nutrition-related chronic disease risk while increasing nutrition-related infectious disease risk. share.google/UehmnDrKHWOd...

Metabolic Assessment 101: A) Assess Anthropometrics🟢 B) Assess Dietary Intake🟢 C) Assess Clinical Chemistries 🟢 D) Look at the pediatric patient to diagnose mitochondrial and inflammatory disease 🚫

More evidence that intensive lifestyle interventions make a meaningful impact - yet in the USA, there's such a poor coverage for these interventions. This new trial is great but we've known this since the early 2000s with the publishing of the DPP. When are we going to cover preventive RD services?

This year's Annual Review of Nutrition is out and full of really great reads. My contribution details the broad history of nutritional guidance in America & covers the forces (science/politics/culture) that have driven the evolution of nutrition guidance. www.annualreviews.org/content/jour...

Today’s episode of The Ezra Klein Show. Rachael Bedard and David Wallace-Wells on Covid disillusionment and the rise of the MAHA movement. open.spotify.com/episode/6VhH... youtu.be/VCaD4vh4XhI?...

The attempted coercion to have children claiming 'god will provide' is particularly gross coming from Greene, a rep for Georgia that gets a failing grade on most metrics of maternal & infant morbidity/mortality and coverage of social policies. We get a little closer to the Handmaid's Tale every day.