Zhou, Zhang et al. identify a new mechanism driving #kidney #fibrosis. They reveal that IFN-λ, produced by renal tubular epithelial cells, directly activates renal #fibroblasts to cause #fibrogenesis. Blocking IFN-λ signaling can delay progression of renal fibrosis. rupress.org/jem/article/...

Rewiring tumour mechanosensing to overcome CAR T cell resistance

“The science of consciousness & the ethics of moral consideration — what we have learned from rats & monkeys & humans — will have to guide us as we meet artificial minds,” @guitchounts.bsky.social writes. #ai #aiethics #consciousness

Excited to share that our work on ‘How the gut gets patterned during regeneration’ is out now cell.com/cell/fulltext/S0092-8674(26)00696-3 Thanks a lot to @priscaliberali.bsky.social @silviabarbiero.bsky.social @davidbrueckner.bsky.social @ehannezo.bsky.social and all co-authors! 🧵

What is a disease? In our new concept paper, we explore how complex networks, statistical physics, phase transitions and attractors allow us to redefine diseases as multiscale, emergent dynamical states. @manlius.bsky.social @guimaguade.bsky.social www.preprints.org/manuscript/2...

The human genome is no blueprint or algorithm — it’s something else entirely, something living with promiscuous logic. Can new genomic AI models, such as Evo 2 and AlphaGenome, untangle these tricky knots or will the genome confound them, too? www.quantamagazine.org/why-the-huma...

Interesting paper: Somatic embryogensis, like normal embryogenesis, resets the epigenetic state of vernalization. On the other hand, regeneration from callus does not reset that. #PlantScience From: www.nature.com/articles/s41...

New in @natmethods.nature.com: a new human stem cell model of EMT lets us watch cells transition in both 2D and 3D and shows human stem cells can undergo the transition differently depending on how they are grown. 🔗 https://doi.org/10.1038/s41592-026-03096-9

Dynamics of phosphofructokinase condensation are regulated by metabolic and redox cues https://www.biorxiv.org/content/10.64898/2026.06.09.731068v1

Online now: The senescence-stiffening loop: Extracellular matrix remodeling, hypoperfusion, and mitochondrial dysfunction drive tissue aging

It might be hot outside but the rent is freezing.

☕Wei et al. show that Meg3+ #hematopoietic stem cells (HSCs) expand upon #aging and present with an increase in H3K23ac levels observed already at middle age. Inhibiting H3K23ac ameliorates megakaryocyte/platelet and myeloid skewing in aged HSCs. www.nature.com/articles/s41...

Bittersweet: how hyperglycemia exacerbates vitiligo progression through the succinate/SUCNR1 axis: doi.org/10.1172/JCI2... Kaitlyn G. O'Donnell & I. Caroline Le Poole provide a Commentary on Kang et al. doi.org/10.1172/JCI2...

Big congratulations to Sara 🤩 What a privilege it has been to be part of this journey! 🚀

Explaining the clinical association between hyperglycemia and autoimmune skin disease Pan Kang et al. report hyperglycemia aggravates vitiligo through succinate, a metabolite that facilitates CD8+ T cell hyperactivation and skin homing: doi.org/10.1172/JCI2...

Implantable living materials autonomously deliver therapeutics using contained engineered bacteria | Science Another banger from Dave Mooney's lab 🔥 www.science.org/doi/abs/10.1...

8 hours. That’s all fish need to heal wounds 🐟⏱️ Why are they so fast compared to humans? I break down the science of rapid regeneration in a microscopy story 🔬 Watch here: youtu.be/Mt9f61adaP0 #FluorescenceFriday #Microscopy

#HFSP-supported researchers discovered that #mitochondria temporarily reshape into a "beads-on-a-string" pattern to evenly distribute their #DNA. The same physical principle that breaks water into droplets helps cells keep their mitochondrial genomes in order. 💦 #sts 🧪 🔗zurl.co/GH23p

Direct interactions between the cell’s powerhouses and nuclear pores might channel energy straight into the nucleus, fuelling cell division and differentiation. go.nature.com/43n6Fun

Professor Michael Elowitz FRS is elected a Fellow of the Royal Society. He designed the Repressilator, a synthetic genetic oscillator that showed that new behaviors could be programmed in living cells, helping to spark the field of synthetic biology. #RSFellows https://bit.ly/4x6nUgW

A single dose of engineered immune cells has helped two men and one woman to receive life-saving kidney transplants. Their bodies would normally reject donated organs. go.nature.com/4uODvQK

How do cells recognize catastrophically damaged #mitochondria? Erqing Gao, Suhong Xu et al. identified MAI-1, the first genetically encoded reporter of severe mitochondrial membrane damage. This cytosolic protein translocates to damaged mitochondria within milliseconds. rupress.org/jcb/article/...

