Today's #FluorescenceFriday comes from @mblscience.bsky.social’s Embryology course last summer! This 🐢 embryo was cleared by students w/ SmartBatch+, labeled with acetylated tubulin, and imaged by MBL scientists Paul Maier & @carsten-wolff.bsky.social on a #MegaSPIM light sheet microscope.

Hello from the last day of CAN-ACN in Montreal! 🇨🇦 We've had a jam-packed week at @canacn.bsky.social's annual meeting, including checking out the Neural Circuits & Behavior satellite event hosted by @markcembrowski.bsky.social & @franklandlab.bsky.social.

The lab of Dr. Michelle Bedenbaugh studies neural circuits that drive eating, stress responses and other motivated behaviors, including how individuals choose between satisfying hunger and fulfilling other needs. #MBI_Labs @drmbede.bsky.social Learn more: www.bedenbaughlab.com

How do you use c-FOS and other neural activity markers in your research? What if that data were brain-wide and spatially resolved? Check out these studies to see how scientists are using LifeCanvas whole-brain c-FOS mapping to drive their investigations. 🧵 (1/5) #neuroscience

Last week, we dove into 3D #tissueclearing and #lightsheet imaging with researchers at Brigham & Women's Hospital. Thanks @chasjennings.bsky.social & Lai Ding for hosting us at the NeuroTechnology Studio! Want to host a LifeCanvas workshop at your core? ✉️: bit.ly/4aiXQng

Happy #MicroscopyMonday! Today we're highlighting new findings from Conor Liston’s lab at Weill Cornell Medicine that can help us improve non-pharmacological treatments for depression. Read on to learn more... (1/5) 🧵 Check out the paper: www.cell.com/cell/abstrac...

We're excited to share 3D whole-brain data at the 19th Annual Meeting of @canacn.bsky.social! Come chat with us at Booth # 5 to learn how our #spatialbiology pipeline can bring a new dimension to your #neuroscience research. Schedule a meetup: lifecanvastech.com/lets-meet-up/

How does the cerebral cortex form connections with other parts of the CNS? This #SmartSPIM data again comes from @shreyasms.bsky.social, this time showing projections of ET neurons from the visual cortex to different parts of the 🧠. Read the paper to learn more: bit.ly/48YsZxn #FluorescenceFriday

Missed our webinar? You can now watch it on demand: bit.ly/4cSM2vy The sneak peek below is from Dr. Hsuan Lee's intro to the #DALISPIM open-top #lightsheet microscope. DALISPIM makes your 3D imaging workflow easy and scalable, allowing seamless high-res data capture from up to 96-well plates.

ICYMI, this #FluorescenceFriday features a snippet of Dr. Clarence Yapp’s talk yesterday. #Lightsheet microscopy captures heterogeneity in large, geometrically complex tissues like human colon clinical samples. Want to see the whole talk? Comment or message us for the link! @harvardlab.bsky.social

There's still time to make it to our webinar on high-plex 3D imaging in disease research, today at 2PM Eastern! Join us to learn, look at cool 3D data, and ask questions. Register now: bit.ly/4v9aXC1

🔍 👀 Seeking a 3D bioimaging workflow that's both high quality and core user friendly? We can help! Let's bring streamlined tissue processing & #lightsheet imaging solutions to your research community: bit.ly/4aiXQng @paulamonterollopis.bsky.social @andystoneimaging.bsky.social

A new study from Josh Huang’s lab @ Duke combines viral tracing techniques with whole-brain #tissueclearing and #lightsheet imaging to explore how early brain development shapes cortical connections with the rest of the nervous system: bit.ly/48YsZxn #FluorescenceFriday @shreyasms.bsky.social

🏃‍♀️ SONA abstract and regular-rate registration closes today at NOON! 🏃‍♂️ Join us at @mcmasteruniversity.bsky.social on Saturday, May 2, 2026, for a showcase of Southern Ontario’s leading neuroscience research!

Are you heading to #AACR2026 or interested in 3D imaging of human clinical samples for cancer research? Our webinar on “Decoding disease with highly-multiplexed 3D imaging” is in just two weeks: 🗓️ Thurs, 4/30 @ 2PM ET. Register today! bit.ly/4v9aXC1 #FluorescenceFriday #DALISPIM

Can we clear it? 🤔 Most likely, yes! This video highlights some of the diverse sample types that have been cleared and imaged with our techniques. What else do you want to see cleared? Leave us a comment! 👇 #tissueclearing #lightsheet #microscopy

The future of human clinical sample research is 3D. This #FluorescenceFriday data (🔈 sound on!) from Clarence Yapp + Seo Woo Choi shows multiplexed labeling in human tonsil and colon samples imaged on #DALISPIM at 9X. Register for our 4/30 webinar to learn more: bit.ly/4v9aXC1

We recently hosted a fun lunch & learn with Georgia State's Imaging Core Facility. Chris Tsang introduced our 3D #tissueclearing, labeling, imaging, and analysis pipeline to a roomful of engaged researchers. Thanks to all the attendees for your interest and Core Director Kuangcai Chen for having us!

