#onlywithHCR: Bhandiwad et al. utilized #HCRtechnology to map the neural activity underlying tonic immobility. They found that this outlines a complete sensorimotor circuit, revealing how the brainstem circuit suppresses movement when facing threats. Read more: tinyurl.com/4dcxhs38

Stop by Booth #630 and meet the MI team at #2025NSHConvention this weekend! Join us for a joint workshop with Indica Labs to see how HCR™ Pro and AI-powered HALO image analysis come together to advance RNA and protein co-detection assays. 🗓️ Saturday, September 27th 📍 Workshop #30 at 4:45 PM PST

Take a look at this FFPE mouse brain sample showcasing true same-species multiplexing, enabled by the HCR™ HiFi Encoder! Detect multiple same-species primaries with no cross-reactivity, complex steps, or special workarounds. 🔬 Pre-order the Launch Edition: tinyurl.com/mr4295e6

#onlywithHCR: Monroy et al. investigated the timing and localization of key transcription factors during neural crest (NC) development in chicken, quail, and peafowl. They found that quail NC cells initiate expression of SNAI2, SOX9, and SOX10 at earlier stages. Read more: tinyurl.com/yt4fycah

In this premiere episode, we introduce the HCR™ HiFi Encoder – a powerful new tool that lets you rapidly encode any unmodified primary antibody in just minutes. Say goodbye to fixed antibody panels and hello to true flexibility, fidelity, and freedom in your IF workflow! tinyurl.com/y53682bk

📢 Short RNA target detection is now powered by HCR™ Pro RNA-ISH on the Leica Biosystems BOND RX research staining platforms! Streamline your workflow with HCR™ Pro RNA-ISH automated on the BOND RX, now expanded for a wider range of research applications.

#onlywithHCR: Sun et al. uncovered a crucial role for Zic5 in Xenopus eye development. Using #HCRtechnology, they showed Zic5 expression in the RPE and NR at the optic vesicle stage, where it helps tune Hedgehog signaling to ensure proper eye development. Read more: tinyurl.com/mrxru323

We're excited to announce the HCR™ HiFi Encoder, a breakthrough advancement that delivers robust amplification for any primary antibody and enables same-species multiplex immunofluorescence! Read the full PR: tinyurl.com/2ctxx5d6 Pre-order Launch Edition bundles: tinyurl.com/mr4295e6

#BehindMI: Meet some of the members of our Admin team, powering the engine behind the scenes at MI, bringing both our goals and your orders to life. From processing purchase orders to keeping records up to date, they ensure our mission runs smoothly and the HCR™ community stays fully supported!

Submissions for the 3D Imaging World Cup close tonight! This is your last chance to share your best light-sheet images—new or previously published—and compete for prizes. We’re blown away by the incredible submissions so far! Submit your entries here: tinyurl.com/mr3ct9f8

#onlywithHCR: Busby et al. utilized #HCRtechnology to track gene expression during chicken somitogenesis. They revealed a stalled cell state linked to Hox genes, indicating that developmental timing is set intrinsically but can also be influenced by extrinsic cues. Read more: tinyurl.com/pxs5jrcu

#onlywithHCR: Janesick et al. created an RNA-seq atlas of the chicken cochlea, revealing regenerative insights. Using #HCRtechnology to validate gene expression, they found tonotopic gradients along the cochlea, setting up the stage for comparative studies. Read more: tinyurl.com/2t7zhfwn

It’s official—we’re two weeks away from the Final Whistle for the 3D Imaging World Cup! Thank you for your amazing light-sheet submissions, and we can’t wait to see what stunning images come in during this final stretch. Enter your submission here: www.alpenglowbiosciences.com/3d-imaging-w...

#onlywithHCR: With #HCRtechnology, Witch et al. revealed that salamander brain comparisons point to the DVR and neocortex evolving through convergence, while the mammalian olfactory-entorhinal-hippocampal circuit may trace back to ancestral origins. Read more: tinyurl.com/4bwm599u

What an amazing time at West Coast SDB in SLO! Huge thanks to everyone who joined us at Cal Poly to hear our CCO, Dr. Aneesh Acharya, unveil exciting updates to the HCR™ platform. It was a pleasure connecting with the dev bio community and seeing the enthusiasm surrounding the future of MI!

#onlywithHCR: Treen et al. pinpointed two Prdm1 homologs as the earliest FGF-responsive genes. By combining #HCRtechnology with genetic and experimental manipulations, they found a sharp developmental transition between the 8- and 16-cell stages. Read more: genesdev.cshlp.org/content/37/3...

