We’re excited to share that Visiopharm will be attending the HCR™ User Symposium in Boston on Feb 19. Dan Winkowski, their Senior Technical Sales Specialist, will be on site to share a live demo of the #Visiopharm software! Register by February 6:https://tinyurl.com/yfjme2eb

✨ HCR™ Gold Q&A✨ In this segment, we’re breaking down everything you want to know about HCR™ Gold RNA-FISH. Swipe through our carousel to see all the answers and discover why HCR™ Gold is the go-to choice for robust, versatile RNA-FISH. Order HCR™ Gold here: tinyurl.com/4jj6uvvd

We’re excited to announce Jong Gwan Lee and Henry Bushnell as guest speakers for the Boston HCR™ User Symposium! ✅ Free to attend + lunch provided 🎁 Bring a friend! All attendees receive a complimentary HCR™ HiFi Probe. Feb 19 | 10AM - 3PM | Boston, MA RSVP by Feb 6: tinyurl.com/yfjme2eb

We’re excited to welcome Elizabeth Hicks-Kridel as our Senior Director, Global Head of Sales. Elizabeth brings extensive life sciences experience that will further elevate our growing commercial organization, and we’re looking forward to the impact she’ll have as we build and scale together.

We’re excited to announce the first two guest speakers for the Boston HCR™ User Symposium! Discover what’s ahead with a full day of sessions highlighting the newest HCR™ capabilities, exciting talks, and real-world applications in RNA and protein detection. RSVP by Feb 6: tinyurl.com/yfjme2eb

Swipe to see how HCR™ Gold differs from HCR™ (v3.0). v3.0 remains supported for ongoing experiments; however, all new products are compatible only with HCR™ Gold. Simpler, more robust, higher resolution RNA-FISH starts here. 💡 Starter Kit: tinyurl.com/yyuc7bvx 🛒 Shop: tinyurl.com/4jj6uvvd

Join us in Boston for the HCR™ User Symposium! 📍 Feb 19, 2026 | 10am–3pm | Boston, MA Explore the latest in HCR™ technology with insights from leading academic researchers on what’s next in RNA and protein detection. 🔗 RSVP by Feb 6 to join us!: tinyurl.com/yfjme2eb

✨ HCR™ Gold RNA-FISH ✨ Celebrating 1 year of HCR™ Gold! In just a year, HCR™ Gold’s raised the bar for RNA imaging with 10-plex, high-resolution detection, built-in background suppression, and robust performance across sample types and targets. Try the Starter Kit: tinyurl.com/yyuc7bvx

Happy 2026 from all of us at MI! We’re thankful for the HCR™ community and the trust you’ve placed in our tools and team. As we step into the new year, we’re excited to continue supporting your next experiments, ideas, and breakthroughs. Wishing you a healthy, inspiring, and successful year ahead!

As 2025 wraps up, we’re proud of a year of progress at MI, featuring the launches of HCR™ Gold, manual HCR™ Pro, and HCR™ Gold IF to enable faster, more robust, accessible workflows. Thank you to our team, users, and partners for making this work possible, and here’s to the discoveries ahead! 🚀

Thank you, Nipam Patel and Ssanvi Turki from the MBL, for sharing this example of HCR™ Gold IF with four mouse IgG1 encoded antibodies visualized in a whole-mount fruit fly embryo. It’s a great reminder that the HCR™ HiFi Encoders are built for robust multiplexing and straightforward workflows.

Thinking about upgrading your workflow? Get your HCR™ HiFi Probes for just $250 when you transition from v3.0. Reach out to our support team to get started. Plus, all orders placed this month include a free pair of exclusive MI socks (while supplies last). 🧦 Order today: tinyurl.com/4jj6uvvd

Shoutout to Tom Pettini for striking images with the new HCR™ Gold IF assay – overcoming same-species antibody limits to multiplex mouse primaries on cell and nuclear membranes, and showcasing the versatility of the HCR™ HiFi Encoders by working with high-quality primaries from CST and DSHB!

#onlywithHCR: LaBelle et al. reveal that cell–cell collisions are drivers of the dispersal of endodermal cells in zebrafish embryos. With #HCRtechnology, they observed epha2a expression, finding that endodermal cells undergo RhoA-dependent, active repulsion-type CIL. Read more: tinyurl.com/mrx934sc

In this third video, we’ll show you just how straightforward it is to encode your primary antibodies. Follow along with a step-by-step demonstration of the HCR™ HiFi Encoding protocol so you can confidently integrate the HCR™ Gold IF assay into your own workflows! Watch here: youtu.be/f5NCbg2Vwms

#onlywithHCR: Diaz Soria et al. used scRNA-seq with #HCRtechnology to build a cellular atlas of the mother sporocyst, spatially validating 6 major cell types and revealing key regulators of early parasite growth and snail-host interaction. Read the full study @nature.com: tinyurl.com/bp7dbsjx

Get Cozy this December! 🧦 Every order placed in December will come with a free pair of exclusive MI socks, while supplies last. Don't miss your chance to snag this limited-time treat! Order here: www.molecularinstruments.com/shop

What an exciting meeting at this month’s Gene Expression and RNA Series (GEARS) in Boston! Thank you to everyone who joined us for an introduction to the HCR™ platform. Special shoutout to @xiaoliwu.bsky.social, jonmarkert.bsky.social, and @ara-latifkar.bsky.social for helping coordinate the event!

