How does the mycobacterial vacuole go from damage that can still be repaired to full rupture? 👀 Our new preprint shows that EsxA and PDIM act sequentially: EsxA initiates repairable lesions, and PDIM helps push them past host repair capacity toward cytosolic escape. doi.org/10.64898/202...

📣 After 5 years, the last paper from my PhD is finally out in #ScienceTranslationalMedicine! We show that sustained tissue inflammation drives disease progression in #Buruliulcer. And targeting it alongside antibiotics can accelerate healing. www.science.org/doi/10.1126/...

What if better TB therapies start with an amoeba? Our recent chapter highlights the Dd–Mm model as a versatile platform to study infection and explore host-directed therapies. Check this out ⤵️ @nabilhanna3.bsky.social www.sciencedirect.com/science/chap...

📣 Happy to share our new chapter in Live Biological Imaging Across Scales! We discuss how to explore membrane damage responses using Dicty and high-throughput single-cell analyses 👀. Shout-out to @angieprrt.bsky.social and the team onlinelibrary.wiley.com/doi/10.1002/...

All currently approved antibiotics inhibit essential cellular processes. Ever wonder if we could kill bacteria using the opposite strategy? Here, we demonstrate an alternative antibacterial strategy: lethality through pathway over-activation. www.nature.com/articles/s41... (1 out of 3)

🚨 New preprint! Together with @carobarisch.bsky.social lab, we investigated how intracellular compartmentalization shapes lipid acquisition in mycobacteria Interestingly, deleting one FACL enzyme (FACL6) revealed striking compartment-dependent phenotypes 🔬 Check it out: doi.org/10.64898/202...

🎉 Big news! Last Saturday, Thierry was awarded the Egon Naef Foundation Prize for in vitro research 🏆 A wonderful recognition of his innovative work throughout his career developing alternatives to animal testing 👏 www.unige.ch/sciences/chi... @sciencesunige.bsky.social

🚨 Preprint alert 🚨 In this study, we reveal how a calcium-sensing protein coordinates membrane damage sensing with repair pathways in response to damage from intracellular mycobacteria Huge congrats to @guallar-garrido.bsky.social for leading this project! 🤩👏 www.biorxiv.org/content/10.6...

🚨 Want to know how we demonstrated the importance of sterol-rich membrane microdomains for M. marinum infection? Check out our latest paper published in Science Advances 👇 www.science.org/doi/10.1126/... ✨ Big thanks to everyone, especially Cristina Boehm-Bosmani, @soldatilab.bsky.social ! ✨

New paper out! 🚨 We uncover how Mycobacterium marinum (red) exploits host sterol-rich membrane microdomains (green) to damage and escape from its phagosome Huge shoutout to @angieprrt.bsky.social and Cristina Bosmani for their very elegant work! 👏 www.science.org/doi/10.1126/...

🏆 It's a double win for the Soldati Lab! Last Friday, our former PhD students @angieprrt.bsky.social and Jahn Nitschke each received an award for their doctoral work: the Laemmli Prize for Angélique and Best Thesis in Life Sciences for Jahn. So proud of both for these well-deserved honors! 🤩

🚨 Preprint alert 🚨 Don’t miss our latest story on how mycobacterial surface shedding shapes the host response !

A long journey with a fantastic conclusion! Congrats 🍾🧑‍🎓

🇻🇳 What a great week at the BPHCI Conference in Vietnam! @j-toinon.bsky.social and @angieprrt.bsky.social enjoyed sharing their results on M. marinum–Dicty interactions. A small crowd, but packed with brilliant science and great vibes! 🥂

Excited to share Wendy Le Mouëllic’s PhD work, now published in @pnas.org! It reveals that M. tuberculosis depends on inorganic sulfate import to survive inside host cells—fueling essential processes such as redox balance and stress resistance. Huge congrats to Wendy & colleagues! shorturl.at/WbFQC

🦠 Mycobacteria aren't just tough, they're interior designers! 🦠 Check out our latest #preprint 🚨, led by our PhD student @camimille.bsky.social , where we show that #Mycobacterium tuberculosis builds secret cytoplasmic membranes to adapt its metabolism and sneak past immunity 🤫 Thread coming soon!

Be our new colleague! 🎉 The Dept of Molecular and Cellular Biology at the University of Geneva is hiring an Assistant Professor or Associate Professor. 👉 More details here: lnkd.in/e8Z9eAm4 👉 Our department: mocel.unige.ch Please feel free to share this opportunity with your network.

