Still posting cytoskeleton videos, it seems. Actin this time. Sample: Lifeact-eGFP in HeLa cells. Modality: Airyscan confocal Timestamp is mm:ss and the scale bar is 5 µm.

The law of the jungle. Interactions of cells in a collective lead to global rotation. In 80% of the case HUVEC cells turn clockwise. How many cells does it take for this to happen?

I guess it never gets old...bc we love #CellMigration ATP has many roles: energy currency, hydrotrope, and *danger signal* Immune cells are faster after ATP exposure, F-actin (cyan) goes to the rear for nitro boost! www.science.org/doi/full/10.... @focalplane.bsky.social #fluorescencefriday 🧪🔬

Flashback #FluorescenceFriday to some of the first light-sheet imaging we were doing. Video shows the collecting duct system of the developing kidney labeled with a pan-cytokeratin antibody. Courtesy of former talented technician Deanna Hardesty.

What a crazy cool paper! First author @pierreucla.bsky.social with a large crew knocked it out of the park. (GIF below from @the.3i.social LLS) Quantifying cell traction forces at the single-fiber scale in 3D: An approach based on deformable photopolymerized fiber arrays www.pnas.org/doi/10.1073/...

Comment by Prof @icouzin.bsky.social that explores how collective intelligence emerges from local interactions in animal groups, and how these principles inform the design of swarm robotic systems. @natureportfolio.nature.com @natcomms.nature.com #robotics www.nature.com/articles/s41...

Honored to present last week at the Korea-US Collaborative Research Fund Investigator Meeting (kufhls.org) Delighted to share our consortium's vision for bioengineering tumor models, alongside many stimulating talks by Korean and U.S. researchers on biotechnology

Postdoc Jiwon Kim from the @ianywonglab.bsky.social was named one of 30 female Rising Stars in MechE, and invited to a workshop to develop career skills, connect with a cohort of peers, and engage with mentors in anticipation of future careers in academia. engineering.brown.edu/news/2025-10...

Wong lab members are off to the Biomedical Engineering Society (BMES) 2025 Meeting in San Diego! Looking forward to presenting our latest work #BMES2025, @brownengineering.bsky.social @jiwon-kim.bsky.social @htjeong.bsky.social

New Online! The advent of confocal laser scanning microscopy in biological research

I’m not sure as a community we **truely** acknowledged how powerful the #CellMigrationSeminarSeries series was at keeping us connected at such an uncertain time. Thank-you @ankita13jha.bsky.social @adamshellard.bsky.social @drjenmitchell.bsky.social & @simplythebex.bsky.social

University of Wisconsin-Madison feature on Dhananjay Bhaskar PhD '21: engineering.wisc.edu/news/focus-o...

I use a video of #Maru in my talks on confined migration- @retof.bsky.social sent it to me ‘this cat looks like your cells’. 😂 I always have yo explain who #Maru is!

New perspective in @jcb.org by @maikbischoff.bsky.social & @mayorlab.bsky.social about how mesenchymal cells use contact-dependent rules to generate swarm-like behaviors, patterns & organ forms. rupress.org/jcb/article/... #CellBio #CellMigration #Morphogenesis #Development #Science

📕 Our Intermediate Filaments collection explores recent advances in intermediate filament research, focusing on lamins, keratins and vimentin. Explore new and recent JCB studies to accompany this week's European Intermediate Filament Meeting 👉 rupress.org/jcb/collecti... #Euro-IF

In squash, the nick shot is nearly impossible to return—the ball hits the corner and doesn’t bounce. 🎾 In a new Science Sessions episode, Roberto Zenit explains the physics behind it and its surprising link to safety gear. Listen: www.pnas.org/post/podcast...

Expression of vimentin intermediate filaments in epithelial cells promotes cell migration and cell matrix interaction in 3D https://www.biorxiv.org/content/10.1101/2025.09.18.677142v1

A full-scale renovation of Prince Lab, transforming it into a dynamic and central campus hub for project-based learning, cutting-edge research and engineering innovation, will be launched by Brown University, with a generous gift from the Lassonde Family Foundation. www.brown.edu/news/2025-09...

Happy Postdoc Appreciation Week to all of our postdocs! #PostdocAppreciationWeek

Tissues transition between solid & fluid states in development & disease; cytoplasm turns crowded or inert to literally 'solidify'. Any connections? Turns out nothing's known. @sameerthukral.bsky.social & @bipashadey29.bsky.social pulled this review off brilliantly with a conceptual synthesis.

Epithelial-to-mesenchymal transition or EMT is an integral part of development in animals. In this beautifully illustrated review from the lab of Magali Suzanne, they describe and compare and contrast the cellular mechanism of EMT across the different model organisms. doi.org/10.1016/j.cd...

New findings in Science suggest that rodents owe much of their evolutionary success to their thumb-nail (the first digit, D1), an adaptation that gave them dexterous hands for cracking seeds and nuts. Learn more in this week's issue: https://scim.ag/46caVho

Our September issue is here! rupress.org/jcb/issue/22... Airyscan super-resolution immunofluorescence image of HeLa cells stained for two types of intermediate filaments: vimentin (magenta) & keratin-8 (cyan). From Pasolli, @joycemeiri.bsky.social, Akhmanova et al. rupress.org/jcb/article/...

