How does Ras signalling affect actin? Some answers in a new review from Joe Tyler & I @mcb-sheffield.bsky.social authors.elsevier.com/a/1m8v-3PA3s... We discuss how Ras proteins coordinate local and global changes to the actin cytoskeleton and contribute to cytoskeletal plasticity in cancer.

On World Pancreatic Cancer Day, the Sheffield Pancreatic Cancer Interest Network hosted a successful bake sale to raise funds and awareness for PCUK. Thank you to all who participated and supported our efforts. #WorldPancreaticCancerDay

Another fantastic set of talks at the 7th Sheffield Pancreatic Cancer Research Interest Network. A big thank you to Stephen Bradley and Ifeoluwa Oyelade for sharing their inspiring research. #PancreaticCancer #CancerResearch

A beautiful and inspiring location for the #TargetingRAS2025 conference. The pace of discovery in the field is truly astounding. It was such a pleasure to share ideas and meet some great people. #Salamanca #RAS #Biology #CancerBiology

What happens to packed cells in a monolayer during mitosis? @rlawson954.bsky.social presented varying experiments investigating shape and force changes, cell-cell junctions, and mechanics in mitotic cells, suggesting important roles for keratin and desmosomes #MBIMPG2025 @helenkmatthews.bsky.social

Interested in Pancreatic Cancer Research? We are gearing up to host our 7th Sheffield Pancreatic Cancer Research Network meeting! Check out the details at: sites.google.com/sheffield.ac... @mcb-sheffield.bsky.social @fohsheffield.bsky.social

Two fantastic talks at the 6th Pancreatic Cancer Research Network meeting by Megan Poxon and @isabelladavis00.bsky.social . Fancy speaking at the next one? Just get in touch! p.s. Don't forget to check out our new website 🔬https://sites.google.com/sheffield.ac.uk/pancreatic-cancer-network/home

Great talks by PhD students @isabelladavis00.bsky.social and Meg at the Sheffield Pancreatic Cancer Research Network meeting 👏

A beautiful day in the sunshine for our lovely lab summer social ☀️ @isabelladavis00.bsky.social @helenkmatthews.bsky.social @rlawson954.bsky.social

Last day of the #SmallGproteins meeting, great evening last night meeting researchers in the field hearing about people’s journeys, and gave advice on expressing a phosphorylated GTPase. Looking forward to Session 6 kicked off by @vickysanzmoreno.bsky.social! @biochemsoc.bsky.social #BiochemEvent

Now some adhesion and migration at #SGP25 🔬 hunting for Ras allies 🧫 polarised trafficking regulation adaptability during change 🧬 RhoA and Cdc42 pathway crosstalk Now onto the party! @biochemsoc.bsky.social #BiochemEvent

Now some adhesion and migration at #SGP25 🔬mechanosensing in cancer development 🧫 Rac1 driven plasticity in small cell lung cancer 🧬 actin in organelle transport 🧪 tool development to study spatial organisation of receptors @biochemsoc.bsky.social #BiochemEvent

Moving to a translational space 🔬 how we can revitalise therapies in response to resistance to Ras inhibitors 🧫 Arf6 alters matrix for metastatic niche in ovarian cancer 🧬 Novel phosphorylation regulates Arfs 🧪 Rac1 involvement in breast cancer metastases @biochemsoc.bsky.social #BiochemEvent

As day 3 of #SGP25 opens we heard brilliants talks covering… 🔬Ras lipid sensing to control localisation 🧫 Rnd3/RhoE importance in hepatocellular carcinoma 🔥 the role of Cdc42 in inflammation in response to wildfire smoke 🧪 the RhoA mutational landscape @biochemsoc.bsky.social #BiochemEvent

Next, we look at how to target our small G proteins 🔬innovations in the targeting of Ras from Revolution Medicines 🧫 translating non-canonical functions of kRas to find targeting combinations 🧬 developing and testing a GAP glue 🧪 mutant and WT Ras crosstalk @biochemsoc.bsky.social #BiochemEvent

As a side what a beautiful site for a conference, flowers everywhere in the sunshine ☀️ @biochemsoc.bsky.social #BiochemEvent

And we continue #SGP25 with 🔬RAP1GDS1 isoform specific importance in lung cancer 🧫 how kRas oncogenic enhanced proliferation can occur without hyperactive ERK or Akt 🧬 RhoGAP family interactions in endometrial cancer @biochemsoc.bsky.social #BiochemEvent

SGP25 Session 2 (Part 1): ⚙️ “Branchgetic” Ras mutations indicate effector selection 🔬 RAF biosensors to monitor acivity in live cells 💥 C2 domain boosts RasGAP activity 💊 RhoB-Ral complex a target for EGFR TK inhibition? @biochemsoc.bsky.social #BiochemEvent

Day 2 of #SGP25 of to a great start with ✨ unpicking Ras effector binding in different tissues ✨ developing RAF based biosensors ✨ C2 domains and GAP functionality ✨ how RhoB and Ral affect EGFT therapy in lung cancer @Biochemsoc #BiochemEvent

SGP25 Session 1 (Part 1): ⛓️ Mapping KRAS interactomes in organoid models 🧬 Isoform-specific KRAS vulnerabilities: one mutation, big difference 🔬 Novel tool tracks Ras mutation dynamics in vivo ✨ And a reminder that clear science communication empowers patients! @biochemsoc.bsky.social #BiochemEvent

Excited to be selected as a Social Media Contributor for Small G proteins in cellular signalling and disease 2025! 🧬 Follow along for insights into how these tiny but mighty proteins shape health and disease! #BiochemEvent @BiochemSoc #SmallGProteins #CellBiology #SciComm

I am excited to share our new Sheffield Pancreatic Cancer Research Network website! Please check it out at... sites.google.com/sheffield.ac... @fohsheffield.bsky.social @mcb-sheffield.bsky.social

A brilliant talk that sparked great discussions!

Great to hear about the research going on in @mcb-sheffield.bsky.social at University of Sheffield. Short talks from @helenkmatthews.bsky.social and @erainerolab.bsky.social about the projects going on in their labs 😊

loved having to opportunity to discuss our work and have plenty of great suggestions! #biologists100

Excited to be in the lovely Liverpool for the 100 year anniversary of the @biologists.bsky.social.