Matthias Krause
@matthias-krause.bsky.social
📤 285
📥 366
📝 30
Cell migration and endocytosis research lab
https://cytoskeleton.wixsite.com/krauselab
pinned post!
Exciting new findings: Wnt-receptor endocytosis is required for canonical Wnt activation, yet uptake mechanisms has been controversial. We resolve this by showing that Wnt3a triggers rapid Clathrin- and Fast Endophilin-Mediated LRP6 endocytosis at low concentrations sufficient for Wnt activation.
loading . . .
The Actin regulator Mena promotes Wnt signalosome endocytosis and Wnt signalling
Wnt signaling controls embryonic development and tissue maintenance. Endocytosis of Wnt-receptors is required for signalling, yet uptake mechanisms remain poorly understood. Here, we identify the acti...
https://www.biorxiv.org/content/10.1101/2025.11.24.690281v1
3 months ago
1
17
5
reposted by
Matthias Krause
Leone Rossetti
2 days ago
Interested in a PhD in collective cell migration & mechanobiology? I'm looking to support a candidate applying for a fully funded UK/Home PhD. The project studies the biophysics of migrating cells, using force measurements & optogenetics, with collaborators in Japan.
#mechanobiology
#PhD
eb4bm.org
loading . . .
Home - Engineering Biology For Biomedicine
Engineering Biology for Biomedicine A UKRI:BBSRC Centre for doctoral training Why EB4BM “ Our graduates bridge fundamental biological design principles with biomedical bottlenecks, delivering engineer...
https://eb4bm.org/
0
7
5
reposted by
Matthias Krause
Karen J Liu
4 days ago
Fully funded PhD post, UK/Home student, starting 01/06/26. Interested in working at the interface of dev bio, biophysics and cell biology? Great collaboration with Amy Beedle and
@leonerossetti.bsky.social
Informal enquiries welcome. Deadline 15/03
#neuralcrest
www.kcl.ac.uk/study-legacy...
loading . . .
Multiscale Models for Life (MM4L) Centre for Doctoral Training Funded Studentship: How ECM changes shape cellular decision making
Embryo, neural crest, developmental biology, cell biology, cell migration, biophysics, mechanobiology, bioengineering.
https://www.kcl.ac.uk/study-legacy/funding/multiscale-models-for-life-mm4l-centre-for-doctoral-training-funded-studentship-how-ecm-changes-shape-cellular-decision-making
0
8
11
reposted by
Matthias Krause
David Drubin
4 days ago
Class-I myosin responds to changes in membrane tension during clathrin-mediated endocytosis in human induced pluripotent stem cells | PNAS
www.pnas.org/doi/10.1073/...
loading . . .
Class-I myosin responds to changes in membrane tension during clathrin-mediated endocytosis in human induced pluripotent stem cells | PNAS
Clathrin-mediated endocytosis (CME) is an essential cellular process that needs to operate efficiently across a wide range of conditions. Internali...
https://www.pnas.org/doi/10.1073/pnas.2532817123
0
9
5
Abstract deadline this Sat 21 Feb 2026! Don't miss the Dynamic Cell VI conference, Reading, UK, April 2026! Co-organised by
@bscb-official.bsky.social
and
@biochemsoc.bsky.social
with
@royalmicrosoc.bsky.social
and the Chinese Society for Cell Biology. Register now:
bit.ly/Dynamic-Cell-VI
loading . . .
Dynamic Cell VI
https://bit.ly/Dynamic-Cell-VI
9 days ago
1
2
1
reposted by
Matthias Krause
Michael Way
12 days ago
Closing date is 19th Feb so why not go for it to enjoy the rain in London!
add a skeleton here at some point
0
8
13
reposted by
Matthias Krause
Brett Collins
13 days ago
Looking forward to the 93rd UK Biochemical Society Harden Conference on “Endosomal-lysosomal network dysfunction in neurodegenerative disease” over the 1st to 4th of September 2026. Early bird deadline 1st June 2026.
www.eventsforce.net/biochemsoc/f...