Automated optogenetic control of hundreds of cells in parallel. Each cell is individually steered, collectively acting as a "tissue printer". Preprint & code out! www.biorxiv.org/content/10.1...

Cells are particularly good at solving mazes, according to a 2020 Science study that demonstrates how they are able to navigate long and complicated routes through the body using self-generated chemoattractant gradients. Learn more: https://scim.ag/45HBSZM #ScienceMagArchives

This is an airyscan confocal movie of mitochondria (white) moving around in a mouse astrocyte. Actin filaments are in orange and microtubules are in blue.

We all need mentors, and the further we go in our careers, the more mentors we need. Whether it’s dealing with increasingly complex career situations, considering a career transition, or coping with a career ending, mentors can be an essential source of wisdom and support.

Remebering Paul Kulesa (1962–2025) We honor Dr. Paul Kulesa, whose pioneering work on neural crest cell development has profoundly impacted neuroscience and pediatric cancer research. His loss has deeply impacted the Developmental Biology community and everyone he graced with his presence in life.

Circulating tumor cells: Blood-based detection, molecular biology, and clinical applications

First real-time human embryo implantation recorded (in 2D and 3D). Time lapse video of 2 embryos (200 μm apart) implanting in the 3D platform science.org/doi/10.1126/...

with the gorgeous fluorescence image of the cytoskeleton by @aaandmoore.bsky.social now highlighted on the @natcellbio.nature.com website nature.com/articles/s41...

A biotech development collaboration between Brown's @ianywonglab.bsky.social and KAIST's Shin Lab is one of 17 projects chosen for the Boston Korea Project. Read more: engineering.brown.edu/news/2025-08...

👩‍🔬 Check out the stunning AI-analysed videos of aB7H3 CAR-T killing clumps of patient-derived neuroblastoma generated by our colleagues Prinses Maxima 🔬 CD4 CAR (blue), CD8 CAR (green), live tumours (yellow), dead tumours (red) Full story nature.com/articles/s41... @natureportfolio.nature.com

A rubber duck has made it to our cover! Why? It’s the latest tool to help solve a formidable challenge - design an adhesive that remain effective in wet environments. @nature.com 🧪 Further details here (spoiler - inspiration comes from biology) www.nature.com/articles/s41...

Mechanotransduction in the nucleus Multiple TFs transmit mechanical forces into transcriptional regulation. Nuclear shape, size, and chromatin abnormalities are common features of many diseases.

Engineers and biologists join forces to explore the mysteries of vimentin intermediate filaments! Learned so much from Ming Guo, @aaandmoore.bsky.social, Ohad Medalia, Jennifer Lippincott-Schwartz, Dave Weitz, and Bob Goldman. Thanks to @natcellbio.nature.com for thoughtful edits rdcu.be/ezkWF

The Anti-Cancer Avengers: Meet Brown’s Interdisciplinary Immunoengineering Team @brownengineering.bsky.social @weldeiry.bsky.social ibeam.brown.edu/news/2025-07...

Random cat facts can increase the odds an LLM gets a math problem wrong by as much as 700% (To be fair to the AIs, cats are pretty confusing). That and more of the best in @science.org and science in this edition of #ScienceAdviser: www.science.org/content/arti... 🧪

Congratulations to alum Dhananjay Bhaskar PhD 2021, now Assistant Professor of Biomedical Engineering at the University of Wisconsin - Madison! Jay fearlessly dove into topological data analysis and computational modeling of living systems in the lab, with lots of amazing work since. Best of luck!

Two-thirds of cats prefer a leftward sleeping position, giving their left visual field and thus their right brain half a privileged view of approaching animals without being obstructed by their own body. www.sciencedirect.com/science/arti...

turkey sighting outside @brownengineering.bsky.social !

ICYMI: New Online! Collective migration modes in development, tissue repair and cancer

Andy Moore @hhmijanelia.bsky.social created this video showing a cytoskeletal mechanism called an actin wave in a so-called HeLa cell. In orange are the actin filaments and in blue are the mitochondria, some of which appear to move with or be shifted by the active wave.

Today's office view: giant crane for something under construction

In reality, epithelial sheets do not exist in isolation. Tissue is often a thin sheet attached to a foundation of mesenchyme. When these are compressed uniaxially, they generate wrinkles or undulations.

The beauty and chaos of structure. HFF cells stained for cytoskeletal proteins Actin (⚪), Septin (🟡), Tubulin (🟣) and DNA (🔵). #FluorescenceFriday #SciArt

"Snatched from a life of obscurity and installed in contemporary glass and plastic palaces, cells are in danger of becoming Pygmalion’s proteges. Housed in residences constructed of water and collagen instead of plastic or glass, do cells lead primitive, less cultured lives?" -Elsdale JCB 1972

Many thanks to Brown Engineering and @tejaladesai.bsky.social for the Dean's Award for Excellence in Mentoring Grateful for the talented students and postdocs in my lab - it's a privilege to work with you during these formative stages of your careers. engineering.brown.edu/news/2025-05...