At #AACR26, we’re sharing how the HCR™ platform is helping advance oncology research through flexible, multiplexed approaches. We're featuring several posters that highlight #HCRtechnology across multiplex IF, spatial biology, and tumor profiling. Schedule a meeting with us: tinyurl.com/y662n5zz

Last chance to RSVP 📢 Our Joint Symposium with Glint Lab and Visiopharm is this Friday, and we’re excited to bring together a great lineup of speakers to highlight the latest breakthroughs in in situ hybridization and advanced image analysis. RSVP here: hcrimaging.typeform.com/to/Mery7VKI

We’re excited to co-sponsor the San Diego #MultiomicsMixer and help bring the community together for an evening focused on advancing multiomics. Join us at Mission Brewing in East Village on April 20th for great conversations, live music, tacos, headshots, and more! RSVP here: luma.com/ue2ikq08

Ahead of #AACR2026, we’re revisiting a poster developed with St. Jude and Bruker: Development of a multi-omic spatial phenotyping assay for affirmative detection of CAR-T cells in the tumor immune microenvironment of solid pediatric tumors. Schedule a 1-1 with us at AACR: tinyurl.com/y662n5zz

We’re excited to bring the broader research community together for a Joint Symposium in San Diego on April 17 from 12-2:30 PM, just ahead of the AACR Annual Meeting. Reserve your spot here: hcrimaging.typeform.com/to/Mery7VKI

Join us for an upcoming Lunch and Learn at the @ucsfcancer.bsky.social in San Francisco, CA! 🗓️ Wednesday, April 8 | 11:45 AM – 1:30 PM 📍 Bakar Room, Helen Diller Family Comprehensive Cancer Center Register here: hcrimaging.typeform.com/to/pEUzaiv2

On behalf of MI, Glint Lab, and Visiopharm, we’re excited to invite you to our Joint User Symposium! 📍 San Diego, CA 🗓️ April 17th / 12 - 2:30 PM This event is designed to highlight the latest breakthroughs in in situ hybridization and advanced image analysis. RSVP here: tinyurl.com/4ehfktv7

We were thrilled by the turnout for our webinar! A special thank you to the Miller Lab for sharing their research on how #HCRtechnology can visualize gene expression in the developing kidney and study how genetic variants disrupt nephron development. Watch the replay here: tinyurl.com/54eyp4ed

Meet our team from April 19-22 at Booth #2017 and learn how the HCR™ platform is empowering real-world cancer research! We’ll be sharing how researchers use #HCRimaging to get more out of every sample while producing data that stands up to real-world analysis in oncology. See you at #AACR26!

Last call! Join us for our upcoming webinar, “Spatial Mapping of Kidney Development and Disease Mechanisms in Xenopus laevis,” with the Miller Lab. 🗓️ Wednesday, April 1 🕤 8:00 AM PT / 10:00 AM CT Register today: my.demio.com/ref/2ZwGxz9P...

Tune in on April 1 at 8:00 AM PT / 10:00 AM CT for a preview of never-before-shared images, and see how #HCRtechnology helps the Miller Lab investigate genes linked to CAKUT and better understand the mechanisms driving congenital kidney disease. Register here: my.demio.com/ref/2ZwGxz9P...

Join Molecular Instruments, Glint Lab, and Visiopharm for an engaging session, exploring the latest advances in in situ hybridization, image analysis, and their growing impact in cancer research and beyond. 🗓️April 17 / 12:00 – 2:30 PM 📍Wyndham San Diego Bayside Register today: tinyurl.com/4ehfktv7

Discover how the Xenopus pronephros serves as a powerful system for studying nephrogenesis and human kidney disorders, and learn how the Miller Lab uses #HCRimaging to map gene expression across nephron segments! 🗓️ Wednesday, April 1 🕤 8:00 AM PT / 10:00 AM CT Register today: tinyurl.com/2hxemxss

Submissions are open for the HCR™ Image Contest: Best-In-Suit. From whole-mount Xenopus embryos to FFPE cancer tissue sections, we can’t wait to see your images with HCR™ Gold and HCR™ Pro. 🏆 Winners will be featured in and receive our limited-edition deck of cards! Submit here: lnkd.in/gyBws_yY

New Webinar: Spatial Mapping of Kidney Development and Disease Mechanisms in Xenopus laevis Join us on April 1 at 8:00 AM PT / 10:00 AM CT for a webinar to learn how the Miller Lab uses Xenopus laevis to study nephron development in the embryonic kidney. Register here: tinyurl.com/2hxemxss

We had a fantastic time at Neurocrine yesterday connecting with the broader team and showcasing the latest HCR™ technology and its translational research applications. Thank you to Robby Johnson for helping coordinate the event. We had a great time and look forward to continuing the conversation!