Watch @maxgg.bsky.social, Group Leader at the Crick, as he explains what happens to cells that are infected with tuberculosis and how his lab is studying our bodies’ response to this infection. www.youtube.com/watch?v=VWCt...

Long live Dicty! ✨ So grateful for the chance to attend this wonderful meeting one last time. Always a joy to reconnect with old colleagues and friends

How does evolution shape ancient cellular processes? Our new paper uncovers the mosaic evolution of conserved and diverging endocytic traits in fungi! www.cell.com/current-biol...

Last week was a fantastic opportunity for @lucasceseti.bsky.social to share his work on Xanthomonas and Dicty at #ETOX25 🦠 The Basque Country was the place to hear great science on toxins🤩

Come and Join our Dpt in Beautiful #Geneva ! We are looking for a #Microscopy & #Image #Analysis expert to help all of us at the Dpt.

Check our latest methods chapter on how to use Dictyostelium–Mycobacterium marinum as a high-throughput screening platform for anti-infective compounds 👇 www.frontiersin.org/journals/mic... @nabilhanna3.bsky.social

Last week’s ESCRT meeting was full of great science and engaging discussions! 🤩 Such a great place to share our work on ESCRT during Mycobacterium marinum infection 🦠

💥 Very excited to share this review in Nature Reviews Microbiology. Contributing to this review with Val, Digby and Amy was an enlightening experience! Hope people in the community find it useful- we managed to cite around 200 papers... www.nature.com/articles/s41... www.nature.com/articles/s41...

Jinich et al. present an important new resource for the Mtb community! The Mycobacterium tuberculosis Transposon Sequencing Database (MtbTnDB) is an interactive web resource summarizing 150+ published screens. #MicroSky #Mycobacterium #tuberculosis onlinelibrary.wiley.com/doi/10.1111/...

🚨 Great story released by @gm-charriere.bsky.social and co.! They identified and characterised a natural interaction between amoebae and Vibrio, pointing to Paramoeba as a potential reservoir of oyster pathogens 🦪 Congrats! 🥂 enviromicro-journals.onlinelibrary.wiley.com/doi/10.1111/...

🥳🙌

What better way to wrap up the Soldati tour than with a fantastic talk from @mel-foulon.bsky.social? 🎤 She enjoyed “shedding” her enthusiasm for Myco lipids with such a brilliant crowd of passionate scientists at #EMBOcellBioHostPath! 🧫✨

Yesterday, @nabilhanna3.bsky.social had the fantastic opportunity to present one of his projects during another vibrant and successful poster session at #EMBOcellBioHostPath! 👏 Stay tuned for @mel-foulon.bsky.social ‘s talk

🤩 Great start to the #EMBOcellBioHostPath! Justine had the honor of kicking off the Soldati lab presentations with her fantastic poster! Not too late to catch up if you missed it! 📍Stay tuned for @nabilhanna3.bsky.social poster tomorrow and @mel-foulon.bsky.social talk on Thursday!

Did you know the cell wall of mycobacteria isn’t just for protection? 🧱👀 Here, Mycobacterium marinum sheds its outer capsule right after being eaten by Dicty! A sneaky move that affects even nearby cells… #FluorescenceFriday #Mycobacteria #CellBiology #Infection #3Rmodels #Phagocytosis

It was good to see @carobarisch.bsky.social back in town! Thanks for the career view and advices ✨

A short reminder that registrations for the EMBO ESCRT meeting 2025 in Montreux June 23rd-June27th are still opened! Please register online at meetings.embo.org/event/25-escrt

Congratulations to Dr. @guallar-garrido.bsky.social on her new lecturer position at the Autonomous University of Barcelona! She will keep working on mycobacteria using amoeba host model. Best of luck on this exciting new chapter! 👏🔬✨

Please repost: Postdoc position in antibiotic discovery in a large multidisciplinary project combining high-throughput approaches, microscopy, AI, and hit-to-lead optimization at @umontreal.ca and @mila-quebec.bsky.social. Apply to [email protected]. See lnkd.in/dVVk4N3s. #microsky

🇨🇭 What better way to start than with a tradition renewal ? First post on BluePlanet celebrates Geneva's culture with the Marmitte breaking! 🎉 🥂