Matthias Krause
@matthias-krause.bsky.social
📤 277
📥 363
📝 28
Cell migration and endocytosis research lab
https://cytoskeleton.wixsite.com/krauselab
pinned post!
Exciting new findings: Wnt-receptor endocytosis is required for canonical Wnt activation, yet uptake mechanisms has been controversial. We resolve this by showing that Wnt3a triggers rapid Clathrin- and Fast Endophilin-Mediated LRP6 endocytosis at low concentrations sufficient for Wnt activation.
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The Actin regulator Mena promotes Wnt signalosome endocytosis and Wnt signalling
Wnt signaling controls embryonic development and tissue maintenance. Endocytosis of Wnt-receptors is required for signalling, yet uptake mechanisms remain poorly understood. Here, we identify the acti...
https://www.biorxiv.org/content/10.1101/2025.11.24.690281v1
about 1 month ago
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British Society for Cell Biology
20 days ago
Don't forget to register for our Spring Meeting: Dynamic Cell VI A joint meeting with the
@biochemsoc.bsky.social
Super early bird registration ends 21st Jan
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Helen Matthews
19 days ago
Excited to be a speaker at Dynamic Cell VI. Always a great meeting
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Lucien Hinderling
6 months ago
PAPER OUT ✨ What if you could use your microscope as a 3D printer? Prototype microfluidics in-house, <5$ in material costs per chip. From idea to experiment within a day. Now published in Lab-on-a-Chip (open-access):
doi.org/10.1039/D5LC...
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epithelial mechanics fan club
24 days ago
Want even smaller features? We recently published a method to convert your microscope into a microfabrication station, printing features from μm to cm scale for less than $5 in materials per design. Thread:
bsky.app/profile/lhin...
Paper:
bsky.app/profile/epim...
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Romet/Jegou lab
28 days ago
📢 Deadline approaching fast 📢 to submit an abstract for the great cytoskeleton extravaganza!
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Michael Way
about 1 month ago
Are you interested in cytoskeleton and looking for a postdoc position? I will be advertising positions in the new year but happy to chat in person if you are attending ASCB
@ascbiology.bsky.social
in Philadelphia. Just drop me a line.
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Guillaume Jacquemet
about 1 month ago
Your periodic reminder that science is not done by a few selected "stars scientists". Science is done by hundred of thousands. Siloed money mean a few flashy discoveries and a lot of waste. Want to change things? Make funding accessible and stop funding calls with less than 2% success rate.
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Early bird registration: Save £100 - 21 January 2026! Dynamic Cell VI conference, Reading, UK, April 2026! Co-organised by
@bscb-official.bsky.social
and
@biochemsoc.bsky.social
with
@royalmicrosoc.bsky.social
and the Chinese Society for Cell Biology. Register now:
bit.ly/Dynamic-Cell-VI
about 1 month ago
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Exciting new findings: Wnt-receptor endocytosis is required for canonical Wnt activation, yet uptake mechanisms has been controversial. We resolve this by showing that Wnt3a triggers rapid Clathrin- and Fast Endophilin-Mediated LRP6 endocytosis at low concentrations sufficient for Wnt activation.
loading . . .
The Actin regulator Mena promotes Wnt signalosome endocytosis and Wnt signalling
Wnt signaling controls embryonic development and tissue maintenance. Endocytosis of Wnt-receptors is required for signalling, yet uptake mechanisms remain poorly understood. Here, we identify the acti...
https://www.biorxiv.org/content/10.1101/2025.11.24.690281v1
about 1 month ago
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Matthias Krause
Maik Bischoff
about 1 month ago
Super proud to be part of SFB1348 — and excited to share that I now officially have my own lab in Münster! 🎉🪰 We’ll study
#cellbio
&
#morphogenesis
, focusing on organ sculpting and
#chirality
in
#Drosophila
. I’ll soon hire my first
#PhD
student — feel free to reach out!
#juniorPI
#Science
#devbio
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Karen J Liu
about 1 month ago
Exciting new findings on mechanisms of Wnt signalosomes --from Sheng-yuan Wu's PhD project in
@matthias-krause.bsky.social
lab! Great collaborators, great story.