This year's SfN was a valuable opportunity to connect with the neuroscience community, share our latest work, and demonstrate how the HCR™ HiFi Encoder supports more adaptable multiplex IF. Thank you to everyone who stopped by! We look forward to seeing you all again at future meetings.

With the HCR™ HiFi Encoder, @dhouston.bsky.social (@uiowabiology.bsky.social) ran two @dshb-antibodies.bsky.social mouse IgG1 antibodies directly from supernatant and achieved robust double-labeling using HCR™ Gold IF. 🔬 Ready to try HCR™ Gold IF? Get a free Starter Kit here: tinyurl.com/37dfdenf

We can't wait to be at SFN this year! Visit Booth #833, and see how HCR™ technology is empowering researchers to advance discoveries in neuroscience! Come chat with our team, and discover how MI can support your next breakthrough.

🪧 SITC Poster Spotlight In our final SITC Poster Spotlight, we showcased the newly launched HCR™ HiFi Encoders and their ability to enable rapid, flexible multiplex IF with off-the-shelf antibodies –– no carrier-free or glycerol-free storage media required. 🔬Read more: tinyurl.com/5dn5y4a4

🪧 SITC Poster Spotlight Our next spotlight establishes an RNA-first translational workflow for diagnostic development with the lateral flow assay. This poster highlights how the HCR™ platform facilitates molecular tracking from discovery to clinical diagnostics. 🔬Read more: tinyurl.com/5dn5y4a4

🪧 SITC Poster Spotlight Last weekend, we shared how the next-gen HCR™ HiFi Probe architecture enables background-suppressed in situ detection of short RNA targets by integrating full-length HCR™ initiators with a novel background suppression strategy. 🔬Check out the poster: tinyurl.com/5dn5y4a4

#onlywithHCR: Goldman et al. created the Aedes aegypti Mosquito Cell Atlas, revealing novel cell types, the organization of sensory neuron chemoreceptors, and sexually dimorphic gene expression in the antenna and brain. 🦟 Read more: tinyurl.com/2rtk4bz2

We’re thrilled to be attending #SITC2025 this year! Visit us at Booth #626 and don’t miss our poster presentations, as we’ll be sharing exciting new findings and real-world applications! 🗓️ Friday (Nov 7) — Abstract #171 & Abstract #75 🗓️ Saturday (Nov 8) — Abstract #68

#BehindMI: Meet Sulan Wu and Adam Maddox, two of the leaders on our Operations Strategy Team, who guide cross-functional coordination, optimize processes, and strengthen product validation. Their work positions MI to support cutting-edge research around the world with speed, reliability, and scale!

Happy Halloween from the MI team! Check out this spooky-themed rat hippocampus image by Jamuna Tandukar using #HCRimaging. 🧠 🟣 Mettl3 ⚪️ astrocytes 🟢 nuclei 🟠 rRNA

#onlywithHCR: Gillis et al. used #HCRtechnology to visualize gene expression during gill slit formation in skate embryos, revealing a precise sequence of epithelial interactions between the endoderm and ectoderm. 🔬 Read more: tinyurl.com/3mvj2wu2

Fast. Simple. High-fidelity IF. The HCR™ HiFi Encoder gives you the power to encode any unmodified primary in just 10 minutes at RT. Use your existing antibodies and achieve high-fidelity multiplex IF with HCR™ Gold. 🔬Place your HCR™ Gold IF order here: tinyurl.com/57f8nmb8

We’re proud to partner with Abcam to make multiplex IF simpler, faster, and more flexible! The HCR™ HiFi Encoder offers broad compatibility with Abcam’s primary antibodies, providing HCR™ Gold amplification for the antibodies you already know and trust. Full press release: tinyurl.com/5a43h8cr

#onlywithHCR: Rajan et al. illuminated how multicellular dynamics shape olfactory neurogenesis in zebrafish. These findings show how coordinated signaling supports ongoing neuron production in a complex organ system. Read more: tinyurl.com/3tpmf4v3

🚀The HCR™ HiFi Encoder is now live, bringing plug-and-play practicality to multiplex IF. ✅ Multiplex same-species primaries, no cross-reactivity ✅ Encode in 10 min at RT, no affinity loss ✅ Unlock high-fidelity amplification with HCR™ Gold 🛒Order today: tinyurl.com/mr4295e6

#onlywithHCR: Romero et al. explored how pathogenic TP53 variants contribute to congenital anomalies of the kidney and urinary tract and genital defects. Using Xenopus embryos, they observed that the expression of mutant TP53 disrupted kidney morphogenesis. Read more here: tinyurl.com/mr3yfwzy

Episode 2 of the HCR™ HiFi Encoder series is now live! This time, we’re walking through the entire encoding protocol from start to finish. See just how easy it is to integrate into your workflow: no purification, no conjugation, only 10 minutes at room temperature. www.youtube.com/watch?v=1rRJ...

