PhD project alert: if interested in learning more about stroke, vascular dementia and mitochondria (yes there is some matrix there as well!) Come and join us! collaboration with Kostas Tokatlidis Email me if interested. Application deadline: 12 January 2026 www.gla.ac.uk/colleges/mvl...

New paper out from Markus Ruegg lab on gene therapy for muscular dystrophy due to laminin mutations: Dual AAV gene therapy using laminin-linking proteins ameliorates muscle and nerve defects in LAMA2-related muscular dystrophy. www.biorxiv.org/content/10.1...

Really excited to tell you about our paper just out in the journal Matrix Biology. @erinboland.bsky.social set out to investigate what the impact of basement membrane defects are on adult heart function/biology. www.sciencedirect.com/science/arti...

"My" latest review is online now. We need your creativity! 😎 👇👇👇 Collagen Biosynthesis and Its Molecular Ensemble: What Remains Unexplored | Biochemistry pubs.acs.org/doi/10.1021/...

Here's what it gets you

Am I back from the best conference ever? Yes! But do I also see a crucial tool for the analysis of the #ECMatrix in scRNAseq? Also yes!! Another fantastic tool in collaboration with @nabalabuic.bsky.social 🔥🔥🔥

Perfect timing on the last day of the 2025 #Collagen Gordon Research Conference! Our paper, in collaboration with @valerioizzi.bsky.social describing #MatriCom, a tool to infer ECM communication systems from scRNA-Seq datasets, is now published in @jcellsci.bsky.social! doi.org/10.1242/jcs....

New data from the Deltas lab on targeting ER stress in Alport Syndrome. Chemical chaperone 4-phenylbutyrate treatment alleviates the kidney phenotype in a mouse model of Alport syndrome with a pathogenic variant in Col4a3 www.sciencedirect.com/science/arti...

New paper in Nature Cell Biol from @johannaivaska.bsky.social and @ivaskalab.bsky.social Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells rdcu.be/eoAUD

Really excited to work with the Ruggiero lab over the summer as visiting professor at the Institute Genomics Functional De Lyon, ENS de Lyon. #Collagen. #Matrix and #disease treatments. @uofgmvls.bsky.social @uofgscmh.bsky.social

And how are you meant to drive away from here? Parking in Barcelona

And we recreated it 150 years later. www.gla.ac.uk/news/archive...

20 degrees in Edinburgh. those of you who know Scottish tenement flats built in early 1900s (in which I live) know this means opening the windows to warm the house 😂

Another collagen IV paper on the "to read" list... new review just out in the journal #matrix_biology "The life cycle of type IV collagen" by David Sherwood www.sciencedirect.com/science/arti...

So excited to share our first neuro focused paper from the lab, we show that CXCL4 (PF4) is transported into the brain by proteoglycans within the endothelial glycocalyx and that GAG binding also mediates the pro neurogenesis effects of CXCL4. www.biorxiv.org/content/10.1...

Curious about collagen?? There is an amazing program for the Collagen Gordon in New Hampshire this year. We have ample speaker slots reserved for abstract submissions. Come and join us! www.grc.org/collagen-con... July 6 - 11, 2025 www.grc.org/collagen-grs... July 5 - 6, 2025 Doug,Rachel,Alex

To all our undergraduate student's at @uofglasgow.bsky.social ..good luck with your exams!

Heard from a former (undergrad) student who just defended her PhD. Students: tell your old profs about your successes and achievements. It's not bragging, and we love to hear about it. It's one of the best parts of being an educator. #academicsky

Collagen IV of basement membranes: I. Origin and diversification of COL4 genes enabling metazoan multicellularity, evolution and adaptation www.sciencedirect.com/science/arti...

Protocol for extraction and characterization of mouse brain-derived extracellular matrix for neuronal cell culture www.sciencedirect.com/science/arti...

Delighted our first adventure into #collagen III mutations in #vascular Ehlers Danlos Syndrome is out. In patient cells, ER stress is part of mechanism; targeting via clinically approved chemical chaperones rescued intracellular - and #matrix defects. rdcu.be/ejhSR

🚨I promised I'd say more on the Royal Society and Elon Musk, so here it is. 🚨 I've resigned my position as Associate Editor at Royal Society's journal Open Science in protest at their lack of action over Elon Musk. My op-ed in @theguardian.com www.theguardian.com/commentisfre...

Around campus at @uofglasgow.bsky.social this morning.

