Now in #Science #Immunology: @griffithslab.bsky.social report that when #CD8 #TCells encounter their targets, #nucleus localizes to the #ImmuneSynapse (IS) & facilitates delivery of newly synthesized cytokines to the IS. They find nuclear polarization represents key step in #CTL -mediated killing!

Looking forward to a great meeting next week! Email or DM me if you would like to chat!

The August issue of #Science #Immunology is out! This week: T peripheral helper cells expressing IGFL2 contribute to rheumatoid #arthritis; vagal TRPV1+ sensory #neurons protect against #influenza virus infection; & transfer of #Tregs alleviates #inflammaging in mice! wwwscience.org/toc/sciimmun...

The July issue of #Science #Immunology is out now! This week: • Additional levels of #IL13RA1 gene regulation help explain susceptibility to #allergy! • Spi-B is a #checkpoint of #type2 immunity by restraining #TuftCell activation in gut! New content each week! www.science.org/toc/sciimmun...

This month in #Science #Immunology, Shivangi Dave & André Ballesteros Tato at the #NIH review the noncanonical contributions of #TFollicularHelper ( #TFH ) cells cells to immune regulation beyond their traditional roles in #BCell help! science.org/doi/10.1126/sciimmunol.adr1052

The June issue of #Science #Immunology has launched! This week: inducible #FoxP3 degradation in #Tregs; the immune landscape of human #psoriatic #arthritis; & #IL12 gives #mRNA #vaccines a boost! New content every week! Check it out! www.science.org/toc/sciimmun...

This month in #Science #Immunology: @nickmroz.bsky.social, @phagocyticpai.bsky.social, @annamolofskylab.bsky.social, & @arimolofskylab.bsky.social pen an insightful & timely Review on crosstalk between the #nervous system & #type2 immunity! #WeekendRead #neuroimmunology #allergy #Alzheimers #itch

This is a public service announcement: late-breaking abstract submissions for #IUIS2025 will close tomorrow (May 6)! You can submit your abstracts here: iuis2025.org/abstracts/ I hope to see many of you this August in beautiful Vienna!!! #Immunology #Science2025 #CallForAbstracts #IUIS

The May issue of #Science #Immunology is out now! This week: #interferon regulates #thymic epithelial cell differentiation; #efferocytosis determines #alveolar #macrophage functional plasticity: & mapping the #stromal cell landscape of human #LymphNodes! science.org/toc/sciimmunol/10/107

Happy Int'l #DayofImmunology! To celebrate, here are some recent Reviews from the pages of #Science #Immunology!!! First up: Kumagai, Momoi, & Nishikawa survey recent literature on links between #cancer genetic abnormalities & #immunosuppression that cause clinical resistance to #immunotherapy!

On #WorldMalariaDay, check out this brand new study on human T cell memory responses to #malaria from the lab of Pras Jagannathan at Stanford! 🦟🩸 www.science.org/doi/10.1126/...

A new #ScienceImmunology study in mice suggests that bacterial skin infections can imprint eosinophils with innate immune memory and enhance allergic inflammation in the lungs.

#Immunology out now @science.org After initial priming in the lymph nodes, mouse CD8 T cells undergo a second phase of stable interactions with dendritic cells that can preferentially stimulate those with a high-affinity for antigen. buff.ly/49bKcTG By Jobin, Seetharama, Rüttger et al.

The April issue of #Science #Immunology is out now! This past week: two papers describe how #skin #inflammation can drive #type2 immune responses in other #mucosal tissues, while a third describes how #hunger perception in the #brain regulates peripheral immune cell dynamics! Check it out!

1/ Excited to share my first-ever first-author paper out now in Science Immunology! from @knapplab.bsky.social and co-supervised by @miershawig.bsky.social We show that hematopoietic aging, independent of lung tissue aging, is sufficient to exacerbate fibrosis. 🔗 www.science.org/doi/10.1126/...

#Bluetorial: In our latest paper on #gdTcells and #IBD in #ScienceImmunology we found that γδ IEL number and regulatory function are severely compromised BEFORE ileal inflammation occurs, suggesting that γδ IELs may maintain IEL homeostasis in response to a pro-inflammatory microenvironment. 1/n

We are thrilled to share our new manuscript @science.org , in which we uncovers a critical role for macrophage peroxisomes in lung repair after viral infection. Could targeting peroxisomes be the key to mitigating long COVID?! www.science.org/doi/10.1126/...

To celebrate with the @keystonesymposia.bsky.social #myeloid cell meeting happening now in Hannover, we have released a free collection of 6 recent #Science #Immunology papers focused on myeloid cells! Check 'em out! They will be available until the end of April! bit.ly/SciImm_free #KSmyeloid25

To commemorate #RareDiseaseDay, here are some recent #Science #Immunology research papers that elucidate the immune mechanisms underlying certain rare human diseases and/or report new strategies to treat them! @science.org

This week in #Science #Immunology: A comprehensive review from Darrell Irvine and co-authors on recent advances in understanding #vaccine #adjuvant mechanisms of action, which could guide adjuvant design for vaccines against emerging and challenging pathogens:

Timely study by Katherine Kedzierska and Jamie Rossjohn and colleagues defining key structural features of #Tcell binding to circulating #influenza strains from 1918 to ~present #ImmunoSky www.science.org/doi/10.1126/...

