#onlywithHCR: Diaz Soria et al. used scRNA-seq with #HCRtechnology to build a cellular atlas of the mother sporocyst, spatially validating 6 major cell types and revealing key regulators of early parasite growth and snail-host interaction. Read the full study @nature.com: tinyurl.com/bp7dbsjx

Get Cozy this December! 🧦 Every order placed in December will come with a free pair of exclusive MI socks, while supplies last. Don't miss your chance to snag this limited-time treat! Order here: www.molecularinstruments.com/shop

What an exciting meeting at this month’s Gene Expression and RNA Series (GEARS) in Boston! Thank you to everyone who joined us for an introduction to the HCR™ platform. Special shoutout to @xiaoliwu.bsky.social, jonmarkert.bsky.social, and @ara-latifkar.bsky.social for helping coordinate the event!

This year's SfN was a valuable opportunity to connect with the neuroscience community, share our latest work, and demonstrate how the HCR™ HiFi Encoder supports more adaptable multiplex IF. Thank you to everyone who stopped by! We look forward to seeing you all again at future meetings.

With the HCR™ HiFi Encoder, @dhouston.bsky.social (@uiowabiology.bsky.social) ran two @dshb-antibodies.bsky.social mouse IgG1 antibodies directly from supernatant and achieved robust double-labeling using HCR™ Gold IF. 🔬 Ready to try HCR™ Gold IF? Get a free Starter Kit here: tinyurl.com/37dfdenf

We can't wait to be at SFN this year! Visit Booth #833, and see how HCR™ technology is empowering researchers to advance discoveries in neuroscience! Come chat with our team, and discover how MI can support your next breakthrough.

🪧 SITC Poster Spotlight In our final SITC Poster Spotlight, we showcased the newly launched HCR™ HiFi Encoders and their ability to enable rapid, flexible multiplex IF with off-the-shelf antibodies –– no carrier-free or glycerol-free storage media required. 🔬Read more: tinyurl.com/5dn5y4a4

🪧 SITC Poster Spotlight Our next spotlight establishes an RNA-first translational workflow for diagnostic development with the lateral flow assay. This poster highlights how the HCR™ platform facilitates molecular tracking from discovery to clinical diagnostics. 🔬Read more: tinyurl.com/5dn5y4a4

🪧 SITC Poster Spotlight Last weekend, we shared how the next-gen HCR™ HiFi Probe architecture enables background-suppressed in situ detection of short RNA targets by integrating full-length HCR™ initiators with a novel background suppression strategy. 🔬Check out the poster: tinyurl.com/5dn5y4a4

#onlywithHCR: Goldman et al. created the Aedes aegypti Mosquito Cell Atlas, revealing novel cell types, the organization of sensory neuron chemoreceptors, and sexually dimorphic gene expression in the antenna and brain. 🦟 Read more: tinyurl.com/2rtk4bz2

We’re thrilled to be attending #SITC2025 this year! Visit us at Booth #626 and don’t miss our poster presentations, as we’ll be sharing exciting new findings and real-world applications! 🗓️ Friday (Nov 7) — Abstract #171 & Abstract #75 🗓️ Saturday (Nov 8) — Abstract #68

#BehindMI: Meet Sulan Wu and Adam Maddox, two of the leaders on our Operations Strategy Team, who guide cross-functional coordination, optimize processes, and strengthen product validation. Their work positions MI to support cutting-edge research around the world with speed, reliability, and scale!

Happy Halloween from the MI team! Check out this spooky-themed rat hippocampus image by Jamuna Tandukar using #HCRimaging. 🧠 🟣 Mettl3 ⚪️ astrocytes 🟢 nuclei 🟠 rRNA

#onlywithHCR: Gillis et al. used #HCRtechnology to visualize gene expression during gill slit formation in skate embryos, revealing a precise sequence of epithelial interactions between the endoderm and ectoderm. 🔬 Read more: tinyurl.com/3mvj2wu2

Fast. Simple. High-fidelity IF. The HCR™ HiFi Encoder gives you the power to encode any unmodified primary in just 10 minutes at RT. Use your existing antibodies and achieve high-fidelity multiplex IF with HCR™ Gold. 🔬Place your HCR™ Gold IF order here: tinyurl.com/57f8nmb8

We’re proud to partner with Abcam to make multiplex IF simpler, faster, and more flexible! The HCR™ HiFi Encoder offers broad compatibility with Abcam’s primary antibodies, providing HCR™ Gold amplification for the antibodies you already know and trust. Full press release: tinyurl.com/5a43h8cr

#onlywithHCR: Rajan et al. illuminated how multicellular dynamics shape olfactory neurogenesis in zebrafish. These findings show how coordinated signaling supports ongoing neuron production in a complex organ system. Read more: tinyurl.com/3tpmf4v3

