We are thrilled to have Daniel De Carvalho (@daniel-decarvalho.bsky.social) from Princess Margaret Cancer Centre / University of Toronto as our Keynote speaker at #EREHD25. What a way to close 3 days of wonderful science. Thank you for being with us in Mexico Daniel!

Thank you to @maialab.bsky.social , @rdrapkin8-penn.bsky.social and all organizers for a great OMCF meeting!

This week, that idea reached patients: Viral-mimicry priming + anti-PD-1 in relapsed/refractory NK/T-cell lymphoma delivered 47.6% complete responses, 66.7% ORR, and ~50% 2-year OS, even after prior PD-1 failure (Huang, Cancer Discovery 2025).

Ten years ago, we discovered that reactivating transposable elements triggers an antiviral state in cancer cells, a process we named viral mimicry, unmasking tumors to the immune system (Roulois, Cell 2015).

Congratulations @daniel-decarvalho.bsky.social !

The 2025 Canada Gairdner Awards Gala celebrated the eight laureates whose discoveries are transforming global human health — bringing together Canada’s science community for an inspiring evening at the ROM. #GairdnerScienceWeek #GairdnerAwards

Excited to share the Ovarian Cancer Research Syndicate line-up of speakers for the fall. Please share. We have amazing trainees presenting and the latest from leaders in the field. @powelldrescher.bsky.social @srocf.bsky.social @pennmedcso.bsky.social @penncancer.bsky.social

"Unmasked: transposable elements as drivers and targets in cancer" by Ting Wang & colleagues "This review synthesizes a growing body of work that positions TEs as both catalysts and antagonists of the tumor state." Check it out! authors.elsevier.com/sd/article/S...

Excited to have this paper out today! Repeats mimic pathogen-associated patterns across a vast evolutionary landscape." It was a fun and productive collaboration with Benjamin Greenbaum John LaCava, Simona Cocco, Petr Šulc and many others! www.cell.com/cell-genomic...

We published a detailed protocol for our Plate-CUT&Tag method on @protocolsio.bsky.social to accompany our recent preprint (www.biorxiv.org/content/10.1...) give it a try! Feedback welcome! dx.doi.org/10.17504/protocols.io.n2bvjed5wgk5/v1

In his memory, Western has opened an equity-based graduate scholarship. Please consider supporting his final initiative if you are able: www.westernconnect.ca/beier ; thank you for all the time you spent and laughs you shared with him. We love and miss him so much already. - The Beiers

Congratulations to VAI's Dr. H. Josh Jang, who has been appointed to assistant professor in our Department of Cell Biology. www.vai.org/article/van-...

Sharon Dent inducted to the National Academy of Sciences #nas162 @ekoutelou.bsky.social @srdent47.bsky.social @angelating.bsky.social @francescacole.bsky.social

Dear @mdanderson.bsky.social , Please join us today in auditorium 4SCR1.1110 at 4pm for our Dept. seminar series. Today we welcome Dr. Marco Gallo from Baylor College of Medicine who will share the latest breakthroughs towards understanding chromatin regulation in brain malignancies.

Check out Dr. Mendez-Dorantes' recent preprint for more details on his exciting research! www.biorxiv.org/content/10.1... 42/

Looking forward to #AACR25! If you want to learn more about transposable elements in cancer, our educational session is at 10 am on Saturday 4/26! @bengrbm.bsky.social @theaacr.bsky.social

Such a great article by Mitch Leslie in @science.org about the potential of inhibiting LINE-1 RT – a genomic, virus-like repetitive element – to address a spectrum of diseases, including ROME’s focus: #neurodegenerative and #autoimmune diseases. www.science.org/content/arti... #darkgenome

Congrats to the 4 winners of our Spatial Xcellerator Grant Program who are using Stereo-seq technology for spatial transcriptomics to uncover deeper insights into complex challenges like cancer, spinal cord injury, Alzheimer’s, and pediatric brain tumors. www.completegenomics.com/spatial-xcel...

🌟“Surprise is always the strongest signal that you found something new.” Research from Gairdner awardee @daniel-decarvalho.bsky.social is unlocking powerful new tools impacting cancer clinical care, from interception, detection to therapy design and monitoring. youtu.be/VpDpouQi8Wg

Congratulations to my postdoctoral mentor Dr. @daniel-decarvalho.bsky.social on receiving the 2025 Gairdner Momentum Award from the @gairdnerawards.bsky.social ! This is an amazing achievement!

Down to earth (as always) interview with @danieljdrucker.bsky.social on the impact of GLP1 agonists in fields of biology that he’d never anticipated but is leading the way on understanding - as awardee of th3 Breakthrough Prize with colleagues. www.ctvnews.ca/sci-tech/art...

Surprising findings of BRCA mutations on the Fallopian tubes. Result of a tremendous team effort with @shenhui1986.bsky.social @vainstitute.bsky.social, Chuck Drescher @fredhutch.bsky.social, and Jarrod Marto @danafarber.bsky.social. @pennmedcso.bsky.social www.nature.com/articles/s41...

exciting news for our scientific community! www.nygenome.org/news-events/...

So happy to join the dream dean team at the UT MD Anderson Cancer Center UTHealth Houston Graduate School of Biomedical Sciences!

