We are very happy to share our latest work exploring the role of newly synthetized integrin-α5 using RUSH. We found that a subset goes to the PM via unconventional secretion! Big thanks to all involved! Read more at doi.org/10.1083/jcb.... @mathildemathieu.bsky.social @martina-lerche.bsky.social

I am super happy to see this published in @jcb.org ! If you are interested in cell adhesion and trafficking go have a look !

Delighted to share that our work “Uridine Phosphorylase-1 supports metastasis by altering immune and extracellular matrix landscapes” was published today in @emboreports.org, describing how neutrophil metabolism influences niche priming to support metastasis (1/14) www.embopress.org/doi/full/10....

Rijuta Lamba, Alexandra Naba @nabalabuic.bsky.social, @valerioizzi.bsky.social and team present MatriCom, a single-cell RNA-sequencing data mining tool to infer cell–ECM interactions. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/... #OpenAccess

Pleased that our latest paper is now out in @jcellsci.bsky.social, in collaboration with @drmcjones.bsky.social and others from Manchester and Plymouth: Differential roles of cyclin–CDK1 complexes in cell migration and invasion url: journals.biologists.com/jcs/article/...

Latest from Ivaska Lab ▶️ Niklas Jäntti et al delve deep into the roles of EPLINα/β on integrin trafficking and breast cancer outcomes! Congratulations to all the authors! Check the paper out here: www.sciencedirect.com/science/arti...

Excited to share our most recent study on #integrintraffic #cancer #migration #focaladhesion by @ivaskalab.bsky.social @drpaulinamoreno.bsky.social Niklas Jäntti et al www.sciencedirect.com/science/arti...

Great opportunity for a Research Support Officer to join @cellbiol-mrclmb.bsky.social, supporting @deriverylab.bsky.social in their studies of the molecular mechanisms behind receptor sorting in endosomes. More info: www.nature.com/naturecareer... Apply by 10 JUL #ScienceJobs

Are you looking for a postdoc? I will be looking for 2-4 people after the summer to join the lab !! Do not hesitate to reach out and disseminate !!

☕Conway et al. show that #integrin β1 phosphorylation is regulated through balanced activities of tyrosine kinases, such as Src and Arg, and phosphatases, such as PTP-PEST and Shp2, facilitating invadopodia formation and invasion of #BreastCancer cells. bit.ly/4n4v3JS

Congratulations @louisefets.bsky.social and team, beautiful work!! 👏👏 www.biorxiv.org/content/10.1...

1/ Beyond thrilled to see my #PhD work now published in @jcb.org A short thread (🧵) for #metastasis #metabolism #ExtracellularVesicles (EVs) aficionados

Latest from @ivaskalab.bsky.social @jrwconway.bsky.social in NCB. We find that SHP-2 inhibition stops TNBC invasion and limits metastasis by blocking integrin dephosphorylation! Read more at: www.nature.com/articles/s41...

Our newest paper is out in NCB. @jrwconway.bsky.social‬ designed a new FRET reporter, Illusia, to show the importance of integrin β1 phosphorylation dynamics in 3D invasion! Video: TNBC cells expressing Illusia with a Src (Saracatinib) or SHP2 (SHP099) inhibitor. www.nature.com/articles/s41...

New paper from @ivaskalab.bsky.social out now! 🍾 Watch how cancer cell adhesion dynamics are disrupted by inhibiting the phosphatase Shp2 - key to integrin β1 phosphorylation. Blocking Shp2 impairs adhesion and reduces invasion potential. 🎥👇 Read more at: www.nature.com/articles/s41...

"Academics tend to be averse to discussing mental health openly, and higher education’s mental health safety net is patchy—a forgotten footnote that all too often fails its students." #MentalHealthAwarenessMonth scim.ag/4m61iaU

Happy to share our Tensin 1 phase separation project is now on bioRxiv. www.biorxiv.org/content/10.1... This wouldn't be possible without @johannaivaska.bsky.social @ivaskalab.bsky.social #VattulainenLab #MSCA by @ec.europa.eu @turkubioscience.bsky.social @inflames-flagship.bsky.social

In Memoriam: Wolfenson, Giannone, and Schwartz recall the life and many contributions of Michael Sheetz, who passed away on January 30, 2025. rupress.org/jcb/article/...

We are looking for a doctoral candidate to join the lab! If you are interested in working with human breast tissue samples straight from the clinic and do not fear large data sets, this might just be your dream project ☺️ Apply now ⬇️ ats.talentadore.com/apply/vaitos... 📸 @oonapaavolainen.bsky.social

Check this one out! This is a great read (I am bias). But Joanna and Stefania did an amazing job putting the article together.

Congratulations to the superbly talented @marthamz.bsky.social @labvousden.bsky.social 👏👏 So well-deserved, can't wait to see your exciting research 🥳

Chikireddy, Romet-Lemonne, Jégou et al. @romet-jegou-lab.bsky.social investigate how the crosslinker fascin delays cofilin-induced #actin filament disassembly. https://buff.ly/3EBL34j In #Mechanobiology 2025: https://buff.ly/3EK0uaq

A truly amazing and inspiring session on Advances in Mechanobiology!!! Huge thanks to @drsarahboyle.bsky.social @carstenschulte4.bsky.social @mathildemathieu.bsky.social for sharing their research with the rest of us and @ccstorytime.bsky.social for moderating!!!! See u all in the next!!!

For early career researchers interested in the Fibronectin, Integrins and Related Molecules GRS/GRC this May, don’t forget to sign up! The deadline for submitting an abstract to be considered for an oral presentation for the GRS is less than a week away! Register here: www.grc.org/fibronectin-...

New PI positions @mrc-lms.bsky.social 👀 It's truly a great place to start a lab, definitely worth a look if you're on the job market. Please share with your networks!

🎉 The latest paper from out lab by #Montse_Llanses with Keqian Nan, Zhe Bao, Rachele Bacchetti Shengnan Yuan & Joe Tyler is out!!! @plosbiology.org @mcb-sheffield.bsky.social journals.plos.org/plosbiology/...

The IOP Mechanobiology meeting starts strong with @johannaivaska.bsky.social telling us that cells do not necessarily migrate towards stiff and that nuclear YAP does not necessarily correlate with cell spreading. 💪

Let's share some other classic, the beautiful Cells in culture film directed by Michael Abercrombie one of the father of quantitative cell imaging (University College London, 1955) is available here identity.wellcomecollection.org/works/z6h7jzv4

I have moved to 🦋 as well ! Looking forward to reconnecting with old and initiating new science contacts here

🚨 Please share 🔔 2x fully funded #Postdoc positions available If you are interested in - #epigenetic memory of stem and #cancer cells. - functional analyses of #microbes in cancer please get in touch. We have two cracking projects with collaborators in the EMBL Partnership.

We are happy to report that our journals and community sites now have Bluesky accounts. Follow them at: @dev-journal.bsky.social @jcellsci.bsky.social @jexpbiol.bsky.social @dmmjournal.bsky.social @biologyopen.bsky.social @the-node.bsky.social @prelights.bsky.social @focalplane.bsky.social

Ivaska Lab at the Turku Bioscience Pikkujoulu party 🥳 Can you recognize our costumes? 😉 @omkarjoshi.bsky.social @mathildemathieu.bsky.social @mchastney.bsky.social @gounismichalis.bsky.social @sanshiya04.bsky.social

Introductory post on 🦋! We're a research group headed by Prof. Johanna Ivaska interested in understanding how integrins contribute to every step of cancer progression. We're located at the Turku Bioscience Center in Turku, Finland! Find out more about us and our interests here: ivaskalab.utu.fi