New preprint: #Microglia don't just clear debris - they undergo a massive metabolic overhaul after phagocytosis, including adaptive mitochondrial changes, which may make them pro-regenerative! 🥳🧠💪 #Neuroscience #Mitochondria #Metabolism #BioRxiv www.biorxiv.org/content/10.1...

#PhD position available! Our collaborator Roberta Magliozzi is looking for a motivated student to map the meningeal immune landscape in #MultipleSclerosis. This is a great opportunity for anyone interested in neuroimmunology! 🧠 Please SHARE and APPLY here: www.imperial.ac.uk/brain-scienc...

Session Six featured fantastic talks by Prof. Vendeuscolo from the Dept. of Chemistry @cam.ac.uk, Prof. Peruzzotti-Jametti from the Dept. of Clinical Neurosciences @cam.ac.uk, and the Andrew Huxley Plenary Lecture by our special guest Prof. Studer from the Sloan Kettering Cancer Center, NY #CNS2025

Human myelinated brain organoids with integrated #microglia as a model for #myelin repair and remyelinating therapies | Science Translational Medicine www.science.org/doi/10.1126/...

An interview with Dr. Luca Peruzzotti Jametti on the topic of #Myelin repair. ms-perspektive.de/en/129-luca-... #MSchat #MultipleSclerosis #Neurology #StemCells @pluchinolab.bsky.social @restorems.bsky.social @lpjlab.org

Groundbreaking new paper on #Alzheimers disease: researchers found widespread "epigenome erosion" that is linked to cell-type-specific and region-specific changes that correspond with #microglial cell shifts, cognitive decline, and even cognitive resilience! www.cell.com/cell/fulltex...

Excited to share that I was a guest on MS-Perspektive - The #MultipleSclerosis #Podcast with Nele von Horsten! 🎧 We had a great chat about the latest research in MS and how we're working to find new treatments. 💪 Listen to the full episode here 👇 ms-perspektive.com/129-luca-per...

www.nature.com/articles/s43... reproduced in vitro thanks to #FluidFM

PERSPECTIVE | W Wu, H Chen et al. (Wash U St Louis) An overview of historical and more recent approaches for the induction of synthetic torpor and their potential medical application https://bit.ly/4mBb9FF ?utm_source=bluesky&utm_medium=social_&utm_campaign=natmetab

Beyond understanding the #brain, our goal is to heal it! www.lpjlab.org/news-1/8dgsijj0s02907evez1bmai1fht6pa Join us on September 10-11 at the 8th #Cambridge #Neuroscience Symposium to explore the latest breakthroughs that are poised to transform #patient care! Register here: tinyurl.com/27rzs5ku

The debate on intercellular mitochondrial transfer is heating up! In this new Viewpoint, eminent scientists in the field of mitochondrial biology, including our friend @rubenqc-lab.bsky.social, share their views on the topic. Dive in and let us know what you think! www.nature.com/articles/s42...

Cool event alert! 🧠 The next European Microglial Webinar is happening on Tuesday, 02/09 at 5pm CEST / 3pm GMT. Michael Dolan will be speaking on "Formation and Function of Microglial States in Remyelination." Zoom Link: unil.zoom.us/j/93018596158 #Microglia #Neuroscience

The source of dietary fat influences anti-tumour immunity in obese mice #immunometabolism Great work from @lydialynch.bsky.social lab and colleagues www.nature.com/articles/s42...

What a night! Our lab traded pipettes for axes, and let's just say we honed our missing skills with expert precision! 😉 It was an absolute blast seeing everyone de-stress and have a laugh, no matter where the axes landed 🪓🎯 Huge thanks to everyone! 👏 #Neuroscience #AxeThrowing #TeamBuilding

A super cool #single-cell spatial transcriptomic mouse #brain atlas is out! 🐭🧠🔬 Unveiling cell types, #gene expression, & TF dynamics across the whole brain! Awesome! ✨ #neuroskyence #neuroscience #compneurosky www.cell.com/neuron/fullt...

Thrilled to share our latest paper showing that the transplantation of directly induced neural #StemCells enhances #remyelination of chronic demyelinating lesions! 💉🧠=💪 A great team effort with @pluchinolab.bsky.social and all our collaborators! #MultipleSclerosis academic.oup.com/brain/advanc...

An @cam.ac.uk study published in Brain shows stem cell grafts can restore myelin in #MS lesions in mice. This holds promise for chronic demyelinating disorders & progressive multiple sclerosis. Congrats to @lpjlab.org @pluchinolab.bsky.social The paper: academic.oup.com/brain/advanc...

Biotechnological approaches and therapeutic potential of #mitochondria transfer and transplantation 💉 www.nature.com/articles/s41...

Get ready for a scientific breakthrough! 🧑‍🔬 #DeepMind AlphaGenome is here: cutting-edge #AI to decode the mysteries of the human #genome! This isn't just about data; it's about unlocking entirely new ways to understand health & disease #Genomics #FutureOfMedicine deepmind.google/discover/blo...

📢 Exciting Welcome to Sinéad and Ishan! 📢 We're thrilled to welcome both to the LPJ Lab for their #SummerInternship! Under Evridiki's guidance, they'll contribute to the understanding of #Microglia in #MultipleSclerosis. Here's to a #summer of groundbreaking neurobiology and exciting insights!

The immunoproteasome modulates cell metabolism and actively drives neurodegeneration in #MultipleSclerosis. This really underscores the complex interplay between #immunity, #metabolism, and #brain health! 🧠 #Neuroscience #Neuroskyence www.cell.com/cell/fulltex...