0
6
1
reposted by
Matthias Krause
Loïc A. Royer 💻🔬🧪
20 days ago
1/ 🚀🧪🤖 Big update for
#Omega
— the LLM-powered autonomous agent for bioimage analysis in
@napari.org
! Custom LLM endpoints, layer actions, plugin extensibility, agentic widget maker, modernized UI, & 30+ fixes. Here's what's new in version *2026.2.8.2*:
loading . . .
2
53
20
reposted by
Matthias Krause
Michael Way
23 days ago
2nd postdoc job alert in the Crick Institute in London. Project will examine the role of motors & the cytoskeleton (actin, septins and microtubules) during vaccinia virus egress using biochemical, structural & cellular approaches + live cell imaging. spread the word.
crick.ac.uk/WayPostdoc20...
loading . . .
Postdoctoral Fellow - Cellular signalling and cytoskeletal function lab
http://crick.ac.uk/WayPostdoc2026-2
0
30
41
reposted by
Matthias Krause
Biochemical Society
24 days ago
Do you know a exceptional PhD candidate whose very promising research career has been interrupted for non-academic reasons? Encourage them to apply for the Krebs Memorial Scholarship - now accepting applications for the 2026/27 academic year! Deadline 3 April
https://ow.ly/Pufm50Y7K5G
0
3
5
reposted by
Matthias Krause
26 days ago
Reconstructing Actin Dynamics of the Leading Edge from Observational Data
www.biorxiv.org/content/10.6...
0
5
4
Early bird deadline: Save £100: This Wed 21 January 2026! Dynamic Cell VI conference, Reading, UK, April 2026! Co-organised by
@bscb-official.bsky.social
and
@biochemsoc.bsky.social
with
@royalmicrosoc.bsky.social
and the Chinese Society for Cell Biology. Register now:
bit.ly/Dynamic-Cell-VI
loading . . .
Dynamic Cell VI
https://bit.ly/Dynamic-Cell-VI
about 1 month ago
0
3
3
reposted by
Matthias Krause
Jennifer Waters
about 2 months ago
PIs & Group Leaders, do your trainees need to learn light microscopy and image analysis? Send them to us! Financial aid is available! Applications due Friday 1/30.
meetings.cshl.edu/courses.aspx...
loading . . .
Quantitative Imaging: From Acquisition to Analysis
Cold Spring Harbor Laboratory Meetings & Courses -- a private, non-profit institution with research programs in cancer, neuroscience, plant biology, genomics, bioinformatics.
https://meetings.cshl.edu/courses.aspx?course=C-QICM&year=26
0
23
20
reposted by
Matthias Krause
Pablo J. Sáez
about 2 months ago
#FluorescenceFriday
Proud of our the last paper
@cellcommlab.bsky.social
& 1st one of
@jboixcampos.bsky.social
We continue to study
#CellMigration
& how cells decide where to go: ↖️↗️⬇️? (movie of the actin
#cytoskeleton
) Full
www.science.org/doi/10.1126/...
@focalplane.bsky.social
@science.org
🧪🔬
loading . . .
2
49
12
reposted by
Matthias Krause
British Society for Cell Biology
2 months ago
Don't forget to register for our Spring Meeting: Dynamic Cell VI A joint meeting with the
@biochemsoc.bsky.social
Super early bird registration ends 21st Jan
0
9
9
reposted by
Matthias Krause
Helen Matthews
2 months ago
Excited to be a speaker at Dynamic Cell VI. Always a great meeting
add a skeleton here at some point
0
5
3
reposted by
Matthias Krause
Lucien Hinderling
8 months ago
PAPER OUT ✨ What if you could use your microscope as a 3D printer? Prototype microfluidics in-house, <5$ in material costs per chip. From idea to experiment within a day. Now published in Lab-on-a-Chip (open-access):
doi.org/10.1039/D5LC...
add a skeleton here at some point
4
91
26
reposted by
Matthias Krause
epithelial mechanics fan club
3 months ago
Want even smaller features? We recently published a method to convert your microscope into a microfabrication station, printing features from μm to cm scale for less than $5 in materials per design. Thread:
bsky.app/profile/lhin...
