New review out from my lab on class I PI3Ks www.sciencedirect.com/science/arti..., was fun to write where we are and where we are going in PI3K research Great work from Isobel and Alex in my lab @alexlouiseshaw.bsky.social

Announcing our new PA biosensor, PILS-Nir1 – seen here in HeLa cells during PLC activation #lipidtime #phospholipids Read the OA paper in JCB

How do swelling lysosomes not burst? Because they literally suck more lipids into their membranes from the ER via this protein straw. Amazing piece of this particular molecular puzzle from my colleague jay tab!

Have you published lipid-protein interactome data? Please let us know, we’d love to include it in the repository. The goal is to build a centralized hub for the scientific community. Huge thanks to Gaelen Guzman, a graduate student/postdoc in the lab who built it from scratch.

New review out with @jburkevic.bsky.social! We highlight recent advances in our understanding of the role the phosphoinositide PIP3 plays in regulating the protein kinases Akt, PDK1, and BTK from a structural perspective. #kinase #phosphoinositides portlandpress.com/biochemsoctr...

Excited to share our new preprint 🥳. We dev’ed a high-affinity nanobody that binds MR1 & blocks MR1-restricted T cell activation, a powerful tool to dissect MR1 biology in infection, inflammation & cancer. @jburkevic.bsky.social @ohsunews.bsky.social www.biorxiv.org/content/10.1...

Check out the view today from the venue—scoping for the IUBMB Focussed meeting on (pseudo)kinases! Abstracts and early bird registrations closes this week! www.ivvy.com.au/event/IUBMB25/ @pseudokinase.bsky.social @iubmb.bsky.social

Only one week left to submit your abstract and register at early bird rates for the IUBMB Focussed Meeting - (pseudo)kinases in signal transduction. Sign up and register by June 20!! Join @pseudokinase.bsky.social Natalia Jura, and a who's who of kinase research! www.ivvy.com.au/event/IUBMB25/

We have some #lipids talks at #asbmb25 on PI signaling that will blow your mind! Join us Sunday at 9 a.m. in room W179

SCAM ALERT. This is a fake conference that ripped off my and other people’s names to trick people into registering. There is no such conference that I or the others shown were invited or agreed to. We are working to try to get this fraud taken down from the web. chemsymposia.com

A really exciting new preprint out from the Jura and Verba labs looking at conformational dynamics of PI3K on membrane surfaces using cryo-EM. This is truly groundbreaking, and provides a ton of exciting insight into PI3K activation www.biorxiv.org/content/10.1...

New work out from my lab by my graduate student Isobel in collaboration with Josh Pemberton and Tamas Balla. Provides some new cool tools to manipulate PI3,5P2 levels, as well as some new insight into PIKfyve regulation. rupress.org/jcb/article-...

Really exciting to share the peer-reviewed version of our study of the DET1 adaptor for the CUL4 Ub ligase. A cryptic E2-binding site and recruitment mechanism for COP1—another E3! www.science.org/doi/10.1126/...

I'm looking forward to this Signalling Symposium which celebrates the achievements of Len Stephens and Phill Hawkins during their 30-yr tenure at the Babraham Institute @babrahaminst.bsky.social Registration details below

The most frequently asked question we get: do #lipidtime genetically encoded lipid biosensors compete out cells’ native effector proteins? Victoria Holmes and Morgan Ricci led a paper in JCB that answers this question: rupress.org/jcb/article/... Read on for a brief thread.

Exciting to open registration for the IUBMB Focussed Meeting on Emerging roles of (pseudo)kinases! Fantastic speakers in an unmatched location, lots of speaking slots available for ECRS. Interested in kinases or pseudokinases? We would love to see you in Queenstown! www.ivvy.com.au/event/IUBMB2...

new paper using an optopharmacology approach to target the opioid receptor gpcr out in biorxiv today. This will be a perfect addition to the teaching of the gpcr section of my 4th year course. www.biorxiv.org/content/10.1... Fun fact I worked in Dirk Trauner’s lab during my senior year at Berkeley

First post up, sharing some cool work from my lab by @alexlouiseshaw.bsky.social and @sushantsuresh.bsky.social out today in Science Advances (www.science.org/doi/10.1126/...)