I am very proud of this piece as it embodies what I really want my lab to do. Developing and using advanced (image) analysis methods to study complex biological phenomena. This paper contains a lot of methodology, but even more biology. It is foundational for the work we are currently doing.

We are thrilled to share our new pre-print on the molecular anatomy of nuclear proteasome in human sperm cells! #In-cellcryo-ET + #SPA + #LM! @piotrkolata.bsky.social @a-dsantos.bsky.social, @tomdendooven.bsky.social!! doi.org/10.64898/202...

This review was a fun collaboration with Pere Roca-Cusachs - just published in a journal! www.tandfonline.com/doi/full/10....

Come on, do it. You know you want to. ⬇️

And that’s a wrap for the @cbias.bsky.social napari workshop as well. Two days of learning, working collaboratively and finished off with a presentation from each of five project groups detailing the progress they made. Organised by Rocco D’Antuono, @giuliapaci.bsky.social and yours truly

Exciting new findings: Wnt-receptor endocytosis is required for canonical Wnt activation, yet uptake mechanisms has been controversial. We resolve this by showing that Wnt3a triggers rapid Clathrin- and Fast Endophilin-Mediated LRP6 endocytosis at low concentrations sufficient for Wnt activation.

Early bird registration: Save £100 - 21 January 2026! Dynamic Cell VI conference, Reading, UK, April 2026! Co-organised by @bscb-official.bsky.social and @biochemsoc.bsky.social with @royalmicrosoc.bsky.social and the Chinese Society for Cell Biology. Register now: bit.ly/Dynamic-Cell-VI

Are you interested in studying in the UK for your Masters? Please join our program director for the MSc Cancer Biology and Therapy at the University of Liverpool for an on-line event. 19th November at 5pm (GMT). To sign up please use the link below: lnkd.in/efsXw-ke

The first to be shared is this one: lnkd.in/euACxRhz With Marisa Merino, co-supervisers Prof. Hilary Ashe & Prof. Harish Poptani.: Interested in How Organisms Cope with Growth in Challenging Environments? Open to international applicants. #DevBio #Microscopy #CellBio #PhDPositions #Genetics

A PhD position is available in the lab of @zech-lab.bsky.social co-supervised @christoseland.bsky.social An exciting project to understand cellular ageing in health and disease www.findaphd.com/phds/project... #CellBio #SuperResolutionMicroscopy #MolecularBio #AgeingResearch #PhDOpportunity

Independent validation of the SnxA biosensor as a sensitive reporter of PI(3,5)P₂ dynamics by Gerald R Hammond and team: www.biorxiv.org/content/10.1...

🧠 Fully funded 4-year PhD studentship 🧠 Please repost BBSRC NWD project with @parikki.bsky.social and @iamabyron.bsky.social Come join us to look at how mechanical and oxidative stress signalling pathways converge on the synaptic scaffold protein talin. www.findaphd.com/phds/project...

The project is now live on FindaPhD and open for applications. Deadline December 4th

Vinculin is a simple adapter protein right? Wrong! That’s been the prevailing view for the 46 years since it was discovered. Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains. www.science.org/doi/10.1126/...

Please repost - Multiple PhDs available www.findaphd.com/phds/project... www.findaphd.com/phds/project... www.findaphd.com/phds/project...

Please Repost! Tobi Zach and I have an MRC DiMeN PhD position available! Come join us! www.findaphd.com/phds/project...

Come and work with us 5-year position available for a University Researcher in Bioimaging 1.11.2025-31.12.2030 abo.rekrytointi.com/paikat/index...

Excited to share our new preprint in @biorxiv-neursci.bsky.social "Cyclin-dependent kinase-like 5 (CDKL5) binds to talin and is anchored at the postsynaptic density via direct interaction with PDZ domains" Instead of a 🧵 the paper is summarised in this video. www.biorxiv.org/content/10.1...

Thrilled for the publication of our latest paper on the role of SAS-6 in invasion. This was a pre-pandemic and post-pandemic effort that would not have been possible without our students and the support of so many colleagues and friends! @zech-lab.bsky.social @cengem.bsky.social #cilia #centrioles

SAS-6 promotes invasion through YAP pathway activation @cengem.bsky.social @tanosbarbara.bsky.social www.life-science-alliance.org/content/8/10...

Keen about High Performance Computing & #imageanalysis? Search for #75 at #ELMI2025 this evening @sebastianmunck.bsky.social‬ @makaefer.bsky.social

👋 Are you looking for a postdoc position? Do you think microtubules are fascinating? Then we might have the job for you! 2-year funded postdoc to join our lab! 👉 deadline 20/06 👇 check it out www.godinholab.com

The @livunihls.bsky.social has published their strategy 2025-2031. We cannot get past the cover page though: stunning image taken by our very own image analyst @makaefer.bsky.social before she became the image analyst. @livuni-livsrf.bsky.social @bwilm.bsky.social @raphavisses.bsky.social

Gustavo Pacheco, Douglas DeSimone and colleagues discover that mitochondrial membrane potential is spatially regulated in collectively migrating tissue by integrin adhesion and signalling in leader row cells. journals.biologists.com/jcs/article/... #JCSMitoSI #Mitochondria

Don't miss the First UK Zebrafish Meeting @lsiexeter.bsky.social in Exeter, sponsored by @brukercorporation.bsky.social @brukerspatial.bsky.social al.bsky.social! 🐠 Join us Sept 10 - 12. Early bird registration closes soon! Secure your spot. www.exeter.ac.uk/research/ins...

