How did vertebrates evolve kidneys? Pascal Schmidt et al. used #SmartSPIM light sheet microscopy to visualize kidney development in the catshark by mapping expression of the early pronephric marker gene PAX2, revealing a somitic origin: www.science.org/doi/full/10....

This #MicroscopyMonday video shows whole-mount acetylated tubulin staining in a stage E10 mouse embryo, cleared with SmartBatch+ and imaged with DALISPIM as part of @mblscience.bsky.social's Embryology course. Thanks Paul Maier for the sample! #DevBio

First data set collected at #Sample2Image #EMBO by @lifecanvastech.bsky.social SmartSPIM team rocking Oeiras PT

For #AlzheimersAwarenessMonth, we’re highlighting how 3D spatially-resolved data can help us understand the biology of neurodegeneration, enabling earlier diagnoses and interventions. 🧵 (1/4)

🔬 For #3DThursday: a whole cleared mouse embryo imaged with DALISPIM from @lifecanvastech.bsky.social A theme from #FOM2026 + #ELMI2026 was that light microscopy innovation can come from rethinking imaging geometries, in this case an open-top inverted #lightsheet. 🎬: #syGlass v2.6.0

Bring a little #MicroscopyMonday to your YouTube recommendations. We'll be sharing new light sheet data, old favorites, free webinars, and more to our channel. Let us know what you want to see! Subscribe to stay in the loop: youtube.com/@lifecanvast...

How can the relationship between #Alzheimers pathology & sleep quality help us diagnose & treat the disease at earlier stages? Nicholas Constantino et al. used LifeCanvas whole 🧠 mapping to uncover a key role for microglia in amyloid-related sleep disruption: bit.ly/4vR6BPy @macauleylab.bsky.social

We think #lightsheet microscopy can be more flexible, more scalable, & more intuitive. Meet up with @edwardlachica3.bsky.social at #ELMI2026 next week to learn about our light sheet systems & our sample-to-data approach! 🔬🇵🇹 @ppbioimaging.bsky.social @eurobioimaging.bsky.social @eulimi.bsky.social

📽️ SYFP2 expression data from Dr. Tanya Daigle & Emily Kussick, imaged with #SmartSPIM!

Also incredibly honored that our image was selected as the cover art for this issue. We used viral tracing and whole-brain light sheet microscopy to map the brain-wide collateral targets of primary somatosensory cortex neurons that project to the insula.

Really excited to finally have this paper published 🎉🎊. A true team effort spanning many years and multiple lab members. Special thanks to former MS student Amanda Salazar for launching the project and current PhD student Tatiyana Adkins for leading the final push. Proud of everyone who contributed!

We got to introduce the LSFM community to #DALISPIM light sheet imaging at @mdibl.org last week! The excitement was palpable as we had a packed demo schedule, with students getting to see firsthand how easy DALISPIM is to use. #MicroscopyMonday

How can we get gene therapies to the heart more safely & effectively? 🫀 A research team led by Daniel Siegwart & Eric Olson at the UT Southwestern Medical Center has developed optimized lipid nanoparticles (LNPs) that demonstrate robust, targeted mRNA delivery & therapeutic potential 🧵 (1/3)

Calling all SmartBatch+ users! Have you validated a new antibody or tissue type? Send us proof and receive: 👉 15% off your next reagent order for 1 new validation 👉 25% off for 2+ validations 👉 A chance to be featured in our User Newsletter 📆 Submit your data by June 17th: bit.ly/4ekYzsj

The quality of your #lightsheet microscopy data is directly dependent on how your sample was prepared. This video shows a general comparison of some popular #tissueclearing methods, followed by Clear+ results from several mouse tissue types. Questions? Email us at [email protected]!

If you're going to LSFM at @mdibl.org next week, you can check out DALISPIM in person and get a hands-on demo! @lsfm-na.bsky.social

What tissue type do you study? DALISPIM makes lightsheet imaging simple + scalable for... 🧫 Organoids and other NAMs 👥 Human clinical tissue samples 🐁 Rodents and other animal models These were all imaged directly in multiwell plates, with no sample transfer or immersion baths! #FluorescenceFriday

A new study from @steinmetzneuro.bsky.social's lab dissects the neural circuitry of context-dependent responses – like deciding what to do during a fire drill vs a random fire alarm – honing in the role of a region called the midbrain reticular formation (MRF). (1/3) 🧵

Today's #FluorescenceFriday comes from @mblscience.bsky.social’s Embryology course last summer! This 🐢 embryo was cleared by students w/ SmartBatch+, labeled with acetylated tubulin, and imaged by MBL scientists Paul Maier & @carsten-wolff.bsky.social on a #MegaSPIM light sheet microscope.

