The future of human clinical sample research is 3D. This #FluorescenceFriday data (🔈 sound on!) from Clarence Yapp + Seo Woo Choi shows multiplexed labeling in human tonsil and colon samples imaged on #DALISPIM at 9X. Register for our 4/30 webinar to learn more: bit.ly/4v9aXC1

We recently hosted a fun lunch & learn with Georgia State's Imaging Core Facility. Chris Tsang introduced our 3D #tissueclearing, labeling, imaging, and analysis pipeline to a roomful of engaged researchers. Thanks to all the attendees for your interest and Core Director Kuangcai Chen for having us!

🎉 Our data science team's paper has been accepted to #CVPR2026! You can read it at arxiv.org/abs/2603.29842 and check out the benchmark page at canvas.lightsheetdata.com. Read on 🧵to learn more about CANVAS, a whole-brain #lightsheet benchmark for cell detection. @cvprconference.bsky.social

Students from the MBL's Embryology course cleared this turtle embryo last year using LifeCanvas Technologies Inc.'s SmartBatch+, labeled with acetylated tubulin to visualize the nervous system, and imaged with the #MegaSPIM light-sheet microscope. #microscopy

Heading to Stockholm this weekend for #FOM2026? You can learn about #DALISPIM and our other 3D microscopy innovations in Dr. Andrew Allan’s talk, “From Tissue to Terabytes: An End-to-End Integrated Solution for Whole-Organ Light-Sheet Imaging”! 🗓️ Tuesday, 3/31 at 16:50 - 17:10 📌 Room M12

We have a special offer for #ABRF2026 attendees supporting neural activity studies! Let us handle clearing, labeling, imaging, & analyzing your samples with our whole-brain c-FOS mapping pipeline. Learn more at bit.ly/4rYBRdf and read on for recent studies using our c-FOS CRO... @abrf.bsky.social

Join us for a webinar on the future of human clinical sample research with @harvardlab.bsky.social! Learn how advances in 3D #microscopy are enabling more accurate cell classification & exploration of novel biology, focusing on samples from melanoma patients. Register: bit.ly/4s4va9G #DALISPIM

In a new Nature paper, @maayanlevy.bsky.social & @christophthaiss.bsky.social's labs demonstrate how age-related changes in the gut #microbiome impair neuronal activation in the hippocampus, leading to memory loss and cognitive decline. Read the study: www.nature.com/articles/s41...

Happy #MicroscopyMonday! Our Head of Innovation Hsuan Lee shared these photos from Peter Sorger's lab (@harvardlab.bsky.social), where we just installed our first #DALISPIM open-top light sheet microscope. Stay tuned for another exciting announcement later this week!

To mark the close of #BrainAwarenessWeek, we have a jam-packed roundup of 3D brain data from our #neuroscience community, spanning research areas from Alzheimer’s to psychedelics. Read on to learn more about the brains in this video! 📖 #FluorescenceFriday

In @sarahstern.bsky.social's lab @mpfneuro.bsky.social, Sébastien Bullich + Elisa Mizrachi study the #neurobiology of how chronic stress contributes to eating disorders, and why they impact men & women differently. What did they learn from a mouse model of sustained stress hormone exposure? 🧵 (1/4)

We had a blast last week at @mpfneuro.bsky.social 's Sunposium, learning from researchers studying the neural circuitry underlying everything from sensory processing to metabolism, and sharing our innovative approach to 3D circuit mapping. Read on for our highlights... 🧵 (1/4)

Somatostatin-expressing (SST) neurons are a subpopulation of highly heterogeneous GABAergic interneurons that play a variety of functions in the brain. This #FluorescenceFriday video shows SST labeling in a whole mouse brain, labeled with SmartBatch+ and imaged with #SmartSPIM.

We are excited to present our new study at @nature.com, led by Tim Cox and performed in collaboration with the lab of @maayanlevy.bsky.social, in which we explore the impact of gut-brain axis aging on cognitive decline. nature.com/articles/s41...

Dysfunction in cortical interneurons (cINs), which are critical regulators of information flow in the cortex, can lead to neurological and neurodevelopmental disorders like #epilepsy. A new paper by Lim et al. explores how these dysfunctions arise: bit.ly/4dfEjbs 🧵 (1/3)

Last week, our resident SmartBatch+ wizard Chris Pfeiffer-Kelly got to introduce and demonstrate high-throughput #tissueclearing and labeling at @feinberg.northwestern.edu. Thank you to Dr. Rizaldy Scott and the Mouse #Histology and Phenotyping Laboratory for hosting us!

