Xiaoyu Zhang
@xiaoyuzhang.bsky.social
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Assistant Professor of Chemistry at Northwestern University
https://zhanglabnu.com/
reposted by
Xiaoyu Zhang
Dan Nomura
7 months ago
Excited to highlight our latest preprint by graduate student Lauren Orr on the discovery of a covalent degradative handle that acts through two unique C173 and C178, on the E3 ligase DCAF16 that can be used to modularly design monovalent and bifunctional degraders.
www.biorxiv.org/content/10.1...
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DCAF16-Based Covalent Degradative Handles for the Modular Design of Degraders
Targeted protein degradation (TPD) is a powerful strategy for targeting and eliminating disease-causing proteins. While heterobifunctional Proteolysis-Targeting Chimeras (PROTACs) are more modular, th...
https://www.biorxiv.org/content/10.1101/2025.04.25.650514v1
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Xiaoyu Zhang
Brian Liau
8 months ago
Interested in small molecule mechanism? If you’re at
#ACSSpring2025
, stop by the Eli Lilly Symposium Wed 9am–12pm @ Room 31A in the convention center. Cool talks from
@michael-erb.bsky.social
, Yuh Min Chook &
@xiaoyuzhang.bsky.social
. I’ll discuss our program on chemical genomics. Come check it out!
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Xiaoyu Zhang
Brian Liau
9 months ago
Today in
@nature.com
we share our back-to-back stories with Ning Zheng’s lab revealing chemical-genetic convergence between a molecular glue degrader & E3 ligase cancer mutations. 1/5
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Xiaoyu Zhang
Northwestern Chemistry
9 months ago
🚨 Don't miss this recent research from the Zhang Lab 🚨 'Harnessing the FBXW7 Somatic Mutant R465C for Targeted Protein Degradation'
#Cancer
#Chemistry
#ProteinDegredation
Out now in @J_A_C_S ➡️
pubs.acs.org/doi/full/10....
@xiaoyuzhang.bsky.social
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Harnessing the FBXW7 Somatic Mutant R465C for Targeted Protein Degradation
Targeted protein degradation (TPD) is a pharmacological strategy that eliminates specific proteins from cells by harnessing cellular proteolytic degradation machinery. In proteasome-dependent TPD, exp...
https://pubs.acs.org/doi/full/10.1021/jacs.4c17331
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Xiaoyu Zhang
Adam Gilbert
10 months ago
Thoughts on why DCAF11, DCAF16 and FBXO22 could be the next workhorse E3 ligases in TPD
doi.org/10.1038/s415...
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Implications of frequent hitter E3 ligases in targeted protein degradation screens - Nature Chemical Biology
This Perspective discusses recent strategies to expand the scope of targeted protein degradation (TPD) and the implications of unexpected convergence of diverse screening efforts on a small subset of ...
https://doi.org/10.1038/s41589-024-01821-z
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Xiaoyu Zhang
Behnam Nabet
11 months ago
🧪 Ready, set, degrade! So proud to share our work in the
@jclinical-invest.bsky.social
, establishing a versatile approach for creating transgenic dTAG mice to degrade oncoproteins. We showcase that KRAS G12V degradation triggers antitumor immunity in lung cancer. Link:
www.jci.org/articles/vie...
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reposted by
Xiaoyu Zhang
Ryan Potts - real
11 months ago
Somatic FBXW7-R465C mutant shows promise in targeted protein degradation in cancer cells. This approach enhances protein degradation specificity in diseased cells. Congrats Xiaoyu Zhang and colleagues. 🧪
#chembio
#TPD
#CancerResearch
www.biorxiv.org/content/10.1...
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Harnessing the FBXW7 somatic mutant R465C for targeted protein degradation
Targeted protein degradation (TPD) is a pharmacological strategy that eliminates specific proteins from cells by harnessing cellular proteolytic degradation machinery. In proteasome-dependent TPD, exp...
https://www.biorxiv.org/content/10.1101/2024.12.03.626601v1.full.pdf+html
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Xiaoyu Zhang
Abhishek Chatterjee
11 months ago
Got the chance to put together the "Click of Chemical Biologists" starter pack v1 and v2 over the Thanksgiving Break. Feel free to ping me on who else I might be missing! V1:
go.bsky.app/3P5i7nJ
V2:
go.bsky.app/Cr4ej7
add a skeleton here at some point
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