Hello from the last day of CAN-ACN in Montreal! 🇨🇦 We've had a jam-packed week at @canacn.bsky.social's annual meeting, including checking out the Neural Circuits & Behavior satellite event hosted by @markcembrowski.bsky.social & @franklandlab.bsky.social.

The lab of Dr. Michelle Bedenbaugh studies neural circuits that drive eating, stress responses and other motivated behaviors, including how individuals choose between satisfying hunger and fulfilling other needs. #MBI_Labs @drmbede.bsky.social Learn more: www.bedenbaughlab.com

How do you use c-FOS and other neural activity markers in your research? What if that data were brain-wide and spatially resolved? Check out these studies to see how scientists are using LifeCanvas whole-brain c-FOS mapping to drive their investigations. 🧵 (1/5) #neuroscience

Last week, we dove into 3D #tissueclearing and #lightsheet imaging with researchers at Brigham & Women's Hospital. Thanks @chasjennings.bsky.social & Lai Ding for hosting us at the NeuroTechnology Studio! Want to host a LifeCanvas workshop at your core? ✉️: bit.ly/4aiXQng

Happy #MicroscopyMonday! Today we're highlighting new findings from Conor Liston’s lab at Weill Cornell Medicine that can help us improve non-pharmacological treatments for depression. Read on to learn more... (1/5) 🧵 Check out the paper: www.cell.com/cell/abstrac...

We're excited to share 3D whole-brain data at the 19th Annual Meeting of @canacn.bsky.social! Come chat with us at Booth # 5 to learn how our #spatialbiology pipeline can bring a new dimension to your #neuroscience research. Schedule a meetup: lifecanvastech.com/lets-meet-up/

How does the cerebral cortex form connections with other parts of the CNS? This #SmartSPIM data again comes from @shreyasms.bsky.social, this time showing projections of ET neurons from the visual cortex to different parts of the 🧠. Read the paper to learn more: bit.ly/48YsZxn #FluorescenceFriday

Missed our webinar? You can now watch it on demand: bit.ly/4cSM2vy The sneak peek below is from Dr. Hsuan Lee's intro to the #DALISPIM open-top #lightsheet microscope. DALISPIM makes your 3D imaging workflow easy and scalable, allowing seamless high-res data capture from up to 96-well plates.

ICYMI, this #FluorescenceFriday features a snippet of Dr. Clarence Yapp’s talk yesterday. #Lightsheet microscopy captures heterogeneity in large, geometrically complex tissues like human colon clinical samples. Want to see the whole talk? Comment or message us for the link! @harvardlab.bsky.social

There's still time to make it to our webinar on high-plex 3D imaging in disease research, today at 2PM Eastern! Join us to learn, look at cool 3D data, and ask questions. Register now: bit.ly/4v9aXC1

🔍 👀 Seeking a 3D bioimaging workflow that's both high quality and core user friendly? We can help! Let's bring streamlined tissue processing & #lightsheet imaging solutions to your research community: bit.ly/4aiXQng @paulamonterollopis.bsky.social @andystoneimaging.bsky.social

A new study from Josh Huang’s lab @ Duke combines viral tracing techniques with whole-brain #tissueclearing and #lightsheet imaging to explore how early brain development shapes cortical connections with the rest of the nervous system: bit.ly/48YsZxn #FluorescenceFriday @shreyasms.bsky.social

🏃‍♀️ SONA abstract and regular-rate registration closes today at NOON! 🏃‍♂️ Join us at @mcmasteruniversity.bsky.social on Saturday, May 2, 2026, for a showcase of Southern Ontario’s leading neuroscience research!

Are you heading to #AACR2026 or interested in 3D imaging of human clinical samples for cancer research? Our webinar on “Decoding disease with highly-multiplexed 3D imaging” is in just two weeks: 🗓️ Thurs, 4/30 @ 2PM ET. Register today! bit.ly/4v9aXC1 #FluorescenceFriday #DALISPIM

Can we clear it? 🤔 Most likely, yes! This video highlights some of the diverse sample types that have been cleared and imaged with our techniques. What else do you want to see cleared? Leave us a comment! 👇 #tissueclearing #lightsheet #microscopy

The future of human clinical sample research is 3D. This #FluorescenceFriday data (🔈 sound on!) from Clarence Yapp + Seo Woo Choi shows multiplexed labeling in human tonsil and colon samples imaged on #DALISPIM at 9X. Register for our 4/30 webinar to learn more: bit.ly/4v9aXC1

We recently hosted a fun lunch & learn with Georgia State's Imaging Core Facility. Chris Tsang introduced our 3D #tissueclearing, labeling, imaging, and analysis pipeline to a roomful of engaged researchers. Thanks to all the attendees for your interest and Core Director Kuangcai Chen for having us!