#xenopus
🐸
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Endocytosis of Wnt-receptors is required for signalling, yet uptake mechanisms remain poorly understood. We resolve a longstanding controversy by showing that Wnt3a triggers rapid Clathrin-Mediated and Fast Endophilin-Mediated LRP6 endocytosis at low concentrations sufficient for Wnt activation.
about 1 month ago
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Grill Lab @ MPI-CBG
2 months ago
The Lab of Stephan Grill at MPI-CBG has finally made it to Bluesky and we also have a brand new homepage:
grill-lab.org
Check it out.
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Rainero lab
2 months ago
📣 Fully funded PhD position available in collaboration with
@jasonkinglab.bsky.social
in
@mcb-sheffield.bsky.social
BBSRC Yorkshire Bioscience DLA Programme: How do cells coordinate nutrient scavenging pathways? 📅 Deadline: 7th January 2026 More info 👇
www.findaphd.com/phds/project...
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BBSRC Yorkshire Bioscience DLA Programme: How do cells coordinate nutrient scavenging pathways? at University of Sheffield on FindAPhD.com
PhD Project - BBSRC Yorkshire Bioscience DLA Programme: How do cells coordinate nutrient scavenging pathways? at University of Sheffield, listed on FindAPhD.com
https://www.findaphd.com/phds/project/bbsrc-yorkshire-bioscience-dla-programme-how-do-cells-coordinate-nutrient-scavenging-pathways/?p189984
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Vicki Metzis
3 months ago
I am absolutely delighted to share the invited speakers for our upcoming
@bsdb.bsky.social
"Molecules to Morphogenesis" meeting! Registration and abstract submission is now open - join us!
bsdb.org/meetings/
March 23-26, 2026 - UK
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The cell dynamics conference in 2026 not to be missed: Dynamic Cell VI conference, Reading, UK, April 2026! Co-organised by
@bscb-official.bsky.social
and
@biochemsoc.bsky.social
with
@royalmicrosoc.bsky.social
and the Chinese Society for Cell Biology. Register now:
bit.ly/Dynamic-Cell-VI
3 months ago
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Krista Koeller
3 months ago
Dear funding agencies, I know we all want to discover the wonder drug that will cure the horrible diseases, but to do that, we need to invest in basic, unsexy, foundational research on how the systems work. Funding can’t all be drug development. Sincerely, Looking for basic research grants.
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British Society for Cell Biology
3 months ago
Registration is OPEN for our Spring Meeting: Dynamic Cell VI co-organised with
@biochemsoc.bsky.social
@royalmicrosoc.bsky.social
and the Chinese Society for Cell Biology
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bioRxiv Cell Biology
3 months ago
Optogenetic control of PLC-γ1 activity polarizes cell motility
https://www.biorxiv.org/content/10.1101/2025.10.09.681531v1
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In our revised NHSL1/2-FEME manuscript led by
@jonny-cope.bsky.social
we provide the additional functional insights that NHSL1 is not required for Dynamin recruitment but promotes carrier formation in Fast Endophilin Mediated Endocytosis (FEME) by increasing actin polymerisation at sites of FEME.
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Nance-Horan Syndrome-like 1 interacts with endophilin A2 and Ena/VASP proteins to promote fast endophilin-mediated endocytosis.
Endocytosis, crucial for various physiological processes, facilitates receptor and extracellular material uptake. Fast endophilin-mediated endocytosis (FEME), driven by endophilin A2 (EndoA2), enables...
https://www.biorxiv.org/content/10.1101/2024.10.23.619882v3
3 months ago
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Register for the Dynamic Cell VI conference, Reading, UK, April 2026! This conference focusses on all aspects of cell dynamics, co-organised by
@bscb-official.bsky.social
and
@biochemsoc.bsky.social
with
@royalmicrosoc.bsky.social
and the Chinese Society for Cell Biology.
bit.ly/Dynamic-Cell-VI
3 months ago
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Ankita Jha
3 months ago
If anyone ever wants to brush up on a lot of cell migration concepts don't forget we have several wonderful scientists who have given talks previously in cell migration seminars. I find it so comforting to go look at old videos, maybe someone else who will do as well!!
youtube.com/@cellmigrati...