🚀The HCR™ HiFi Encoder is now live, bringing plug-and-play practicality to multiplex IF. ✅ Multiplex same-species primaries, no cross-reactivity ✅ Encode in 10 min at RT, no affinity loss ✅ Unlock high-fidelity amplification with HCR™ Gold 🛒Order today: tinyurl.com/mr4295e6

#onlywithHCR: Romero et al. explored how pathogenic TP53 variants contribute to congenital anomalies of the kidney and urinary tract and genital defects. Using Xenopus embryos, they observed that the expression of mutant TP53 disrupted kidney morphogenesis. Read more here: tinyurl.com/mr3yfwzy

Episode 2 of the HCR™ HiFi Encoder series is now live! This time, we’re walking through the entire encoding protocol from start to finish. See just how easy it is to integrate into your workflow: no purification, no conjugation, only 10 minutes at room temperature. www.youtube.com/watch?v=1rRJ...

Check out this whole-mount fruit fly image from Dr. Nipam Patel and Saanvi Turki, powered by the HCR™ HiFi Encoder. With the Encoder, you can functionalize any unmodified primary antibody with no purification, no reformulation, and no signal loss. 🔬Pre-order the Launch Edition: tinyurl.com/mr4295e6

#BehindMI: Meet Mohamad and Jawad, two of the software engineers driving MI's digital infrastructure forward. From developing robust software to tackling complex technical challenges, they ensure our digital platform runs seamlessly today and is ready for tomorrow's possibilities.

#onlywithHCR: Bhandiwad et al. utilized #HCRtechnology to map the neural activity underlying tonic immobility. They found that this outlines a complete sensorimotor circuit, revealing how the brainstem circuit suppresses movement when facing threats. Read more: tinyurl.com/4dcxhs38

Stop by Booth #630 and meet the MI team at #2025NSHConvention this weekend! Join us for a joint workshop with Indica Labs to see how HCR™ Pro and AI-powered HALO image analysis come together to advance RNA and protein co-detection assays. 🗓️ Saturday, September 27th 📍 Workshop #30 at 4:45 PM PST

Take a look at this FFPE mouse brain sample showcasing true same-species multiplexing, enabled by the HCR™ HiFi Encoder! Detect multiple same-species primaries with no cross-reactivity, complex steps, or special workarounds. 🔬 Pre-order the Launch Edition: tinyurl.com/mr4295e6

#onlywithHCR: Monroy et al. investigated the timing and localization of key transcription factors during neural crest (NC) development in chicken, quail, and peafowl. They found that quail NC cells initiate expression of SNAI2, SOX9, and SOX10 at earlier stages. Read more: tinyurl.com/yt4fycah

In this premiere episode, we introduce the HCR™ HiFi Encoder – a powerful new tool that lets you rapidly encode any unmodified primary antibody in just minutes. Say goodbye to fixed antibody panels and hello to true flexibility, fidelity, and freedom in your IF workflow! tinyurl.com/y53682bk

📢 Short RNA target detection is now powered by HCR™ Pro RNA-ISH on the Leica Biosystems BOND RX research staining platforms! Streamline your workflow with HCR™ Pro RNA-ISH automated on the BOND RX, now expanded for a wider range of research applications.

#onlywithHCR: Sun et al. uncovered a crucial role for Zic5 in Xenopus eye development. Using #HCRtechnology, they showed Zic5 expression in the RPE and NR at the optic vesicle stage, where it helps tune Hedgehog signaling to ensure proper eye development. Read more: tinyurl.com/mrxru323

We're excited to announce the HCR™ HiFi Encoder, a breakthrough advancement that delivers robust amplification for any primary antibody and enables same-species multiplex immunofluorescence! Read the full PR: tinyurl.com/2ctxx5d6 Pre-order Launch Edition bundles: tinyurl.com/mr4295e6

#BehindMI: Meet some of the members of our Admin team, powering the engine behind the scenes at MI, bringing both our goals and your orders to life. From processing purchase orders to keeping records up to date, they ensure our mission runs smoothly and the HCR™ community stays fully supported!

Submissions for the 3D Imaging World Cup close tonight! This is your last chance to share your best light-sheet images—new or previously published—and compete for prizes. We’re blown away by the incredible submissions so far! Submit your entries here: tinyurl.com/mr3ct9f8

#onlywithHCR: Busby et al. utilized #HCRtechnology to track gene expression during chicken somitogenesis. They revealed a stalled cell state linked to Hox genes, indicating that developmental timing is set intrinsically but can also be influenced by extrinsic cues. Read more: tinyurl.com/pxs5jrcu

#onlywithHCR: Janesick et al. created an RNA-seq atlas of the chicken cochlea, revealing regenerative insights. Using #HCRtechnology to validate gene expression, they found tonotopic gradients along the cochlea, setting up the stage for comparative studies. Read more: tinyurl.com/2t7zhfwn

It’s official—we’re two weeks away from the Final Whistle for the 3D Imaging World Cup! Thank you for your amazing light-sheet submissions, and we can’t wait to see what stunning images come in during this final stretch. Enter your submission here: www.alpenglowbiosciences.com/3d-imaging-w...

