Love worms, molecular genetics, and big questions? We’re hiring a postdoc to build a CRISPRa toolkit to identify new aging mechanisms in C. elegans. Email or DM me to find out more. Please share & repost!

1/6 🧬New paper at @cp-cellsystems.bsky.social led by @sashafanari.bsky.social! Does pseudouridine (Ψ) dynamically respond to cell state? We used nanopore DRS + Mod-p ID to map Ψ in neuron-like cells under “normal” and “perturbed” conditions (healthy differentiation and unhealthy Pb2+ poisoning).

6/6 🙌 Future work will determine whether static sites are critical for cellular function while plastic sites fine-tune gene expression in response to environmental stressors. Huge thanks to the team for all their hard work! @wanunupore.bsky.social @genometdcc.bsky.social

🧪🧬👩‍🔬🖥️ Do immortalized cells have a different RNA modification profile compared to primary cells? 🤔 @sashafanari.bsky.social @wanunupore.bsky.social @srouhanifard.bsky.social assess the most abundant RNA modification, pseudouridine, in primary and immortalized human T cells 👇 doi.org/10.1101/2025...

Unbelievable news. Pancreatic is one of the deadliest cancers. New paper shows personalized mRNA vaccines can induce durable T cells that attack pancreatic cancer, with 75% of patients cancer free at three years—far, far better than standard of care. www.nature.com/articles/s41...

IT'S HAPPENING! The Woodstock of Biology 2.0 meets Night Science @nightsciencepod.bsky.social 10-13 of June in Prague & the Woods of Bohemia... Be there or be REJECTED. #theconferencetoendallconferences

This is the most relevant article to NIH and research cuts I’ve seen. Imagine if this was today , how many people would be saying “Why are we studying Gila Monsters and their impact on diabetes ? That’s wasted money !” globalnews.ca/news/9793403...

The illegal cut of NIH indirect costs will mean at least $115M cut to University of Pittsburgh @fetterman.senate.gov @davemccormick.bsky.social. This means huge loss of middle and working class jobs and research trials for breakthrough treatments for residents of Pennsylvania, Ohio, & West Virginia

They tried this 💩 in the first admin, proposing cuts of indirects to 10%, and it was resisted by Congress Call your congresspeople, and remind them they have defended health research before, and they can do so again

Since there has been a lot of misinformation circulating since last night, I find this AAMC infographic helpful in illustrating which types of expenses are and are not covered by NIH indirect cost reimbursements.

How will indirect cuts affect our research remains to be seen. Scary times! @northeasternu.bsky.social grants.nih.gov/grants/guide...

Happy lunar new year!