First trip to Weatern Canada for ECR workshop and #CCRC2025 in #Calgary. Terrific time making new connections in #cancerresearch and reconnecting with colleagues @pmresearch-uhn.bsky.social @sickkidsto.bsky.social.

What a wonderful place to be…

I’m thrilled to be speaking at the Erasmus Hematology Lecture series, Monday Sept 15th. Grateful to @elsdutchy.bsky.social for the invite. Start: 16.00h /04.00 pm CE(S)T - 10.00 am ET - 09.00 am CT Zoom ID: 844 1856 0786 www.hematologyrotterdam.nl/2626141_the-...

Bye-Bye Bay of Fundy. See you next year.

The quiet beauty of a Sunday morning overlooking St Mary’s Bay. #nofiltersneeded #familyvacation

Check out our new preprint on an epigenetic resistance mechanism to PI3 kinase inhibition in AML and a new combination therapy with an EZH1/2 inhibitor that depletes leukemic stem cells! Great effort by @thehematopoet and the whole team

The Myeloid Workshop is back in ASH! Please contact the organizers if you have an exciting story that will not be out by December they are: Zuzana Tothova , @ernstlaboratory.bsky.social @steidluli.bsky.social @ericpietras.bsky.social @kathrinbernt.bsky.social @gritsmanlab.bsky.social

Travel grants for trainees are available for the stellar FEBS Workshop on Aging in Hematopoiesis that will take place in Crete on October 20-24. Deadline for applications: July 31. More info: aginginhematopoiesis2025.febsevents.org/travel-grants

So proud of Team Stemmy! Interdisciplinary collabs are the way to make a difference for preventing and curing cancer. @pmresearch-uhn.bsky.social @uwaterloo.ca

Those in #Milan for #EHA2025, catch Angelica Varesi in her oral on this story live. 🎤 "Discovery of ATP2B1+ CD49f+ Human Hematopoietic Stem Cells with Superior Long-term Multilineage Reconstitution" 🗓 Thursday, June 12 | 🕔 17:00–17:15 CEST 📍 Brown Hall 1

Preprint alert🚨‼️ I am beyond thrilled to share with the 🧪 community the characterization of ATP2B1, a new human immunophenotypic long-term 🩸hematopoietic stem cell marker across ontogeny in fetal liver, cord blood and adult sources. @pmresearch-uhn.bsky.social #teamscience

This month has been a whirlwind. I am happy to announce I am the newest Scientist @pmresearch-uhn.bsky.social The Xie lab 🧪will focus on understanding how inflammatory and metabolic stress promote aging and cancer risk in human🩸hematopoietic stem cells and preventative interventions.

This is the most deserving of honors. Congratulations to my long-time mentor Dr. John Dick!

Congratulations to our Senior Scientist Dr. John Dick on being elected into the National Academy of Sciences. @nationalacademies.org

Congratulations @stephxie.bsky.social already a star @uhntoronto.bsky.social @pmresearch-uhn.bsky.social

@aircanada.bsky.social Please get your act together. I will miss the plenary session of #AACR2025 and learn about groundbreaking cancer research because my flight got canceled 20 minutes before boarding. Unexpected mechanical failure. Last month too. That’s an awful trend.

This year’s 11 NextGen Stars will share their findings on cancer cartography, the dark proteome, cancer-resistant tissues, and more at #AACR25. Learn more about their work and its future implications on the #AACRBlog: www.aacr.org/blog/2025/04...

I had so much fun. 🙏@eirinipapapetrou.bsky.social, Elvin Wagenblast, Chris Sturgeon, Franco Izzo for the hospitality @sinaiirm.bsky.social A 2 for 1 visit with insightful feedback from the Leukemia Working Group.

Still a New Yorker at heart. I love the skyline of my childhood city. Looking forward to talking 🩸🧪science with colleagues at Icahn Mount Sinai and MSKCC and seeing family.

Huge congratulations to @danieljdrucker.bsky.social and fellow scientists for the Breakthrough Prize in Life Sciences on the 🧪discoveries leading to development of GLP1R agonists. www.theglobeandmail.com/canada/artic...

I am thrilled to be included with this amazing group of scientists as part of the 2025 AACR NextGen Stars. Here are the challenges and future 🧪directions we have identified in our respective areas of cancer research. doi.org/10.1158/2159...

Registration for the 2025 FEBS Workshop on the Molecular and Cellular Pathways of Aging in Hematopoiesis in Crete on October 20-24 is live! Check out the amazing lineup of invited speakers on normal and malignant 🩸🧪, CH, inflammation, niche and much more. lnkd.in/eamN_YHs

Bluetorial: Women, courage, and leadership What follows will include some generalizations based on population averages of what I have experienced over the course of my career. There are, of course, exceptions in every group who are substantially more to one extreme or the other.

important study of 🩸#stemcells in aging mice. huge translational opportunities for decreasing cancer risk if we can uncover the mechanisms underlying HSC clonal dynamics differences from humans. Kudos to @goodell-lab.bsky.social @seungchii.bsky.social

Check out this elegant 🧪publication showing that Fli-1 activity is essential for regenerative 🩸 hematopoiesis from Tomer Itkin and Shanin Rafii. I am delighted to have been included. @weillcornell.bsky.social @pmresearch-uhn.bsky.social www.nature.com/articles/s41...