🎉 Our data science team's paper has been accepted to #CVPR2026! You can read it at arxiv.org/abs/2603.29842 and check out the benchmark page at canvas.lightsheetdata.com. Read on 🧵to learn more about CANVAS, a whole-brain #lightsheet benchmark for cell detection. @cvprconference.bsky.social

Students from the MBL's Embryology course cleared this turtle embryo last year using LifeCanvas Technologies Inc.'s SmartBatch+, labeled with acetylated tubulin to visualize the nervous system, and imaged with the #MegaSPIM light-sheet microscope. #microscopy

Heading to Stockholm this weekend for #FOM2026? You can learn about #DALISPIM and our other 3D microscopy innovations in Dr. Andrew Allan’s talk, “From Tissue to Terabytes: An End-to-End Integrated Solution for Whole-Organ Light-Sheet Imaging”! 🗓️ Tuesday, 3/31 at 16:50 - 17:10 📌 Room M12

We have a special offer for #ABRF2026 attendees supporting neural activity studies! Let us handle clearing, labeling, imaging, & analyzing your samples with our whole-brain c-FOS mapping pipeline. Learn more at bit.ly/4rYBRdf and read on for recent studies using our c-FOS CRO... @abrf.bsky.social

Join us for a webinar on the future of human clinical sample research with @harvardlab.bsky.social! Learn how advances in 3D #microscopy are enabling more accurate cell classification & exploration of novel biology, focusing on samples from melanoma patients. Register: bit.ly/4s4va9G #DALISPIM

In a new Nature paper, @maayanlevy.bsky.social & @christophthaiss.bsky.social's labs demonstrate how age-related changes in the gut #microbiome impair neuronal activation in the hippocampus, leading to memory loss and cognitive decline. Read the study: www.nature.com/articles/s41...

Happy #MicroscopyMonday! Our Head of Innovation Hsuan Lee shared these photos from Peter Sorger's lab (@harvardlab.bsky.social), where we just installed our first #DALISPIM open-top light sheet microscope. Stay tuned for another exciting announcement later this week!

To mark the close of #BrainAwarenessWeek, we have a jam-packed roundup of 3D brain data from our #neuroscience community, spanning research areas from Alzheimer’s to psychedelics. Read on to learn more about the brains in this video! 📖 #FluorescenceFriday

In @sarahstern.bsky.social's lab @mpfneuro.bsky.social, Sébastien Bullich + Elisa Mizrachi study the #neurobiology of how chronic stress contributes to eating disorders, and why they impact men & women differently. What did they learn from a mouse model of sustained stress hormone exposure? 🧵 (1/4)

We had a blast last week at @mpfneuro.bsky.social 's Sunposium, learning from researchers studying the neural circuitry underlying everything from sensory processing to metabolism, and sharing our innovative approach to 3D circuit mapping. Read on for our highlights... 🧵 (1/4)

Somatostatin-expressing (SST) neurons are a subpopulation of highly heterogeneous GABAergic interneurons that play a variety of functions in the brain. This #FluorescenceFriday video shows SST labeling in a whole mouse brain, labeled with SmartBatch+ and imaged with #SmartSPIM.

We are excited to present our new study at @nature.com, led by Tim Cox and performed in collaboration with the lab of @maayanlevy.bsky.social, in which we explore the impact of gut-brain axis aging on cognitive decline. nature.com/articles/s41...

Dysfunction in cortical interneurons (cINs), which are critical regulators of information flow in the cortex, can lead to neurological and neurodevelopmental disorders like #epilepsy. A new paper by Lim et al. explores how these dysfunctions arise: bit.ly/4dfEjbs 🧵 (1/3)

Last week, our resident SmartBatch+ wizard Chris Pfeiffer-Kelly got to introduce and demonstrate high-throughput #tissueclearing and labeling at @feinberg.northwestern.edu. Thank you to Dr. Rizaldy Scott and the Mouse #Histology and Phenotyping Laboratory for hosting us!

