They did it!! 🧡🔵🟠🔵🟠💙 No better illustration of tRump’s uncanny knack for screwing up everything he touches than the Knicks’ only loss in the 4-1 NBA Finals occurring when he upends & offends our entire town by attending game 3. They did it!! 💙🟠🔵🟠🔵🧡

Infuriating. www.nytimes.com/2026/06/02/w...

A helluva lot nicer than the Tang-colored octogenarian who wants to put his own scowling visage on American banknotes.

Via Lustgarten.org, a webinar All about Daraxonrasib, a first-of-its-kind RAS-targeting therapy that demonstrated a near doubling of survival for patients with previously treated metastatic pancreatic cancer. JUNE 17 12:00 PM EDT. Register here! ⬇️ events.zoom.us/ev/AkDCv123Y...

Via pancan.org, a virtual event. KRAS AND PANCREATIC CANCER: A New Era Of Treatment Thursday, June 25, 2026 | 11 a.m. PT |2 p.m. ET Register here! pancan.org/facing-pancr...

How is it that we are not TERRIFIED by a mad POTUS ranting in real time in the middle of the night & his finger on the nuclear codes? He is berserk, he is dangerous, & he is showing us his mental illness day & night. Dispirited some hosts at MSNOW play him 4 laughs as they share his maniacal posts.

I’m sure Jack Schlossberg is a perfectly nice person, & he should take some of that quirky energy & put it to good use. But many of us are over the Kennedy coronation thing….as his mother Caroline learned during her short quest to be appointed to HRC’s senate seat. www.nytimes.com/2026/05/28/o...

- Political Appointees Take Control of Grant Awards (§200.205) - DEI, Gender Research, and Related Topics Banned as Grant Conditions (§200.300) - Peer Review Is No Longer Binding (§200.205(d)) - Applicants Can Be Denied Based on Organizational “Affiliations” (§200.206) 2/x

Via NPR.org The tRump administration is finding new ways to punish science. Money approved by Congress is not reaching scientists at the rate it should be, & a lack of transparency at the NIH is compromising the integrity and reliability of research. www.npr.org/2026/05/21/n...

Hard to reconcile the comments of Letai & Kennedy (X screenshot) with the reality of pediatric cancer funding as described in the NY Times. www.nytimes.com/2026/05/13/o...

RFK may have gone underground with it, but he's continuing to work aggressively to turn HHS against vaccines. Don't let the relative public silence fool you. www.nytimes.com/2026/05/11/h...

Today, thousands of Nat Academies Science, Engineering, & Medicine members have signed & submitted an Open Letter to Congress demanding Trump restore the 22 National Science Board members he illegally fired on April 24th. Support by adding your name here ⬇️ www.standupforscience.net/nasem-letter...

Via lustgarten.org Your Mother’s Day gift in support of pancreas cancer research will be doubled today! PDAC has a 5-yr survival rate of just 13%. Lustgarten drives research in 3 priority areas: early detection, personalized medicine, & therapeutics development. Donate ⬇️ lustgarten.org/mothersday/

Profiteering, grift, corruption, graft. The tRump family has used the presidency to steal billions: crypto deals, government contracts, foreign influence & payments, upgrades to tRump properties, & pay to play. Is tracking this all we are doing about it?! oversightdemocrats.house.gov/trump-family...

Cancer cachexia a baffling aspect of J’s PDAC history. Post Whipple, he regained nearly all weight & we worked hard 2 maintain. For 6 yrs, success; last 2 yrs not. Scans continued 2 show stable disease whilst continuing chemo/parp inhibitor….yet profound weight loss www.medrxiv.org/content/10.6...

Immigration changes R driving foreign researchers to leave the U.S. - or not come at all. “International scholars will stay home," said Matthew Alexander, prof of pediatric neurology & genetics at the U of Alabama. "They'll stay in Europe and they'll stay in Asia." www.statnews.com/2026/05/04/t...

Watching this dummy Pete Hegseth reminds me of the homicide detective character in Monk — Lt Disher — who inanely insists on giving names to his detecting endeavors (“We’ll call this ‘The Lipstick Killer’ Case”) while others are processing the crime scene.

#11DayPowerPlay raises $ (>$11M since 2017) for cancer causes in WNY. 11DPP has >2,300 pairs of skates hitting the ice in 3-hr shifts in an 11-day hockey game! My bsky buddy‘s sons are participating⬇️ communityshift.11daypowerplay.com/AlexSmiraglia communityshift.11daypowerplay.com/ChristianSmi...

tRump gutted US science by historic margins as it reduced the workforce at research agencies by tens of thousands & terminated grants. The admin also terminated >100 independent advisory panels comprising uni scientists who help guide science priorities. www.scientificamerican.com/article/key-...

UPDATE (5/1/2026): The FDA has just authorized expanded access to daraxonrasib, a targeted therapy designed to treat KRAS-driven cancers. This treatment will now be available outside of clinical trials as a second-line option for pancreatic cancer patients. lustgarten.org/a-turning-po...

My kind of CONNECTIONS today, where word meanings & usages take precedence over pop culture & other references that go right over my head. Fast & easy!

$2.1B in perfectly timed oil bets across five presidential announcements. Every one flagged. Every report filed. Zero prosecutions in fourteen years. I pulled the case files. gothburz.substack.com/p/i-flagged-...

"I'm hopeful these treatments allow the disease to be incorporated into someone's life," says Dr. O'Reilly, "as opposed to their life being overtaken by the treatment of cancer."

Tfw you order $75+ worth of cold meds (ok, includes 2 candy bars & a covid test) from your local pharmacy, you add a $15 tip, only to find a teeny bag w/the candy bars & a refund for the meds (not the tip) at your door. So now I still have to go out for what I needed, AND I paid a fortune for candy.

