Thank you @aacrjournals.bsky.social for highlighting our recent study on PARP inhibitors and histone turnover! 🧬💊

Sarah Moser ( @sarahmoser.bsky.social) from the lab of Jos Jonkers, Netherlands Cancer Institute (@nkinl.bsky.social) & Oncode Institute (@oncodeinstitute.bsky.social). 👏🏾 5/

Exciting news! We're thrilled to announce the six outstanding laureates of the International Birnstiel Award for Doctoral Studies in Molecular Life Sciences 2025! 🏆Congratulations to all awardees and honourable mentions! 🎉 1/ ➡️ www.imp.ac.at/news/article...

We have lift off!! 🚀 Yesterday was the official opening of EpiC! The DNRF Center for Epigenetic Cell Memory at the Danish Cancer Institute! Our EpiC team with director Anja Groth @groth-anja.bsky.social, were joined by Jesper Fisker, CEO @cancer.dk & Niels Mejlgaar, CEO @dg.dk to celebrate 🎉

Breaking the chain: uncovering a hidden weakness in PARP-resistant cancers ➡️ www.nki.nl/news-events/... #fundamentalresearch #cancerresearch #NKI #breastcancer #ovariancancer

Nature research paper: NASP modulates histone turnover to drive PARP inhibitor resistance go.nature.com/45vRWhd

Happy to see this impressive work from Sarah, Abdel, Jos, and colleagues out! Congratulations!! and happy we could contribute a tiny bit. Changes in histone dynamics is a mechanism of drug (PARPi) resistance in tumors, and it may be exploited in therapy.

This project has been a truly exciting chapter of my PhD journey and I am deeply grateful to everyone involved. A heartfelt thank you to my mentors, @josjonkers.bsky.social and @amazouzi.bsky.social for their guidance in solving the histone puzzle.

Thrilled to share our latest work, just published in @nature.com ⬇ www.nature.com/articles/s41... We discovered that PARP inhibitors 💊 trigger histone eviction from the chromatin and this creates a hidden vulnerability in PARPi resistant tumors. 🧵 (1/8)

Extremely cool!

new out in Nature yesterday www.nature.com/articles/s41...

I am thrilled to share with you my first co-corresponding author Nature paper with Jos Jonkers. This project was led by the extraordinary @sarahmoser.bsky.social . Congratulations, and thank you to all the authors, @nkinl.bsky.social , and @oncodeinstitute.bsky.social for their support.

@science.org Zincore-coregulator dedicated to zinc🖐️ TFs essential in development www.science.org/doi/10.1126/... @rborza.bsky.social @sgregoricchio.bsky.social @amazouzi.bsky.social @zwartlab.bsky.social @lindersimon.bsky.social @tassosperrakis.bsky.social @thijnbrummel.bsky.social + al.

In today’s publication in Science we introduce Zincore: a novel protein of QRICH1 and SEPHS1 and functions as a transcriptional coregulator dedicated to zinc finger transcription factors. Here’s how we found it: 🧵 www.science.org/doi/10.1126/... 1/11

Proud! 💙 Our scientific director Thijn Brummelkamp receives the Spinoza Prize, a prize for scientists who belong to the best researchers worldwide. A wonderful recognition for his groundbreaking research. Congrats Thijn! 🎉 @thijnbrummel.bsky.social Full article ➡️ bit.ly/40p4KnK

Excited our paper is out! G-quadruplex (G4) unwinding via an intricate G-loop assembly and disassembly mechanism maintains genome integrity. Pioneered by Koichi Sato with great collaborators Jing Lyu and @simonelsasser.bsky.social Check it out: www.science.org/doi/10.1126/science.adr0493 🧵(1/4)

Hey my fellow Germans! I wasn't aware, but there is an AvH-JSPP postdoc fellowship, dedicated to German citizens aiming to do their postdoc in Japan. It covers salary + travel to Japan + startup for your life in Japan. Let me know if you are interested! www.humboldt-foundation.de/en/apply/spo...

Great news from The ERC : erc.europa.eu/news-events/...:

Really cool story highlighting one of the most beautiful genetic suppression interactions between SRBD1 and condensin II! #CoolScience www.linkedin.com/feed/update/...

Some DNA damage, RAD51, MND1, cohesin and RAD54L with a lot of imaging! www.biorxiv.org/content/10.1...

Extensive review of 30 years of BRCA1 biology by @sarahmoser.bsky.social and @josjonkers.bsky.social! Such a fascinating protein, and this is probably just the tip of the iceberg of what BRCA1 can do. I am sure more surprises are coming in the next three decades!

