🚀 Big news! Meet the new leadership team at #CenGEM!🧬🔬 We are excited to announce the appointment of Dr. Alessandro Esposito as Director and Dr. Sibylle Ermler as Deputy Director of the Centre for Genome Engineering and Maintenance. #GenomeMaintenance #BrunelUniversity #BioScience

When is a #modelsystem relevant? Interesting reflections by Dr Christian Rudolph rudolphlab.com/blog/on-narr...

Are you interested in oncogenic #KRAS and #metabolism? Our latest study reveals how specific KRAS G12D and G12V alleles rewire #glutamine and #nitrogen metabolism in #colorectalcancer through a #FOXO1-dependent pathway. www.embopress.org/doi/full/10....

Very exciting few days this week as we attended and presented our work at the 5th Crick International Cancer Conference. Well done Rebecca! @crick.ac.uk @cengem.bsky.social @cancerresearchuk.org

The Authors have found that overexpression of the centriolar protein SAS-6 causes an increase in cell invasion through the activation of the YAP/TAZ pathway @cengem.bsky.social @tanosbarbara.bsky.social www.life-science-alliance.org/content/8/10...

Happy new academic year for all our students and colleagues at Brunel. #bruneluniversity #success @cengem.bsky.social

SAS-6 promotes invasion through YAP pathway activation @cengem.bsky.social @tanosbarbara.bsky.social www.life-science-alliance.org/content/8/10...

Thrilled for the publication of our latest paper on the role of SAS-6 in invasion. This was a pre-pandemic and post-pandemic effort that would not have been possible without our students and the support of so many colleagues and friends! @zech-lab.bsky.social @cengem.bsky.social #cilia #centrioles

We now have the audio summary of "#BMP antagonist #CHRDL2 enhances the #cancer #stemcell phenotype and increases #chemotherapy resistance in #colorectal cancer" by Eloise Clarkson and Annabelle Lewis published in Molecular Oncology open.spotify.com/episode/3vv8...

Centre for Genome Engineering and Maintenance at Brunel University of London Research Showcase at Senate House.

When the work of centre members has an impact on people. News from Dr Victor Hernandez and Axovia Therapeutics. #gentherapy #cengem axoviatherapeutics.com/axovia-thera...

#Microscopills Episode 1. A brief refresher about what #FRET is and FRET #microscopy can do. A primer in a conversational podcast format. open.spotify.com/episode/4JoK...

Dear Colleagues, I want to ask you a favour. As you know, I joined Brunel two years ago and I am committed to making Biosciences, @cengem.bsky.social and Brunel University of London grow. Bunel is a very special project for me.

Single nucleic acids probe imaged by #FLIM exemplifies how #fluorescence #lifetimes can reveal physicochemical characteristics of the sample hidden within the mere brightness of the sample. Shared just for fun :) red: high lifetime; blue: low lifetime. Probe: to be announced ;) #livecellimaging

Very humbled and honored to share my story. Thank you @jcellsci.bsky.social and Sara Morais da Silva for the interview! journals.biologists.com/jcs/article/... @cengem.bsky.social

[new review] Zhang Lab. Recent advances and applications of artificial intelligence in 3D bioprinting. Biophys Rev (Melville) http://dlvr.it/TGbPnR

[New paper] Roberts Lab. 5-aza-2'-deoxycytidine induces #telomere dysfunction in #breast #cancer cells. Biomed Pharmacother. http://dlvr.it/TGZ4HL

[New review] Tosi Lab. The role of #diet in #cancer: the potential of shaping public #policy and #clinical outcomes in the UK. Genes Nutr http://dlvr.it/TGWz87

Scientists have developed an automated tool to study cell growth and division, including hard-to-study, free-floating blood cancer cells.

Useful orders of magnitude

[new paper ] Rudolph Lab. Repurposing Proximity-Dependent Protein Labeling (#BioID2) for Protein Interaction Mapping in E. coli. Methods Mol Biol http://dlvr.it/TGTj3D

[new review] Karteris Lab. The "Road" to Malignant Transformation from #Endometriosis to Endometriosis-Associated #Ovarian #Cancers (EAOCs): An #mTOR-Centred Review. Cancers (Basel) http://dlvr.it/TGSRX0

[new paper] Drenos Lab. No Evidence That Vitamin D Levels or Deficiency Are Associated with the Risk of Open-Angle #Glaucoma in Individuals of European Ancestry: A Mendelian Randomisation Analysis. Genes http://dlvr.it/TGSQdz

[New #preprint] Sisu Lab. #GENCODE: massively expanding the #lncRNA catalog through capture long-read #RNA sequencing. http://dlvr.it/TGPqVQ

[new paper] Sisu lab. GENCODE 2025: reference gene annotation for human and mouse http://dlvr.it/TGNfV3

[new review paper] Silva Lab. #Breast #cancer risk and prevention in 2024: An overview from the Breast Cancer UK - Breast Cancer Prevention Conference - Cancer Medicine http://dlvr.it/TGMWyN

Signaling downstream of tumor-stroma interaction regulates mucinous colorectal adenocarcinoma apicobasal polarity https://www.biorxiv.org/content/10.1101/2024.11.20.624298v1

Very excited to be co-chairing the British Society of Antimicrobial Chemotheraphy Antibiotic Resistance and Mechanisms conference with @friendlymicrobe.bsky.social Looking forward to 2 days of great talks and networking @kateduncan.bsky.social @craigmaclean.bsky.social @catrinm.bsky.social

Transient histone deacetylase inhibition induces cellular memory of gene expression and three-dimensional genome folding https://www.biorxiv.org/content/10.1101/2024.11.21.624660v1

Certain strains of a bacterium found in the gut of some animals, Lactobacillus plantarum, are able to counter hyperuricemia, a condition caused by high levels of uric acid in the blood. https://buff.ly/3Cr8xYO

Full disclosure, I curate also @cengem.bsky.social the research centre I am Deputy Director of at the College of Health, Medicine and Life Science at Brunel

Hello BlueSky! CenGEM at #Brunel University of London here, a diverse #research network focused on molecular, cellular, organismal and computational aspects of #genome #biology. www.brunel.ac.uk/research/Cen...