Single-arm Phase 1b trial of patients with locally advanced PDAC. I hope this leads to further investigation in a Phase 2 trial. One notable outcome was that 23% of patients went on to achieve an RO resection.

Fat chance, Columbia.

Good summary of the marked benefit of the molecular glue drug (daraxonrasib) vs pancreatic cancer, from Revolution Medicines, and other progress (adds to the neoantigen vaccine with 6-year survival) gift link wsj.com/opinion/revo...

I have so many thoughts. As caregiver to my partner for 8 yrs, l took care of all, went to every treatment. His final 2 yrs were harrowing & I wanted a different life. But I was there for him, & now consider it my greatest demonstration of ❤️. messaging-custom-newsletters.nytimes.com/dynamic/rend...

Every cycle, as 5 year grants awarded before 2024 start to term, we’ll be hearing the stories of labs shutting down. In one ear, I’m hearing about all of the amazing successes of research initiated 10+ years ago at AACR. In the other, I’m reminded of the disastrous dismantling of the NIH.

“Rulings with no explanation or reasoning, like the sparse paragraph from that February night [2016, involving Obama’s Clean Power Plan] have become routine. The emergency docket is now a central legacy of the court led by Chief Justice Roberts.” The Shadow Docket ⬇️ www.nytimes.com/2026/04/18/u...

Democrats on the House Judiciary Committee are investigating Jared Kushner over conflicts of interest between his business activities and his work as a peace negotiator for the Trump administration. trib.al/uKwyoNu

Via Lustgarten.org Sunday 19 April NYC Walk to Support Pancreatic Cancer Research. Battery Park City. Ceremony 9:30 AM; Walk begins 10:00 AM. Be Part of a Community United in the Vision to Transform Pancreas Cancer into a Curable Disease! Register below ⬇️ hope.lustgarten.org/event/newyor...

Swalwell: a huge disappointment. I recall with hilarity the 2016 campaign when tRump continuously tweeted about caravans of illegals arriving at the southern border & Swalwell tweeted a reply that went something like “These caravans. Do you see them in the room with you now?” But he’s gotta go.

Done! Thanks to you & everyone at HFPCC for all you do.

Done! Thanks for all you do, @kittyswink.bsky.social

How I wish I had the training & tools to fully understand this study! An analysis of cells (primary & metastatic) taken from a single pt via rapid autopsy shows how cancer adapts to different environments. Discussion of peritoneal mets of particular interest to me. aacrjournals.org/cancerres/ar...

Today is why CONNECTIONS is my worst game. You have to know ACTUAL STUFF — like popular descriptions of a certain food category, or physical aspects of pop culture characters. Often I know them; many times I do not & I’m just taking wild guesses after the first 2 categories. Poor finish. Bah humbug.

tRump started a war to distract from Epstein. Then, after threatening imminent, next day annihilation, he is forced to retreat & utter his favorite phrase (“2 weeks”). Now, Melania rehashes Epstein to distract from tRump’s Iran adventure & his utter humiliation on the world stage. Head is splitting.

Seriously, here's a pretty good summary from Claude of the applicable legal principles:

If I were in Trump's Cabinet, I would spend Easter calling constitutional lawyers about the 25th Amendment. This is completely, utterly unhinged. He's already killed thousands. He's going to kill thousands more.

I wrote today about a big study on replication--and why it's so hard to know if a study will hold up or not. Gift link: nyti.ms/4sNu3MF

You need to read this dean's description of science dissolving around him. From Nara Parameswaran at @michiganstateu.bsky.social #scicomm #sciwri #cuts @theconversation.com theconversation.com/panicking-sc...

communityshift.11daypowerplay.com/AlexSmiraglia communityshift.11daypowerplay.com/ChristianSmiraglia

My sons are joining some of their Shamrocks friends for a 3hrs shift in the 11DPP (Friday June 26th 6pm-9pm). If you’re in the area come cheer them on and if you feel so inclined you can contribute to their fundraiser (links in the response below) or more broadly to their team, the Clover Hockey

Prominent climate scientist Kate Marvel resigns from NASA. Dr. Marvel joins an estimated 95,000 employees who have left federal science agencies through layoffs, retirements or resignations since Trump returned to the White House last year. www.nytimes.com/2026/03/25/c...

So let me see if I have this straight. Senate Dems signed on to a DHS funding deal that doesn’t include any of the Dem demands regarding ICE masking & warrant requirements. And Schumer has the nerve to say “I’m very proud of our Democratic caucus. We held the line.” Where are the ICE reforms???!!

Just learned that today is ‘Make Up Your Own Holiday’ Day, so this is my day to share a favorite movie that nobody remembers. It’s “Local Hero,” a quirky & sublimely funny charmer from 1983. It will calm you & remediate all the chaos in your life. Trust me: you need this. You won’t be disappointed.

I enjoy the rare occasions when I solve CONNECTIONS backwards from most difficult to least. Connections Puzzle #1019 🟪🟪🟪🟪 🟩🟩🟩🟩 🟦🟦🟦🟦 🟨🟨🟨🟨

Via @PanCAN, virtual event, on March 26 (11 PT/2 ET) Nutritional challenges related to pancreas cancer. Learn about new research into cancer cachexia, pancreatic enzymes, and how good nutrition can help you feel better, stay stronger, & tolerate treatment. Register here⬇️ pancan.org/facing-pancr...

Via Lustgarten.org Early-Stage Clinical Trials, April 8, 12-1PM ET. Register ⬇️ for an online forum designed to demystify Phase 1 cancer clinical trials – where promising discoveries first reach patients & begin the journey toward becoming tomorrow’s standard of care. ⬇️ events.zoom.us/ev/AhS6swBQg...