Paper:
bsky.app/profile/epim...
add a skeleton here at some point
1
18
6
reposted by
Matthias Krause
Romet/Jegou lab
3 months ago
📢 Deadline approaching fast 📢 to submit an abstract for the great cytoskeleton extravaganza!
add a skeleton here at some point
0
18
13
reposted by
Matthias Krause
Michael Way
3 months ago
Are you interested in cytoskeleton and looking for a postdoc position? I will be advertising positions in the new year but happy to chat in person if you are attending ASCB
@ascbiology.bsky.social
in Philadelphia. Just drop me a line.
0
34
34
reposted by
Matthias Krause
Guillaume Jacquemet
3 months ago
Your periodic reminder that science is not done by a few selected "stars scientists". Science is done by hundred of thousands. Siloed money mean a few flashy discoveries and a lot of waste. Want to change things? Make funding accessible and stop funding calls with less than 2% success rate.
add a skeleton here at some point
12
208
79
Early bird registration: Save £100 - 21 January 2026! Dynamic Cell VI conference, Reading, UK, April 2026! Co-organised by
@bscb-official.bsky.social
and
@biochemsoc.bsky.social
with
@royalmicrosoc.bsky.social
and the Chinese Society for Cell Biology. Register now:
bit.ly/Dynamic-Cell-VI
3 months ago
0
3
3
Exciting new findings: Wnt-receptor endocytosis is required for canonical Wnt activation, yet uptake mechanisms has been controversial. We resolve this by showing that Wnt3a triggers rapid Clathrin- and Fast Endophilin-Mediated LRP6 endocytosis at low concentrations sufficient for Wnt activation.
loading . . .
The Actin regulator Mena promotes Wnt signalosome endocytosis and Wnt signalling
Wnt signaling controls embryonic development and tissue maintenance. Endocytosis of Wnt-receptors is required for signalling, yet uptake mechanisms remain poorly understood. Here, we identify the acti...
https://www.biorxiv.org/content/10.1101/2025.11.24.690281v1
3 months ago
1
17
5
reposted by
Matthias Krause
Maik Bischoff
3 months ago
Super proud to be part of SFB1348 — and excited to share that I now officially have my own lab in Münster! 🎉🪰 We’ll study
#cellbio
&
#morphogenesis
, focusing on organ sculpting and
#chirality
in
#Drosophila
. I’ll soon hire my first
#PhD
student — feel free to reach out!
#juniorPI
#Science
#devbio
add a skeleton here at some point
25
105
23
reposted by
Matthias Krause
Karen J Liu
3 months ago
Exciting new findings on mechanisms of Wnt signalosomes --from Sheng-yuan Wu's PhD project in
@matthias-krause.bsky.social
lab! Great collaborators, great story.
#xenopus
🐸
add a skeleton here at some point
0
12
4
Endocytosis of Wnt-receptors is required for signalling, yet uptake mechanisms remain poorly understood. We resolve a longstanding controversy by showing that Wnt3a triggers rapid Clathrin-Mediated and Fast Endophilin-Mediated LRP6 endocytosis at low concentrations sufficient for Wnt activation.
3 months ago
1
11
4
reposted by
Matthias Krause
Grill Lab @ MPI-CBG
4 months ago
The Lab of Stephan Grill at MPI-CBG has finally made it to Bluesky and we also have a brand new homepage:
grill-lab.org
Check it out.
0
80
24
reposted by
Matthias Krause
Rainero lab
4 months ago
📣 Fully funded PhD position available in collaboration with
@jasonkinglab.bsky.social
in
@mcb-sheffield.bsky.social
BBSRC Yorkshire Bioscience DLA Programme: How do cells coordinate nutrient scavenging pathways? 📅 Deadline: 7th January 2026 More info 👇
www.findaphd.com/phds/project...
loading . . .