We're thrilled to be at the 2025 SDB West Coast Meeting tomorrow! Join Dr. Acharya as he shares exciting updates on the HCR™ platform. 📍Cal Poly SLO 🗓️ Friday, 8/15 | 2:00–2:45 PM We’re looking forward to connecting with the dev bio community. Don’t miss your chance to grab limited-edition merch!

#onlywithHCR: Kim et al. dissected how human pyramidal neurons connect to inhibitory interneurons in a cell type-specific manner. Using #HCRtechnology to confirm cell types and gene expression, they discovered conserved synaptic motifs in human brain circuits. Read more: tinyurl.com/4nrsm275

The countdown is on for the 3D Imaging World Cup 2025! Don’t miss your chance to share your best light-sheet images—new or previously published—and compete for prizes. 💡Early submissions by August 8th will earn an extra 50 bonus points! Submit your entry here: tinyurl.com/mr3ct9f8

The countdown is on for the 3D Imaging World Cup 2025! Don’t miss your chance to share your best light-sheet images—new or previously published—and compete for prizes. 💡Early submissions by August 8th will earn an extra 50 bonus points! Submit your entry here: tinyurl.com/mr3ct9f8

#BehindMI: Meet Wudy Yang, Jacob Prohroff, Randy Chen, and Alexandra Delgadillo — the team driving innovation at MI. Driven by curiosity and grounded in scientific rigor, their work ensures that HCR™ technology remains a trusted tool for researchers, enabling precise and efficient discovery.

#onlywithHCR: Lin et al. mapped ~500K nuclei across 19 CNS regions in marmoset to chart glial diversity. With #HCRtechnology, they visualized key gene expression patterns in OLIG2+ cells, revealing transcriptional shifts in white matter glia within a 3D context. Read more: tinyurl.com/bdfadjnr

#onlywithHCR: Colquitt et al. mapped how the loss of auditory feedback destabilizes learned motor behaviors. Using #HCRimaging, they were able to observe the widespread gene expression changes across the birdsong sensorimotor circuit caused by deafening. 🔬Read the full story: tinyurl.com/3fb2hpps

We're excited to announce major upgrades to the HCR™ platform! 🧬 HiFi Architecture enables miRNA/siRNA detection with unmatched clarity. 🧪 RTU Dispensers now ship for DISCOVERY ULTRA, enabling scalable, low-variability workflows. Explore the full announcement: tinyurl.com/39je4x8x

#onlywithHCR: Task et al. mapped the expression of all major chemosensory co-receptors in Drosophila melanogaster. This revealed that Ir25a is co-expressed with Orco, suggesting a more integrated receptor network. Explore the full story here: elifesciences.org/articles/725...

It’s time to meet the judges for the 2025 3D Imaging World Cup—a panel of scientific experts representing diverse fields! These leaders will be reviewing your work anonymously and voting to select our finalists. Ready to compete? Enter your submission here: tinyurl.com/mr3ct9f8

With HCR Pro, we deliver ultra-sensitive detection, ideal for low-abundance targets or highly autofluorescent samples. Learn more about how HCR™ Pro enables RNA + protein codetection in yolk-rich Xenopus embryos. 🔬Get your free kit: tinyurl.com/2hkzbppj 📄 Case study:https://tinyurl.com/yeep56t3

Join us for a Lunch & Learn at the Harvard Center for Biological Imaging! This session will feature a talk by Dr. Aneesh Acharya, who will share new and exciting updates on #HCRtechnology. 📍 16 Divinity Ave, BioLabs RM1080 🗓️ July 22nd, 2025 at 12:00 PM

#onlywithHCR: In a remarkable study, O’Gorman et al. explored how traits evolve in tandem in Astyanax mexicanus. The team mapped oca2 gene expression in hybrid fish—uncovering a shared molecular signature in pigmentation and sleep behavior. Dive into the full story here: tinyurl.com/4uya4xzz

We’ve been getting a lot of excitement and questions about the 3D Imaging World Cup 2025—so we’re here with some answers! Swipe through this carousel to learn more about the prizes, requirements, and competition structure. This is your time to shine! Enter your submission here: tinyurl.com/mr3ct9f8

We’re thrilled to be at #IZFC in Madison, Wisconsin! Visit us at Booth #6 to meet our team and explore how HCR™ technology can elevate your manual workflows. We’re excited to share the latest updates and connect with the dynamic zebrafish research community – see you there!

HCR™ Pro RNA-ISH for manual workflows delivers high-fidelity RNA-ISH signal across both brightfield and fluorescence detection modalities – giving you flexibility without having to buy new probes. Request your free HCR™ Pro Starter Kit today: hcrimaging.typeform.com/manual-HCR-Pro

Say hello to Brian Kang, Kelly Tran, Britney Lozano, and Caitlyn Starman—the talented team responsible for manufacturing every HCR™ amplifier we ship! Thanks to their precision and dedication, we’re able to consistently deliver reliable reagents that empower cutting-edge research across the globe.