Whether it’s extreme sensitivity or a visually stunning field of view, we want to see the power of your HCR™ platform in action. 🏆Selected Best-in-Suit winners will be featured in and receive our limited-edition HCR™ deck of cards! 📥 Submit your entry here: hcrimaging.typeform.com/image-contest

A study from Jimenez et al. brings high-res molecular readouts to Paroedura picta. Using #HCRtechnology, the team mapped gene expression in the embryonic gecko brain, enabling clear mRNA visualization in a system with limited species-specific antibody options. Read more: tinyurl.com/5dnwkm3h

We’re inviting you to share your most compelling HCR™ Gold or HCR™ Pro images! Selected entries will receive and be featured in our limited-edition deck of cards, showcasing standout research and the visual power of the HCR™ platform. 📥 Submit your entry here: tinyurl.com/mpem2yj6

Last week, we were proud to bring the HCR™ User Symposium to Boston and connect with so many individuals! Thank you to everyone who joined us and contributed to such an engaging event. We hope these conversations throughout the day sparked meaningful dialogue that extends well past our event.

HCR™ Pro RNA-ISH just got more flexible! Now you can pair HCR™ HiFi Probes you know and trust, seamlessly across X1-X10 systems, delivering high sensitivity and robust signal-to-background performance for challenging, low-abundance targets. 🔬Get started with a free Starter Kit: lnkd.in/gsYapMnA

Today’s the last day to secure a spot and join us in Boston for the HCR™ User Symposium! ✔️Bring a colleague! All attendees will receive a complimentary HCR™ HiFi Probe for any target of their choice ✔️Networking opportunity ✔️Free to attend with a provided lunch RSVP today: tinyurl.com/yfjme2eb

Join us on February 19th at the Boston HCR™ User Symposium for a live, hands-on session with Maciej Zerkowski, featuring a walkthrough of @indicalabs.bsky.social’s HALO® software and a deep dive into AI-powered RNA-ISH analysis. RSVP by Friday, February 6: hcrimaging.typeform.com/to/qAGFCv2L

Manual HCR™ Pro RNA-ISH now supports all X1-X10 systems! Use your existing HCR™ HiFi Probes for extreme-sensitivity detection of low-abundance targets. 👉 Get started with the Starter Kit: tinyurl.com/2hkzbppj 🛒 Explore and order manual HCR™ Pro: tinyurl.com/awnn5v38

We’re thrilled to have Nipam Patel joining the HCR™ User Symposium to share real examples of how multiplex HCR™ imaging can reveal developmental patterns in context. 🎁 All attendees will receive a complimentary HCR™ HiFi Probe. Feb 19 | 10AM - 3PM | Boston, MA RSVP by Feb 6: tinyurl.com/yfjme2eb

We’re excited to share that Visiopharm will be attending the HCR™ User Symposium in Boston on Feb 19. Dan Winkowski, their Senior Technical Sales Specialist, will be on site to share a live demo of the #Visiopharm software! Register by February 6:https://tinyurl.com/yfjme2eb

✨ HCR™ Gold Q&A✨ In this segment, we’re breaking down everything you want to know about HCR™ Gold RNA-FISH. Swipe through our carousel to see all the answers and discover why HCR™ Gold is the go-to choice for robust, versatile RNA-FISH. Order HCR™ Gold here: tinyurl.com/4jj6uvvd

We’re excited to announce Jong Gwan Lee and Henry Bushnell as guest speakers for the Boston HCR™ User Symposium! ✅ Free to attend + lunch provided 🎁 Bring a friend! All attendees receive a complimentary HCR™ HiFi Probe. Feb 19 | 10AM - 3PM | Boston, MA RSVP by Feb 6: tinyurl.com/yfjme2eb

We’re excited to welcome Elizabeth Hicks-Kridel as our Senior Director, Global Head of Sales. Elizabeth brings extensive life sciences experience that will further elevate our growing commercial organization, and we’re looking forward to the impact she’ll have as we build and scale together.

We’re excited to announce the first two guest speakers for the Boston HCR™ User Symposium! Discover what’s ahead with a full day of sessions highlighting the newest HCR™ capabilities, exciting talks, and real-world applications in RNA and protein detection. RSVP by Feb 6: tinyurl.com/yfjme2eb

Swipe to see how HCR™ Gold differs from HCR™ (v3.0). v3.0 remains supported for ongoing experiments; however, all new products are compatible only with HCR™ Gold. Simpler, more robust, higher resolution RNA-FISH starts here. 💡 Starter Kit: tinyurl.com/yyuc7bvx 🛒 Shop: tinyurl.com/4jj6uvvd

Join us in Boston for the HCR™ User Symposium! 📍 Feb 19, 2026 | 10am–3pm | Boston, MA Explore the latest in HCR™ technology with insights from leading academic researchers on what’s next in RNA and protein detection. 🔗 RSVP by Feb 6 to join us!: tinyurl.com/yfjme2eb

✨ HCR™ Gold RNA-FISH ✨ Celebrating 1 year of HCR™ Gold! In just a year, HCR™ Gold’s raised the bar for RNA imaging with 10-plex, high-resolution detection, built-in background suppression, and robust performance across sample types and targets. Try the Starter Kit: tinyurl.com/yyuc7bvx

Happy 2026 from all of us at MI! We’re thankful for the HCR™ community and the trust you’ve placed in our tools and team. As we step into the new year, we’re excited to continue supporting your next experiments, ideas, and breakthroughs. Wishing you a healthy, inspiring, and successful year ahead!