*Tenured full Professorship in Genetics and Molecular Cell Biology* at the University Of Cologne, Germany It's an opportunity to rebuild the place that used to be home to luminaries including Benno Müller-Hill, Max Delbruck, Campos-Ortega, Diethard Tautz Maria Leptin, Thomas Langer

Identification of critical factors of the replication stress response in human cells https://www.biorxiv.org/content/10.1101/2025.01.12.632149v1

Happy to have contributed to this issue 🎉 @akhalizieva.bsky.social did an amazing job exploring our current knowledge on our two favourite genes, BRCA1 and BRCA2, and how this is being used to target BRCA1/2-mutated tumors. Check it out ⬇️ genesdev.cshlp.org/content/39/1...

Excited to share our new paper! Here we reveal USP1/UAF1 as a highly efficient DUB for K63- and K48 polyubiquitinated PCNA and give detailed insights into its mechanism that may drive pathway choice in DNA damage tolerance. Preprint is available now: www.biorxiv.org/content/10.1...

Despite the black picture below, we're really happy to have this illuminating story online! Careful molecular mechanistic from Niels and others in the lab work giving unexpected biological insight!

Blown away by David Baker's Nobel Prize lecture in chemistry. Just wow! www.youtube.com/live/HnT1VWz...

I find this a quite useful summary from Nature’s Hiring in Science Survey 2024.

Based on Nature’s Hiring in Science Survey 2024, the majority of hirers are not using AI as part of the application process. Those in academia are particularly unlikely to embrace it in the future. I find it difficult to believe—do you? figshare.com/s/7aea1f12aa...

What are your plans for October 2025? It would be a fantastic time to visit Norway for the Endogenous DNA Damage and Repair conference with a stellar set of speaker covering a wide range of topics. www.endodnadamage.com

We just opened a search for a lab-based faculty position at Dana-Farber @danafarber.bsky.social @harvardmed.bsky.social Any area of cancer research is fair game and MD, PhD, or MD/PhD are encouraged to apply. Please spread the word: www.nejmcareercenter.org/job/829239/l...

An update on our Dept faculty search. We had 165 applications and after reviewing, we discussed the top 30. 12 were selected for Zoom interviews, and then we discussed and selected 5 for in person interviews which start soon. For those still interviewing, Zoom questions are attached. Good luck!

Looking for a host institution for your group leader level fellowship application(s)? Apply to our department! www.ucl.ac.uk/work-at-ucl/... This is how I started my lab here, so very happy to chat with anyone interested in this route - drop me a message! 🧪🧠 #neuroskyence

"Negative reinforcement, such as receiving overly harsh criticism or being scolded by a research mentor, and being held to unreasonable expectations were two of the most detrimental aspects of research affecting student mental health." www.nature.com/articles/s41...

Application review starts 11/30! Please share, new Bluesky friends!

Are you a #postdoc with an innovative vision for starting your own lab in #Syntheticbiology, #Genomics, #GeneRegulation, #Development, #Cancer, #Immunology or #InfectionBiology? @IMPvienna is inviting applications for group leader positions: www.imp.ac.at/career/open-... Pls share!

Post a picture you took (no description) to bring some zen to the timeline.

Multiple faculty position in Bioengineering and Immunoengineering at the University of Chicago: apply.interfolio.com/157759

I'm so excited to announce that my department is now hiring TWO ECOLOGISTS at the Assistant Professor Level. We will be really excited to substantially expand research in ecology in our EEOB Department at UCR. Please Repost and share widely! aprecruit.ucr.edu/JPF01983

🚀 Excited to share my first preprint on bioRxiv www.biorxiv.org/content/10.1... AlphaBridge simplifies protein structure predictions for experts and novices by combining complex analysis with visual representations and interactive tools in one user-friendly platform.

Nice to see in Bluesky a couple of posts about our new preprint about #CHAOS&Disorder :)

Great to see this out: STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment Great collaboration with Jurgen Marteijn and Anisha Ramadhin; All biochem.and #cryoEM by Shun-Hsiao Lee: www.cell.com/molecular-ce...

Official website for EMBO meiosis 2025 is live now! Looking forward to seeing you in Switzerland next June! #meiosis4eva meetings.embo.org/event/25-mei...

Our department at UC Irvine is recruiting for a tenure-track position in RNA biology! Assistant or Associate level, any area of RNA biology including in microbiology are encouraged to apply. Come join our vibrant research community in SoCal! recruit.ap.uci.edu/JPF09320

Announcing the next EMBO Chromosome Segregation and Aneuploidy Meeting! Italy 2025. Please register and join us for another exciting and friendly meeting in a beautiful location meetings.embo.org/event/25-ane...