An advanced head-to-tail mouse embryo model with hypoxia-mediated neural patterning https://www.biorxiv.org/content/10.1101/2025.06.17.660116v1

Catch up on our recent Community Lecture with Blaise Agüera y Arcas! The lecture, Computing, Life, and Intelligence, is available on SFI’s YouTube channel: www.youtube.com/live/75PAyV8... @blaiseaguera.bsky.social

In which we discuss the homologies between amphibian and mammalian organizers from the perspective of #gastruloids with special relevance to recently described A and C gastruloids as containing Spemann/Mangold and Trunk/Tail organizers www.sciencedirect.com/science/arti...

Check out our "In Preprints" @dev-journal.bsky.social w/ Yonit Maroudas-Sacks & Marc Trani Bustos @mpi-cbg.de @poldresden.bsky.social, putting recent #gastruloid work from @viktri08.bsky.social @thomasgregor.bsky.social @amartinezarias.bsky.social labs in broader perspective: doi.org/10.1242/dev....

Why are biological membranes asymmetric, with different lipids in the two bilayer leaflets? Discovered in the 70s, lipid asymmetry is linked to many cellular processes, but why the cell needs it is largely unclear. @pavelbarahtjan.bsky.social addresses this question: www.biorxiv.org/content/10.1...

It is also good to get some perspective, such as given by ballpark numbers and recent policies, since announcements were made. With the help of Perplexity. (1) The two systems start on different scales:

😱 A very hungry #PacManoid ate the original post 🍬🍬🍬 Here’s the 🧵 on our latest in @cp-cellstemcell.bsky.social again! Gastruloids w/ a sweet tooth better model natural embryos: doi.org/10.1016/j.st... Spearheaded by @cryaaa.bsky.social & Alba Villaronga-Luque @mpi-cbg.de @poldresden.bsky.social

Spatial multi-omics reveals cell-type-specific nuclear compartments @nature.com www.nature.com/articles/s41...

A methodology to reduce the localization error in multi-loci microscopy provides new insights into enhancer biology https://www.biorxiv.org/content/10.1101/2025.04.05.647393v1

The Dark Energy Spectroscopic Instrument (DESI) has determined the distances to enough galaxies by now to conclude that the cosmological constant is not in fact constant.

Martino Ugolini and I wrote a review on how useful embryos are to understand the role of transcription bodies in gene expression. I am sure @mirlab.bsky.social, @harrisonflylab.bsky.social, @lennarthilbert.bsky.social and others would agree. Enjoy the read! portlandpress.com/biochemsoctr....

We are excited to be launching the next phase of our Fast & Fair peer review initiative: offering high-quality peer review within 7 working days. #fastandfairpeerreview Read the Editorial by EiC Daniel Gorelick @danielgorelick.bsky.social at: bit.ly/4kYD1mL

I'm so happy to report that our preprint on light-induced collective cell migration has now been published in Cell Systems! This project was a lot of fun and will be the basis for a lot of our ongoing & future work.

How many cells do you need to establish PCP? The magic number is 3! Beautiful work by Lena Basta in Danelle Devenport's lab. Happy to have contributed. www.science.org/doi/10.1126/...

The Barcelona #gastruloid meeting has been a blast. A witness to a field that is maturing and a statement of a promise that lurks in its horizon. Thank you @joshifrenster.bsky.social @dias-andre.bsky.social and Ulla Fiuza for the organization, @EMBO, @ERC and the community for support.

still possible to apply: phygenome.sciencesconf.org

⭐️ Please Fwd. Are you in Paris on 16th May? See👇 poster of symposium on « Information processing in biological systems » @collegedefrance.bsky.social Fantastic line of speakers 🤩. It is free, w/o registration, and it will be exciting.m! Follows from my series of lectures at CdF last fall.

N2B27 media formulations influence gastruloid development https://www.biorxiv.org/content/10.1101/2025.03.15.643474v1

There's increasing evidence that in organoid/embryoids conditions of cells at start of experiments is crucial/ determines outcome. Much to be learnt still. Taking advantage of mouse #gastruloids, two groups explore this here. Important work to calibrate the field www.biorxiv.org/content/10.1...

We would love feedback on a new NCBI-BLAST service we are launching today: sky-blast.com Under the hood it's the same BLAST executable and databases provided by NCBI, with a replica of the NIH's interface - providing an alternative to the US gov service that's less congested, faster & more reliable

Excited to share our new work with Frank Jülicher on noise control & concentration buffering in intracellular condensates! There has been confusion about these concepts, which we aim to address in this paper. www.cell.com/cell-systems...