Uncovering molecular mechanisms of longevity in an 116yo woman by multiomics profiling. She had 3 CHIP mutations (2 TET2 mutations and 1 SF3B1) but she had a remarkably high composition of memory T cells and B cells in her 🩸. How many distinct #HSC clones did she have? tinyurl.com/SuperagerM116

Very cool new study showing inflammation driven epigenetic memory encoded by AP-1 in colon stem cells increases cancer risk.

A shining example....there are 1,000s of these fundamental science discoveries that NIH supports to promote human health

Congratulations @milsommick.bsky.social and team. Lovely work!

This #HSC 🩸biologist is so excited to attend my first #memory#immunity @keystonesymposia.bsky.social meeting. 🙏 @drshrutinaik.bsky.social @labfairfax.bsky.social @ostunilab.bsky.social for organizing and the opportunity to present. #KDINNATEIMMUNE25

Our researcher Stephanie Xie’s News & Views article is published in Nature Immunology 🎉 It highlights work from Stanley Adoro’s team on how the IRE1α–XBP1 pathway plays a surprising role in safeguarding blood stem cells while suppressing leukemia-promoting programs: www.nature.com/articles/s41...

Assuming we make it through the next couple of decades, this will be an incredible image for future historians/students of the Trump era

In the Jan issue of @isehsociety.bsky.social journal, the very first “Society Voices article: Advice for effective leadership and hitting the ground running as a new group leader - Experimental Hematology www.exphem.org/article/S030...

It was already very special to coordinate the manuscript with my (former) mentor Joanna. But the preview by @mariekeoudelaar.bsky.social puts the cherry on top! Thank you!

IRE1α–XBP1 moonlighting to restrict leukemia. tinyurl.com/Ire1xbpHSC News&views I penned on the Adoro group’s elegant study. @natimmunol.bsky.social #hemesky #HSC #AML #immunosky

Congratulations to Dr. Abdulazeez Salawu (Princess Margaret), recipient of the inaugural MOHCCN Patient Voices in Research Initiative award! 👏 His project addresses disparities in cancer research trials, making precision oncology more inclusive for all. > www.uhnresearch.ca/news/increas...

Erasmus MC Hematology Lecture speaker lineup never fails to impress! #hemesky 🧪🩸 mcusercontent.com/71bcc0f3bb8a...

A French study of 3,066 patients who received CAR T-cell therapy found an extremely low incidence (0.03%) of T-cell malignancies post-treatment. Only one case was observed over six years, suggesting the treatment is largely safe in this regard. www.nature.com/articles/s41...

The t-shirt my husband bought me for Christmas. How did he know my Christmas wish?

This one hits close to home. I was a beneficiary of a targeted program to introduce basic 🧪research to high school students from a disadvantaged socio-economic background. Let’s bring $ and attention to such endeavors. www.acs.org/education/st...

Our latest work is now available to read on bioRxiv! Very proud of this and its potential implications for patients with acute myeloid leukemia 🩸 🧪 🔬💊 **eIF4A-mediated translation initiation as an AML cell vulnerability that can be co-targeted with BCL-2 inhibition** www.biorxiv.org/content/10.1...

Many academics point to bioRxiv as “the one thing improving science publishing”. If so, the one thing you all can do is persuade colleagues to submit and make this a norm. 1/2

It’s the first day of the winter school holidays and this #scientistmom has been doing double duty taking care of 104F feverish child and trying to clear off 🧪commitments. The wisdom of the 11-year old tween “I think you should be paid for reviewing papers”. #nofreelabor

Thrilled to see this paper out!! 🧪 Spatial transcriptomics of brain aging and 'spatial aging clocks' identify cells that have pro-aging or pro-rejuvenating effects on their neighbors! Huge CONGRATS to Eric Sun and all authors! Fantastic collaboration with @jameszou.bsky.social! rdcu.be/d33uQ 🧵

Our new review “Insights into Leukemia from Single-Cell Genomics” is out! Great work by Nurefsan Sariipek @nursariipek.bsky.social 📝 www.annualreviews.org/content/jour... #hemesky 🩸🧬

Excited to share my latest paper, published today at @natureportfolio.bsky.social ! A big thank you to all our collaborators. The paper shows how RANK drives intestinal epithelial expansion during reproduction. #intestine #stemcells #pregnancy www.nature.com/articles/s41...