Great flash talk by Eric at #NECB2025 @breastcancernow.bsky.social @mcb-sheffield.bsky.social

#NPAW2025 #PostdocAppreciationWeek Rachele is a @yorkshirecancer.bsky.social funded postdoc, investigating the role of the Rab25/ADAMTS5 axis in ovarian and pancreatic cancer peritoneal metastasis. You can read more about this here: sheffield.ac.uk/biosciences/... @mcb-sheffield.bsky.social

Great talk by our own Zhe Bao at the School of Biosciences 3rd year PGR symposium!! @mcb-sheffield.bsky.social

#NPAW2025 #PostdocAppreciationWeek Eric is a @breastcancernow.bsky.social funded postdoc, investigating the mechanisms of breast cancer cell growth and spread. You can read more about this here 👇: breastcancernow.org/our-research... @mcb-sheffield.bsky.social

#NPAW2025 #PostdocAppreciationWeek Mona is a @cancerresearchuk.org funded postdoc in our lab. She demonstrated that the #ECMatrix supports breast cancer cell growth under starvation by promoting tyrosine catabolism. You can read more about this here: 👇 pubmed.ncbi.nlm.nih.gov/38227562/

Here are our fantastic postdocs: Mona, Rachele & Eric @mcb-sheffield.bsky.social #NPAW2025 #PostdocAppreciationWeek

Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer click.notification.elsevier.com/CL0/https:%2...

HT SpaceM: A high-throughput and reproducible method for small-molecule single-cell metabolomics: Cell www.cell.com/cell/fulltex...

Our own Ife will present her PhD work!!

SMART: A Spatio-Molecular Atlas of Response Trajectories in Triple-Negative Breast Cancer https://www.biorxiv.org/content/10.1101/2025.08.27.672673v1

We present our MetaProViz #Rpackage for #metabolomics analysis & prior knowledge integration to generate mechanistic hypotheses on how metabolic changes affect metabolite classes, pathways & environment interaction 🔗 www.biorxiv.org/content/10.1... 📦 saezlab.github.io/MetaProViz/ 🧵 Thread ⬇️

The kinesin KIF3AC recycles endocytosed integrin to polarize new adhesion formation toward the leading edge. pubmed.ncbi.nlm.nih.gov/40705420/

EPLINα controls integrin recycling from Rab21 endosomes to drive breast cancer cell migration. pubmed.ncbi.nlm.nih.gov/40669465/

A unified pan-cancer proteome atlas www.cell.com/cancer-cell/...

Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration. pubmed.ncbi.nlm.nih.gov/40614209/

On my way to #CRUKAllFellows meeting. Looking forward to it!

Outside influences: The impact of extracellular matrix mechanics on cell migration. pubmed.ncbi.nlm.nih.gov/40571339/

Calling all meeting organizers… @biologists.bsky.social now have a calculator to estimate your event’s carbon footprint and to test various reduction scenarios. thenode.biologists.com/event-carbon...

Welcome to the lab Fatmagul!! Joining the lab summer walk is a great way to start! @mcb-sheffield.bsky.social

Fantastic lab walk with @helenkmatthews.bsky.social ! Thanks to Bian, Rachele and @vichart33.bsky.social for organising

Vimentin intermediate filaments coordinate actin stress fibers and podosomes to determine the extracellular matrix degradation by macrophages www.cell.com/developmenta...

🚨 JOB ALERT 🚨 We're hiring a Research Assistant – no PhD needed! Join us to explore the molecular mechanisms of receptor sorting in endosomes. Experience in protein expression/purification, cloning & cell culture desired 🧫🔬 Apply now 👉 www.nature.com/naturecareer... #STEMCareers #ResearchJobs

I am excited to share our new Sheffield Pancreatic Cancer Research Network website! Please check it out at... sites.google.com/sheffield.ac... @fohsheffield.bsky.social @mcb-sheffield.bsky.social

We are delighted to host @cassiejclarke.bsky.social today from the @cruk-si.bsky.social! "Neutrophil metabolism supports metastasis of mammary cancer by altering immune and extracellular matrix landscapes" 📍 Alfred Denny Conference Room 📅 10th June - 1pm

Our own Alice presenting her MRes poster #biosciences @mcb-sheffield.bsky.social @sheffielduni.bsky.social

Extracellular matrix plays an important role in #cancer. "Understanding spatial matrix heterogeneity and its interactions with immune cells is critical for improving immunotherapy responses in matrix-rich cancers, such as pancreatic cancer." 🧪🧬 #Science #Biology #Health www.cell.com/trends/cance...