BBSRC Yorkshire Bioscience DLA Programme: How do cells coordinate nutrient scavenging pathways? at University of Sheffield on FindAPhD.com
PhD Project - BBSRC Yorkshire Bioscience DLA Programme: How do cells coordinate nutrient scavenging pathways? at University of Sheffield, listed on FindAPhD.com
https://www.findaphd.com/phds/project/bbsrc-yorkshire-bioscience-dla-programme-how-do-cells-coordinate-nutrient-scavenging-pathways/?p189984
1
8
9
reposted by
Matthias Krause
Vicki Metzis
4 months ago
I am absolutely delighted to share the invited speakers for our upcoming
@bsdb.bsky.social
"Molecules to Morphogenesis" meeting! Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
1
68
32
The cell dynamics conference in 2026 not to be missed: Dynamic Cell VI conference, Reading, UK, April 2026! Co-organised by
@bscb-official.bsky.social
and
@biochemsoc.bsky.social
with
@royalmicrosoc.bsky.social
and the Chinese Society for Cell Biology. Register now:
bit.ly/Dynamic-Cell-VI
4 months ago
0
2
2
reposted by
Matthias Krause
Krista Koeller
5 months ago
Dear funding agencies, I know we all want to discover the wonder drug that will cure the horrible diseases, but to do that, we need to invest in basic, unsexy, foundational research on how the systems work. Funding can’t all be drug development. Sincerely, Looking for basic research grants.
43
2303
401
reposted by
Matthias Krause
British Society for Cell Biology
5 months ago
Registration is OPEN for our Spring Meeting: Dynamic Cell VI co-organised with
@biochemsoc.bsky.social
@royalmicrosoc.bsky.social
and the Chinese Society for Cell Biology
add a skeleton here at some point
0
5
2
reposted by
Matthias Krause
bioRxiv Cell Biology
5 months ago
Optogenetic control of PLC-γ1 activity polarizes cell motility
https://www.biorxiv.org/content/10.1101/2025.10.09.681531v1
0
4
3
In our revised NHSL1/2-FEME manuscript led by
@jonny-cope.bsky.social
we provide the additional functional insights that NHSL1 is not required for Dynamin recruitment but promotes carrier formation in Fast Endophilin Mediated Endocytosis (FEME) by increasing actin polymerisation at sites of FEME.
loading . . .
Nance-Horan Syndrome-like 1 interacts with endophilin A2 and Ena/VASP proteins to promote fast endophilin-mediated endocytosis.
Endocytosis, crucial for various physiological processes, facilitates receptor and extracellular material uptake. Fast endophilin-mediated endocytosis (FEME), driven by endophilin A2 (EndoA2), enables...
https://www.biorxiv.org/content/10.1101/2024.10.23.619882v3
5 months ago
1
3
0
Register for the Dynamic Cell VI conference, Reading, UK, April 2026! This conference focusses on all aspects of cell dynamics, co-organised by
@bscb-official.bsky.social
and
@biochemsoc.bsky.social
with
@royalmicrosoc.bsky.social
and the Chinese Society for Cell Biology.
bit.ly/Dynamic-Cell-VI
5 months ago
1
28
25
reposted by
Matthias Krause
Ankita Jha
5 months ago
If anyone ever wants to brush up on a lot of cell migration concepts don't forget we have several wonderful scientists who have given talks previously in cell migration seminars. I find it so comforting to go look at old videos, maybe someone else who will do as well!!
youtube.com/@cellmigrati...
loading . . .
Cell Migration Seminars
Cell Migration Seminars every Tuesday at 16:00 BST.
https://youtube.com/@cellmigrationseminars4300?si=Ec_AanFyoUoqA0-4
1
43
12
reposted by
Matthias Krause
Siân Culley
5 months ago
BioImage analysis friends - King's are recruiting for a full-time, permanent facility position! Come and work with fun microscopes and fun people (and me!) - please share!
www.kcl.ac.uk/jobs/126345-...
loading . . .