Studying neural circuits is all about connectivity. So why cut up your sample? This #FluorescenceFriday, we're highlighting some mesmerizing 3D neural circuit data scientists have generated with our sample processing techniques and #SmartSPIM imaging on whole mouse brains.

For @drmbede.bsky.social, whole-brain mapping opened up a world of discoveries. Read our convo to learn more about Michelle’s research, how to set up a new #neuroscience lab, and the importance of scientific community during challenging times: bit.ly/4rIgq0P

Everything you ever wanted to know about spinocerebellar development - all in one place! So much remains to be discovered, from specification, to axon guidance, to circuit formation. Such fun assembling what we know and framing future questions. Free share link urldefense.com/v3/__https:/...

We know #Alzheimers disease drastically alters brain structure. But are there structural benchmarks we can use to test potential drugs? A new study combines MRI & #SmartSPIM microscopy to map brain-wide structural effects of mutations associated with Alzheimer's: bit.ly/46AAYzK 🧵 (1/3)

This #FluorescenceFriday is brought to you by a newly validated alpaca 🦙 Biotium nanobody for GFAP, which is pre-conjugated to a photostable CF dye & easy to multiplex. Sign up for our newsletter to get early updates & protocols for new applications: bit.ly/3MIZecf @biotium.bsky.social

How do you set up a new #neuroscience lab? 🤔 We caught up with @drmbede.bsky.social about being a new PI @ufmbi.bsky.social & why she chose to bring LifeCanvas along on her next big scientific journey. Check out this video for a peek at our convo, and stay tuned for the whole interview on our blog!

This week we're spotlighting Dr. Amberlene De La Rocha, who completed her recent dissertation in Dr. X. William Yang's lab at UCLA. Amberlene’s work introduces two new genetic tools for studying #Alzheimers in mice. Learn more: escholarship.org/uc/item/8sn2...

#HappyFluorescenceFriday #microscopycommunity - join the conversation with the T&E working group on core operations, community building, and strategies for sustainable growth. Learn More: buff.ly/zMOwyg8

How long does it take to get #FluorescenceFriday data from an organoid on your microscope? With #DALISPIM, it only took us 53 seconds per channel (MAP2 in cyan, and Pax6 in yellow) – and it can be even faster! Learn more: bit.ly/49pqjKd

Next month, we'll be sharing 3D data from our pipeline at @mpfneuro.bsky.social's Sunposium, a conference focusing on basic neural circuit research. Come chat with us to learn how whole-brain circuit mapping can further your investigations 🌞 Learn more and register by 2/23: mpfi.org/events/sunpo...

This #FluorescenceFriday comes from Scott Baraban's lab at UCSF: a new paper by Joseane Righes-Marafiga et al. sheds light on how dysregulation in the C1qa gene, which has been linked to neurological disorders like #epilepsy, affects inhibitory neural circuits. (1/4) 🧵

Also thank you to @andystoneimaging.bsky.social for shouting out #SmartSPIM in your talk on Brandeis' Light Microscopy Core Facility!

We had a great time sharing 3D data from our pipeline at the Massachusetts Life Sciences Center's Convening of the Cores! Thanks to Sony and syGlass for making our data pop on the Spatial Reality Display. MA researchers, check out LifeCanvas tools at cores near you: bit.ly/3O8SgO0

What if we could see 3D #biodistribution of cancer drugs at the cellular level... throughout an entire model animal? 🧐 A new paper from Li Ye's lab @scripps.edu, Zhengyuan Pang & Verina Leung et al. introduce a technique for doing just that. (1/3) 🧵

This #FluorescenceFriday we're spotlighting #organoids! Unlike 2D cultures, organoids provide spatial context for biological processes & cellular interactions. DALISPIM lets you study these systems in both high res & high throughput, which is essential for improving their translational relevance 🧫🔬

The innervation of the tibialis anterior muscle in a rat has never been so clear! Processed with SmartBatch+ by the UIC/Structural Circuits Core, for @greisinglab.bsky.social in the UMN School of Kinesiology. Red = nerves, yellow = neuromuscular junctions. #3DThursday @lifecanvastech.bsky.social

We’re excited to announce our collaboration with the Laboratory of Systems Pharmacology (LSP) at @harvardmed.bsky.social, led by Professor Peter Sorger, to investigate solid human tumors in 3D. Read the full press release for more info: bit.ly/4qoHPDy @harvardlab.bsky.social #CancerResearch