As 2025 wraps up, we’re proud of a year of progress at MI, featuring the launches of HCR™ Gold, manual HCR™ Pro, and HCR™ Gold IF to enable faster, more robust, accessible workflows. Thank you to our team, users, and partners for making this work possible, and here’s to the discoveries ahead! 🚀

Thank you, Nipam Patel and Ssanvi Turki from the MBL, for sharing this example of HCR™ Gold IF with four mouse IgG1 encoded antibodies visualized in a whole-mount fruit fly embryo. It’s a great reminder that the HCR™ HiFi Encoders are built for robust multiplexing and straightforward workflows.

Thinking about upgrading your workflow? Get your HCR™ HiFi Probes for just $250 when you transition from v3.0. Reach out to our support team to get started. Plus, all orders placed this month include a free pair of exclusive MI socks (while supplies last). 🧦 Order today: tinyurl.com/4jj6uvvd

Shoutout to Tom Pettini for striking images with the new HCR™ Gold IF assay – overcoming same-species antibody limits to multiplex mouse primaries on cell and nuclear membranes, and showcasing the versatility of the HCR™ HiFi Encoders by working with high-quality primaries from CST and DSHB!

#onlywithHCR: LaBelle et al. reveal that cell–cell collisions are drivers of the dispersal of endodermal cells in zebrafish embryos. With #HCRtechnology, they observed epha2a expression, finding that endodermal cells undergo RhoA-dependent, active repulsion-type CIL. Read more: tinyurl.com/mrx934sc

In this third video, we’ll show you just how straightforward it is to encode your primary antibodies. Follow along with a step-by-step demonstration of the HCR™ HiFi Encoding protocol so you can confidently integrate the HCR™ Gold IF assay into your own workflows! Watch here: youtu.be/f5NCbg2Vwms

#onlywithHCR: Diaz Soria et al. used scRNA-seq with #HCRtechnology to build a cellular atlas of the mother sporocyst, spatially validating 6 major cell types and revealing key regulators of early parasite growth and snail-host interaction. Read the full study @nature.com: tinyurl.com/bp7dbsjx

Get Cozy this December! 🧦 Every order placed in December will come with a free pair of exclusive MI socks, while supplies last. Don't miss your chance to snag this limited-time treat! Order here: www.molecularinstruments.com/shop

What an exciting meeting at this month’s Gene Expression and RNA Series (GEARS) in Boston! Thank you to everyone who joined us for an introduction to the HCR™ platform. Special shoutout to @xiaoliwu.bsky.social, jonmarkert.bsky.social, and @ara-latifkar.bsky.social for helping coordinate the event!

This year's SfN was a valuable opportunity to connect with the neuroscience community, share our latest work, and demonstrate how the HCR™ HiFi Encoder supports more adaptable multiplex IF. Thank you to everyone who stopped by! We look forward to seeing you all again at future meetings.

With the HCR™ HiFi Encoder, @dhouston.bsky.social (@uiowabiology.bsky.social) ran two @dshb-antibodies.bsky.social mouse IgG1 antibodies directly from supernatant and achieved robust double-labeling using HCR™ Gold IF. 🔬 Ready to try HCR™ Gold IF? Get a free Starter Kit here: tinyurl.com/37dfdenf

We can't wait to be at SFN this year! Visit Booth #833, and see how HCR™ technology is empowering researchers to advance discoveries in neuroscience! Come chat with our team, and discover how MI can support your next breakthrough.

🪧 SITC Poster Spotlight In our final SITC Poster Spotlight, we showcased the newly launched HCR™ HiFi Encoders and their ability to enable rapid, flexible multiplex IF with off-the-shelf antibodies –– no carrier-free or glycerol-free storage media required. 🔬Read more: tinyurl.com/5dn5y4a4

🪧 SITC Poster Spotlight Our next spotlight establishes an RNA-first translational workflow for diagnostic development with the lateral flow assay. This poster highlights how the HCR™ platform facilitates molecular tracking from discovery to clinical diagnostics. 🔬Read more: tinyurl.com/5dn5y4a4

🪧 SITC Poster Spotlight Last weekend, we shared how the next-gen HCR™ HiFi Probe architecture enables background-suppressed in situ detection of short RNA targets by integrating full-length HCR™ initiators with a novel background suppression strategy. 🔬Check out the poster: tinyurl.com/5dn5y4a4

#onlywithHCR: Goldman et al. created the Aedes aegypti Mosquito Cell Atlas, revealing novel cell types, the organization of sensory neuron chemoreceptors, and sexually dimorphic gene expression in the antenna and brain. 🦟 Read more: tinyurl.com/2rtk4bz2