🎉 Our data science team's paper has been accepted to #CVPR2026! You can read it at arxiv.org/abs/2603.29842 and check out the benchmark page at canvas.lightsheetdata.com. Read on 🧵to learn more about CANVAS, a whole-brain #lightsheet benchmark for cell detection. @cvprconference.bsky.social

Students from the MBL's Embryology course cleared this turtle embryo last year using LifeCanvas Technologies Inc.'s SmartBatch+, labeled with acetylated tubulin to visualize the nervous system, and imaged with the #MegaSPIM light-sheet microscope. #microscopy

Heading to Stockholm this weekend for #FOM2026? You can learn about #DALISPIM and our other 3D microscopy innovations in Dr. Andrew Allan’s talk, “From Tissue to Terabytes: An End-to-End Integrated Solution for Whole-Organ Light-Sheet Imaging”! 🗓️ Tuesday, 3/31 at 16:50 - 17:10 📌 Room M12

We have a special offer for #ABRF2026 attendees supporting neural activity studies! Let us handle clearing, labeling, imaging, & analyzing your samples with our whole-brain c-FOS mapping pipeline. Learn more at bit.ly/4rYBRdf and read on for recent studies using our c-FOS CRO... @abrf.bsky.social

Join us for a webinar on the future of human clinical sample research with @harvardlab.bsky.social! Learn how advances in 3D #microscopy are enabling more accurate cell classification & exploration of novel biology, focusing on samples from melanoma patients. Register: bit.ly/4s4va9G #DALISPIM

In a new Nature paper, @maayanlevy.bsky.social & @christophthaiss.bsky.social's labs demonstrate how age-related changes in the gut #microbiome impair neuronal activation in the hippocampus, leading to memory loss and cognitive decline. Read the study: www.nature.com/articles/s41...

Happy #MicroscopyMonday! Our Head of Innovation Hsuan Lee shared these photos from Peter Sorger's lab (@harvardlab.bsky.social), where we just installed our first #DALISPIM open-top light sheet microscope. Stay tuned for another exciting announcement later this week!

To mark the close of #BrainAwarenessWeek, we have a jam-packed roundup of 3D brain data from our #neuroscience community, spanning research areas from Alzheimer’s to psychedelics. Read on to learn more about the brains in this video! 📖 #FluorescenceFriday

In @sarahstern.bsky.social's lab @mpfneuro.bsky.social, Sébastien Bullich + Elisa Mizrachi study the #neurobiology of how chronic stress contributes to eating disorders, and why they impact men & women differently. What did they learn from a mouse model of sustained stress hormone exposure? 🧵 (1/4)

We had a blast last week at @mpfneuro.bsky.social 's Sunposium, learning from researchers studying the neural circuitry underlying everything from sensory processing to metabolism, and sharing our innovative approach to 3D circuit mapping. Read on for our highlights... 🧵 (1/4)

Somatostatin-expressing (SST) neurons are a subpopulation of highly heterogeneous GABAergic interneurons that play a variety of functions in the brain. This #FluorescenceFriday video shows SST labeling in a whole mouse brain, labeled with SmartBatch+ and imaged with #SmartSPIM.

We are excited to present our new study at @nature.com, led by Tim Cox and performed in collaboration with the lab of @maayanlevy.bsky.social, in which we explore the impact of gut-brain axis aging on cognitive decline. nature.com/articles/s41...

Dysfunction in cortical interneurons (cINs), which are critical regulators of information flow in the cortex, can lead to neurological and neurodevelopmental disorders like #epilepsy. A new paper by Lim et al. explores how these dysfunctions arise: bit.ly/4dfEjbs 🧵 (1/3)

Last week, our resident SmartBatch+ wizard Chris Pfeiffer-Kelly got to introduce and demonstrate high-throughput #tissueclearing and labeling at @feinberg.northwestern.edu. Thank you to Dr. Rizaldy Scott and the Mouse #Histology and Phenotyping Laboratory for hosting us!