1/3 Metacells boost power in single-cell RNA-seq & multiome analysis. But without checking homogeneity, they risk forming dubious metacells that bias discoveries. We introduce mcRigor: a statistical safeguard for rigorous metacell analysis. 👉 www.nature.com/articles/s41...

Excited to share our method ClipperQTL published in Genome Biology. Built on our p-value-free FDR control framework Clipper, ClipperQTL performs on par with FastQTL and runs up to 500× faster. Big thanks to my former PhD student Heather Zhou! genomebiology.biomedcentral.com/articles/10.... #eQTL

I’m honored to join Fred Hutch as Professor and Program Head of Biostatistics, and as the Donald and Janet K. Guthrie Endowed Chair in Statistics. Excited to be part of a deeply collaborative and scientifically vibrant community with a rich legacy of impact. @fredhutchbiostat.bsky.social

I’ll speak on July 16 (2:30pm ET) at NSF@75: Advancing Statistical Science for a Data‑Driven World Conference, by ASA & Instats My talk is about an info-theoretic criterion (ITCA) for combining ambiguous class labels: jmlr.org/papers/v23/2... Free registration: instats.org/seminar/nsfa...

@guggfellows.bsky.social I’m deeply honored to be named a 2025 Guggenheim Fellow—especially as part of the Foundation’s historic 100th class. Grateful to be in the company of so many brilliant artists, scholars, and scientists. #guggfellows2025

How do we detect spatially variable genes (SVGs) in spatial transcriptomics? In our Nature Communications review, we categorize 34 computational methods into three categories: ✅ Overall SVGs ✅ Cell-type-specific SVGs ✅ Spatial-domain-marker SVGs www.nature.com/articles/s41...