Check out this whole-mount fruit fly image from Dr. Nipam Patel and Saanvi Turki, powered by the HCR™ HiFi Encoder. With the Encoder, you can functionalize any unmodified primary antibody with no purification, no reformulation, and no signal loss. 🔬Pre-order the Launch Edition: tinyurl.com/mr4295e6

#BehindMI: Meet Mohamad and Jawad, two of the software engineers driving MI's digital infrastructure forward. From developing robust software to tackling complex technical challenges, they ensure our digital platform runs seamlessly today and is ready for tomorrow's possibilities.

#onlywithHCR: Bhandiwad et al. utilized #HCRtechnology to map the neural activity underlying tonic immobility. They found that this outlines a complete sensorimotor circuit, revealing how the brainstem circuit suppresses movement when facing threats. Read more: tinyurl.com/4dcxhs38

Stop by Booth #630 and meet the MI team at #2025NSHConvention this weekend! Join us for a joint workshop with Indica Labs to see how HCR™ Pro and AI-powered HALO image analysis come together to advance RNA and protein co-detection assays. 🗓️ Saturday, September 27th 📍 Workshop #30 at 4:45 PM PST

Take a look at this FFPE mouse brain sample showcasing true same-species multiplexing, enabled by the HCR™ HiFi Encoder! Detect multiple same-species primaries with no cross-reactivity, complex steps, or special workarounds. 🔬 Pre-order the Launch Edition: tinyurl.com/mr4295e6

#onlywithHCR: Monroy et al. investigated the timing and localization of key transcription factors during neural crest (NC) development in chicken, quail, and peafowl. They found that quail NC cells initiate expression of SNAI2, SOX9, and SOX10 at earlier stages. Read more: tinyurl.com/yt4fycah

In this premiere episode, we introduce the HCR™ HiFi Encoder – a powerful new tool that lets you rapidly encode any unmodified primary antibody in just minutes. Say goodbye to fixed antibody panels and hello to true flexibility, fidelity, and freedom in your IF workflow! tinyurl.com/y53682bk

📢 Short RNA target detection is now powered by HCR™ Pro RNA-ISH on the Leica Biosystems BOND RX research staining platforms! Streamline your workflow with HCR™ Pro RNA-ISH automated on the BOND RX, now expanded for a wider range of research applications.

#onlywithHCR: Sun et al. uncovered a crucial role for Zic5 in Xenopus eye development. Using #HCRtechnology, they showed Zic5 expression in the RPE and NR at the optic vesicle stage, where it helps tune Hedgehog signaling to ensure proper eye development. Read more: tinyurl.com/mrxru323

We're excited to announce the HCR™ HiFi Encoder, a breakthrough advancement that delivers robust amplification for any primary antibody and enables same-species multiplex immunofluorescence! Read the full PR: tinyurl.com/2ctxx5d6 Pre-order Launch Edition bundles: tinyurl.com/mr4295e6

#BehindMI: Meet some of the members of our Admin team, powering the engine behind the scenes at MI, bringing both our goals and your orders to life. From processing purchase orders to keeping records up to date, they ensure our mission runs smoothly and the HCR™ community stays fully supported!

Submissions for the 3D Imaging World Cup close tonight! This is your last chance to share your best light-sheet images—new or previously published—and compete for prizes. We’re blown away by the incredible submissions so far! Submit your entries here: tinyurl.com/mr3ct9f8

#onlywithHCR: Busby et al. utilized #HCRtechnology to track gene expression during chicken somitogenesis. They revealed a stalled cell state linked to Hox genes, indicating that developmental timing is set intrinsically but can also be influenced by extrinsic cues. Read more: tinyurl.com/pxs5jrcu

#onlywithHCR: Janesick et al. created an RNA-seq atlas of the chicken cochlea, revealing regenerative insights. Using #HCRtechnology to validate gene expression, they found tonotopic gradients along the cochlea, setting up the stage for comparative studies. Read more: tinyurl.com/2t7zhfwn

It’s official—we’re two weeks away from the Final Whistle for the 3D Imaging World Cup! Thank you for your amazing light-sheet submissions, and we can’t wait to see what stunning images come in during this final stretch. Enter your submission here: www.alpenglowbiosciences.com/3d-imaging-w...