Mechanical thrombectomy for ischemic stroke improves blood-brain barrier permeability and minimizes secondary injury! Our latest study used DP-pcASL to measure BBBP www.sciencedirect.com/science/arti...

Cardiomyocyte SORBS2 expression increases in heart failure and regulates integrin interactions and extracellular matrix composition academic.oup.com/cardiovascre...

@ccstorytime.bsky.social one for you?

New review on small vessel disease, a major but poorly understood cause of vascular dementia and stroke, by Hugh Markus and Anne Joutel. journals.physiology.org/doi/abs/10.1...

Labor hasn’t delivered on more effective nature laws. It’s not just embarrassing, it’s calamitous

Update on the Measles outbreak in Texas and New Mexico www.nytimes.com/2025/02/22/u... There likely hundreds of cases, so many not being diagnosed. And many more to come. All preventable.

#ECMatrix guides #CellFate and patterning www.nature.com/articles/s41...

Luminescent sensing of conformational integrin activation in living cells www.cell.com/cell-reports...

Brain pericytes and perivascular fibroblasts are stromal progenitors with dual functions in cerebrovascular regeneration after stroke www.nature.com/articles/s41...

Great new work by Brian MacVicar's team, showing that pericytes and perivascular fibroblasts are distinct subpopulations of stromal progenitor cells in the adult brain that coordinate revascularization and scar formation after injury. #cerebrovascular #stroke #pericytes

🧪This is just a teaser. Stay tuned for more information coming soon! #6thISMB

Check out this paper in Advanced Science, great collaboration between UMONS Research, Innovation & Entrepreneurship @sgabriele.bsky.social & @giusciccone.bsky.social, @manuelsalmeron.bsky.social, both @ibecbarcelona.eu & @theglasgowcemi.bsky.social @uofglasgow.bsky.social: 👉 doi.org/10.1002/advs...

And with the anti-vaccine sentiment coming from government this will unfortunately only get worse

Australian governments are failing to conserve biodiversity, meaning their extraordinary values are being lost and global conservation targets will likely fail. The next federal government must do better. My letter with @biodiversityguy.bsky.social in @science.org. www.science.org/doi/10.1126/...

An AI-generated small-molecule inhibitor treats fibrosis in vivo and in phase I clinical trials go.nature.com/3IvPOuI rdcu.be/d8EOQ

"Imagine a DAPI-like stain, but for the extracellular matrix." That's basically how this work was pitched to me by Kayvon and Antonio a year or so ago. Now the final product really delivers. Read about their versatile label for ECM in living tissues here: www.nature.com/articles/s41...

‼️Typos happen to everyone. So small correction RE: "Advances on Mechanobiology" session. Thursday, Feb. 6 and not Tuesday. Still, plenty of time to register for this session. All things mechanobiology coming your way. Detailed program below! Join us: themeshwork2020.wixsite.com/info/up-comi...

🧪Two more days to apply to @dev-journal.bsky.social's Pathway to Independence programme. Apply by 31 January. #ECR #DevBio

YouGov find just 30% of people think we were right to leave the EU. The lowest number yet. Just 10% of 18-24 year olds think it was the right decision.

Alert for Cardiovascular Grant writers, a must-archived 620-page paper😆 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association Table 29 At-a-Glance Summary✌️ #Circulation 2025 @ahajournals.bsky.social www.ahajournals.org/doi/10.1161/...

🚨 Brand new website for Matrix Biology Italy #MBIta (formerly know as Italian Society for the Study of Connective Tissue) www.matrixbiology.it @valerioizzi.bsky.social @themeshwork.bsky.social @nabalabuic.bsky.social @tomvanagtmael.bsky.social @amrohussien.bsky.social @tcox.bsky.social

Truly honoured to be elected Vice President of International Society for Matrix Biology Excited to start working with President @valerioizzi.bsky.social Exec Committee and members to help ISMB grow and promote extracellular matrix research globally. @uofglasgow.bsky.social @uofgmvls.bsky.social

JCI Insight - Map2k6 is a potent genetic modifier of arterial rupture in vascular Ehlers-Danlos syndrome mice insight.jci.org/articles/vie...

Please spread the word and sign up for our exciting spring meeting in Nottingham with amazing speakers on the topic of ECM, immunity and infection. An exciting and developing field! paacr4.wixsite.com/bsmb-spring2...

Remarkable study showing plasticity of the brain using mice that lack microglia "Typical development of synaptic and neuronal properties can proceed without microglia in the cortex and thalamus" rdcu.be/d50UX