Oops...that happens when your inner rocker forgets you have an important and formal Zoom meeting...😶

@FehrLab has new research on the antiviral functions of PARP14 which shows PARP14 represses both coronavirus and herpes simplex virus 1 (HSV-1) replication. Learn more at journals.asm.org/doi/10.1128/mbio.02299-25

CellPose 4.0 is a beast. Segmented human microglia, in brightfield. Credit to Sydney Houser.

I love my trainees ❤️#littlejoyindarktimes

Post a PERFECT album from the 90s that isn't Nirvana or Pearl Jam.

Indeed. It's ruining an entire generation of trainees in science. They've just stopped thinking. And reading.

This is very good news

I’m fighting this AI nonsense every single day. Trainees who answer even simple emails using ChatGPT. Trainees looking for hypotheses using ChatGPT. Trainees who don’t read papers because ChatGPT summarizes literature (in a very shitty way).

How many lab members is too many lab members? #newPI

As soon as my wife leaves town, my insomnia kicks in. Arsh 😡

Our protocol for gene editing is online and all plasmids are on @addgene.bsky.social! CRISPR away everybody and get in touch if you need anything 🤩

Slightly diminish a band: The Palliative

This is the stupidest time ever.

Ginger(bread Man) 🐕

You are walking through a crowd. One in ten people you meet believes the Earth is flat. 😑

I see more and more often trainees using AI to generate hypotheses. Brain is shrinking very fast nowadays.

Found this inspirational quote as a bookmark in a used book. Very relevant.

With all due respect, why do you need to image at 12ms for 7 min, it is a mystery to me.

The National Institutes of Health’s budget, and structure, would be preserved under a Senate bill for the 2026 fiscal year.

Wise geneticists/CRISPRists out there. I am knocking out two genes (encoding for two isoforms) with a dual sgRNA Cas9 plasmid. I can get a dual knock-out (isoforms A and B) and a knock-out of isoform B, but no knock-out of isoform A alone. Any guess? Done this two times already, very reproducible.

Structural and cell biology NPG publication two-fer today: lysosome signaling structural biology tinyurl.com/mt3uc96k with @robzonculab.bsky.social and mitophagy initiation tinyurl.com/3rpjyfjt with @martenslab.bsky.social @lazaroulab.bsky.social and @hummerlab.bsky.social

Another reason to consider HaloTag as an alternative to GFP for tagging

#Aging reduces the ability to make new proteins, so can stimulating protein synthesis in old age be beneficial? This study shows that boosting #ProteinSynthesis in #neurons by inhibiting #RNApolymerase repressor Maf1 improves health & survival into old age in flies @plosbiology.org 🧪 plos.io/3IwLiPZ

Researchers introduce UltraID-LIPA, an innovative platform that combines the light-inducible protein aggregation (LIPA) system with the UltraID proximity-dependent biotinylation assay to identify #Parkinsons-associated α-synuclein-interacting proteins www.cell.com/iscience/ful...

🙄

Key numbers in cell biology Having a sense of scale helps to think more rigorously and realistically about biological systems.

🧑‍🔬📰🚀 #RxivMaker is here! A framework automating the creation of publication-ready scientific #preprints from simple Markdown. Goodbye manual formatting, and hello gorgeous manuscripts! A great adventure with @guijacquemet.bsky.social's lab 📜: zenodo.org/records/1575... 👨‍💻: github.com/HenriquesLab...

The ESCRT complexes are a fascinating membrane cutting machine with roles in countless cell pathways, but they are also ubiquitous in disease and offer new opportunities as drug targets. See our new review with Alyssa Coyne, Marta Miączyńska, and Harald Stenmark at tinyurl.com/yex3trem

Damn scam text. They know my weaknesses!

It was important to be here, today. #pride

Another ND. Argh 😡

65 applicants total. Many US-based researchers who have lost their job due to funding being terminated. This is bad.

I have to screen 58 applications, 100% increase from last round. A LOT of US-based postdocs whose funding have been recently lost. This is bad.

New paper alert! Huge congrats to my graduate student Jesse Velasco on his first author publication in physiological reports. physoc.onlinelibrary.wiley.com/doi/10.14814...

This position is open until May 31st. Lots of brilliant US-based applicants this round, probably due to NIH and NSF funding issues. Unfortunately, I can only take one postdoc.

Wonder doesn’t flinch. It’s our compass pulling us toward curiosity, creativity It reminds us: #science & #discovery are good. Here’s a moment that stirred mine: a new PI(3,4)P₂ probe illuminating the cell membrane & endosomes. Marvel with me. Captured on #FluorescenceFriday for #MicroscopyMonday

🚨Our new paper is online🚨 We use zero-distance⚡photo-crosslinking⚡to reveal direct protein-DNA interactions in living cells, enabling quantitative analysis of the DNA-interacting proteome on a timescale of minutes. #DNA #Chromatin #Proteomics www.cell.com/cell/fulltex...

I.NEED.IT

“Tell me about your mentoring strategies. How’s your daily interaction with your team?” Well…🙄

Cool paper.

The cryo-em core at kumc is looking for a lab manager. This is an exciting opportunity to join a growing facility. kumc.wd5.myworkdayjobs.com/en-US/kumc-j...

mTORC1 is activated when cells are fed with amino acids. New preprint with @robzonculab.bsky.social led by Rachel Jansen shows how the massive "CastiGATOR" complex is formed when arginine-free CASTOR1 binds to the GATOR2 complex to antagonize mTORC1 starved cells. tinyurl.com/yr6en6f4

Charles Russell Middaugh was born July 13, 1947 and passed on May 3, 2025. A celebration of his life is planned for August 23 in Lawrence, Kansas. For information about the celebration, please email [email protected]. www.legacy.com/us/obituarie...

The Department of Pharmaceutical Chemistry at KU is on BlueSky! @kupharmchem.bsky.social This is where pharmaceutical chemistry was born!

Spoiler alert: it’s not Godzilla 😔

Open postdoctoral position in my lab, focused on the assembly of metabolic complexes. I am looking for a talented and motivated scientist with experience in mass spectrometry proteomics. We have state-of-the-art facilities and are located in beautiful Lawrence, KS. employment.ku.edu/staff/30523BR

Never NEVER had one. And the few people I profoundly admire have passed away long long before I was even conceived 💀

My family has a big EVOO farm in Italy. These numbers are real, driven by climate adversity in the Mediterranean area. Summers are unbearable. Precipitations unpredictable.

I don’t know what’s going on with my job yet but I’m an NIH funded scientist and I’ve been waiting for the other shoe to drop. Here’s my LinkedIn. I’m a human geneticist and computational biologist. I very much want to stay in Seattle for family reasons. Please repost www.linkedin.com/in/nparmalee

I got hit by some rather sudden and extreme financial hardship so if anyone is in need of remote wetlab contract research, strictly BSL1, do let me know. Currently scrambling for gigs. Plant, Bacterial, Archaeal Non-model Bioeng Custom Lab Hardware Turn Key Genetic Design Please repost for reach 💚