🥇 The award of the ”Most Likable American Politician” goes to:

Decoding the origins of cellular self-organization for engineered biology - @qichen-lab.bsky.social @zernickagoetz.bsky.social go.nature.com/4e1m3Br

T-cell #mechanobiology: how molecular forces shape immune function. New review from Judith Zubia-Aranburu, Lingxiao Zhang, and Mingdong Dong @au.dk: rupress.org/jcb/article/... #Biophysics #Immunology #Tcells

“On cloudy days when they could not see the sun, pigeons whose magnetic #macrophages had been depleted were unable to navigate home. The authors conclude that these liver-based macrophages are required for navigation when the sun doesn’t shine.” Wow & WTF! 🔥

Nature research paper: Cellular water-potential sensing through biomolecular condensation go.nature.com/4ux038v

TopoVelo infers cell differentiation stages and rate parameters of gene expression using spatially coupled differential equations go.nature.com/4lyR02w rdcu.be/fjOvI

Thrilled to share our new publication in Nature. We define an “inflammatory memory” HSC state (HSC‑iM), linking lifelong inflammatory exposure to aging and disease. Grateful to an incredible team and global collaborators! www.nature.com/articles/s41...

How do we assess research excellence in a way that reflects today’s scientific reality? 🧪 Read the report from EMBO’s recent #policy workshop exploring this question: https://www.embo.org/wp-content/uploads/2026/04/Revisiting-the-EMBO-Funding-Criteria-A-Workshop-Report.pdf DORA CoARA

"I would like to emphasize the importance of question-driven science...young scientists might enjoy science more if they are thinking about questions rather than just collecting data" journals.biologists.com/jcs/article/...

“Long ago it became evident that the key to every biological problem must finally be sought in the cell; for every living organism is, or at some time has been, a cell” EB Wilson The cell in development and heredity 3rd edition 1925 #CellsRUs #MasterBuilder #NotInOurGenes

Want to know how histone marks regulate your favorite gene? Go single molecule with ChromSMF: integrated measure of chromatin accessibility and histone marks + DNA methylation, TF footprints and genotype for free! Very proud of @mpalamin.bsky.social ! @embl.org

RESEARCH | E Manduchi, KH Kaestner, D Avrahami et al (UPenn, US; HUJ, IL) Mapping of genome-wide DNA methylation patterns in human islet alpha and beta cells highlights age and type 2 diabetes dependent adaptations🧪

Wyss Institute study developed donor-specific microfluidic Organ Chip models of colon that replicate major hallmarks of IBD in an unprecedented way. This work was published in @natbiomedeng.nature.com.

A stress-function tradeoff organizes epithelial heterogeneity across spatial scales in the human thyroid https://www.biorxiv.org/content/10.64898/2026.03.12.711294v1

Claudio Mauro @unibirmingham.bsky.social and co-workers show that DNA methylation-mediated memory of obesity in CD4 T lymphocytes perpetuates immune dysregulation. -> link.springer.com/article/10.1...

As humans co-evolve with AI systems, there are two forms of autonomy emerging, Daniele Cavalli writes. One belongs to the intelligent machine — think not only of self-driving cars & drones, but also digital minds. The other belongs to humans. #ai #autonomy www.noemamag.com/how-to-prote...

Peritoneal macrophages regulate distal wound healing via endocrine release of plasma fibronectin: www.jci.org/articles/vie... Figure: intravital imaging, revealing fluorescent fibronectin signal at the remote skin wound site upon adoptive transfer of Fn1-mEGFP cells and peritoneal stimulation (PS)

First PROTAC gains FDA approval, bolstering targeted protein degradation and induced proximity ambitions www.nature.com/articles/d41...

Cook, Green et al. @manchester.ac.uk show that #macrophages sense cell volume disruption as a danger signal promoting transcriptional reprogramming and inflammatory responses via type I interferon signaling. rupress.org/jcb/article/... #Inflammation #CellSignaling #Immunology

Improved sensors for fructose-1,6-bisphosphate enable in vivo imaging of glycolysis by Alison Tebo and team: www.biorxiv.org/content/10.6...

Doing the periodic cleaning of used plasmid miniprep columns and realized in honor of Earth Day it may be worth reminding you molecular biologists: Plasmid miniprep columns can be cleaned and reused essentially indefinitely! Just add 1 M HCl, soak overnight and wash 3x w/ water. Save $ and plastic

We spoke with Annette Oxenius, ETH Zurich Vice President for Research, EMBO Member, former EMBO Young Investigator and Postdoctoral Fellow, about her vision, personal #research as well as the role of EMBO in her #career: https://www.embo.org/people/an-interview-with-professor-annette-oxenius/#research🧪

In celebration of Founding Director Don Ingber's 70th birthday, learn more about him, including his hobbies, his vision for the future, & his work in this 20-ish Questions video. @harvardseas.bsky.social @harvardmed.bsky.social @bostonchildrens.bsky.social

Online Now! An in vitro menstrual cycle using organoids captures epithelial cell transitions during menstruation and regeneration of the human endometrium #stemcells

A gene-therapy approach to thwart the AIDS virus that has long struggled to gain traction may have new momentum after a study found it could “functionally cure” at least some monkeys. https://scim.ag/4upKfnQ

Excited to launch #MatriSpace: a framework for mining #SpatialTranscriptomic data with a focus on matrisome genes co-developed with @valerioizzi.bsky.social 🔗 @biorxivpreprint.bsky.social: doi.org/10.64898/202... 🔗 ShinyApp: matrinet.shinyapps.io/matrispace/ #ECM #Matrisome #MatriTool #OpenAccess

Happy to share our new paper on collective cell dynamics. Great work from Yuan Shen @ijmonod.bsky.social ! Dynamic heterogeneity and hidden fluidity in dense epithelial tissues | Science Advances www.science.org/doi/10.1126/...