#onlywithHCR: With #HCRtechnology, Witch et al. revealed that salamander brain comparisons point to the DVR and neocortex evolving through convergence, while the mammalian olfactory-entorhinal-hippocampal circuit may trace back to ancestral origins. Read more: tinyurl.com/4bwm599u

What an amazing time at West Coast SDB in SLO! Huge thanks to everyone who joined us at Cal Poly to hear our CCO, Dr. Aneesh Acharya, unveil exciting updates to the HCR™ platform. It was a pleasure connecting with the dev bio community and seeing the enthusiasm surrounding the future of MI!

#onlywithHCR: Treen et al. pinpointed two Prdm1 homologs as the earliest FGF-responsive genes. By combining #HCRtechnology with genetic and experimental manipulations, they found a sharp developmental transition between the 8- and 16-cell stages. Read more: genesdev.cshlp.org/content/37/3...

We're thrilled to be at the 2025 SDB West Coast Meeting tomorrow! Join Dr. Acharya as he shares exciting updates on the HCR™ platform. 📍Cal Poly SLO 🗓️ Friday, 8/15 | 2:00–2:45 PM We’re looking forward to connecting with the dev bio community. Don’t miss your chance to grab limited-edition merch!

#onlywithHCR: Kim et al. dissected how human pyramidal neurons connect to inhibitory interneurons in a cell type-specific manner. Using #HCRtechnology to confirm cell types and gene expression, they discovered conserved synaptic motifs in human brain circuits. Read more: tinyurl.com/4nrsm275

The countdown is on for the 3D Imaging World Cup 2025! Don’t miss your chance to share your best light-sheet images—new or previously published—and compete for prizes. 💡Early submissions by August 8th will earn an extra 50 bonus points! Submit your entry here: tinyurl.com/mr3ct9f8

The countdown is on for the 3D Imaging World Cup 2025! Don’t miss your chance to share your best light-sheet images—new or previously published—and compete for prizes. 💡Early submissions by August 8th will earn an extra 50 bonus points! Submit your entry here: tinyurl.com/mr3ct9f8

#BehindMI: Meet Wudy Yang, Jacob Prohroff, Randy Chen, and Alexandra Delgadillo — the team driving innovation at MI. Driven by curiosity and grounded in scientific rigor, their work ensures that HCR™ technology remains a trusted tool for researchers, enabling precise and efficient discovery.

#onlywithHCR: Lin et al. mapped ~500K nuclei across 19 CNS regions in marmoset to chart glial diversity. With #HCRtechnology, they visualized key gene expression patterns in OLIG2+ cells, revealing transcriptional shifts in white matter glia within a 3D context. Read more: tinyurl.com/bdfadjnr

#onlywithHCR: Colquitt et al. mapped how the loss of auditory feedback destabilizes learned motor behaviors. Using #HCRimaging, they were able to observe the widespread gene expression changes across the birdsong sensorimotor circuit caused by deafening. 🔬Read the full story: tinyurl.com/3fb2hpps

We're excited to announce major upgrades to the HCR™ platform! 🧬 HiFi Architecture enables miRNA/siRNA detection with unmatched clarity. 🧪 RTU Dispensers now ship for DISCOVERY ULTRA, enabling scalable, low-variability workflows. Explore the full announcement: tinyurl.com/39je4x8x

#onlywithHCR: Task et al. mapped the expression of all major chemosensory co-receptors in Drosophila melanogaster. This revealed that Ir25a is co-expressed with Orco, suggesting a more integrated receptor network. Explore the full story here: elifesciences.org/articles/725...

It’s time to meet the judges for the 2025 3D Imaging World Cup—a panel of scientific experts representing diverse fields! These leaders will be reviewing your work anonymously and voting to select our finalists. Ready to compete? Enter your submission here: tinyurl.com/mr3ct9f8

With HCR Pro, we deliver ultra-sensitive detection, ideal for low-abundance targets or highly autofluorescent samples. Learn more about how HCR™ Pro enables RNA + protein codetection in yolk-rich Xenopus embryos. 🔬Get your free kit: tinyurl.com/2hkzbppj 📄 Case study:https://tinyurl.com/yeep56t3

Join us for a Lunch & Learn at the Harvard Center for Biological Imaging! This session will feature a talk by Dr. Aneesh Acharya, who will share new and exciting updates on #HCRtechnology. 📍 16 Divinity Ave, BioLabs RM1080 🗓️ July 22nd, 2025 at 12:00 PM