Mandatory reading.

What I have been seeing is that young PIs fail at being just professional. We train individuals to be masters in their field; we don't teach them how to behave with their peers, to meet a deadline, or to properly answer an email. Honestly: last two months have been a series of 'WTF?!?'.

“As 2025 comes to a close…”, followed by 100% guaranteed AI bullshit. Totally losing interest in “content”.

ULK1 knockout suppresses pancreatic cancer progression by inhibiting autophagy and enhancing antitumor immunity 🧪 #PancreaticCancer www.nature.com/articles/s12...

KU’s Steven Soper was named to the 2025 Class of the National Academy of Inventors Fellows — the highest professional distinction awarded solely to academic inventors. Soper is the 8th faculty member to receive the honor while at the @universityofkansas.bsky.social. news.ku.edu/news/article...

Grad students + PI at the annual KUCC Research Week.

oh wow.

Our lab was awarded both a Tina's Wish Team Science Award (with Godwin, Soper, and Whelan labs at KUMC-KU) and the inaugural KUCC Obesity, Metabolic Health, and Cancer Pilot project. Every penny counts. :-)

I have a strong feeling that science is being killed day by day by this. Oligarchs should keep their hands off science.

So, it looks like we're gonna get some money to build CRISPR-Cas13 miRNA sensors for cancer detection...any other suggestions/new approaches other than SHERLOCK? #crispr #newPI

Uhhh...😑

Three years ago I was farming in Southern Italy to replace dad who had a terrible accident. Social media made me remember this picture: a detail in my dad’s workers van. It’s a tough life.

😒

Jeff Tweedy warming our hearts yesterday evening.

You have a dozen active grants, half of them the size of an R01. You have committed 100% of your effort to them. Your >300k damn salary is covered. Is it even ethical to ask for more $$? At what point this becomes just a greedy game?

This is something I have often wondered about - how DNA damage alters genome architecture and if it is heritable across the cell cycle even after repair? Well here is a nice study addressing this fundamental question 👇👇👇😍

😶

Lactate biosensor

Thanks @freudlab.bsky.social for the kind invitation at @kumedcenter.bsky.social BMB. 😁

As a reviewer, please don't overuse AI to write your grants. I understand the need for a quick editing/grammar check, but the structure of the paragraphs and the logic is absolutely awful. I can spot it in a nanosecond.

🖤

I still contend that >90% of the benefit of writing a review isn't the audience. It's for the author going through the literature, finding gaps in knowledge, learning how experiments are done, etc. It really isn't about writing a review. It's about doing the review yourself. AI can't do that for you

This was a great meeting, with outstanding speakers.

On LinkedIn, everybody is “thrilled”.

Oops...that happens when your inner rocker forgets you have an important and formal Zoom meeting...😶

@FehrLab has new research on the antiviral functions of PARP14 which shows PARP14 represses both coronavirus and herpes simplex virus 1 (HSV-1) replication. Learn more at journals.asm.org/doi/10.1128/mbio.02299-25

CellPose 4.0 is a beast. Segmented human microglia, in brightfield. Credit to Sydney Houser.

I love my trainees ❤️#littlejoyindarktimes

Post a PERFECT album from the 90s that isn't Nirvana or Pearl Jam.

Indeed. It's ruining an entire generation of trainees in science. They've just stopped thinking. And reading.

This is very good news

I’m fighting this AI nonsense every single day. Trainees who answer even simple emails using ChatGPT. Trainees looking for hypotheses using ChatGPT. Trainees who don’t read papers because ChatGPT summarizes literature (in a very shitty way).

How many lab members is too many lab members? #newPI

As soon as my wife leaves town, my insomnia kicks in. Arsh 😡

Our protocol for gene editing is online and all plasmids are on @addgene.bsky.social! CRISPR away everybody and get in touch if you need anything 🤩

Slightly diminish a band: The Palliative

This is the stupidest time ever.

Ginger(bread Man) 🐕

You are walking through a crowd. One in ten people you meet believes the Earth is flat. 😑

I see more and more often trainees using AI to generate hypotheses. Brain is shrinking very fast nowadays.

Found this inspirational quote as a bookmark in a used book. Very relevant.

With all due respect, why do you need to image at 12ms for 7 min, it is a mystery to me.

The National Institutes of Health’s budget, and structure, would be preserved under a Senate bill for the 2026 fiscal year.

Wise geneticists/CRISPRists out there. I am knocking out two genes (encoding for two isoforms) with a dual sgRNA Cas9 plasmid. I can get a dual knock-out (isoforms A and B) and a knock-out of isoform B, but no knock-out of isoform A alone. Any guess? Done this two times already, very reproducible.

Structural and cell biology NPG publication two-fer today: lysosome signaling structural biology tinyurl.com/mt3uc96k with @robzonculab.bsky.social and mitophagy initiation tinyurl.com/3rpjyfjt with @martenslab.bsky.social @lazaroulab.bsky.social and @hummerlab.bsky.social

Another reason to consider HaloTag as an alternative to GFP for tagging

#Aging reduces the ability to make new proteins, so can stimulating protein synthesis in old age be beneficial? This study shows that boosting #ProteinSynthesis in #neurons by inhibiting #RNApolymerase repressor Maf1 improves health & survival into old age in flies @plosbiology.org 🧪 plos.io/3IwLiPZ

Researchers introduce UltraID-LIPA, an innovative platform that combines the light-inducible protein aggregation (LIPA) system with the UltraID proximity-dependent biotinylation assay to identify #Parkinsons-associated α-synuclein-interacting proteins www.cell.com/iscience/ful...

🙄

Key numbers in cell biology Having a sense of scale helps to think more rigorously and realistically about biological systems.