Happy to share our new preprint in collaboration with Natalia Jura's lab! 🧬 CNPY4 is a lipid-binding regulator of sphingolipid homeostasis 👉 biorxiv.org/content/10.1101/2025.10.13.682155v1 Sphingolipids shape membranes & signaling — but how their balance is maintained is still unclear.

🔔SAVE THE DATE!🔔 Leanne Jones and I are super excited to announce the 3rd Intestinal Stem Cell conference is taking place next November in Mexico. Registration now open, ECR grants available and our Keynote, Hans Clevers, is confirmed. More info➡️ bit.ly/474De1E

YOUR PHONE EXISTS because the government invested in "useless" basic research decades ago! It's the same with medical research - today's basic science leads to tomorrow's life-saving treatments. Visit FundResearch.org to tell Congress to keep funding research #SaveOurCures #PhoneForGood #FundNIH

🎉 INTRODUCING #SaveOurCures🎉 Federal biomedical research represents less than 1% of the federal budget but delivers life-saving treatments for millions of American families. 93% of cancer treatments started with American government-funded research. 🧵: 1/8

Trump Is Shutting Down the War On Cancer www.nytimes.com/2025/09/14/m...

We're very excited to launch a search for a founding director of our new reproductive sciences program at Cedars-Sinai! careers.cshs.org/job/los-ange...

🎖️Congratulations to Carole Ober, PhD, winner of the ASHG 2025 Mentorship Award! Learn more about the award and Dr. Ober's work: https://www.ashg.org/membership/awards/2025-awardees/ #ASHG #HumanGenetic

Final version @science.org "Recent evolution of the developing human intestine affects metabolic and barrier functions". Evolutionary preparation for microbiota, diet, and pathogen exposure is fascinating! Thank you @erc.europa.eu for supporting our vision! www.science.org/doi/10.1126/...

UCLA professor Bill Lowry: My current basic-research grant from the National Institutes of Health, which is a continuation of the work that led to this discovery on alopecia, was suspended last week. I don’t know what interesting discoveries won’t be made the longer this thing stays suspended. 🧪

Excited to share our new paper by Jessi Cook in collaboration with Michelle Griffin from Mike Longaker's group at Stanford. www.science.org/stoken/autho... As nicely described by our communications team:

Join us in Crete in the fall to discuss stem cells! The early bird deadline has been extended to July 15th. This date will be the final deadline for abstracts being considered for short talk selection. www.aegeanconferences.org/src/App/spea... Looking forward to seeing you there!

Activation of angiotoxin receptor–like signaling and suppression of focal adhesion kinase allow for regenerative healing in the oral mucosa www.science.org/doi/10.1126/... @ophirklein.bsky.social

Here Is All the Science at Risk in Trump’s Clash With Harvard www.nytimes.com/interactive/...

Help Save the NIH www.congressweb.com/UCSF/9?frame...

Talked to @KateZernike at @nytimes about my journey and the current moment for scientists in the U.S. “Ardem Patapoutian’s story is not just the American dream, it is the dream of American science.” Read the article here. No subscription required: www.nytimes.com/2025/06/03/u...

Europe’s choice is clear. To put science at the heart of its economy. To become the home of scientific freedom and collaboration. And to welcome talent from all over the world. I’m glad to present the first elements of our Choose Europe Initiative. → europa.eu/!TTbWbJ

Urge Congress to Reject the President's Budget Proposal to Cut NIH, NSF www.congressweb.com/ASHG/32?fram...

This is something I keep asking myself: www.nytimes.com/2025/04/11/o...

It was an honor to speak at the Shanthi Sitaraman Symposium at Emory yesterday, and to hear about Shanthi from her colleagues, friends and family. She was a remarkable physician, scientist and teacher.

Was great to visit @newyorkuniversity.bsky.social dental school today and to hear all the terrific science going on. A highlight of the trip was spending time with our former lab member @rkzwick.bsky.social in her beautiful new space and meet her growing group - she is off to a great start!

Just recruited two more grad students to be appreciated on Bluesky! @jasminegarciia.bsky.social @davidsungtooth.bsky.social @ophirklein.bsky.social

Killing the goose that lays the golden eggs www.nytimes.com/2025/03/31/b...

Was great to hear @ardemp.bskyverified.social 's lecture @cedars-sinai.bsky.social annual research day - amazing science and a remarkable life journey. He's so committed to understanding Piezo proteins that he got one tattooed on his arm!

Thank you for lending your voice to @standupforscience.bsky.social 🙏

Save the date: The 6th Int’l Conference on Stem Cells will be held at the Kalimera Kriti Hotel in Sissi, Crete, Greece from October 1-6, 2025. Looking forward to our next iteration of this exciting and fun meeting! www.aegeanconferences.org/src/App/conf...

Appreciate NIDCR highlighting our paper from last year in this nice piece: www.nidcr.nih.gov/news-events/... NIDCR support has been fundamental to our work since we began in this field, and its continued survival is essential to supporting essential dental, oral and craniofacial research

Francis Collins, the NIH Director for 12 years, led the Human Genome Project and other NIH efforts for 32 years, resigned today. Key words from his resignation letter www.nytimes.com/2025/03/01/u...

Looking forward to this!

This is sobering: kucharski.substack.com/p/the-bigges...

Viewpoint: Recent disruptions and funding cuts at the National Institutes of Health (NIH) undermine the infrastructure and stability of US scientific research, threatening the nation's global leadership and scientific productivity. ja.ma/41hBnoc #MedSky

ASHG is concerned about the cuts to NIH-funded research support, its impacts on biomedical research, and the effect on local, state, and national economies. We join our advocacy partners to ensure essential progress is not stalled. Read our statement: www.ashg.org/publications... #ASHG

Research Funding at Stake: Urgent Advocacy Needed for NIH Indirect Cost Policy www.congressweb.com/ASHG/31?fram...

February is Ectodermal Dysplasias Awareness Month! Please help to spread the word nfed.org/get-involved...

Excited that our new lab website is starting to come together - thanks to the team, particularly Pauline Marangoni and Zhulin Dixon, for assembling this, and stay tuned for additional updates ophirkleinlab.org

Happy birthday Pauline! And welcome Jose Tomas to the lab!

The devastating wildfires in LA have taken an enormous toll on our community. Even those not directly impacted have had the air they breath affected - our colleague Dr. Dralyuk @cedars-sinai.bsky.social Guerin Children's offers some advice here: www.cedars-sinai.org/newsroom/los...

📢Call for papers. Submit your latest research to our upcoming special issue – Lifelong Development: the Maintenance, Regeneration and Plasticity of Tissues Guest Editors: Meritxell Huch and Mansi Srivastava 📅 Deadline: 15 May 2025 https://buff.ly/4iItxeg #DevBio

Synthetic organizer cells, engineered to spatially self-assemble around stem cells, can be used to create specific morphogen gradients and systematically guide in vitro development www.cell.com/cell/fulltex... @cellcellpress.bsky.social @ophirklein.bsky.social

Very cool! One genomic test can diagnose nearly any infection! Comes out of the lab of Charles Chiu @ucsfhealth.bsky.social www.ucsf.edu/news/2024/11...

#NCB2024 In February, @ophirklein.bsky.social & co examined transcriptional patterns across the entire mouse and human small #intestine and found that it comprises five domains of #NutrientAbsorption and three regional #StemCell populations. rdcu.be/d2FlY www.nature.com/articles/s41...