Xiaoyu Zhang
@xiaoyuzhang.bsky.social
📤 388
📥 281
📝 0
Assistant Professor of Chemistry at Northwestern University
https://zhanglabnu.com/
reposted by
Xiaoyu Zhang
Dan Nomura
9 months ago
Excited to highlight our latest preprint by graduate student Lauren Orr on the discovery of a covalent degradative handle that acts through two unique C173 and C178, on the E3 ligase DCAF16 that can be used to modularly design monovalent and bifunctional degraders.
www.biorxiv.org/content/10.1...
loading . . .
DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders
Targeted protein degradation (TPD) is a powerful strategy for targeting and eliminating disease-causing proteins. While heterobifunctional Proteolysis-Targeting Chimeras (PROTACs) are more modular, th...
https://www.biorxiv.org/content/10.1101/2025.04.25.650514v1
1
27
6
reposted by
Xiaoyu Zhang
Brian Liau
10 months ago
Interested in small molecule mechanism? If you’re at
#ACSSpring2025
, stop by the Eli Lilly Symposium Wed 9am–12pm @ Room 31A in the convention center. Cool talks from
@michael-erb.bsky.social
, Yuh Min Chook &
@xiaoyuzhang.bsky.social
. I’ll discuss our program on chemical genomics. Come check it out!
1
12
3
reposted by
Xiaoyu Zhang
Brian Liau
11 months ago
Today in
@nature.com
we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
5
88
45
reposted by
Xiaoyu Zhang
Northwestern Chemistry
11 months ago
🚨 Don't miss this recent research from the Zhang Lab 🚨 'Harnessing the FBXW7 Somatic Mutant R465C for Targeted Protein Degradation'
#Cancer
#Chemistry
#ProteinDegredation
Out now in @J_A_C_S ➡️
pubs.acs.org/doi/full/10....
@xiaoyuzhang.bsky.social
loading . . .
Harnessing the FBXW7 Somatic Mutant R465C for Targeted Protein Degradation
Targeted protein degradation (TPD) is a pharmacological strategy that eliminates specific proteins from cells by harnessing cellular proteolytic degradation machinery. In proteasome-dependent TPD, exp...
https://pubs.acs.org/doi/full/10.1021/jacs.4c17331
0
9
2
reposted by
Xiaoyu Zhang
Adam Gilbert
11 months ago
Thoughts on why DCAF11, DCAF16 and FBXO22 could be the next workhorse E3 ligases in TPD
doi.org/10.1038/s415...
loading . . .
Implications of frequent hitter E3 ligases in targeted protein degradation screens - Nature Chemical Biology
This Perspective discusses recent strategies to expand the scope of targeted protein degradation (TPD) and the implications of unexpected convergence of diverse screening efforts on a small subset of ...
https://doi.org/10.1038/s41589-024-01821-z
0
5
3
reposted by
Xiaoyu Zhang
Behnam Nabet
about 1 year ago
🧪 Ready, set, degrade! So proud to share our work in the
@jclinical-invest.bsky.social
, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer. Link:
www.jci.org/articles/vie...
6
122
26
reposted by
Xiaoyu Zhang
Ryan Potts - real
about 1 year ago
Somatic FBXW7-R465C mutant shows promise in targeted protein degradation in cancer cells. This approach enhances protein degradation specificity in diseased cells. Congrats Xiaoyu Zhang and colleagues. 🧪
#chembio
#TPD
#CancerResearch
www.biorxiv.org/content/10.1...
loading . . .
Harnessing the FBXW7 somatic mutant R465C for targeted protein degradation
Targeted protein degradation (TPD) is a pharmacological strategy that eliminates specific proteins from cells by harnessing cellular proteolytic degradation machinery. In proteasome-dependent TPD, exp...
https://www.biorxiv.org/content/10.1101/2024.12.03.626601v1.full.pdf+html
0
33
6
reposted by
Xiaoyu Zhang
Abhishek Chatterjee
about 1 year ago
Got the chance to put together the "Click of Chemical Biologists" starter pack v1 and v2 over the Thanksgiving Break. Feel free to ping me on who else I might be missing! V1:
go.bsky.app/3P5i7nJ
V2:
go.bsky.app/Cr4ej7
add a skeleton here at some point
12
82
35
you reached the end!!
feeds!
log in
