Another fantastic set of talks at the 7th Sheffield Pancreatic Cancer Research Interest Network. A big thank you to Stephen Bradley and Ifeoluwa Oyelade for sharing their inspiring research. #PancreaticCancer #CancerResearch

A beautiful and inspiring location for the #TargetingRAS2025 conference. The pace of discovery in the field is truly astounding. It was such a pleasure to share ideas and meet some great people. #Salamanca #RAS #Biology #CancerBiology

What happens to packed cells in a monolayer during mitosis? @rlawson954.bsky.social presented varying experiments investigating shape and force changes, cell-cell junctions, and mechanics in mitotic cells, suggesting important roles for keratin and desmosomes #MBIMPG2025 @helenkmatthews.bsky.social

Interested in Pancreatic Cancer Research? We are gearing up to host our 7th Sheffield Pancreatic Cancer Research Network meeting! Check out the details at: sites.google.com/sheffield.ac... @mcb-sheffield.bsky.social @fohsheffield.bsky.social

Two fantastic talks at the 6th Pancreatic Cancer Research Network meeting by Megan Poxon and @isabelladavis00.bsky.social . Fancy speaking at the next one? Just get in touch! p.s. Don't forget to check out our new website 🔬https://sites.google.com/sheffield.ac.uk/pancreatic-cancer-network/home

Great talks by PhD students @isabelladavis00.bsky.social and Meg at the Sheffield Pancreatic Cancer Research Network meeting 👏

A beautiful day in the sunshine for our lovely lab summer social ☀️ @isabelladavis00.bsky.social @helenkmatthews.bsky.social @rlawson954.bsky.social

Last day of the #SmallGproteins meeting, great evening last night meeting researchers in the field hearing about people’s journeys, and gave advice on expressing a phosphorylated GTPase. Looking forward to Session 6 kicked off by @vickysanzmoreno.bsky.social! @biochemsoc.bsky.social #BiochemEvent

Now some adhesion and migration at #SGP25 🔬 hunting for Ras allies 🧫 polarised trafficking regulation adaptability during change 🧬 RhoA and Cdc42 pathway crosstalk Now onto the party! @biochemsoc.bsky.social #BiochemEvent

Now some adhesion and migration at #SGP25 🔬mechanosensing in cancer development 🧫 Rac1 driven plasticity in small cell lung cancer 🧬 actin in organelle transport 🧪 tool development to study spatial organisation of receptors @biochemsoc.bsky.social #BiochemEvent

Moving to a translational space 🔬 how we can revitalise therapies in response to resistance to Ras inhibitors 🧫 Arf6 alters matrix for metastatic niche in ovarian cancer 🧬 Novel phosphorylation regulates Arfs 🧪 Rac1 involvement in breast cancer metastases @biochemsoc.bsky.social #BiochemEvent

As day 3 of #SGP25 opens we heard brilliants talks covering… 🔬Ras lipid sensing to control localisation 🧫 Rnd3/RhoE importance in hepatocellular carcinoma 🔥 the role of Cdc42 in inflammation in response to wildfire smoke 🧪 the RhoA mutational landscape @biochemsoc.bsky.social #BiochemEvent

Next, we look at how to target our small G proteins 🔬innovations in the targeting of Ras from Revolution Medicines 🧫 translating non-canonical functions of kRas to find targeting combinations 🧬 developing and testing a GAP glue 🧪 mutant and WT Ras crosstalk @biochemsoc.bsky.social #BiochemEvent

As a side what a beautiful site for a conference, flowers everywhere in the sunshine ☀️ @biochemsoc.bsky.social #BiochemEvent

And we continue #SGP25 with 🔬RAP1GDS1 isoform specific importance in lung cancer 🧫 how kRas oncogenic enhanced proliferation can occur without hyperactive ERK or Akt 🧬 RhoGAP family interactions in endometrial cancer @biochemsoc.bsky.social #BiochemEvent

SGP25 Session 2 (Part 1): ⚙️ “Branchgetic” Ras mutations indicate effector selection 🔬 RAF biosensors to monitor acivity in live cells 💥 C2 domain boosts RasGAP activity 💊 RhoB-Ral complex a target for EGFR TK inhibition? @biochemsoc.bsky.social #BiochemEvent

Day 2 of #SGP25 of to a great start with ✨ unpicking Ras effector binding in different tissues ✨ developing RAF based biosensors ✨ C2 domains and GAP functionality ✨ how RhoB and Ral affect EGFT therapy in lung cancer @Biochemsoc #BiochemEvent

SGP25 Session 1 (Part 1): ⛓️ Mapping KRAS interactomes in organoid models 🧬 Isoform-specific KRAS vulnerabilities: one mutation, big difference 🔬 Novel tool tracks Ras mutation dynamics in vivo ✨ And a reminder that clear science communication empowers patients! @biochemsoc.bsky.social #BiochemEvent

Excited to be selected as a Social Media Contributor for Small G proteins in cellular signalling and disease 2025! 🧬 Follow along for insights into how these tiny but mighty proteins shape health and disease! #BiochemEvent @BiochemSoc #SmallGProteins #CellBiology #SciComm

I am excited to share our new Sheffield Pancreatic Cancer Research Network website! Please check it out at... sites.google.com/sheffield.ac... @fohsheffield.bsky.social @mcb-sheffield.bsky.social

A brilliant talk that sparked great discussions!

Great to hear about the research going on in @mcb-sheffield.bsky.social at University of Sheffield. Short talks from @helenkmatthews.bsky.social and @erainerolab.bsky.social about the projects going on in their labs 😊

loved having to opportunity to discuss our work and have plenty of great suggestions! #biologists100

Excited to be in the lovely Liverpool for the 100 year anniversary of the @biologists.bsky.social.