Congratulations Carmelo and team, brilliant work showing that mechanostimuli (through sound waves) can provoke nuclear chromatin responses in mesenchymal stem cells which directs the cells towards osteogenic lineage🤩!

The core team of the Tenovus Scotland-funded Small Pilot Grant project "Leveraging mechanobiology for the optimisation of in vitro muscle-related disease models" is on the case😊, with a strong 4th&5th year students-driven component! @unistrathclyde.bsky.social @theglasgowcemi.bsky.social

Strathclyde named Scottish University of the Year and Runner-Up UK University of the Year by The Times and Sunday Times www.strath.ac.uk/whystrathcly...

Very interesting story on the nuclear mechanoresponse to sono-stimulation!

EpiSci - 🧬 - 🧪 - 👇🏽👇🏽👇🏽👇🏽👇🏽👇🏽👇🏽 We just submitted an updated version of the previous preprint. Sonoepigenetic Modification Mechanoprimes Early Osteogenic Commitment in Mesenchymal Stem Cells www.biorxiv.org/content/10.1...

We are very happy 😄 that our Rheinland-Pfalz & Scotland exchange project started, jointly awarded by @sulsa.bsky.social and JGU Scotland Hub, sponsored by the governments of 🏴󠁧󠁢󠁳󠁣󠁴󠁿 & Rheinland-Pfalz. 1/2 @unistrathclyde.bsky.social @theglasgowcemi.bsky.social @imbmainz.bsky.social @unimainz.bsky.social

BioMedEng25 is over! I really enjoyed my talk&the opportunity present my research. I also talked about unpublished work from a collaboration with @carmeloferrai.bsky.social that is getting closer&closer to being deposited on @biorxivpreprint.bsky.social. Stay tuned 😀! @biomedeng25.bsky.social

This is an airyscan confocal movie of mitochondria (white) moving around in a mouse astrocyte. Actin filaments are in orange and microtubules are in blue.

Our study on the mechanosensitive behavior of cell adhesion, showing the existence of a force-transmission mechanism that behaves very differently from the well-known 'load-and-fail' mechanism, was published in Nature Physics: www.nature.com/articles/s41...

A little more than a year that @carmeloferrai.bsky.social and I published our review "Mechanotransduction in stem cells"🤯! I'm happy that it was received well 😃! Stay tuned, more to come in this direction in a not too far future😎.

A paper that I published as a co-first author in 2014 (with G.M. Ferraris and V. Buttiglione, supervised by N. Sidenius, not on bluesky) reached 100 citations. Science social media weren't that big yet back then, so I seize this occasion to make a 🧵 about it now: 👉 www.embopress.org/doi/full/10....

Getting something done at work

So ist es, liebes BMFTR: Die Chancen sind für jede Generation ✨vergleichbar schlecht✨! 12 Jahre prekäre Beschäftigung & anschließend fliegen die nicht mehr ganz so jungen Wissenschaftler_innen ins Weltall 🚀 … ah Moment … doch nicht … sie fliegen: RAUS! Das sind Chancen! #RundumSorglos #IchBinHanna

📜 A comprehensive strategy to strengthen bioimaging in Africa through the Africa Microscopy Initiative 🧑‍🔬 Michael Anton Reiche, Teng-Leong Chew, et al. 📔 Nature Cell Biology 🔗 www.nature.com/articles/s41... #️⃣ (Feeds) #Microscopy #CellBiology #AfricaMicroscopyInitiative

Please RT and/or give me a name if you think someone from underrepresented countries deserves a forum:

#Science Bluesky, do your thing: We're organising the International Symposium on Mechanobiology (ISMB) 2026 in #Glasgow & we're looking for research groups in Latin America & Africa who are doing great work in #Mechanobiology or adjacent areas. Can you indicate some names to me?

A brilliant idea that become a fantastic approach🤯:

At the Center of the Cellular Microenvironment’s impact workshop. Really enjoying the space to think together about where cell engineering and mechanobiology are headed. @theglasgowcemi.bsky.social @unistrathclyde.bsky.social

Very important publication highlighting the need for more realistic cell culture disease models that recapitulate better (patho)physiological conditions.

“The results revealed that researchers who received renewals without a funding gap were less likely to switch research topics and investigate a wide array of subjects than were those in the control group, and they produced papers featuring newer or more unconventional combinations of ideas”

Retroactive or retrospective paper 🧵 (I like the term, thanks @nicopedroncelli.bsky.social):

This ligand binding-independent integrin signalling was driven by membrane tension. Indeed, the induction of this non-canonical integrin signalling was not restricted to uPAR/vitronectin interaction. This work introduced the cell membrane as a critical component of the molecular clutch.

I delved even deeper into this a few years later, further highlighting the importance of talin-mediated molecular clutch force loading in this process: 👉 www.sciencedirect.com/science/arti...

