Benjamín Cartes-Saavedra
@btcartes.bsky.social
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Mitochondrial Biologist. Postdoctoral Research Fellow at MitoCare, Thomas Jefferson University.
Happy to have contributed to this beautiful work led by
@elenaberezhnaya.bsky.social
and Dr. Gyorgy Hajnoczky, and thrilled to see it finally out! 👏🏽👏🏽👏🏽 MICU2 controls mitochondrial calcium signaling and migration in neurons during development: Cell Reports
www.cell.com/cell-reports...
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MICU2 controls mitochondrial calcium signaling and migration in neurons during development
Berezhnaya et al. showed that MICU2 is present in the brain during development but is replaced during maturation by MICU3. MICU2 loss during development results in neuronal overmigration in the cortex...
https://www.cell.com/cell-reports/fulltext/S2211-1247%2825%2901355-5
28 days ago
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Benjamín Cartes-Saavedra
bioRxiv Cell Biology
9 months ago
Disease-causing MFN2 mutants impair mitochondrial fission dynamics by distinct DRP1 dysregulation
https://www.biorxiv.org/content/10.1101/2025.04.03.647131v1
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Benjamín Cartes-Saavedra
David Pla Martin
9 months ago
Excited to share our latest paper in Science Advances! We finally dissected a new pathway for mitochondrial quality control upon mtDNA replication stress! Let’s start a short thread! 🧵
www.science.org/doi/10.1126/...
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Retromer promotes the lysosomal turnover of mtDNA
Lysosomal uptake of mtDNA controls mitochondrial quality.
https://www.science.org/doi/10.1126/sciadv.adr6415
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Happy to share this research paper in where I had the opportunity to contribute! Click below to read more about the dependence of mitochondrial calcium signaling and mitochondrial fusion dynamics on the IMS dissagregase CLPB
www.nature.com/articles/s41...
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Dependence of mitochondrial calcium signalling and dynamics on the disaggregase, CLPB - Nature Communications
CLPB is a protein disaggregase that has been linked to human disease. Here, the authors show that in different models of chronic or acute loss of the mitochondrial disaggregase, mitochondrial Ca2+ han...
https://www.nature.com/articles/s41467-025-57641-9
9 months ago
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Benjamín Cartes-Saavedra
eLife
9 months ago
Watching axons on the move Check out this study, ranked ‘Fundamental’, on how the ligand Netrin mediates axon guidance through haptotaxis and chemotaxis.
elifesciences.org/articles/100...
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Benjamín Cartes-Saavedra
Trends in Cell Biology
10 months ago
Quality control of mitochondrial nucleoids
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Quality control of mitochondrial nucleoids
Mitochondrial nucleoids, organized complexes that house and protect mitochondrial DNA (mtDNA), are normally confined within the mitochondrial double-membrane system. Under cellular stress conditions, particularly oxidative and inflammatory stress, these…
http://dlvr.it/TJPlqb
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👏🏽👏🏽👏🏽
add a skeleton here at some point
9 months ago
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Our last review from Hajnoczky Lab! It is a comprehensive view about the different roles of mitochondria in global al local calcium signals
add a skeleton here at some point
9 months ago
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