Diaz and @mayorlab.bsky.social show that epithelial and mesenchymal cells navigate chemical cues via fundamentally different force-generating mechanisms, offering new insight into how diverse cell types achieve collective movement during development and disease. rupress.org/jcb/article/...

Honored to see our work featured in a JCB Spotlight by Pacheco and @drericabiophd.bsky.social (@UCSF). The piece discusses our study revealing distinct force-generating mechanisms in epithelial and mesenchymal collective migration 🔬🐸 Thank you for your careful review of our work! hubs.la/Q042GFYY0

So proud to share my paper on collective chemotaxis and force coordination in epithelial and mesenchymal cells, developed in the Mayor Lab and now published in JCB. Deeply grateful for everything I learned from Xenopus NC and the amphibian world, where adaptation is everything🐸

A new paper published in @jcb.org by postdoc Jorge Diaz from the Mayor lab at UCL shows that during collective migration, epithelial-like clusters generate traction force mainly through cryptic protrusions at the centre, while mesenchymal clusters do so at their periphery: doi.org/10.1083/jcb....