New review out from my lab on class I PI3Ks www.sciencedirect.com/science/arti..., was fun to write where we are and where we are going in PI3K research Great work from Isobel and Alex in my lab @alexlouiseshaw.bsky.social

Really just had something like this feeling this afternoon. It’s the high that keeps you coming back for more

Great collaborative work where we developed a nanobody based tool to block EFR3 mediated recruitment of PI4KA. A potential therapeutic window maybe? Thanks @alexlouiseshaw.bsky.social for the assist!

New preprint from the lab headed up by @sushantsuresh.bsky.social! Late last year, we published the molecular basis of PI4KA plasma membrane recruitment by EFR3 (PMID:39705356). This work builds on these findings and identifies a new potential therapeutic avenue! Check it out!

New review out with @jburkevic.bsky.social! We highlight recent advances in our understanding of the role the phosphoinositide PIP3 plays in regulating the protein kinases Akt, PDK1, and BTK from a structural perspective. #kinase #phosphoinositides portlandpress.com/biochemsoctr...

After years parked at a Polara, I’m excited to share that my PhD work is finally out! We figured out why imaging at liquid helium temperatures wasn’t working—and how to fix it. 🔗 www.pnas.org/doi/10.1073/...

New work out from my lab by my graduate student Isobel in collaboration with Josh Pemberton and Tamas Balla. Provides some new cool tools to manipulate PI3,5P2 levels, as well as some new insight into PIKfyve regulation. rupress.org/jcb/article-...

An advanced toolset to manipulate and monitor subcellular phosphatidylinositol 3,5-bisphosphate. New study from Joshua Pemberton, John Burke, Tamas Balla (National Institute of Child Health and Human Development) and colleagues: rupress.org/jcb/article/... #Biochemistry #CellSignaling #lipid

Back from vacation and really glad to share some work from my PhD research. Great collaborative effort @alexlouiseshaw.bsky.social Check out this post from my PI to learn more about Lipid kinase PI4KA and its regulation!

No better way to start the holidays then being able to share that some of my PhD research is live on Science Advances today!😄 A great collaborative effort! Check out this thread from my PI!