Exciting opportunity to join the cancer research community in Sheffield!!

New addition to our lab's PhD Wall of Fame - Bian 🇸🇾 #WeAreInternational @mcb-sheffield.bsky.social @sheffielduni.bsky.social

Delighted to share the work of @gounismichalis.bsky.social describing how metabolic reprogramming of micrometastatic cells influences EV release to generate invasive microenvironments.Michalis is an immense talent & it really is an honour to share his PhD work & my first senior author paper #ProudPI

2 weeks left to apply for our new fully funded postdoc position studying plasticity regulators in metastatic CRC!

🧵1/6 — Preprint Alert! I am super proud to present the latest work of our lab. Earthlings and those just visiting, I introduce you…. EndoNB: A better, smarter and versatile way to study the dynamics of cell surface proteins. 🧪 www.biorxiv.org/content/10.1...

Congratulations Bian on passing you PhD viva!!! Thanks to @zech-lab.bsky.social, @helenkmatthews.bsky.social and John for examining @mcb-sheffield.bsky.social

Nice to see our work reviewed in @febsj.bsky.social by @fbaschieri.bsky.social The Rab25-ADAMTS5 axis as a previously undescribed mechanism for sensing tumor microenvironment complexity. pubmed.ncbi.nlm.nih.gov/40406984/

We are delighted to host @vickysanzmoreno.bsky.social today from the @icr.ac.uk! "Biomechanical hallmarks and vulnerabilities of metastatic cancer cells" 📍 Alfred Denny Conference Room 📅 4th June - 1pm @insigneoinstitute.bsky.social @sheffielduni.bsky.social @sheffielduni.bsky.social

In a new study led by InFLAMES PI Professor Johanna Ivaska and Dr James Conway have developed a new fluorescent probe to visualise signaling dynamics in moving cancer cells which they used to uncover a new therapeutic possibility for limiting breast cancer spread. #Illusia @ivaskalab.bsky.social

mTORC1 shutdown unleashes TFEB to drive triple-negative breast cancer invasion click.notification.elsevier.com/CL0/https:%2...

Dynamic regulation of integrin β1 phosphorylation supports invasion of breast cancer cells. pubmed.ncbi.nlm.nih.gov/40419795/

Totally agree!! It was an amazing meeting

Amazing talk by Ife at the @mcb-sheffield.bsky.social 2nd year PGR symposium

📣 New paper alert! The El-khamisy lab uncovered how a key protein, NuMA, helps repair damaged DNA and protect important control regions of our genome, especially after oxidative stress. 🛡️ Protecting the genome = protecting health. www.cell.com/cell-reports...

I cannot wait for this meeting, it's going to be awesome

Congratulations to Rachele for passing her PhD viva!!! Well done!!! Thanks to Bian for the amazing cake

We did it! 🧪 After years of fiddling with gels, lasers, cells, and infinite lines of custom codes, our first preprint is out! We integrated TFM & FRET-based tension probes into one workflow to zoom in on focal adhesions mechanics 🔬 Already 400 downloads and I’m only mildly panicking 😅

Happy to share our Tensin 1 phase separation project is now on bioRxiv. www.biorxiv.org/content/10.1... This wouldn't be possible without @johannaivaska.bsky.social @ivaskalab.bsky.social #VattulainenLab #MSCA by @ec.europa.eu @turkubioscience.bsky.social @inflames-flagship.bsky.social

Using #CRISPR/Cas9 to genetically modify cells to produce extracellular matrices with altered compositions. elifesciences.org/reviewed-pre...

Happy to publish this News & Views article highlighting exciting new work from Rod Bremner's lab that shows that cell populations with a short cell cycle are intrinsically more susceptible to forming tumours

Phosphoinositide signalling in cell motility and adhesion links.springernature.com/f/a/fzmzANLa...

ECM, integrins, and DDRs: A nexus of cancer progression, therapy, and future directions. pubmed.ncbi.nlm.nih.gov/40350240/

The people are definitely a highlight of this conference, such a great community to be a part of @erainerolab.bsky.social @integrintraffic.bsky.social @mchastney.bsky.social @gounismichalis.bsky.social

Had an amazing time at the GRC Fibronectin, integrins and related molecules. Great talks, posters and opportunities to catch up with everyone