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Cell Migration Seminars
Cell Migration Seminars every Tuesday at 16:00 BST.
https://youtube.com/@cellmigrationseminars4300?si=Ec_AanFyoUoqA0-4
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Siân Culley
3 months ago
BioImage analysis friends - King's are recruiting for a full-time, permanent facility position! Come and work with fun microscopes and fun people (and me!) - please share!
www.kcl.ac.uk/jobs/126345-...
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Bioimage Analysis Specialist | King's College London
https://www.kcl.ac.uk/jobs/126345-bioimage-analysis-specialist
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Migle Gabrielaite
3 months ago
Next, at
#EYSF2025
@reviewcommons.org
is presented by
@saramonaco-rc.bsky.social
. It’s journal-agnostic, concentrates on science only and can save time as the peer-reviewed preprints can easily be resubmitted. How great would it be if we could ditch publishing and switch to reviewed preprints?
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A/Prof Sam Stehbens PhD (She/Her)
3 months ago
I’m not sure as a community we **truely** acknowledged how powerful the
#CellMigrationSeminarSeries
series was at keeping us connected at such an uncertain time. Thank-you
@ankita13jha.bsky.social
@adamshellard.bsky.social
@drjenmitchell.bsky.social
&
@simplythebex.bsky.social
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Daniel J. Cohen (Princeton)
4 months ago
SCHEPHERD--the bioelectric cell herding platform built for YOU. Single cells, monolayers, organoids--this herds them all + new tricks. Plz try it-- we will *give* you parts! Teaser here of a steering a single cell. GS Yubin Lin's lifeblood with J. Yodh on piano; Celeste R. and Paul K. Thread 1/N
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Karen J Liu
5 months ago
Dev biologists! 3-yr postdoc position at King's, collaboration with Trizzino lab
@marcotrizzino.bsky.social
modelling CHD3 neural crest. We are looking for postdocs with mad embryology skills
@the-node.bsky.social
#developmental
@ccrb27.bsky.social
thenode.biologists.com/jobs/postdoc...
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Postdoctoral Research Associate: Modelling Neural Crest Anomalies (mouse/human) - the Node
The Liu lab is looking for a postdoc with a love of embryos and developmental biology! This post is part of an MRC-funded collaboration between Karen Liu’s lab at King’s College London and Marco Trizz...
https://thenode.biologists.com/jobs/postdoctoral-research-associate-modelling-neural-crest-anomalies-mouse-human/
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Christophe Le Clainche
5 months ago
🎓 My team is seeking a PhD student in Biochemistry & Cell Biology at I2BC, Paris-Saclay! 🔬 Study cytoskeletal signaling in collective cell migration 🌍 Fully funded, 3 yrs | 📍 Gif-sur-Yvette, France 🗓️ Apply by Aug 22 via the following link:
emploi.cnrs.fr/Offres/Docto...
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Matthias Krause
5 months ago
Drosophila as a model system to understand
#collagen
IV-related genetic disease. Learn how fly genetics and exploding brain tissue can inform on
#ECM
defects and pathological mechanisms. Team effort led by a very talented recent PhD graduate, Angus Nichols.
doi.org/10.1016/j.ma...
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Rockefeller University Press
6 months ago
In new
@jcb.org
study from Muziyue Wu et al.
@oweinerlab.bsky.social
, in vivo biochemistry sheds new light on how the WAVE complex templates the characteristic shape of lamellipodial protrusions.
rupress.org/jcb/article/...
#Cytoskeleton
#Actin
#Migration
#Motility
#Biophysics
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Juan Martin Serrano
6 months ago
I am so proud of
@jezcarlton.bsky.social
. What a magnificent inaugural lecture, many congratulations Professor Carlton!
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Anh Hoang Le, PhD 🏳️🌈
6 months ago
OMG, this is such a cool paper from Patrick Caswell's lab. They express Rab25-mCherry-GFP-nanobody in cells, microinject GFP-magnetic particles, then use a magnet to pull Rab25 to the plasma membrane to show that it can trigger actin protrusions! I want this system.
www.science.org/doi/10.1126/...
