Daniel De Carvalho
@daniel-decarvalho.bsky.social
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Ten years ago, we discovered that reactivating transposable elements triggers an antiviral state in cancer cells, a process we named viral mimicry, unmasking tumors to the immune system (Roulois, Cell 2015).
7 months ago
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reposted by
Daniel De Carvalho
Fusion Conferences
7 months ago
We are thrilled to have Daniel De Carvalho (
@daniel-decarvalho.bsky.social
) from Princess Margaret Cancer Centre / University of Toronto as our Keynote speaker at
#EREHD25
. What a way to close 3 days of wonderful science. Thank you for being with us in Mexico Daniel!
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reposted by
Daniel De Carvalho
The Gairdner Foundation
7 months ago
Today, Gairdner hosted the 2025 Laureate Lectures â a highlight of
#GairdnerScienceWeek
. All eight laureates shared the stories behind their award-winning science, alongside talks from two Early Career Investigators driving the future of discovery.
#GairdnerAwards
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Excited to have this paper out today! Repeats mimic pathogen-associated patterns across a vast evolutionary landscape." It was a fun and productive collaboration with Benjamin Greenbaum John LaCava, Simona Cocco, Petr Ĺ ulc and many others!
www.cell.com/cell-genomic...
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Repeats mimic pathogen-associated patterns across a vast evolutionary landscape
An emerging hallmark of disease is transcription of pathogen-associated molecular patterns from within the genomeâknown as viral mimicry. We propose a statistical physics framework to measure âselecti...
https://www.cell.com/cell-genomics/fulltext/S2666-979X(25)00267-8
8 months ago
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reposted by
Daniel De Carvalho
Fusion Conferences
11 months ago
Are you currently in the ERE related field & want to find new collaborative opportunities? Join our Chairs
@chiappinellilab.bsky.social
,
@shenhui1986.bsky.social
, Ting & Tao at
#EREHD25
this Nov! đď¸Talk Submission extended to 03 Sept đ°Final few $500 grants remaining Don't Miss out!
bit.ly/4eRq9Mp
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reposted by
Daniel De Carvalho
Fusion Conferences
12 months ago
Don't forget to register for
#EREHD25
! Our talk submission deadline has been extended to 12 JUNE 2025, so submit your abstract today to join our incredible speaker line up in Mexico this November đď¸âď¸ đ
bit.ly/4kHWbw0
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Risky moves: Can blocking âjumping genesâ treat diseases and aging? Great piece in Science Magazine highlighting recent efforts to understand and target transposonsâalso known as "jumping genes"âin human disease and aging.
about 1 year ago
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Thank you
@gairdnerawards.bsky.social
! I'm truly humbled and grateful for this recognition. Science is never a solo journey and this award reflects the hard work, creativity, and persistence of many amazing scientists I had the privilege to work with.
add a skeleton here at some point
about 1 year ago
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reposted by
Daniel De Carvalho
AndrĂŠ Picard @picardonhealth
about 1 year ago
The brain trust with a difference: 2025 Gairdner award winners have taken big strides in the U.S., at a time when Trump-era cuts cast doubt on the future, by
@ivansemeniuk.bsky.social
@jenniferyang.bsky.social
www.theglobeandmail.com/canada/artic...
@theglobeandmail.com
@gairdnerawards.bsky.social
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In a time of despair for U.S. scientists, Gairdner Award winners shine brighter than usual
The winners of this yearâs Canadian science prizes are all based in the United States, where Trump-era cutbacks to research and medical regulation have sown doubt in the future
https://www.theglobeandmail.com/canada/article-in-a-time-of-despair-for-us-scientists-gairdner-award-winners-shine/
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reposted by
Daniel De Carvalho
The Gairdner Foundation
about 1 year ago
Congratulations to the 2025 Canada Gairdner Award laureates! This yearâs laureates represent some of the worldâs most significant biomedical and global health research and discoveries. Learn more about their award-winning research here:
gairdner.org/resource-hub...
#GairdnerAwards
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reposted by
Daniel De Carvalho
Princess Margaret Cancer Centre
about 1 year ago
New Links: Cancer and Immune Evasion Cancer cells without the tumor suppressor protein p53 become more resistant to the body's immune response and more likely to survive. A study led by Dr. Daniel De Carvalho at UHNâs Princess Margaret Cancer Centre.
www.uhnresearch.ca/news/new-lin...
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Happy to see this paper out!
add a skeleton here at some point
over 1 year ago
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Our recent work on Viral mimicry escape in Ovarian Cancer is out at Cancer Discovery:
aacrjournals.org/cancerdiscov...
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Chronic viral mimicry induction following p53 loss promotes immune evasion
Abstract. Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through âviral mimicryâ responses. Paradoxically, cancer-initiating events also facili...
https://aacrjournals.org/cancerdiscovery/article-abstract/doi/10.1158/2159-8290.CD-24-0094/750833/Chronic-viral-mimicry-induction-following-p53-loss?redirectedFrom=fulltext
over 1 year ago
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reposted by
Daniel De Carvalho
Elizabeth McKenna
over 1 year ago
Now online in Cancer Discovery: Chronic
#ViralMimicry
Induction Following
#p53
Loss Promotes Immune Evasion - by
@cishak.bsky.social
, Sajid Marhon,
@daniel-decarvalho.bsky.social
, and colleagues
@pmresearch-uhn.bsky.social
@mdanderson.bsky.social
doi.org/10.1158/2159...
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