Thrilled to share our new study on bioRxiv (www.biorxiv.org/content/10.1...) uncovering a previously unrecognized, cell-autonomous mechanism that drives myelin repair in the brain. We show that WWOX is a central regulator of OPC differentiation and remyelination.

"Breaking the Script: Transcriptional Addiction as a Driver of Genome Instability in Cancer" by Rami Aqeilan (@ramiaqeilan.bsky.social) & co "Transcriptional reprogramming in cancer leads to frequent DNA breaks at hyperactive oncogenes..." FREE till Jan 9th: authors.elsevier.com/a/1m8ApcQbJF...

Excited to share our new Trends in Genetics review article on how transcriptional addiction drives genome instability in cancer. We discuss how hypertranscription, super-enhancers, R-loops, and TOP1/TOP2 create promoter- and gene-body DSBs — a true Achilles’ heel of oncogenes.

Excited to join #ASGCT2025 in New Orleans and present our work: “From Gene to Therapy: Unraveling WWOX and its Role in Neurological Diseases” in the Organoids & iPSC Disease Modeling for Drug Discovery session. See you there! #GeneTherapy #WWOX #Neuroscience

Excited to share our latest research revealing how WWOX deficiency impairs neurogenesis and neuronal function in human brain organoids, providing new insights into the mechanisms underlying WOREE and SCAR12 syndromes. This work is now online biorxiv.org/cgi/content/...

Grateful for the opportunity to speak at Stanford University’s Wu Tsai Neurosciences Institute yesterday! A big thank you to Dr. Monther Abu-Remaileh for the kind invitation and exceptional hospitality. It was inspiring to share insights and connect with brilliant minds!