What music should we play to our cells? This was the start of an amazing journey from @ivaskalab.bsky.social at @turkubioscience.bsky.social with Jasmin Kaivola and collaborators @sarawickstrom.bsky.social and others to explore larynx cancer mechanosensitivity! www.nature.com/articles/s41...

@mathildemathieu.bsky.social @ivaskalab.bsky.social New discovery from us! Leupaxin, a paxillin family member typically expressed in immune cells, negatively regulates durotaxis and mechanoresponsiveness in metastatic breast cancer cell variants and in cells cultured on soft ECM lnkd.in/diEk8DSR

I am very excited to share this preprint which has been my main postdoc project! We identified leupaxin as a negative regulator of durotaxis via paxillin-FAK inhibition in MDA-MB-231 brain and bone tropic metastatic variants. www.biorxiv.org/content/10.6...

I will be recruiting two postdocs early next year. - One image analyst - one biologist interested in working on lymphatics! Reach out if you are interested 👍

There is a permanent positon open at our centre. Read more & apply 👉 ats.talentadore.com/apply/erikoi...

🚨 Job Alert! 🚨 We have an opening at our Microscopy Core Facility in Turku 🇫🇮. If you love imaging 🔬 and helping scientists succeed, we want you! 👇 abo.rekrytointi.com/paikat/index... #Microscopy #ScienceJobs #CoreFacility #Imaging @turkubioscience.bsky.social

Postdocs wanted - Please spread the word! We are looking for one bioinformatician and 1-2 cell biologists with different expertise! See the job ad below for more information and links to the job descriptions!

Introductory post on 🦋! We're a research group headed by Prof. Johanna Ivaska interested in understanding how integrins contribute to every step of cancer progression. We're located at the Turku Bioscience Center in Turku, Finland! Find out more about us and our interests here: ivaskalab.utu.fi

Proud to be part of this cool story by @follainga.bsky.social, led by @guijacquemet.bsky.social and @johannaivaska.bsky.social. Go and have a look!

FlowVision: @guijacquemet.bsky.social @johannaivaska.bsky.social et al describe a fast label-free live imaging approach revealing key principles of cancer cell arrest on endothelial monolayers–such as flow dynamics & CD44 interaction with matrix hyaluronic acid link.springer.com/article/10.1...

Honoured and excited to launch this new RCF funded 2026-2031 project MechanoSpace with @ivaskalab.bsky.social. we will be hiring postdocs early next year www.utu.fi/fi/ajankohta...

The first September issue is live. www.embopress.org/toc/14693178... The cover features work by Cassie Clarke @cassiejclarke.bsky.social @cruk-si.bsky.social and co-workers showing that UPP1 supports #metastasis by altering #immune and ECM landscapes. -> www.embopress.org/doi/full/10....

Excited to share our most recent study on #integrintraffic #cancer #migration #focaladhesion by @ivaskalab.bsky.social @drpaulinamoreno.bsky.social Niklas Jäntti et al www.sciencedirect.com/science/arti...

Syövän nykyisillä lääkkeillä ei voida estää syövän leviämistä. Tilanne saattaa muuttua, sillä tutkijamme ovat kehittäneet tavan kuvata syöpäsolun sisäistä signalointia, joka on edellytys solun liikkumiselle. #Illusia @johannaivaska.bsky.social @ivaskalab.bsky.social @turkubioscience.bsky.social

New paper in Nature Cell Biol from @johannaivaska.bsky.social and @ivaskalab.bsky.social Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells rdcu.be/eoAUD

Miten syöpäsolut leviävät ja voidaanko sitä estää? Toistaiseksi ei, mutta tämä saattaa muuttua. Turun biotiedekeskuksen tutkijat löysivät keinon avata syöpäsolujen viestintää, ja tämän tiedon kautta saattaa löytyä lääke syöpäsolujen pysäyttämiseen. @ivaskalab.bsky.social @johannaivaska.bsky.social

Ready to share our work as a poster at the upcoming Lorne Cancer Conference! Looking forward to discussing the role of integrin β1 in cancer invasion, and connecting with experts in the field. #LorneCancer2025

New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...

Our newest paper is out in NCB. @jrwconway.bsky.social‬ designed a new FRET reporter, Illusia, to show the importance of integrin β1 phosphorylation dynamics in 3D invasion! Video: TNBC cells expressing Illusia with a Src (Saracatinib) or SHP2 (SHP099) inhibitor. www.nature.com/articles/s41...

Latest from @ivaskalab.bsky.social @jrwconway.bsky.social in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation! Read more at: www.nature.com/articles/s41...

www.is.fi/kotimaa/art-... Great recognition to @ivaskalab.bsky.social research at @turkubioscience.bsky.social the Finnish Science Prize thanks to all my international friends and colleagues over the years

Warm congratulations to our PI, Professor Johanna Ivaska👏💐🍾🎉🔥🔥🔥! @johannaivaska.bsky.social @ivaskalab.bsky.social

Paljon onnea Suomen tiedepalkinnosta, @johannaivaska.bsky.social Professorin viesti päättäjille: "Minä toivoisin, että Suomen valtiovalta ja poliitikot ymmärtäisivät, että pienessä maassa perustutkimus on se ainoa tapa, millä niitä paljon puhuttuja innovaatioita saadaan." www.ts.fi/uutiset/6665...

