Our new preprint in collaboration with @meisterpeterf.bsky.social uncovers the molecular basis for condensin recruitment to X chromosomes in C. elegans and reveals atomic-level details of a previously unknown auto-inhibited state of condensin. www.biorxiv.org/cgi/content/short/2026.03.13.711519v1

Congratuations to our PhD Student @gurumoorthya.bsky.social on winning the Poster Award for his work on gene regulation by DNA loop extrusion and phase separation at the CNIO-CaixaResearch Frontiers Meeting on "Machines acting on DNA and RNA, a molecular mechanistic perspective"!

In our latest mini review, Toni Valdes and I discuss the potential role(s) of DNA superhelicity in the organization of chromosomes by SMC protein complexes, covering classical biochemistry experiments to recent single-molecule biophysics studies. doi.org/10.1042/BST2...