we found that nuclear envelope rupture triggers rapid DIAPH3 formin influx to generate a actin mesh to prevent further chromatin leakage from damaged nuclei. thanks to Pitter Huesgen @degradomics.bsky.social and @cibss.bsky.social, @chrkam.bsky.social

Thank you!!

Have you ever thought about inflating tissues? Or maybe quickly deflating those inflated tissues? New #EpithelialMechanics pre-print: doi.org/10.1101/2025... 🧵 with pressure control, multiscale buckling, controlled wrinkling

For today's #FluorescenceFriday I'm thrilled to share that ScienceAdvances was so nice to pick my picture as this week's featured image! It's actually a still of a video😊 Check out the paper to learn more science.org/doi/10.1126/... #cellbio #devbio #cellmigration #science Thank you @aaas.org

Our paper is now published! The first encounter of a forming organism with bacteria reveals that innate immunity initiates in epithelial cells of early embryos, even in humans. www.cell.com/cell-host-mi... made in @ibmb-csic.bsky.social @csic.es @idibell.bsky.social 1/9

So cool to see all these in-vivo examples of cell squeezing

On Friday, my son stayed home from school because he had a sore throat and wasn’t feeling well. He went with my husband to his office for the morning while I handled our daughter. When he came back at lunch, he was not interested in eating, saying his throat hurt too much. 1/n

So cool

Excited to share our discovery www.science.org/doi/10.1126/... that the #centrosome is prone to breakage! Using #motile cells, we identify centrosome breakage during #pathfinding, caused by #actin #forces, & prevented by #Dyrk3 Kudos to 1st author Madeleine & thanks to all collaborators! (1/6)

Time line right now- Science , freeze, more freeze, world around me burning, freeze, visas, science, freeze

@evapillai.bsky.social and I had fun writing a brief comment www.science.org/doi/10.1126/... (originally featuring an enlightening comparison to a soufflé au fromage that unfortunately disappeared from the final version per Science house style)

Love confinement studies Read this one!

Check out this new & exciting #postdoc program from Max Planck Society 🤩 - My lab is thrilled to move to MPI MB in Muenster - positions available in #chromatin #mechanobiology #cancer #stemcells #transcription join us!

Excited to share our latest work on how Ca²⁺ regulates actin in cell protrusions—now available as a preprint on bioRxiv! 🎉 Huge congrats to Ernest Iu for leading the project, and a special thanks to our amazing collaborators! www.biorxiv.org/content/10.1...

Feeling of everyone doing science and us burning 🔥

Hyaluronic acid deposition & a soft ECM promote digit regeneration in mice. 🐁 @jontytownson.bsky.social covers the first #preprint from the @storerlab.bsky.social delving into the importance of the ECM in wound regeneration in mice. #preLight ⬇️ 👀 prelights.biologists.com/highlights/h...

Early-peaking caspase-7 activity at the plasma membrane drives apoptotic phosphatidylserine exposure https://www.biorxiv.org/content/10.1101/2025.03.17.643603v1

born too late to get a two Western blot Nature paper, born too early to be a science TikTokker, born just in time to start a postdoc during a global pandemic and look for faculty positions during a historic hiring freeze

This message needs to be heard widely.

Some very clever and interesting membrane biophysicists (and also me) are doing a little webinar on... well, membrane biophysics of today and tomorrow. Check it out if you have time!

Looking for EGFR shrna plasmid urgently if someone has it🙏 if you could please check your connections it would be great as well! Thank you

Happy to share our review on methodology for measuring and manipulating mechanical forces with specific focus on developmental biology! Congrats to authors @clemvilleneuve.bsky.social @mccreery.bsky.social and hats off to the community for developing awesome tools www.nature.com/articles/s41...

Are lipids actively sorted during clathrin mediated endocytosis like proteins? @mathilda95.bsky.social addresses this key open question together with our collaborators from the Honigmann and Modes labs using a new Lipid-STED workflow. www.biorxiv.org/content/10.1...

As scientist I am going through difficult times (this is understatement of the year for me!!). Past one and half months have been horrible, however I am trying to pick myself up and super excited to share my postdoc work with the community! #cellmigration www.biorxiv.org/content/10.1...

Excellent article on the impact of slash-and-burn tactics at NIH by @timdickinson.bsky.social @rollingstone.com www.rollingstone.com/politics/pol...

FAK inhibition combined with the RAF-MEK clamp avutometinib overcomes resistance to targeted and immune therapies in BRAF V600E melanoma www.sciencedirect.com/science/arti...

D’oh! NIH Warns Fired Researchers to be Wary of Foreign Recruitment talkingpointsmemo.com/edblog/doh-n...

😞

Today is the international day of the Woman and Girl in Science. To all badass women, scientists keep doing what you do: discovery, mentorship, and hard work. YOU belong in SCIENE. To others, uplift the Women scientists you know, cite them, promote them, sponsor them, invite them - be an upstander.

Very happy to share our protocol for pair correlation microscopy of intracellular molecular transport. Congratulations @julissasv.bsky.social and thanks to Enrico, @digmanlab.bsky.social, Francesco, Ash! www.nature.com/articles/s41...

It’s been a tough few weeks. My 10yo daughter was diagnosed with a very rare, aggressive cancer called interdigitating dendritic cell sarcoma (IDCS). I’m reaching out to identify clinicians/patients who have encountered pediatric IDCS or other (non-LCH) dendritic or histiocytic sarcomas cases.

NIH grants that created genetic medicine cured my hemophilia in 2020. Here is what the 5-years cured blood test looked like last week. Science works! I hope others get the benefits of such research before regressive Republicans send us back to the 19th Century.

The past few weeks have been exhausting and heartbreaking, to be honest. I have been dreaming of becoming a scientist and having my own lab for as long as I can remember. For that I left family, moved countries and was still okay to do that because I contributed in my own way

Anyone else super exhausted

I hope you will all join me in expressing your thanks to the NIH and NSF staff who are working in an impossibly difficult and chaotic environment to keep science going in our country.

My mood…

Self-generated gradients guide collective cell movement -but often different cell types must move together, e.g. in immune response. We develop a theory of self-generated chemotaxis in mixed populations -are there optimal principles for this cooperation?🤔 www.biorxiv.org/content/10.1...

Read below for the latest from Emily Ho in my lab on in vivo receptor tyrosine kinase biosensors. This has been a *dream* project, seeing endogenous RTK activity in live embryos for the first time. Surprise: they don't always match those of downstream signaling pathways!

Happy New Year!! To celebrate 2025, here is our new pre-print showing a key role for cofilin and actin turnover in embryonic wound healing ... by modulating actin rigidity!! Work led by @anamcarmo.bsky.social, with key contributions by Ji Hong Sayo. 🪰🧪 www.biorxiv.org/content/10.1...

CD44 and Ezrin restrict EGF receptor mobility to generate a novel spatial arrangement of cytoskeletal signaling modules driving bleb-based migration https://www.biorxiv.org/content/10.1101/2024.12.31.630838v1