Bioimage Analysis Specialist | King's College London
https://www.kcl.ac.uk/jobs/126345-bioimage-analysis-specialist
0
63
79
reposted by
Matthias Krause
Migle Gabrielaite
5 months ago
Next, at
#EYSF2025
@reviewcommons.org
is presented by
@saramonaco-rc.bsky.social
. It’s journal-agnostic, concentrates on science only and can save time as the peer-reviewed preprints can easily be resubmitted. How great would it be if we could ditch publishing and switch to reviewed preprints?
0
2
4
reposted by
Matthias Krause
A/Prof Sam Stehbens PhD (She/Her)
5 months ago
I’m not sure as a community we **truely** acknowledged how powerful the
#CellMigrationSeminarSeries
series was at keeping us connected at such an uncertain time. Thank-you
@ankita13jha.bsky.social
@adamshellard.bsky.social
@drjenmitchell.bsky.social
&
@simplythebex.bsky.social
add a skeleton here at some point
2
19
10
reposted by
Matthias Krause
Daniel J. Cohen (Princeton)
5 months ago
SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N
add a skeleton here at some point
4
62
30
reposted by
Matthias Krause
Karen J Liu
7 months ago
Dev biologists! 3-yr postdoc position at King's, collaboration with Trizzino lab
@marcotrizzino.bsky.social
modelling CHD3 neural crest. We are looking for postdocs with mad embryology skills
@the-node.bsky.social
#developmental
@ccrb27.bsky.social
thenode.biologists.com/jobs/postdoc...
loading . . .
Postdoctoral Research Associate: Modelling Neural Crest Anomalies (mouse/human) - the Node
The Liu lab is looking for a postdoc with a love of embryos and developmental biology! This post is part of an MRC-funded collaboration between Karen Liu’s lab at King’s College London and Marco Trizz...
https://thenode.biologists.com/jobs/postdoctoral-research-associate-modelling-neural-crest-anomalies-mouse-human/
0
39
45
reposted by
Matthias Krause
Christophe Le Clainche
7 months ago
🎓 My team is seeking a PhD student in Biochemistry & Cell Biology at I2BC, Paris-Saclay! 🔬 Study cytoskeletal signaling in collective cell migration 🌍 Fully funded, 3 yrs | 📍 Gif-sur-Yvette, France 🗓️ Apply by Aug 22 via the following link:
emploi.cnrs.fr/Offres/Docto...
0
13
15
reposted by
Matthias Krause
7 months ago
Drosophila as a model system to understand
#collagen
IV-related genetic disease. Learn how fly genetics and exploding brain tissue can inform on
#ECM
defects and pathological mechanisms. Team effort led by a very talented recent PhD graduate, Angus Nichols.
doi.org/10.1016/j.ma...
loading . . .
0
5
3
reposted by
Matthias Krause
Rockefeller University Press
8 months ago
In new
@jcb.org
study from Muziyue Wu et al.
@oweinerlab.bsky.social
, in vivo biochemistry sheds new light on how the WAVE complex templates the characteristic shape of lamellipodial protrusions.
rupress.org/jcb/article/...
#Cytoskeleton
#Actin
#Migration
#Motility
#Biophysics
0
10
6
reposted by
Matthias Krause
Juan Martin Serrano
8 months ago
I am so proud of
@jezcarlton.bsky.social
. What a magnificent inaugural lecture, many congratulations Professor Carlton!
2
102
10
reposted by
Matthias Krause
Anh Hoang Le, PhD 🏳️🌈
8 months ago
OMG, this is such a cool paper from Patrick Caswell's lab. They express Rab25-mCherry-GFP-nanobody in cells, microinject GFP-magnetic particles, then use a magnet to pull Rab25 to the plasma membrane to show that it can trigger actin protrusions! I want this system.
www.science.org/doi/10.1126/...
loading . . .
Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration
Repositioning of Rab25 vesicles containing formin and integrin cargos to the cell periphery promotes protrusion formation.
https://www.science.org/doi/10.1126/sciadv.adu6361
1
62
19
Manuscript from our lab on BioRxiv: We provide mechanistic insights that NHSL1 promotes Fast endophilin mediated carrier formation via both endophilin and Ena/VASP proteins thereby may facilitate membrane bending and Ena/VASP mediated actin polymerisation.
www.biorxiv.org/content/10.1...
loading . . .