Ferroptosis contributes to #MultipleSclerosis and its pharmacological targeting suppresses experimental disease progression www.nature.com/articles/s41...

Diving deep into neuroinflammation's impact on neurological disorders! This latest review masterfully synthesizes findings across #MS, stroke, #Alzheimer's, and #Parkinson's, offering crucial insights for the field. #neurology #neuroscience #neuroskyence www.science.org/doi/10.1126/...

Broad rim lesions are a new pathological and imaging biomarker for rapid disease progression in #multiplesclerosis www.nature.com/articles/s41...

"An AAV capsid proposed as microglia-targeting directs genetic expression in forebrain excitatory neurons" www.cell.com/cell-reports... Xiangmin Xu & colleagues @cp-cellrepmethods.bsky.social

Emma Vidal brought our concept to life. For more info about the science produced in the @chopralab.bsky.social and ours, that inspired our geeky idea, please read the paper here: www.cell.com/immunity/abs...

Mitochondrial #DNA signals driving #immune responses: Why, How, Where? #Mitochondria biosignaling.biomedcentral.com/articles/10....

🧠 Always solving problems but not moving forward? You might be the decision bottleneck. 📦 Try asking: “What would you do if I weren’t here?” 🌟 What’s one decision you could delegate today? #LeadershipGrowth #EmpowerYourTeam #LabLeadership #ResearchCulture

Special Issue on Neuroimmunology 🧠 www.cell.com/immunity/iss... In this issue of @cp-immunity.bsky.social, we highlight the progress made in neuroimmunology, outline important next questions, and discuss the future of the field. Image: @ella-maru.bsky.social, working with @jonykipnis.bsky.social

Just presented our findings on the use of nanoparticles & extracellular vesicles 🧪 #EVs to modulate 🧠 #brain #metabolism at the Blankenese Conference in #Hamburg! A lot of inspiring science all around! blankenese-conferences.eu www.lpjlab.org/news-1/p3dufajt9awazywmaxoyoe3m0vis0v

So thrilled to be presenting at the 2025 Symposium on #Mitochondria in #Immunity & #Neurodegeneration in #Copenhagen! Looking forward to sharing our work with all the amazing researchers who are here! 🤟

#Brain tissues, assemble! 🦸🦹 Inside the push to build better brain models www.nature.com/articles/d41...

#Microglia aren't just in the #brain? Introducing "microglial lineage" – resident immune cells with microglial traits throughout the body. #immunity #glia www.cell.com/trends/immun...

Our lab's 1st paper, led by @fchrisbennett.bsky.social & @waisenberg.bsky.social. A decade thinking how to directly assess the impact of microglia replacement. Yrs of hard work. This kind of work is needed to expand brain disease care for kids & the vision for safer, more effective cell therapy.

Interested in #microglia? 🤔 This paper presents comprehensive insights into their heterogeneity and detailed cell-state annotation across development and neurodegenerative conditions. Check it out! #CNS #Immunology #Science #neuroskyence #neuroscience #compneurosky www.nature.com/articles/s41...

Success! The 4th Annual #Cambridge Centre for #Myelin Repair Symposium wrapped up with inspiring #science and fantastic #patient participation! Huge thanks to members of the @lpjlab.org for their contributions! 👏 #stopMS Stop #MultipleSclerosis

Brain-wide #microglia replacement using a nonconditioning strategy ameliorates pathology in mouse models of neurological disorders www.science.org/doi/10.1126/...

Happy Easter everyone! Wishing you a restful holiday to inspire future breakthroughs! ✨🐣 🧠🔬 #Science #Easter

How #Trump 2.0 is slashing #NIH backed #research — in #charts @nature.com analyses which fields of science and US states are being hit hardest by grant terminations www.nature.com/articles/d41...

We are thrilled to share that our lab collaborated with the fantastic @mstrustuk.bsky.social on their new book: "Progression in MS"! 🎉 Huge thanks to Evridiki Asimakidou from our lab for her work! 🙏 #MultipleSclerosis #MS Grab your FREE copy at the link below: shop.mstrust.org.uk/publications...

Cells are swapping their #mitochondria. What does this mean for our health? www.nature.com/articles/d41...

We are in full swing @cambridgefestival.bsky.social with @cambraincns.bsky.social 🧠🧠🧠🧠

Meningeal lymphatics #microglia axis regulates #synaptic physiology www.cell.com/cell/fulltex...

AI is transforming peer review, and some enthusiasts see AI automation as an inevitability. But many researchers, as well as journal publishers, view it as a disaster. Read the Nature feature. 🧪

The fate of #mitochondrial respiratory complexes in #aging 👴🏻 www.cell.com/trends/cell-...

A comparative #transcriptomic analysis of mouse #demyelination models and #MultipleSclerosis lesions 🐭🧠👤 #neuroskyence #neuroscience #compneurosky www.biorxiv.org/content/10.1...

Excited to be presenting at the #Cambridge Neurological Society & Cambridge #Immunology Society! 🧠💥 Join me for a deep dive into the latest research and potential breakthroughs in #Neuroscience #Immunology #Metabolism #Therapeutics

Constructing the Human #Brain #Metabolic Connectome Using MR Spectroscopic Imaging: Insights into Biochemical Organization www.biorxiv.org/content/10.1...

A milestone for the therapeutic #EV field: FDA approves Ryoncil, an allogeneic bone marrow-derived mesenchymal stromal #cell therapy www.oaepublish.com/articles/evc...