Shocking: a pioneer in quantitative developmental biology passed... one of my all-time heroes! He had a dominant influence on many in the early 2000s when this field started to take off. What a loss! Obituary written by two of his former students: biologicalsciences.uchicago.edu/news/john-re...

January has been a plentiful month for #gastruloid #preprints. Here @thomasgregor.bsky.social @denisduboule.bsky.social & colleagues introduce a new family of #hydrogels and probe the effect of mechanical constrains on morphogenesis www.biorxiv.org/content/10.1... #NotInTheGenes #InNumbersWeTrust

Check out this new paper from @thomasgregor.bsky.social 's lab on hydrogel embedding of mouse gastruloids to control gene expression and patterning.

Does anyone know of a search engine which searches all preprint archives, and only preprint archives (i.e., not Google Scholar)? In @europepmc.bsky.social I find @biorxivpreprint.bsky.social and EcoEvoRxiv , but not arXiv-Qbio.

Single molecule approaches across the central dogma! Genomics, imaging and theory! Very excited to host the first edition of Gene regulation, one molecule at a time this July @embl.org! Great lineup and many abstract selected talks!

The Institut Pasteur has decided to leave X (formerly Twitter) to join BlueSky! 🦋 The Institut Pasteur made this decision due to several serious issues observed on the X platform since its acquisition. Join us here to continue advocating for science. www.pasteur.fr/en/home/pres...

Two great articles in Mol Cell about enhancer cooperativity & long-range enhancer activation by @chribue.bsky.social & Wysocka labs: www.sciencedirect.com/science/arti... www.sciencedirect.com/science/arti... Dimitra and I had the pleasure to write a Preview: www.sciencedirect.com/science/arti...

Self-generated gradients guide collective cell movement -but often different cell types must move together, e.g. in immune response. We develop a theory of self-generated chemotaxis in mixed populations -are there optimal principles for this cooperation?🤔 www.biorxiv.org/content/10.1...

UMAP applied to 100 randomly generated points from a multivariate normal distribution simplystatistics.org/posts/2024-1...

New preprint from my colleagues in Naomi Moris's lab at the Crick Human trunk-like structures that model interactions between forming somites & neural tube Nice work showing how tissues talk to each other as they develop www.biorxiv.org/content/10.1...

We've wondered for a while why #gastruloids are so sensitive to initial cell numbers. Here www.biorxiv.org/content/10.1... led by U, Fiuza, we explore this & observe effects of a number of variables on final structure and think what this tells us @ embryogenesis #IInNumbersWeTrust #NotInTheGenes

Registration is open for the 12th Advances in Stem Cell Biology Course #ASCBcourse at the @pasteur.fr Hands-on training in different models, embryonic stem cells, iPS cells and much more on #StemCells. 🕘June23-July04, 2025 👉https://qrfy.io/VEcoKQpGfV

How can randomness be a source of living order? Can physics explain how an embryo emerges out of chaos? In this new paper in Science, Bernat Corominas-Murtra, @ehannezo.bsky.social & cols. show how embryos solve their own Rubik’s cube ist.ac.at/en/news/from...

Very proud to share the latest preprint from my lab by Ellie Degen and co. Here Ellie shows that a concentration threshold in the Bcd morphogen gradient is determined by competition with nucleosomes. Great mix of math, imaging, and genomics!

Très honorée et émue de faire partie des 2 lauréats 2024 du prix Agnes Ullmann, pionnière de la recherche sur la régulation de l'expression des gènes des bactéries. Toute ma gratitude à l'Institut Pasteur, au comité de sélection, et toutes mes collaboratrices et collaborateurs x.com/institutpast...

"The greatest threat to our planet is the belief that someone else will save it." - Robert Swan 🌊The ocean floor is becoming a graveyard for plastic waste! ⚠️It's time to act!♻️ scitechdaily.com/world-first-...

Continuing to go through my trove of cool videos... here is a classic from my work with Philipp Keller's team at @hhmijanelia.bsky.social A developing fly embryo imaged with a SiMView #lightsheet microscope augmented with our Autopilot self-alignment system. www.nature.com/articles/nbt... 🧪🔬🪰💻

I am really happy to announce the first Hubrecht Symposium on March 13th 2025! We will organize these yearly events on a specific topic in molecular and developmental biology to emphasize the importance of fundamental research for Dutch science. Free of charge! www.hubrecht.eu/hubrecht-sym...

We are opening a call for applications 2025 – Creation of new junior research groups at the Institut Pasteur in Paris @pasteur.fr all details on our web site : research.pasteur.fr/en/call/call...