How does an orbiting spherical tissue suddenly break symmetry and sprout invasive strands? We can predict this behavior from the initial morphology! Hi, I’m @jiwon-kim.bsky.social from @ianywonglab.bsky.social.

Hyaluronic acid and tissue mechanics orchestrate mammalian digit tip regeneration | By @storerlab.bsky.social et. al. @science.org #Mechanobiology #Regeneration www.science.org/doi/10.1126/...

Sam Altman promised to be a safe steward for A.I. But some of his colleagues believed that he was not trustworthy enough to, as one put it, “have his finger on the button.” newyorkermag.visitlink.me/aBX6HF

Proud to share this work with @kevinchalut.bsky.social and Byron Mui. Why do some injuries scar while others regenerate? Using digit tip models, we show the ECM is a key driver. HA-rich ECM promotes regeneration, and boosting it can shift healing away from fibrosis. www.science.org/doi/10.1126/...

🚨 Why can’t mammals regenerate limbs like frog tadpoles or salamanders? In our new paper in @science.org , we show that species-specific oxygen sensing acts as a gatekeeper for initiating limb regeneration 🐭🐸 🔗 www.science.org/doi/10.1126/... #EvoDevo

☕Hoffmann et al. show that the glycolytic intermediate fructose-1,6-bisphosphate, which accumulates in the absence of aldolase, regulates focal adhesions by relieving RCC2-mediated Rac1 inhibition. bit.ly/3NLbU2T

“Even organs & cells show hints of behavior once reserved only for beings labeled ‘intelligent.’ So, how far down the scale of complexity does cognition actually go?” —@conorfeehly.bsky.social

ICYMI: New Online! Systemic epigenetic dysregulation as a driver of ageing and a therapeutic target

✨April Issue✨| Mechanisms of fibrotic tissue remodelling The authors discuss the mechanisms that mediate fibrotic tissue remodelling, using insights from SSc. bit.ly/4bB1t9T #Rheumsky #Medsky

New preprint from the lab! How do tissue shapes influence cell fate decisions? By manipulating brain organoid geometry, we show that lumen rounding directs apical progenitor division mode and promotes the emergence of basal progenitors. www.biorxiv.org/content/10.6... 1/

Mechanisms of active wetting and fluidification in epithelial cell collectives go.nature.com/3Pxjq1E

Our paper is out in @science.org describing how epithelial cells retain long-term inflammatory memory www.science.org/doi/10.1126/...

Skin conditions such as psoriasis often flare up in the same spots throughout one’s life. Now scientists think they know why

Very cool study uncovering how stem cells pass on imprints to progeny in vivo from. @thefuchslab.bsky.social @danapeer.bsky.social drawing from beautiful work done by @grothlab.bsky.social on epigenetic inheritance and the mechanisms of information transfer through cell division.

It’s well known that inflammation increases cancer risk, but how? The answer: the epigenome "remembers" inflammation and primes stem cells for cancer. Here is our paper: nature.com/articles/s41... And a special shoutout to the lead author @snaga13.bsky.social A 🧵

Chronic gut inflammation leaves behind “molecular scars” that may raise the risk for developing cancer, according to a new study showing that epigenetic memory of colitis, along with a cancer-promoting mutation, can accelerate tumor growth in mice. @jbuenrostro.bsky.social

Chronic inflammation increases the risk of colon cancer. This inflammation drives epigenetic changes in the nucleus of stem cells that promote tumour formation go.nature.com/4bLQMl0

What happens when scientific debate turns into personal attacks?​ 🧪 A new EMBO Reports Science & Society article explores how hype, #ethics and “dark PR”​ can collide in public #science debates: https://link.springer.com/article/10.1038/s44319-025-00579-2#ethics#science#LifeSciences #research

"Equator is founded on our conviction that the storied titles of the Anglophone West cannot be internally reformed, nor redeemed by their periodic U-turns and belated mea culpas. The time has come to create something new." Today we publish Equator's editorial declaration. Join us: www.equator.org

Our study on shape diversity in cnidarians is now published. The final version includes extensive new data that substantially extend the original bioRxiv preprint. Congrats to everyone who contributed to this work! www.cell.com/cell/fulltex... @embl.org

Wyss Institute researchers, led by @drmichaellevin.bsky.social, create the first-of-its-kind neurobots, autonomously moving self-organizing biological robots with a nervous system that integrates and functions. @tufts.edu

Today we report single-cell APEX-seq (scAPEX-seq)—a method for unbiased mapping of subcellular transcriptomes at single-cell resolution. It reveals cell states invisible to standard scRNA-seq and identifies regulators of CAR T function that improve solid tumor killing. tinyurl.com/32pf6b8p

Comparing the decline in institutional autonomy in the United States with that in other major autocratizing countries like Hungary and Türkiye, the study finds that the decline in the United States has been faster and more pronounced. #AcademicFreedom academic-freedom-index.net/research/Aca...

This is an awesome discovery: A single-celled organism with no brain called Stentor seems capable of Pavlovian learning. Yes, it can actually learn to associate two things despite having no neurons. My latest for @newscientist.com. 🧪 #science #memory #learning www.newscientist.com/article/2519...