My first post on Bluesky! Very excited to share our work just published in @science.org. We find that “Interphase cell morphology defines the mode, symmetry, and outcome of mitosis” - in angiogenesis and other tissues! www.science.org/doi/abs/10.1... www.science.org/doi/abs/10.1...

In their Review, Laura Faure, Valeria Venturini @valeriaventurini.bsky.social and Pere Roca-Cusachs discuss the biological contexts of cell mechanical compression, the associated mechanisms and the experimental systems engineered to compress cells in vitro. journals.biologists.com/jcs/article/...

Interested in how cells respond when squeezed? Check the review paper just published by Laura Faure, @valeriaventurini.bsky.social and myself on this. Really thorough and clear revision by Laura and Valeria!

It's the last day of #biologists100! We'll be sharing more photos of people posing with our polaroid frame. Aymen al-Rawi @aymen-alrawi.bsky.social is the @bscb-official.bsky.social postdoc rep and organised the #ECR session at Biologists @ 100. His key words are #CircadianRhythm #MassSpec #MRC_LMB

If you are attending #biologists100, you can now visit our image gallery with @the-node.bsky.social in the exhibition hall and vote for your favourite image. If you are not at the conference, you can still vote in our poll on FocalPlane: focalplane.biologists.com/2025/03/11/v...

Come and check out our stand at #biologists100 with a chance to enter our mystery prize draw! @biologists.bsky.social @emilyxlucas.bsky.social @harrietasmith.bsky.social

Congratulations to our 2025 Raff PhD medal winner @impeiyee.bsky.social from @liverpooluni.bsky.social bscb.org/bscb-phd-awa...

#biologists100 conference is underway celebrating 100 years of @biologists.bsky.social

Congratulations @helenweavers.bsky.social 2025 Women in Cell Biology Early Career medal winner

We are expanding the London Cell Motility Club cytoskeleton.wixsite.com/londoncellmo... into a UK wide Cell Motility Club: our first symposium will be on Friday, June 13th, 2025, to provide an interdisciplinary forum including mechanobiology, cytoskeleton, tissue morphogenesis, and cell migration.

Really excited to be in Liverpool to celebrate 100 years of CoB @biologists.bsky.social ! Amazing science, great community of cell and dev biologists and lots of fun! @bscb-official.bsky.social @bsdb.bsky.social #biologists100

Don’t forget about the available incentives for travel to our Biologists @ 100 conference: Up to £150 for international train journeys and a prize of £700 in our sustainable travel blog competition. Find out more at 100yearsconference.biologists.com/sustainability #biologists100

We are looking for a doctoral candidate to join the lab! If you are interested in working with human breast tissue samples straight from the clinic and do not fear large data sets, this might just be your dream project ☺️ Apply now ⬇️ ats.talentadore.com/apply/vaitos... 📸 @oonapaavolainen.bsky.social

Whoop The first #CD7 User Group Meeting happening next month in Liverpool. Please register with the link below. Looking forward to welcoming you all to Liverpool, the city of culture, history, music and microscopy. www.zeiss.co.uk/microscopy/l... #Microscopy #HighThroughput #Robotics #ImageAnalysis

"Intrinsic electrical activity drives small-cell lung cancer progression" www.nature.com/articles/s41...

My first post on this forum! 😄 I am happy to share that our #openaccess review on the #molecular mechanisms of #actin filament polymerization and dissasembly is now online @cp-trendscellbio.bsky.social www.cell.com/trends/cell-... Big thanks to my amazing colleagues in Dortmund

A date for your diaries! The Microtubule meeting UK 2025 will take place on the 12th May in Edinburgh. Registration will open very soon. biology.ed.ac.uk/microtubule

One week left to submit an abstract for the @biologists.bsky.social 100 meeting incorporating the @bscb-official.bsky.social & @bsdb.bsky.social annual meetings in Liverpool in March! Don't miss out on an amazing lineup of invited speakers - scan the QR code for the full list

ICYMI: Still a bit of time to get your abstract in for the @biologists.bsky.social 100 conference 24-27th March in Liverpool, incorporating both the annual @bsdb.bsky.social & @bscb-official.bsky.social meetings! Support grants available - apply to BSDB by Jan 10 bsdb.org/membership/

Our friend makes custom rugs, and so my wife sent her one of our structure images and she made it from that. This was the original (it was quite lucky as PyMOL crashed rendering it so the colours are really distinct).

This is going to be a great meeting! Don’t miss it 👌

This week's #FluorescenceFriday is in celebration of the work completed by @milancollins.bsky.social (@zech-lab.bsky.social)- as he defended his PhD this week! The image attached is from a live-cell movie we generated together...