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Live-cell magnetic manipulation of recycling endosomes reveals their direct effect on actin protrusions to promote invasive migration
Repositioning of Rab25 vesicles containing formin and integrin cargos to the cell periphery promotes protrusion formation.
https://www.science.org/doi/10.1126/sciadv.adu6361
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Manuscript from our lab on BioRxiv: We provide mechanistic insights that NHSL1 promotes Fast endophilin mediated carrier formation via both endophilin and Ena/VASP proteins thereby may facilitate membrane bending and Ena/VASP mediated actin polymerisation.
www.biorxiv.org/content/10.1...
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Nance-Horan Syndrome-like 1 interacts with endophilin and Ena/VASP proteins to promote fast endophilin-mediated endocytosis
Endocytosis is crucial for various physiological processes, facilitating the uptake of membrane proteins and extracellular material. Fast endophilin-mediated endocytosis (FEME), driven by endophilin A (EndoA), enables clathrin-independent, ligand-induced receptor uptake at the leading edge of cells. Whilst F-actin polymerisation is essential for FEME, how actin dynamics are regulated at sites of FEME is unknown. NHSL1, a member of the Nance-Horan Syndrome protein family, localises to the leading edge of cells, where it regulates migration, and to vesicular puncta, where its function is undetermined. Here, we show that NHSL1 and its uncharacterised family member NHSL2 co-localise and engage in direct, multivalent interactions with EndoA. NHSL1 also binds Ena/VASP proteins, a family of actin elongators. NHSL1 promotes FEME in cells and its interactions with EndoA and Ena/VASP proteins are required for this function. Thus, NHSL1 may cooperate with EndoA and Ena/VASP proteins to control membrane invagination and actin polymerisation, thereby mediating FEME. ### Competing Interest Statement The authors have declared no competing interest.
https://www.biorxiv.org/content/10.1101/2024.10.23.619882v2
6 months ago
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Interested in applying for a Marie Skłodowska-Curie Postdoc Fellowship? Contact me for exciting postdoc projects in neural crest or cancer cell migration, endocytosis, advanced imaging at King’s College London.
[email protected]
marie-sklodowska-curie-actions.ec.europa.eu/actions/post...
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Postdoctoral Fellowships
The information provided on this page is a summary of the main rules and requirements for Postdoctoral Fellowships (PFs) and who can apply for them.
https://marie-sklodowska-curie-actions.ec.europa.eu/actions/postdoctoral-fellowships
6 months ago
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New from our lab: We identify NHSL3 as a lamellipodial Ena/VASP and Scar/WAVE complex interacting protein binding the latter with a unique mode of interaction and inhibiting Arp2/3 complex activity but unexpectantly promoting mesenchymal cell migration efficiency.
www.biorxiv.org/content/10.1...
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NHSL3 interacts with Ena/VASP proteins and the Scar/WAVE complex and promotes cell migration
Tight control of mesenchymal cell migration is important for embryonic development and its deregulation causes disease. It is driven by lamellipodia protrusion, the leading edge of the migrating cell....
https://www.biorxiv.org/content/10.1101/2025.04.03.647056v1
6 months ago
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Matthias Krause
Xavier Trepat
about 1 year ago
Pre-announcing the EMBO/EMBL symposium "Mechanobiology Across the Tree of Life", Heidelberg, 9-12 June 2026. It is still very very far away, but save the date 🗓️. With Alba Diz-Munoz,
@nicolettapetridou.bsky.social
, Kirsty Wan
@micromotility.bsky.social
, Enrique Rojas.
www.embl.org/about/info/c...
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Mechanobiology across the tree of life
https://www.embl.org/about/info/course-and-conference-office/events/ees26-06/
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Triangle Cytoskeleton Meeting
6 months ago
🚨 Registration Now Open! 🚨 Join us for the 2025 Triangle Cytoskeleton Meeting on Sept. 15 at Trent Semans Center! Speakers: 🔬 Dr. Kris DeMali 🧫 Dr. Rae Cho 🧬 Dr. Stefanie Redemann Showcase your research, exchange ideas, and connect with the Cytoskeleton community! Register now! 💻
#TCM2025
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Matthias Krause
Felix Campelo
6 months ago
Announcing a new
@embo.org
Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at
@icfo.eu
(Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏
#EMBOmechanobio
meetings.embo.org/event/26-org...