Why is this rainbow mouse brain important for #neuroscience ? 🌈 You can see neural activity (green) alongside other features like cortical excitatory neurons (red) and nuclei (blue) throughout the entire brain. Multiplexed 3D data lets us glimpse neural processes in context. #FluorescenceFriday

I cleared this brain last year with the @lifecanvastech.bsky.social SmartBatch and imaged with their SmartSPIM and I am pretty proud of it. As a computational guy, I was low key shocked that it came out as well as it did on the first try bc I forgot how to pipette

Want to see 3D #lightsheet data like never before? Visit our table at the Massachusetts Life Sciences Center's Convening of the Cores! Experience light sheet data on Sony's Spatial Reality Display, a next-generation glasses-free 3D display. Register for free by the end of this week: bit.ly/4sxfsFr

The ideal #MicroscopyMonday combination: high-res data, low-effort protocol. Get a close-up look of cortical neurons in this segment of mouse brain hemisphere, imaged with #DALISPIM at 9X magnification in a 12-well plate.

How did we create this multi-sample, multi-label video for #FluorescenceFriday? 🤔 Actually, pretty easily. These samples were imaged together in a 12-well plate with our new DALISPIM light sheet microscope. No re-plating, no immersion bath.

Astrocytes 🌟 have been shown to play a role in β-amyloid plaque clearance, making them a prospective target for treating neurodegenerative diseases. This #FluorescenceFriday video provides a close-up of astrocytes + plaques in a thick section of human brain tissue imaged w/ #MegaSPIM.

Congrats to newly-minted PhD Dr. Anne Wells! Her work examines the neurodevelopmental role of transcription factor TBX1 in 22q11.2 deletion syndrome, a genetic disorder characterized by cognitive defects & psychiatric symptoms. Read her latest preprint to learn more: bit.ly/4sCURiZ

Calling all MA-based biologists: want to learn about LifeCanvas resources near you? 🔬 Join us at the Massachusetts Life Sciences Center's Convening of the Cores, a free event highlighting core facilities available to the local life sciences community. Learn more and RSVP: bit.ly/4sxfsFr

Safely and thoroughly removing lipids from tissues (like these mouse 🫁s) is crucial for high-quality data worthy of #MicroscopyMonday. From now til the end of Jan, you can share your samples cleared with SmartBatch+, tag us, and kick off your 2026 experiments with a fresh set of discounted reagents.

What a great start to the New Year! 🎉 Thrilled to see the MLSC funding #innovation across the state. We're proud to collaborate with Dr. Peter Sorger's lab, where our tech will enable deep spatial profiling of solid tumors to improve health outcomes. Stay tuned for more details... bit.ly/49ohTBp

2026 Light Sheet Fluorescence Microscopy, May 31–June 6 This course brings together academic, industry and lab innovators to share the latest developments taking place in light-sheet research and its biological applications. #lightsheet #fluorescencemicroscopy #microscopy 🧪 🍎 #microscopymonday

We're thankful for our scientific community and all of the opportunities we've had to learn, experiment, and see the world. Our team has collaborated on amazing projects that are both expanding our knowledge of biological systems and improving lives. Check out some highlights in this 🧵 (1/2)

This festive #FluorescenceFriday 🎄 image shows a close up of CTIP2 (green) and IBA-1 (red) in the striatum of a whole mouse brain. In adults, CTIP2 marks medium spiny neurons in the striatum and some cortical layers. IBA-1 marks microglia, which are key neural immune cells.

Before we all clear our minds of 2026, we want to see what else you’ve cleared! Show us your SmartBatch+ processed tissue and receive 25% off your next full pipeline reagent kit order. #3DThursday #tissueclearing

We had a great time co-hosting a workshop on our 3D #bioimaging pipeline with Dr. @hjchoimd.bsky.social's lab at Seoul National University! We also held a #biotech career mentorship session with members of our Data Engineering & Analysis team. Pictured below: Dr. Younghee Lee introducing our team.

“Basic neuroscience hasn’t produced new drugs.” 💊 Not true - zuranolone (PPD), suzetrigine (pain), gepants (migraine), and more... were born out of a long arc of studies in the lab. I wrote a Perspective on why this matters. @thetransmitter.bsky.social www.thetransmitter.org/drug-develop...

In this study led by Professors Eric Hwang (NYCU), Li-An Chu (NTHU), & Shang-Hsiu Hu (NTHU), Wan-Chi Pan et al. used the LifeCanvas pipeline to demonstrate how electrical stimulation combined with a conductive granular scaffold can promote nerve repair in traumatic #braininjury: bit.ly/44tU8X3