Upcoming sessions during #AACR25 will highlight advances in cancer early detection and interception. Learn more in AACR Annual Meeting News: www.aacrmeetingnews.org/news/session... @daniel-decarvalho.bsky.social @leciasequist.bsky.social

Legitmately thrilled to share our latest work, in which @fernpizza.bsky.social solved an experimental challenge in plasmid biology as old as the field: measuring how plasmids compete and evolve within individual cells!

I'm so happy that I can finally share the results of my first postdoc paper with @baym.lol!!! Turns out plasmids are an amazing system to study multi-scale evolution and we can track within-cell and between-cell dynamics! (1/n) www.biorxiv.org/content/earl...

Congrats to @tuuliavallius.bsky.social on receiving an American Cancer Society Postdoctoral Fellowship! 🎉 Tuulia’s project aims to understand the earliest stages of melanoma development, which will provide insights into new biomarkers to improve melanoma diagnosis and treatment.

We are so grateful for the passion and insight that Jerry Lin brings to our team! Our support from @ludwigcancer.bsky.social enables us to collaborate with scientists and clinicians across the globe on the most challenging problems in cancer. 🤝

Human kidney biopsy exhibiting glomerular deposition disease. 🔎 Image courtesy of Jia-Yun Chen and Yilin Xu, Harvard Program in Therapeutic Science, @harvardmed.bsky.social. Image Details: 18-channel imaging of human kidney acquired in a single scan using the Orion #spatialbiology platform.

Meet Daniel Lu, one of the latest additions to the Sorger Lab! Daniel aims to blend biology with math, physics, and AI to transform cancer diagnostics. 🔬✨ Read more: labsyspharm.org/press-releas...

Making space for spatial biology in the clinic Spatial transcriptomics methods have been slow to move into clinical practice, but spatial proteomics are cheaper and more scalable, and could progress faster go.nature.com/3PoWPkz

This paper is the result of an incredibly fun collaboration with Sandro Santagata and Peter Sorger. Led by an amazing postdoc @tanjinakader.bsky.social and JiaRen Lin, we provide a pre-cancer atlas of Fallopian tube precursors to High-Grade Serous Ovarian Cancer. The data is also on cbioportal!

Now online in Cancer Discovery: Multimodal Spatial Profiling Reveals Immune Suppression and Microenvironment Remodeling in Fallopian Tube Precursors to High-Grade Serous Ovarian Carcinoma - by Tanjina Kader, Jia-Ren Lin, Clemens Hug, Ronny Drapkin, Sandro Santagata, et al. doi.org/10.1158/2159...

And with that.... 2024 is a wrap! 🎉 We are grateful for our incredible members and the hard work and dedication they bring to our lab every day. Wishing you all a happy, restful holiday season and a bright New Year ahead. ✨

1/n New paper alert 🚨 We're thrilled to share our just published paper in #CancerCell Do you ever wonder how the #TME in #HGSC changes during chemotherapy? Check it here: www.sciencedirect.com/science/arti... and let’s dive into the highlights together #spatialbiology #ovariancancer #cancerresarch

We're honored to see work from Peter Sorger and Greg Baker featured in this article! We're optimistic that spatial proteomics will advance our understanding of disease biology. Stay tuned: we have several exciting papers on the way for 2025! 🎉

Excited to announce Sandro Santagata as the new Associate Director of the Lab of Systems Pharmacology @harvardmed.bsky.social! As a pathologist and cell biologist, Sandro brings a clinical perspective to our research. Read about his journey & vision for the future: labsyspharm.org/press-releas...

Here’s a fluorescent #microscopy image of human skin with early-stage melanoma. 🔬🎨 We study human #cancer tissue to uncover the molecular changes that drive cancer development and ultimately improve how it is diagnosed and treated. Explore the image: www.cycif.org/data/mel-3d-...

We're curating a list of our current members and alumni! ✨ 👇 Follow these folks if you want to hear about science that uses diverse methods to improve how diseases are understood, diagnosed, and treated. 📣 Let us know if you're missing from the list! go.bsky.app/QBnMu4A

We are looking for a postdoc (Please share 🙏)! Are you passionate about spatial biology, proteomics, and the TME? Join our culturally diverse, multidisciplinary, and friendly team in 🇫🇮 to make impactful discoveries in ovarian cancer 🧬Details: farkkilab.org/careers/job-... 📅Apply by Dec 11

A list of science journals (mostly biomed) to be updated as more join Bluesky go.bsky.app/5kmzyLp

Get ready to dance, our paper – Phage DisCo: targeted discovery of bacteriophages by co-culture – has been pre-printed! 🪩 This has been a really fun project to work on with @sianowen.bsky.social, @baym.lol, @nquinoneso.bsky.social, and our two talented undergrads Kesther and Carmen!

We've long been able to find new phages and figure out what they interact with. But what about the other direction: if you have a gene, like an antibiotic resistance efflux pump, or a phage defense system, and you want to find phages that do or do not interact with it? Now you can!

Nice to meet you @bsky.app! 👋 🤝 Our lab unites interdisciplinary teams of physicians & scientists to improve how diseases are diagnosed and treated We use quantitative, #AI, & #SpatialBiology 🔬 methods to study #Cancer 👩‍⚕️, #Immunology, #InfectiousDisease🦠, and #Pharmacology 💊 🦋 Excited to connect!

No matter how you distinguish background from foreground in multiplexed imaging, always verify visually. Errors are surprisingly common, even in published papers. This is especially critical when using publicly available image derived data without access to the actual images. #spatialbiology 🧪