I'm proud to share our protocol on CRISPR enzyme delivery in primary human cells using PERC, a non-viral & hardware-independent technology. We previously described PERC in T cells, and here we extend its use to hematopoietic stem/progenitor cells (HSPCs). www.nature.com/articles/s41...

New Links: Cancer and Immune Evasion Cancer cells without the tumor suppressor protein p53 become more resistant to the body's immune response and more likely to survive. A study led by Dr. Daniel De Carvalho at UHN’s Princess Margaret Cancer Centre. www.uhnresearch.ca/news/new-lin...

@uhnresearch.bsky.social @uhntoronto.bsky.social @theaacr.bsky.social

The Ovarian Cancer Research Syndicate schedule is out from the @pennmedicine.bsky.social Ovarian Cancer Research Center. Great line up!

Dear @mdanderson.bsky.social community, We are excited to invite you to our dept. seminar featuring Dr. Katherine Chiappinelli (@chiappinellilab.bsky.social) tomorrow (Thursday March 6) at 4:00pm in auditorium room 4SCR1.1110. Drop by to learn about TEs as therapeutic targets in (ovarian) cancer!

Happy to see this paper out!

Scientists @pmresearch-uhn.bsky.social have uncovered how cancer can evade immune defenses after losing a key tumour-suppressing gene. These findings implicate repetitive elements in DNA and may unlock new targets for cancer interception. Read more ➡️ www.uhnresearch.ca/news/new-lin...

When I opened my Bsky account I didn't expect my first post to be an act of resistance, but here we are!!! So proud of our Chair for speaking out to our Texas Representative about the chaos that the #NIHfreeze is causing throughout the US! #sciencematters #researchmatters #endcancer

I returned to Johns Hopkins for a seminar, reunited with colleagues and luminaries in the field, and sat at my postdoc bench once more. 🧪 #HopkinsMedicine #JHU #CancerResearch #Epigenetics

Thank you to @daniel-decarvalho.bsky.social and all members of the team who made this study possible! This study represents an exciting new direction towards understanding how dsRNAs contribute towards tumorigenesis and considering new ways to exploit viral mimicry!

Now online in Cancer Discovery: Chronic #ViralMimicry Induction Following #p53 Loss Promotes Immune Evasion - by @cishak.bsky.social, Sajid Marhon, @daniel-decarvalho.bsky.social, and colleagues @pmresearch-uhn.bsky.social @mdanderson.bsky.social doi.org/10.1158/2159...

Hello #cancersky! It's official, we're here! Follow us for all things #cancerresearch and #oncology 🥳

I’m excited to share our latest study led by @giuliapasquesi.bsky.social out today in @cellpress.bsky.social , uncovering a new way transposons have been repurposed for human interferon signaling! Read on for a thread on cryptic splice variants, decoy receptors, and viruses (1/N) 👇🧵 #TESky 🧪

What better place than the city of lights to make my transposition to 🦋. Look at all that blue sky!

Tracking transposable element (TE) activity in genomics data can be a pain, but there are solutions! Our lab built TEtranscripts -- which we've updated to work for small RNAs (TEsmall), bulk RNA at the locus level (TElocal), and in single-cell data (TEsingle). Check it out! www.mghlab.org/software

Did you know there’s a site to search for starter packs of people to follow? Built by @mubashariqbal.com blueskydirectory.com/starter-pack...

Look who's here @pnas.org ✔️ @science.org ✔️ @naturecellbiology.bsky.social ✔️ @natrevgenet.bsky.social ✔️ @naturebiotech.bsky.social ✔️ @naturemicrobiol.bsky.social ✔️ @naturechemistry.bsky.social ✔️ @genesdev.bsky.social ✔️ @cellchembiol.bsky.social ✔️ @genomeresearch.bsky.social ✔️ @jcellbiol.bsky.social ✔️

We strongly suggest that academic publishers and other platforms that host research rapidly implement a Share to Bluesky button for their articles. Here's how: docs.bsky.app/docs/advance... #AcademicSky #HigherEd #Altmetrics

Congratulations to my postdoc Matthew Knarr for a lovely example of drug repurposing in ovarian cancer! Thank you to our amazing collaborators, Analisa DiFeo and Dave Hoon. lnkd.in/eCdbk2jD @pennmedcso.bsky.social @pennmedicine.bsky.social

Looking for recs on the best commercial protein purification services that people have used? Ideally reliable for enzymes, good turnaround time, reasonable cost for low-to-mid mg quantities. We do a lot in-house but we only have so much bandwidth...

Hello Bluesky! I am a #NewPI studying #TransposableElements and viral mimicry in cancer initiation. Our projects range from basic to translational, and draw from several fields including #Epigenetics, chromatin regulation, and the ovarian cancer field. If these topics interest you, please reach out!

Scraping who is on the platform working on #TransposableElements or other types of #RepetitiveDNA Have fun! go.bsky.app/7t5GQAP

With some help from @raduzabet.bsky.social, I've created a starter pack of researchers working on #Epigenetics, Chromatin and Gene Regulation who are active on here: go.bsky.app/TKp9YAn I've likely missed many people so let me know if you want to be added. Similarly if you would like to be removed.