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Intracellular mechanics and organelle mechanobiology
Mechanobiology is an interdisciplinary field that emerges at the cross-section of biology, physics and engineering. It aims to understand how living cells, tissues and animals sense and respond to me…
https://meetings.embo.org/event/26-organelle-mechanobiology
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Interested in applying for a Marie Skłodowska-Curie Postdoc Fellowship? Contact me for exciting postdoc projects in neural crest or cancer cell migration, endocytosis, advanced imaging at King’s College London.
[email protected]
marie-sklodowska-curie-actions.ec.europa.eu/actions/post...
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Postdoctoral Fellowships
The information provided on this page is a summary of the main rules and requirements for Postdoctoral Fellowships (PFs) and who can apply for them.
https://marie-sklodowska-curie-actions.ec.europa.eu/actions/postdoctoral-fellowships
6 months ago
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Matthias Krause
New manuscript from our lab: Fast Endophilin Mediated Endocytosis (FEME), facilitates ligand induced endocytosis of a variety of receptors at the leading edge of migrating cells. The mechanism behind how FEME priming patches form is emerging.
about 1 year ago
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Matthias Krause
Another new manuscript from our lab and excellent collaboration with the Bear lab
@coronin.bsky.social
: The Scar/WAVE complex promotes mesenchymal cell migration through Arp2/3 mediated lamellipodia protrusion.
10 months ago
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New from our lab: We identify NHSL3 as a lamellipodial Ena/VASP and Scar/WAVE complex interacting protein binding the latter with a unique mode of interaction and inhibiting Arp2/3 complex activity but unexpectantly promoting mesenchymal cell migration efficiency.
www.biorxiv.org/content/10.1...
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NHSL3 interacts with Ena/VASP proteins and the Scar/WAVE complex and promotes cell migration
Tight control of mesenchymal cell migration is important for embryonic development and its deregulation causes disease. It is driven by lamellipodia protrusion, the leading edge of the migrating cell....
https://www.biorxiv.org/content/10.1101/2025.04.03.647056v1
6 months ago
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Matthias Krause
Robert Insall
6 months ago
All three kids degreed up & off for gainful employment now...
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Guillaume Jacquemet
6 months ago
- A postdoc to work on cancer extravasation (4-year project). - A postdoc help in completing Filopodia-related lab projects (2-year). - Multiple Marie Curie postdoc positions that will open in the fall. - We will open a 5-year position to cover my teaching (70% research and 30% teaching).
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Guillaume Jacquemet
7 months ago
Are you looking for a postdoc? I will be looking for 2-4 people after the summer to join the lab !! Do not hesitate to reach out and disseminate !!
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7 months ago
Doctoral (PhD) student position available - epithelial-immune cell interactions in Drosophila wounding
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This Friday, UK Cell Motility Club symposium in Cambridge, UK: exciting PhD student and Postdoc speaker line up! A few last minute spots available. Follow us on
@uk-cmc.bsky.social
cytoskeleton.wixsite.com/londoncellmo...
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HOME | londoncellmotility
https://cytoskeleton.wixsite.com/londoncellmotility
7 months ago
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Susana Godinho
7 months ago
👋 Are you looking for a postdoc position? Do you think microtubules are fascinating? Then we might have the job for you! 2-year funded postdoc to join our lab! 👉 deadline 20/06 👇 check it out
www.godinholab.com
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Elena Scarpa & The Squeezable Cells Lab
7 months ago
Very excited to share the first preprint from the lab:
www.biorxiv.org/cgi/content/...
We investigated neural crest migration all the way from head to tail of the Zebrafish embryo and we found their nuclei suffer dramatic deformations. Want to know of they cope with feeling squeezed? 🐟🐠🐟
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Carsten Schulte
7 months ago
#Science
Bluesky, do your thing: We're organising the International Symposium on Mechanobiology (ISMB) 2026 in
#Glasgow
& we're looking for research groups in Latin America & Africa who are doing great work in
#Mechanobiology
or adjacent areas. Can you indicate some names to me?
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