#onlywithHCR: In a cross-species study, Guillotin et al. unveiled how domesticated grasses evolved distinct traits through fine-scale changes in root cell types, revealing orthologous gene markers and highlighting which cell types evolved rapidly. Read the full story here: tinyurl.com/peny8r64

We had a great time at ICDB connecting with the developmental biology community. From engaging poster sessions to thoughtful conversations at our booth, it was exciting to see how researchers are leveraging HCR™ technology! Missed our posters or want a second look? tinyurl.com/3axjns8t

HCR™ Pro Detect kits for the DISCOVERY ULTRA platform are now available in a pre-filled, RTU format – designed to minimize hands-on time, streamline setup, and improve consistency across runs. Learn more here: tinyurl.com/4npt8857

#onlywithHCR: Morales et al. explore the hidden world of bacterial–fungal interactions (BFI). Using #HCRimaging, the team overcame key barriers in detecting endohyphal bacteria and visualized bacterial presence within fungal structures. Explore the full findings here: tinyurl.com/ya5vpy66

We’re excited to be in San Juan, Puerto Rico this week for the 20th International Congress of Developmental Biology (ICDB)! Catch us during Poster Session C on Saturday (June 21) from 2:00 – 5:00 PM. Be sure to stop by Booth #10 to meet the team. We're looking forward to connecting with you!

It’s your time to shine! The 3D Imaging World Cup 2025 is in full swing—we’ve gotten so many amazing Light-Sheet image submissions and are excited to see the rest roll in. Enter your submission here: www.alpenglowbiosciences.com/3d-imaging-w...

We're excited to announce the launch of HCR™ Pro RNA-ISH for manual workflows, bringing the extreme sensitivity of enzymatic amplification to researchers working with low-abundance targets and challenging samples. Read the full press release to learn more: tinyurl.com/yws3pbkp

#onlywithHCR: Schember et al. compared the regulatory landscapes of the single-minded (sim) gene in two divergent insects. Using #HCRimaging, their findings highlight the evolutionary rewiring of the gene regulatory network. Read the full study here: journals.plos.org/plosgenetics...

We’re excited to be at this year’s International Congress of Developmental Biology (ICDB) Annual Meeting in San Juan, Puerto Rico. Come visit us at Booth #10, and check out our posters – we can’t wait to share the latest from MI with you!

#onlywithHCR: In a fascinating study, Lopez and Alward used #HCRimaging to visualize cyp19a1 (brain-specific aromatase) mRNA expression in A. burtoni, providing new insight into how androgen signaling may influence social behavior. Read the full study here: pmc.ncbi.nlm.nih.gov/articles/PMC...

We are thrilled to announce the 3D Imaging World Cup 2025 with Alpenglow Biosciences! 🔬 The competition invites researchers to submit their stunning 3D datasets, share groundbreaking work, and compete for exciting prizes. This is your time to shine! 📤 Submit your entry here: tinyurl.com/mr3ct9f8

We're excited to announce our partnership with Alpenglow Biosciences to advance high-resolution 3D RNA imaging in intact biological samples! Read the full press release here: tinyurl.com/5x2ke4xn

#BehindMI: Meet Arturo Ortiz, Caitlyn Neal-Steinkruger, and Justin Romero — the logistics team behind every shipment that leaves our facility and heads straight to you! Their commitment helps us deliver high-quality, reliable products to researchers — efficiently and confidently.

#onlywithHCR: Gray and Lovely leveraged #HCRimaging to fluorescently visualize rar and rxr mRNA in transgenic zebrafish embryos, revealing overlapping expression of multiple rar/rxr genes between 12–32 hours post-fertilization. Read the full study here: tinyurl.com/5crp99fs

Thank you to everyone who attended our webinar! Special thanks to our incredible speakers—Dr. Damsky, Dr. Acharya, and Dr. Ramos—for sharing their expertise and insights into the development of LDTs for psoriasis and atopic dermatitis. The replay is now available here: my.demio.com/recording/xJ...

🇬🇧 Closing Out the MI UK Tour: We ended the week with a visit to the Leica Biosystems Innovation Center in Newcastle — great to connect with their UK team in person. Hard to believe the MI UK Tour has come to an end – thanks to everyone who spent time with us along the way!

🇬🇧 Day 4 of the MI UK Tour: We continued the tour and visited Kelly Hunter from ProPath, and took part in the Methods in Neuroscience seminar at the University of Manchester. The energy this week has been incredible – engaging conversations and such a welcoming atmosphere everywhere we go!