Nicole A. Chittim & coauthors showed that ciprofloxacin treatment in mice causes structural & biological phenotypes commonly associated with fluoroquinolone-induced tendinopathy: onlinelibrary.wiley.com/doi/10.1002/...

Online now: Resident tissue macrophages maintain intraocular pressure homeostasis

Ruslan Medzhitov lab at Yale

A big chunk of my postdoctoral work on cell-state dependent metabolism is now out at @cp-molcell.bsky.social: www.cell.com/molecular-ce... 1/

What happens when single-author science papers become rare? 🧪 An EMBO Reports Science & Society article explores whether solo publications are being edged out by collaborative #research, and what that means​ for #creativity in #science: https://link.springer.com/article/10.1038/s44319-025-00677-1

New paper from the lab led by @ericmulhall.bsky.social addresses how PIEZO1 and PIEZO2 are tuned to different types mechanical forces. From nanometer-scale super-resolution microscopy to in vivo experiments, links single-molecule observations to physiological function. www.nature.com/articles/s41...

This species can become multicellular using two mechanisms previously thought to be mutually exclusive go.nature.com/4aTKdfF

The rules of immunity are different in early life! Lead author Dr. Yue Xing finds that early life DCs sense allergens and trigger inflammation directly in skin. This in-situ activation state emerges from a developing HPA and low glucocorticoids. #Naiklab @nature.com www.nature.com/articles/s41...

New work deciphers how disruptions to #lymphatic drainage drive fibrosis in transplanted lungs and hearts through the accumulation of hyaluronan—and identifies potential therapeutic targets to prevent lung fibrosis in mice. #ScienceTranslationalMedicine https://scim.ag/3ONyh7H

We had covered the history of traction force microscopy (TFM) earlier: bsky.app/profile/epim... But what about applying TFM into more physiologically relevant systems, such as those in 3D? I am @barrasa-fano.bsky.social and I'll be your guide through this thread on #3DTractionForceMicroscopy.

Older people with exceptional memory have a surprisingly high number of young neurons, a study finds

Sometimes, the only way to build back up is to let everything fall apart. This is certainly true at the cellular level. www.quantamagazine.org/break-it-to-...

📢Caroline Uhler and colleagues from Eric and Wendy Schmidt Center at @broadinstitute.org present APOLLO, a framework to integrate diverse data modalities, enabling predicting missing data modalities and identifying the influence of each modality on a phenotype. www.nature.com/articles/s43... 🖥️ 🧬

An #Artificial #Ear that feels just like the #RealThing: in laboratory experiments, researchers have produced ear cartilage that remains form-stable in animal models. Only one element is missing to make the tissue as elastic as a natural ear.

Another interesting example of how cPLA2 senses nuclear deformation and controls immune cell behaviour. Since the enzyme adsorbs to hydrophobic lipid packing defects, membrane tension and high positive curvature can have similar effects as membrane tension. www.science.org/doi/10.1126/...

Both the UK and US Governments have pledged to end research using animals, but is such a goal realistic? And how might it change medical research? ✍️ Talha Burki reports: spkl.io/63320AQdTw

Trimodal single-cell profiling of transcriptome, epigenome and 3D genome in complex tissues with scHiCAR - @yaruidiao.bsky.social @dukehealth.bsky.social go.nature.com/4rZqimf

Recent studies in living animals reveal that the cytoplasm is a thick, jam-like fluid. And yet, miraculously, hoards of molecules find their way to each other in every crowded cell. www.quantamagazine.org/the-biophysi...

Can we accurately map cell family trees using mtDNA? Excited to share MitoDrift, a high-precision single-cell lineage inference tool, enabling reliable mapping of lineage history to cell phenotypes. doi.org/10.64898/202... Joint with @gaoteng.bsky.social. @bloodgenes.bsky.social @jswlab.bsky.social🧵

Kids who grow up in biodiverse environments tend to have fewer allergies—& now we know why. #HHMIInvestigator Ruslan Medzhitov & co have found early exposure to diverse microbes creates broad immune memory, & an antibody that helps block allergic reactions later in life: bit.ly/4rGC59h.

🚨 New Preprint from the Paluch & Chalut Labs 🚨 Ana Raffaelli et al show that the stiffness of substrate (in vitro) / basal membrane (in vivo) determine how cells interpret biochemical signals (BMP4) and which fates they acquire #mechanobiology #hESCs #substratemechanics doi.org/10.64898/202...

In a new Science study, researchers report that the limited number of remaining follicles of aged mice and women with premature ovarian insufficiency can be stimulated to grow and develop by modulating the stroma, the amorphous substance that surrounds them. https://scim.ag/4km7cEh

“Without the cultivated, meaning-laden, embodied intuition of the human scientist who is instinctively driven to ask questions about the nature of the world, AI systems remain rudderless when they enter the realms of uncertainty.” — @conorfeehly.bsky.social #ai #science #scientificdiscoveries

Multimodal analyses of early, untreated systemic sclerosis skin identify a proinflammatory vascular niche of macrophage-fibroblast signaling