Studying neural circuits is all about connectivity. So why cut up your sample? This #FluorescenceFriday, we're highlighting some mesmerizing 3D neural circuit data scientists have generated with our sample processing techniques and #SmartSPIM imaging on whole mouse brains.

For @drmbede.bsky.social, whole-brain mapping opened up a world of discoveries. Read our convo to learn more about Michelle’s research, how to set up a new #neuroscience lab, and the importance of scientific community during challenging times: bit.ly/4rIgq0P

Everything you ever wanted to know about spinocerebellar development - all in one place! So much remains to be discovered, from specification, to axon guidance, to circuit formation. Such fun assembling what we know and framing future questions. Free share link urldefense.com/v3/__https:/...

We know #Alzheimers disease drastically alters brain structure. But are there structural benchmarks we can use to test potential drugs? A new study combines MRI & #SmartSPIM microscopy to map brain-wide structural effects of mutations associated with Alzheimer's: bit.ly/46AAYzK 🧵 (1/3)

This #FluorescenceFriday is brought to you by a newly validated alpaca 🦙 Biotium nanobody for GFAP, which is pre-conjugated to a photostable CF dye & easy to multiplex. Sign up for our newsletter to get early updates & protocols for new applications: bit.ly/3MIZecf @biotium.bsky.social

How do you set up a new #neuroscience lab? 🤔 We caught up with @drmbede.bsky.social about being a new PI @ufmbi.bsky.social & why she chose to bring LifeCanvas along on her next big scientific journey. Check out this video for a peek at our convo, and stay tuned for the whole interview on our blog!

This week we're spotlighting Dr. Amberlene De La Rocha, who completed her recent dissertation in Dr. X. William Yang's lab at UCLA. Amberlene’s work introduces two new genetic tools for studying #Alzheimers in mice. Learn more: escholarship.org/uc/item/8sn2...

#HappyFluorescenceFriday #microscopycommunity - join the conversation with the T&E working group on core operations, community building, and strategies for sustainable growth. Learn More: buff.ly/zMOwyg8

How long does it take to get #FluorescenceFriday data from an organoid on your microscope? With #DALISPIM, it only took us 53 seconds per channel (MAP2 in cyan, and Pax6 in yellow) – and it can be even faster! Learn more: bit.ly/49pqjKd

Next month, we'll be sharing 3D data from our pipeline at @mpfneuro.bsky.social's Sunposium, a conference focusing on basic neural circuit research. Come chat with us to learn how whole-brain circuit mapping can further your investigations 🌞 Learn more and register by 2/23: mpfi.org/events/sunpo...

This #FluorescenceFriday comes from Scott Baraban's lab at UCSF: a new paper by Joseane Righes-Marafiga et al. sheds light on how dysregulation in the C1qa gene, which has been linked to neurological disorders like #epilepsy, affects inhibitory neural circuits. (1/4) 🧵

Also thank you to @andystoneimaging.bsky.social for shouting out #SmartSPIM in your talk on Brandeis' Light Microscopy Core Facility!

We had a great time sharing 3D data from our pipeline at the Massachusetts Life Sciences Center's Convening of the Cores! Thanks to Sony and syGlass for making our data pop on the Spatial Reality Display. MA researchers, check out LifeCanvas tools at cores near you: bit.ly/3O8SgO0

What if we could see 3D #biodistribution of cancer drugs at the cellular level... throughout an entire model animal? 🧐 A new paper from Li Ye's lab @scripps.edu, Zhengyuan Pang & Verina Leung et al. introduce a technique for doing just that. (1/3) 🧵

This #FluorescenceFriday we're spotlighting #organoids! Unlike 2D cultures, organoids provide spatial context for biological processes & cellular interactions. DALISPIM lets you study these systems in both high res & high throughput, which is essential for improving their translational relevance 🧫🔬

The innervation of the tibialis anterior muscle in a rat has never been so clear! Processed with SmartBatch+ by the UIC/Structural Circuits Core, for @greisinglab.bsky.social in the UMN School of Kinesiology. Red = nerves, yellow = neuromuscular junctions. #3DThursday @lifecanvastech.bsky.social

We’re excited to announce our collaboration with the Laboratory of Systems Pharmacology (LSP) at @harvardmed.bsky.social, led by Professor Peter Sorger, to investigate solid human tumors in 3D. Read the full press release for more info: bit.ly/4qoHPDy @harvardlab.bsky.social #CancerResearch

Why is this rainbow mouse brain important for #neuroscience ? 🌈 You can see neural activity (green) alongside other features like cortical excitatory neurons (red) and nuclei (blue) throughout the entire brain. Multiplexed 3D data lets us glimpse neural processes in context. #FluorescenceFriday