Now out in #Science #Immunology (and also featured on the cover!): Lutz, @simonhaas.bsky.social, Weinhold, & al. use single-cell and spatial multiomics to characterize breakout lesions in #multiplemyeloma, identifying regions of immune and tumor cell coevolution:

I’ll be here (joint with T cell Differentiation in Tissue Microenvironments) next week! Send me a message or email if you’d like to set up a time to chat. Looking forward to an exciting meeting!

1/ New in #ScienceImmunologyResearch! We explored how the brain maintains equilibrium with the immune system. Our focus? The key player in immune tolerance and tissue function regulation: regulatory T cells (Tregs). Let’s dive in! www.science.org/doi/10.1126/... @immunoeditor.bsky.social

A #Science #Immunology Instant Release: @mmr2.bsky.social, Diane Mathis, & colleagues at @harvard.edu & @institutocajal.bsky.social describe specialized meningeal #Treg subsets that promote #homeostasis of the mouse #brain #meninges & #parenchyma!

In #Science #Immunology this week: human naïve B cells can bind and neutralize #H5N1, potentially offering protection against #birdflu.

A great review last week in #Science #Immunology from Bhandarkar, Dinter, & Spranger:

I’ll be here (joint with T cell Differentiation in Tissue Microenvironments) next week! Send me a message or email if you’d like to set up a time to chat. Looking forward to an exciting meeting!

Excited to share our work on cytotoxic CD8+ T cells in donor lymphocyte infusions for treatment of AML relapsed after HSCT, out today in @sciimmunology.bsky.social! Great working with @elhamazizi.bsky.social on this exciting area! www.science.org/doi/10.1126/...

Last week in #ScienceImmunology, Cody Elkins, Chaoran Li, & al. reported that visceral adipose tissue Tregs engage Srebf2-dependent cholesterol #metabolism to support their homeostatic functions in mice, which becomes dysregulated during #obesity:

This week in #Science #Immunology: Luigi Notarangelo & >100 colleagues characterize the immune & molecular features of 157 patients w/ various forms of #RAG #immunodeficiency! This is a real tour de force! @niaidnews.bsky.social

In this week’s issue of #ScienceImmunology (and featured on a very timely cover!), Pradeep Ramalingam, Jason Butler, & al. identified thrombospondin-1 as a driver of age-associated changes in hematopoietic stem cells: www.science.org/doi/10.1126/...

Suppression of the inflammation that occurs with aging ("inflammaging") by blocking thrombospondin-1 (Thbs1), prevented age-related blood stem cell defects and expanded lifespan in the mouse model (KO-knockout) www.science.org/doi/10.1126/...

And read my write-up on Bagchi et al. this week in ScienceAdviser!

Check out the rest of the collection here ⤵️

Also from my 2024 Editors’ Choice selections (and free in #ScienceImmunology through February): Dunsmore, Ng, Blériot, Ginhoux, & al. provide a time- and space-resolved picture of tumor-associated #macrophage development in pancreatic tumors:

From my 2024 Editors’ Choice selections (and free in #ScienceImmunology through February): Ruscitti, Radermecker, Marichal, & al. identified a population of lung #macrophages expressing Ly6G (typically found on neutrophils!) that promote alveolar repair after injury caused by #flu infection:

New review out in #science #immunology on tuberculosis immunopathology by @tomscriba.bsky.social et al.🫁🦠 www.science.org/doi/10.1126/...

Out this week @science.org by first release: Specific combinations of nutrients and metabolic enzymes determine T cell differentiation via loci-specific histone acetylations. https://buff.ly/4gvqKTz From Shixin Ma, Sue Kaech @tcellogic.bsky.social and colleagues #Immunology #immunometabolism

Check out the research that inspired this month’s beautiful cover!

#WeAreWhatWeEat! Bosurgi, Gagliani, Liebold &co show @science.org that apoptotic cells of different origin engage distinct phagocytosis receptors determining the response of #macrophages to IL4 & to a parasitic #worm infection! doi.org/10.1126/scie...

Hello BlueSky! Looking forward to sharing all things #Immunology, #Host-pathogen and #hematology! As we are heading towards the end of 2024, I'll post highlights published @science.org so far this year - and hot-of-the press research from our December issues!

Now in #Science #Immunology: Ziang Zhu, Tuoqi Wu, Chen Yao et al at UT Southwestern show that #NRF2 suppression mediated by the #redox sensor #KEAP1 is required for optimal expansion of #CD8 #TCells during chronic antigen exposure!

LRRK2...an important player in apparently unrelated disorders from brain to gut...novel gut insights coming to you right now... just check the latest in Science Immunology! www.science.org/doi/10.1126/...

A #ScienceImmunology review from earlier this year by @kuchroolab.bsky.social and co-authors discusses emerging roles of TIM-3 in immune responses including in #myeloidcells. #WeekendReads

This week in #ScienceImmunology: @jackiheraudfarlow.bsky.social , Carl Walkley, & colleagues used a genome-wide #CRISPRscreen to determine that a GGNBP2– CNOT10/11 complex is required for the accumulation of unedited #immunogenic self- #dsRNA & its sensing by #MDA5!

Last week in #ScienceImmunology: An alternative approach to target TIM-3 for cancer #immunotherapy? Zhang et al. found that palmitoylation of human TIM-3 promoted its stability. Blocking palmitoylation accelerated TIM-3 degradation, prevented immune #exhaustion and promoted anti-tumor #immunity

This month in #ScienceImmunology, @virusesimmunity.bsky.social & colleagues reported that #ERV -reactive #B1Cells secrete #antibodies that recognize GlcNAc moieties on both ERV #glycoproteins as well as glycoproteins of other enveloped #viruses!