Tiedefoorumissa puhetta tieteestä. Onnittelut @johannaivaska.bsky.social Suomen tiedepalkinnosta.

Happy to publish this News & Views article highlighting exciting new work from Rod Bremner's lab that shows that cell populations with a short cell cycle are intrinsically more susceptible to forming tumours

Using #CRISPR/Cas9 to genetically modify cells to produce extracellular matrices with altered compositions. elifesciences.org/reviewed-pre...

Happy to share our Tensin 1 phase separation project is now on bioRxiv. www.biorxiv.org/content/10.1... This wouldn't be possible without @johannaivaska.bsky.social @ivaskalab.bsky.social #VattulainenLab #MSCA by @ec.europa.eu @turkubioscience.bsky.social @inflames-flagship.bsky.social

We did it! 🧪 After years of fiddling with gels, lasers, cells, and infinite lines of custom codes, our first preprint is out! We integrated TFM & FRET-based tension probes into one workflow to zoom in on focal adhesions mechanics 🔬 Already 400 downloads and I’m only mildly panicking 😅

@midibu.bsky.social uncovers a FUNCTIONAL role for Tensin- 1 condensates acting as reservoirs of inactive focal adhesion proteins under the control of p38, ERK and AKT kinase activity. Protein-release from TNS1 condensates facilitate adhesion dynamics, filopodia, cell migration and cell invasion

Thanks for an amazing meeting GRC Fibronectin, integrins and related molecules @sarawickstrom.bsky.social and Guy

Well done GRS chairs Martina and @mchastney.bsky.social

As promised, here a fast acquisition of a migrating cell videoed under a microscopy, look those membrane dynamics @ the leading edge ! Bonus: nuclear deformation once the cell rear snaps. (Fluo nucleus, for the #fluorescencefriday) @focalplane.bsky.social @cellcommlab.bsky.social #CellMigration 🧪🔬

#CellMigration meets #SciArt Naomi Wee (naomiwee.com) did this great movie to explain how amoeboid migration works (also mesenchymal & cancer migration) Wanna know what happens if this leukocyte chooses the wrong path? Watch this ! www.youtube.com/watch?v=mPwn... @focalplane.bsky.social #SciSky

Applications open for a new cohort of @dev-journal.bsky.social *Pathway to Independence* fellows Know a #devbio post-doc about to enter the academic job market? Would they benefit from a little support & mentoring? Spread the word Deadline 31 Jan 2025 journals.biologists.com/dev/pages/pi...

Histology-Guided Single-Cell Mass Spectrometry Imaging using Integrated Bright-field and Fluorescence Microscopy https://www.biorxiv.org/content/10.1101/2024.12.03.626022v1

Fantastic work done by @follainga.bsky.social @sujanghimire.bsky.social @jwpylvanainen.bsky.social, Monika Vaitkevičiūtė, Diana Wurzinger, Camilo Guzmán, James Conway, Michal Dibus, Sanna Oikari Great collaboration with @johannaivaska.bsky.social @ivaskalab.bsky.social, Kirsi Rilla and Marko Salmi

🎈New preprint! We study how single cells move up, down and about fibronectin gradients. Experiments by @icfortunato.bsky.social, theory by David Bruckner. Collaboration with @raimonsunyer.bsky.social and @ehannezo.bsky.social 👇https://biorxiv.org/cgi/content/short/2024.12.02.626413v1

Excited to get to know the European Mechanobiology scientist better and meet old friends here in London

My first @epimechfc.bsky.social thread posted on X👇 What do star fish, snowflakes, and even cells have in common? I would like to take you on a journey into the field of soft matter and give you a brief overview of experimental observations on symmetries in biological systems. #EpithelialMechanics

@ivaskalab.bsky.social is here now 🎉🦋

Here is the most recent preprint from our most recent PhD graduate, Dr Nicolas Pasquier. Orientation of mucinous CRC apicobasal polarity is regulated by tumor-stroma interactions. This work was a collaboration with the Jaulin lab at the Gustave Roussy Institute. www.biorxiv.org/content/10.1...

Ivaska Lab at the Turku Bioscience Pikkujoulu party 🥳 Can you recognize our costumes? 😉 @omkarjoshi.bsky.social @mathildemathieu.bsky.social @mchastney.bsky.social @gounismichalis.bsky.social @sanshiya04.bsky.social

We are all excitedly awaiting Jasmin to defend her PhD. A big thanks to her opponent, @rachellennon.bsky.social for being here today!

We have a new doctor from the lab! Well done Jasmin! You did a wonderful job and are now the 22nd PhD student to graduate from the lab. We are immensely proud of you and we really enjoyed the discussion between you and @rachellennon.bsky.social, to whom we are very grateful. Now, it's party time!

I have moved to 🦋 as well ! Looking forward to reconnecting with old and initiating new science contacts here