Nance-Horan Syndrome-like 1 interacts with endophilin and Ena/VASP proteins to promote fast endophilin-mediated endocytosis
Endocytosis is crucial for various physiological processes, facilitating the uptake of membrane proteins and extracellular material. Fast endophilin-mediated endocytosis (FEME), driven by endophilin A (EndoA), enables clathrin-independent, ligand-induced receptor uptake at the leading edge of cells. Whilst F-actin polymerisation is essential for FEME, how actin dynamics are regulated at sites of FEME is unknown. NHSL1, a member of the Nance-Horan Syndrome protein family, localises to the leading edge of cells, where it regulates migration, and to vesicular puncta, where its function is undetermined. Here, we show that NHSL1 and its uncharacterised family member NHSL2 co-localise and engage in direct, multivalent interactions with EndoA. NHSL1 also binds Ena/VASP proteins, a family of actin elongators. NHSL1 promotes FEME in cells and its interactions with EndoA and Ena/VASP proteins are required for this function. Thus, NHSL1 may cooperate with EndoA and Ena/VASP proteins to control membrane invagination and actin polymerisation, thereby mediating FEME. ### Competing Interest Statement The authors have declared no competing interest.
https://www.biorxiv.org/content/10.1101/2024.10.23.619882v2
8 months ago
0
2
1
reposted by
Matthias Krause
Interested in applying for a Marie Skłodowska-Curie Postdoc Fellowship? Contact me for exciting postdoc projects in neural crest or cancer cell migration, endocytosis, advanced imaging at King’s College London.
[email protected]
marie-sklodowska-curie-actions.ec.europa.eu/actions/post...
loading . . .
Postdoctoral Fellowships
The information provided on this page is a summary of the main rules and requirements for Postdoctoral Fellowships (PFs) and who can apply for them.
https://marie-sklodowska-curie-actions.ec.europa.eu/actions/postdoctoral-fellowships
8 months ago
0
0
2
reposted by
Matthias Krause
New from our lab: We identify NHSL3 as a lamellipodial Ena/VASP and Scar/WAVE complex interacting protein binding the latter with a unique mode of interaction and inhibiting Arp2/3 complex activity but unexpectantly promoting mesenchymal cell migration efficiency.
www.biorxiv.org/content/10.1...
loading . . .
NHSL3 interacts with Ena/VASP proteins and the Scar/WAVE complex and promotes cell migration
Tight control of mesenchymal cell migration is important for embryonic development and its deregulation causes disease. It is driven by lamellipodia protrusion, the leading edge of the migrating cell....
https://www.biorxiv.org/content/10.1101/2025.04.03.647056v1
8 months ago
0
2
1
reposted by
Matthias Krause
Xavier Trepat
over 1 year ago
Pre-announcing the EMBO/EMBL symposium "Mechanobiology Across the Tree of Life", Heidelberg, 9-12 June 2026. It is still very very far away, but save the date 🗓️. With Alba Diz-Munoz,
@nicolettapetridou.bsky.social
, Kirsty Wan
@micromotility.bsky.social
, Enrique Rojas.
www.embl.org/about/info/c...
loading . . .
Mechanobiology across the tree of life
https://www.embl.org/about/info/course-and-conference-office/events/ees26-06/
4
172
80
reposted by
Matthias Krause
Triangle Cytoskeleton Meeting
8 months ago
🚨 Registration Now Open! 🚨 Join us for the 2025 Triangle Cytoskeleton Meeting on Sept. 15 at Trent Semans Center! Speakers: 🔬 Dr. Kris DeMali 🧫 Dr. Rae Cho 🧬 Dr. Stefanie Redemann Showcase your research, exchange ideas, and connect with the Cytoskeleton community! Register now! 💻
#TCM2025
1
3
5
Load more
feeds!
log in