Similar tumors can often respond very differently to immunotherapy. Why? A simple mathematical model reveals the possibility of two alternative evolutionary strategies, dictated by mutational loads www.sciencedirect.com/science/arti...

☀️ 2026 Summer School in the Pyrenees - Unifying Mathematical Models of Biodiversity Applications are now open! This school offers a state-of-the-art overview for interdisciplinary theoreticians. 🗓️ July 5-11 🎯 PhD students to senior researchers ℹ️ intp.science/en/summer26.... 📭 [email protected] 🌐🧪

Excited to share a new PhD thesis from my student and soon Dr @vmaull.bsky.social on synthetic ecosystems, preventing tipping points, and a new concept: emergent bioengineering. Very proud of this achievement, and thankful to @sfiscience.bsky.social, where many of these ideas came to life.

Cooperation is a universal feature of complex systems, from the origins of life and microbiomes to societies. What universal patterns can be found in these systems? Here's our new @pnas.org paper. @jordipinero.bsky.social @artemyte.bsky.social @sfiscience.bsky.social www.pnas.org/doi/epdf/10....

Why do some cancers respond to immunotherapy while others don’t? A new paper by @guimaguade.bsky.social shows, using maths, that as tumors mutate, they face a trade-off: growing faster can also make them easier for the immune system to spot. @sandyanderson.bsky.social www.biorxiv.org/content/10.1...

Who is afraid of HGT? True, antibiotic resistances disseminate through it. But we can also leverage the same channels for spreading good stuff at a very large scale and fortifying the env microbiome with beneficial activities www.biorxiv.org/content/10.1... by Victor Maull & @ricardsole.bsky.social

Can synthetic biology help save endangered ecosystems? Our new paper with @vmaull.bsky.social explores how engineered genes can spread through soil microbes. We model how synthetic gene transfer can support biodiversity. @vdlorenzo.bsky.social @guimaguade.bsky.social www.biorxiv.org/content/10.1...

We are so close to start the @cs3conference.bsky.social Spainish Chapter (CS3) School !! 🎉 One of our invited talks will be delivered by Guim Aguadé-Gorgorió @guimaguade.bsky.social , about a really fascinating topic 👇

A central finding is that, even if we could measure pairwise interactions up to a certain precision, strong indirect effects can make our efforts useless: at high collectivity, pairwise interactions no longer inform about community coexistence www.biorxiv.org/content/10.1...

Some tumors with many mutations are eliminated by immunotherapy, while others evade immune surveillance and eventually relapse. A new mathematical model could help us understand the complex role of mutational load in immunotherapy resistance www.biorxiv.org/content/10.1... @ricardsole.bsky.social

Immunotherapy fails at curing heterogeneous cancers. Why? Modeling and clinical data suggest a limit to tumor heterogeneity, beyond which T cells fail at controlling highly-diverse tumors. Can we take advantage of this limit? @ricardsole.bsky.social royalsocietypublishing.org/doi/full/10....

Microbial communities can harbor many species that do not coexist in pairs, yet can coexist in the full community. Here we provide the mathematical foundations of emergent coexistence, and explain why it can't be predicted from pairwise tests www.biorxiv.org/content/10.1...

Tumors harbor hundreds of different cell types that compete and cooperate, mirroring a natural ecosystem. Can we model cancer as a complex ecosystem of many interacting species? An honor to work w/ @ricardsole.bsky.social and Sandy Anderson while bringing in recent work in ecology with Sonia Kéfi!