Consistently, some years later (2019), Changede et al. (Sheetz group) showed the existence of integrin nanoclusters bridges build up by activated, but unliganded, integrins. The binding to the thin matrix fibres was mediated by integrins in this case, but it's intriguing to think that this 1/2

...can involve also other cell adhesion receptors (e.g., GPI-anchored, such as uPAR, or maybe syndecans, DDRs?) 2/2:

Interesting 🧵on a classic mechanotransduction paper of one of our members introducing the concept of ligand binding-independent integrin signalling driven by membrane tension:

This study assessed the possibility of ligand-independent adhesion signalling by integrins, which was a quite controversial hypothesis at the time (maybe still is). We found that e.g. uPAR-mediated adhesion to vitronectin can induce integrin signalling that does not require integrin ligand binding:

A paper that I published as a co-first author in 2014 (with G.M. Ferraris and V. Buttiglione, supervised by N. Sidenius, not on bluesky) reached 100 citations. Science social media weren't that big yet back then, so I seize this occasion to make a 🧵 about it now: 👉 www.embopress.org/doi/full/10....

The abstract submission deadline of BioMedGen2025 @biomedeng25.bsky.social has been extended. You still have the chance to submit until the 19th of May. Meet us all in Glasgow😊: 👉 biomedeng.org/biomedeng25/

Totally agree. If Europe was serious in positioning itself as a new strong research hub in the world, we would need to invest hundreds of billions (as made available for weapons) not millions, that's basically just a drop in the ocean...

If Europe was serious in positioning itself as a new strong research hub in the world, we would need to invest hundreds of billions (as made available for weapons) not millions, that's basically just a drop in the ocean...

If Europe was serious in positioning itself as a new strong research hub in the world, we would need to invest hundreds of billions (as made available for weapons) not millions, that's basically just a drop in the ocean...

It is a fantastic and rare opportunity that doesn't come up very often, our Department of Biomedical Engineering is searching for a new Head of Department at @unistrathclyde.bsky.social in Glasgow (deadline 9th of May): strathvacancies.engageats.co.uk/Vacancies/W/...

Great to see that our work on #viscoelastic #hydrogels for #cartilage #TissueEngineering was one of the most-read papers in Advanced Healthcare Materials @mattjwalker.bsky.social @delphe.bsky.social @manlio-tassieri.bsky.social Check it out here doi.org/10.1002/adhm... 🧪

In this work my team and co-workers demonstrated a purely mechanically regulated route for #StemCell #Chondrogenesis via engineering of the hydrogels #viscous nature. No #growthfactors needed. Conducted @uofglasgow.bsky.social @theglasgowcemi.bsky.social Funded @ukri.org

Maybe the opportunity of your life, become the Head of the wonderful Department of Biomedical Engineering @unistrathclyde.bsky.social in Glasgow in beautiful 🏴󠁧󠁢󠁳󠁣󠁴󠁿 : 👉 jobs.sciencecareers.org/job/671921/h...

Maybe the opportunity of your life, become the Head of the wonderful Department of Biomedical Engineering @unistrathclyde.bsky.social in Glasgow 🏴󠁧󠁢󠁳󠁣󠁴󠁿 : 👉 www.nature.com/naturecareer...

Imo what we are witnessing right now is the weirdest possible blend of the biggest scam in human history, colossal corruption, and mind-boggling stupidity with the "stable genius" robber baron Trump functioning as a tool: www.theguardian.com/us-news/2025...

That looks interesting:

Our colleagues at the Department of Biomedical Engineering of the @unistrathclyde.bsky.social are searching for a new Head of Department:

It is a fantastic and rare opportunity that doesn't come up very often, our Department of Biomedical Engineering is searching for a new Head of Department at @unistrathclyde.bsky.social in Glasgow (deadline 9th of May): strathvacancies.engageats.co.uk/Vacancies/W/...

It was very special to have the opportunity to hear about David Weitz' research first hand. Thanks for making this possible 😊!

Thanks @kimiawitte.bsky.social for organising this special event 😊! Many members of @theglasgowcemi.bsky.social had the pleasure to listen to David Weitz' talk and to discuss cool science with him afterwards.

'Bluesky has overtaken its flailing rival X in hosting posts related to new academic research, indicating the platform is fast becoming the go-to place for scholars to share their work.'

A very useful review for everyone who wants to learn more about the importance of ECM viscoelasticity in mechanotransduction and (patho)physiology.

Thrilled to share our new review article! “The role of extracellular matrix viscoelasticity in development and disease” written together with Olivia Courbot is now published in npj Biological Physics and Mechanics. www.nature.com/articles/s44... #ECM #Mechanobiology #DevelopmentalBiology

Vereinbarkeit von Familie & Beruf an Hochschulen: Dass da noch viel zu tun ist, liegt wesentlich an prekären Arbeitsbedingungen ohne Perspektive. Ich freue mich, #IchBinHanna heute als Anzuhörende zu diesem Thema im Ausschuss für Wissenschaft & Forschung des Abgeordnetenhauses Berlin zu vertreten.

In the midst of all the insanity in the world, things like this get easily lost. That's really worrying (can anyone elaborate on the reasons for this, pesticide abuse, forever chemicals, microplastic?: www.theguardian.com/us-news/2025...

Great article by my collaborator @lankylaste.bsky.social and @guijacquemet.bsky.social @jwpylvanainen.bsky.social software development for life science application: journals.biologists.com/jcs/article/...

I knew there would be an effect! This has been one of the questions that I had for the longest time. Changing the mechanics of the substrate affects phagocytosis. Very interesting paper! www.cell.com/iscience/ful...